Review of Signal Pathway of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Gastric Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Xinzu ¹ , JIANG Kun ² , HU Jiankun ¹

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Gastric carcinoma; Apoptosis; Tumor necrosis factor-related apoptosis-inducing ligandSignal pathway

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Objective 　To review the current researches about tumor necrosis factor-related apoptosis ligand (TRAIL) and its receptors in gastric carcinoma.
Methods 　Relevant articles of researches on TRAIL and its receptors in gastric carcinoma were searched in electronic databases of PUB-MEDLINE and Chinese Journal Fulltext Database.
Results 　The reported TRAIL expression level of gastric carcinoma was diverse, which was highly correlated to the histological differentiation degree, serosa invasion and lymph node metastasis. Its receptors DR4 and DR5 were both positive in gastric carcinoma tissue, while some researches reported DcR1 and DcR2 were also positive expressed. caspase-3, -8 and survivin were the important factors for regulation of TRAIL signal pathway. 5-Aza-CdR, doxorubicin, 5-fluorouracil, α-TOS and X-ray irradiation might enhance the TRAIL-induced apoptosis of gastric carcinoma cells.
Conclusion 　Gastric carcinoma may be potentially sensitive to TRAIL targeting therapy, but the mechanism of TRAIL-induced apoptosis is quite complex and is regulated by multi-factors. Up to now, there are still many issues to research further, such as how to efficiently enhance and regulate the TRAIL-induced apoptosis of gastric carcinoma, whether any potential toxicities existing, etc.

Citation： CHEN Xinzu,JIANG Kun,HU Jiankun. Review of Signal Pathway of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(3): 371-375. doi: Copy

