• 1. Department of General Surgery, The Affiliated Hospital of Dali University, Dali 671000, China;;
  • 2. Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;
Abdominal aortic aneurysm; 　　Extracellular matrix; 　　Matrix metalloproteinases; 　　 Treatment
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Objective　To investigate pathogenesis and therapeutic prospect of abdominal aortic aneurysm (AAA). Methods　 Relevant literatures about pathogenesis and ways of treatment for AAA in recent years were reviewed. Results　The formation of AAA are associated with heredity, anatomy, environment and biochemistry and other factors. All factors influence and interact with each other. The metabolic disequilibrium of aortic intermediate extracellular matrix plays an important role in the pathogenesis of AAA. The main reasons for the formation of AAA may be the increase of activity of matrix metalloproteinases and the disequilibrium of genetic expressions of elastin and collagen. The therapy of AAA includes surgical and medical treatment. The methods of medical treatment are still in the process of exploration and research. Conclusion　The formation of AAA is a synergistical result of multiple factors, and medical treatment is an important supplement of surgical treatment.

Citation： LIU Rengui,ZHAO Jichun. Pathogenesis and Therapeutic Prospect of Abdominal Aortic Aneurysm. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(6): 422-425. doi: Copy