Mutual Regulation of Hematopoietic Stem Cell Niche_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIANG Yueyang , WU Chengyi

Department of Endocrine Surgery, The First Affiliated Hospital, Chongqing University of Medical Sciences ， Chongqing 400016, China;

Corresponding author：

Keywords：

Hematopoietic stem cell,Niche,Osteoblastic cell

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【Abstract】Objective To give a summary of the current researches on hematopoietic stem cell niche. Methods Through extensive reviewing the related domestic and abroad literatures, the present summary reviews the components of hematopoietic stem cell niche, related cell factors and related cell signaling pathway participating in regulation of hematopoietic stem cell. Results The activities of hematopoietic stem cells are regulated by the niche (microenvironment), which is composed of hematopoietic stem cell and its surrounding cells. The regulation cannot be completed through one signaling pathway. Also, the self-renewal and differentiation of hematopoietic stem cell cannot be completed only through osteoblastic cells. Conclusion The niche regulates hematopoietic stem cells by different ways. With study in-depth, we will comprehensively understand the nature of stem cells and the study will provide a broader space to stem cell-based therapy.

Citation： LIANG Yueyang,WU Chengyi. Mutual Regulation of Hematopoietic Stem Cell Niche. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(3): 171-173. doi: Copy

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19.	Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’-Kinase/Akt signal transduction pathway [J]. Circ Res, 2000; 86(1)∶24.
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1. 31 Semerad CL, Christopher MJ, Liu F, et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow [ J ] . Blood, 2005; 106(9) ∶ 3020.
2. Gordon A Ed. Regulation of hematopoietic stem cells [M]. New York: Appleton Century Crofts， 1970∶161-185.
3. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell [J]. Blood Cells, 1978; 4(1-2)∶7.
4. Moore KA. Recent advances in defining the hematopoietic stem cell niche [J]. Curr Opin Hematol, 2004; 11(2)∶107.
5. Perkins S, Fleischman RA. Hematopoietic microenvironment. Origin, lineage, and transplantability of the stromal cells in long-term bone marrow cultures from chimeric mice [J]. J Clin Invest, 1988; 81(4)∶1072.
6. 付相建, 陈幸华. 造血微环境对急性白血病细胞的作用研究进展 [J]. 西南军医, 2006; 8(1)∶66.
7. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells [J]. Science, 1999; 284(5411)∶143.
8. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche [J]. Nature, 2001; 414(6859)∶98.
9. 冯振月, 潘敏慧, 鲁成. 果蝇生殖腺干细胞和它们的微环境 [J]. 细胞生物学杂志, 2006; 28(1)∶169.
10. Suda T, Arai F, Shimmura S. Regulation of stem cells in the niche [J]. Cornea, 2005; 24(8 Suppl)∶S12.
11. Cosimo DB, Pringle S, Pitzalis C, et al. The stem cell niche: a new target in medicine [J]. Curr Opin Orthop, 2006; 17(5)∶398.
12. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size [J]. Nature, 2003; 425(6960)∶836.
13. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche [J]. Nature, 2003; 425(6960)∶841.
14. Visnjic D, Kalajzic Z, Rowe DW, et al. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency [J]. Blood, 2004; 103(9)∶3258.
15. Cheshier SH, Morrison SJ, Liao X, et al. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells [J]. Proc Natl Acad Sci USA, 1999; 96(6)∶3120.
16. Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J]. Cell, 2004; 118(2)∶149.
17. Davis S, Aldrich TH, Jones PF, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [J]. Cell, 1996; 87(7)∶1161.
18. Cheng T, Rodrigues N, Shen H, et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1 [J]. Science, 2000; 287(5459)∶1804.
19. Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’-Kinase/Akt signal transduction pathway [J]. Circ Res, 2000; 86(1)∶24.
20. Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis [J]. Circ Res, 2002; 90(12)∶1243.
21. Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival [J]. J Biol Chem, 2002; 277(13)∶11352.
22. Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells [J]. Cancer Res, 2003; 63(1)∶196.
23. Pazianos G, Uqoezwa M, Reya T. The elements of stem cell self-renewal: a genetic perspective [J]. Biotechniques, 2003; 35(6)∶1240.
24. van de Wetering M, de Lau W, Clevers H. WNT signaling and lymphocyte development [J]. Cell, 2002; 109(Suppl)∶S13.
25. Reya T. Regulation of hematopoietic stem cell self-renewal [J]. Recent Prog Horm Res, 2003; 58∶283.
26. Rattis FM, Voermans C, Reya T. Wnt signaling in the stem cell niche [J]. Curr Opin Hematol, 2004; 11(2)∶88.
27. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells [J]. Nature, 2003; 423(6938)∶409.
28. Jamora C, DasGupta R, Kocieniewski P, et al. Links between signal transduction, transcription and adhesion in epithelial bud development [J]. Nature, 2003; 422(6929)∶317.
29. Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance [J]. Nat Immunol, 2005; 6(3)∶314.
30. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J]. Nat Immunol, 2001; 2(2)∶172.
31. Katayama Y, Battista M, Kao WM, et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow [J]. Cell, 2006; 124(2)∶407.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Mutual Regulation of Hematopoietic Stem Cell Niche

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