Expressions and Significance of Ki67 and PTEN in Atypical Hyperplasia and Carcinoma of Stomach_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Hao , LI Yumin , HE Mingyan , LI Xun , ZHOU Wence , MENG Wenbo , ZHANG Lei

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China;

Corresponding author：

Keywords：

Gastric carcinoma; Ki67; Phosphatase and tensin homolog deleted on chromosome ten

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Objective 　To investigate the expressions of Ki67 and PTEN protein in human gastric atypical hyperplasia and carcinoma, and to explore their relations with gastric canceration and the possibility of being early biological markers.
Methods 　The expressions Ki67 and PTEN protein were detected by using immunohistochemical staining SP method in 22 cases of normal gastric tissues and 80 cases of atypical hyperplasia and 60 cases of gastric carcinoma.
Results 　The positive expression level of PTEN in normal gastric tissue was higher than that in atypical hyperplasia tissue, with the lowest level in gastric carcinoma, whereas, it was opposite for the expressions of Ki67 in these samples. The positive expression rates of PTEN and Ki67 were both well related with pathological grading of gastric tissues (r=-0.461 and 0.301， respectively， P＜0.01). The expression of PTEN was not obviously related with Lauren type, infiltration degree and differentiation level of gastric carcinoma, but it was associated with lymph node metastasis. For Ki67, it was found that there were correlations between the expression of Ki67 and Lauren type， lymph node metastasis， but not with infiltration degree， differentiation level of gastric carcinoma. Negative correlation was found between the expressions of PTEN and Ki67 protein in gastric carcinoma (r=-0.316， P＜0.05).
Conclusion 　Abnormal expressions of Ki67 and PTEN protein were associated with canceration in stomach. Therefore, both of them may act as useful biomarkers for early detection of gastric carcinoma.

Citation： CHEN Hao,LI Yumin,HE Mingyan,LI Xun,ZHOU Wence,MENG Wenbo,ZHANG Lei. Expressions and Significance of Ki67 and PTEN in Atypical Hyperplasia and Carcinoma of Stomach. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(3): 304-307. doi: Copy

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10.	Gottschalk AR, Basila D, Wong M, et al. p27Kip1 is required for PTEN-induced G1 growth arrest [Ｊ]. Cancer Res， 2001; 61(5)∶2105.
11.	Deng H, Wu RL, Zhou HY, et al. Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer [Ｊ]. World Journal of Gastroenterology, 2006; 12(7)∶1013.
12.	Im SA, Lee KE, Nam E, et al. Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas [Ｊ]. Tumori, 2005; 91(6)∶513.

1. Hlobilkova A, Guldberg P, Thullberg M, et al. Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity [Ｊ]. Exp Cell Res， 2000; 256(2)∶571.
2. 江明, 王红阳. PTEN/MMAC1/TEP1基因——一种新的肿瘤抑制基因和蛋白酪氨酸磷酸酶的研究进展 [Ｊ]. 国外医学·肿瘤学分册， 1998； 25（2）∶70.
3. Oki E, Kakeji Y, Tokunage E, et al. Impact of PTEN/AKT/PI3K signal pathway on the chemotherapy for gastric cancer [Ｊ]. Journal of Clinical Oncology, 2006; 24(18)∶187S.
4. Xu M, Jin YL, Fu J, et al. The abnormal expression of retinoic acid receptor-beta, p53 and Ki67 protein in normal, premalignant and malignant esophageal tissues [Ｊ]. World J Gastroenterol， 2002; 8(2)∶200.
5. 王舒宝，王俊. 胃癌复发与转移的有关问题及综合治疗 [Ｊ]. 中国普外基础与临床杂志， 2006； 13（1）∶9.
6. Ito K, Sasano H, Yabuki N, et al. Immunohistochemical study of Ki-67 and DNA topoisomerase Ⅱ in human endometrium [Ｊ]. Mod Pathol, 1997; 10(4)∶289.
7. Sulis ML, Parsons R. PTEN: from pathology to biology [Ｊ]. Trends Cell Biol, 2003; 13(9)∶478.
8. 陈道达，陈剑英. 早期胃癌诊断中的问题及可行对策 [Ｊ]. 中国普外基础与临床杂志， 2006； 13（1）∶7.
9. Tamura M, Gu J, Tran H, et al. PTEN gene and integrin signaling in cancer [Ｊ]. J Natl Cancer Inst， 1999; 91(21)∶1820.
10. Gottschalk AR, Basila D, Wong M, et al. p27Kip1 is required for PTEN-induced G1 growth arrest [Ｊ]. Cancer Res， 2001; 61(5)∶2105.
11. Deng H, Wu RL, Zhou HY, et al. Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer [Ｊ]. World Journal of Gastroenterology, 2006; 12(7)∶1013.
12. Im SA, Lee KE, Nam E, et al. Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas [Ｊ]. Tumori, 2005; 91(6)∶513.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions and Significance of Ki67 and PTEN in Atypical Hyperplasia and Carcinoma of Stomach

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