1.	Gores GJ, Kaufmann SH. Is TRAIL hepatotoxic? [J]. Hepatology， 2001; 34(1)∶3.
2.	Parkin DM. Global cancer statistics in the year 2000 [J]. Lancet Oncol， 2001; 2(9)∶533.
3.	孙秀娣, 牧人, 周有尚, 等. 中国胃癌死亡率20年变化情况分析及其发展趋势预测 [J]. 中华肿瘤杂志, 2004; 26(1)∶4.
4.	Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis [J]. Immunity， 1995; 3(6)∶673.
5.	Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors [J]. Cell Res， 2004; 14(5)∶359.
6.	Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors [J]. Science， 1997; 277(5327)∶818.
7.	僧靖静，张云汉，高冬玲. TRAIL、 Survivin mRNA表达与胃癌凋亡发生的相关关系 [J]. 河南大学学报(医学科学版)， 2005; 24(1)∶25.
8.	Yoo NJ, Kim HS, Kim SY, et al. Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas [J]. APMIS， 2003; 111(3)∶382.
9.	Sinicrope FA, Penington RC, Tang XM. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells [J]. Clin Cancer Res， 2004; 10(24)∶8284.
10.	Koyama S, Koike N, Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor [J]. J Cancer Res Clin Oncol， 2002; 128(2)∶73.
11.	张淑红, 周世庆, 真岩波, 等. 胃癌细胞Trail表达与细胞凋亡检测结果分析 [J]. 山东医药, 2002; 42(21)∶27.
12.	刘胜雄, 汤明, 吴飞跃. TRAIL在胃癌中的表达及其意义 [J]. 中国普通外科杂志, 2005; 14(10)∶789.
13.	程文芳, 易粹琼. 肿瘤坏死因子相关凋亡诱导配体的受体在胃癌中的表达 [J]. 中华内科杂志, 2003; 42(2)∶118.
14.	Kuraoka K, Matsumura S, Sanada Y, et al. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan [J]. Oncol Rep， 2005; 14(2)∶465.
15.	Park WS, Lee JH, Shin MS, et al. Inactivating mutations of KILLER/DR5 gene in gastric cancers [J]. Gastroenterology， 2001; 121(5)∶1219.
16.	张汝钢, 房殿春, 杨柳芹, 等. 5-Aza-CdR增强TRAIL对胃癌细胞的抗瘤活性与caspase-8表达的关系 [J]. 第三军医大学学报, 2005; 27(2)∶95.
17.	Harada K, Toyooka S, Shivapurkar N, et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines [J]. Cancer Res， 2002; 62(20)∶5897.
18.	Zuzak TJ, Steinhoff DF, Sutton LN, et al. Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma [J]. Eur J Cancer， 2002; 38(1)∶83.
19.	Fulda S, Kufer MU, Meyer E, et al. Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer [J]. Oncogene， 2001; 20(41)∶5865.
20.	张汝钢, 房殿春, 杨柳芹, 等. 5-Aza-CdR可提高TRAIL对胃癌细胞Kato3的抗瘤活性 [J]. 重庆医学, 2003; 32(9)∶1141.
21.	张汝钢, 房殿春, 杨柳芹, 等. 胃癌细胞对TRAIL的敏感性与caspase-8基因甲基化状态的关系 [J]. 第三军医大学学报, 2004; 26(2)∶95.
22.	Kanehara I, Nakata B, Hirakawa K. Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells [J]. Oncol Rep， 2005; 14(5)∶1249.
23.	杨柳芹, 房殿春, 张汝钢, 等. 胃癌细胞bcl-2和Caspase3的表达对TRAIL抗瘤作用的影响 [J]. 重庆医学, 2003; 32(9)∶1132.
24.	Yang LQ, Fang DC, Wang RQ, et al. Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand [J]. World J Gastroenterol， 2004; 10(1)∶22.
25.	Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med， 1997; 3(8)∶917.
26.	杨柳芹, 房殿春. 胃癌细胞NF-κB和survivin的表达对TRAIL抗瘤作用的影响 [J]. 第三军医大学学报, 2004; 26(7)∶584.
27.	程文芳, 易粹琼. 死亡配体TRAIL诱导胃癌细胞凋亡的研究 [J]. 中华消化内镜杂志, 2002; 19(4)∶229.
28.	程文芳, 易粹琼. 肿瘤坏死因子相关凋亡诱导配体诱导人胃癌耐药细胞凋亡的研究 [J]. 中华消化杂志, 2003; 23(10)∶590.
29.	Nam SY, Jung GA, Hur GC, et al. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers [J]. Cancer Sci， 2003; 94(12)∶1066.
30.	僧靖静, 张云汉, 高冬玲. TRAIL联合化疗药物诱导人胃癌细胞系BGC-823凋亡观察 [J]. 郑州大学学报(医学版), 2005; 40(3)∶442.
31.	Anderson K, Simmons-Menchaca M, Lawson KA, et al. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA [J]. Cancer Res， 2004; 64(12)∶4263.
32.	Tomasetti M, Rippo MR, Alleva R, et al. Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells [J]. Br J Cancer， 2004; 90(8)∶1644.
33.	杨柳芹, 房殿春. α-生育酚对TRAIL诱导胃癌细胞凋亡的影响及机制 [J]. 　解放军医学杂志, 2005; 30(9)∶779.
34.	Hamasu T, Inanami O, Asanuma T, et al. Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists [J]. J Radiat Res, 2005; 46(1)∶103.
35.	王正兵, 贾筱琴, 陈兵, 等. TRAIL真核表达质粒的构建及抑制肝癌生长的实验研究 [J]. 中国普外基础与临床杂志, 2005; 12（3）∶261.
36.	公伟，刘军，梁飞，等. TRAIL受体在胰腺癌中的表达 [J]. 中国普外基础与临床杂志, 2006; 13(5)∶521.

1. Gores GJ, Kaufmann SH. Is TRAIL hepatotoxic? [J]. Hepatology， 2001; 34(1)∶3.
2. Parkin DM. Global cancer statistics in the year 2000 [J]. Lancet Oncol， 2001; 2(9)∶533.
3. 孙秀娣, 牧人, 周有尚, 等. 中国胃癌死亡率20年变化情况分析及其发展趋势预测 [J]. 中华肿瘤杂志, 2004; 26(1)∶4.
4. Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis [J]. Immunity， 1995; 3(6)∶673.
5. Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors [J]. Cell Res， 2004; 14(5)∶359.
6. Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors [J]. Science， 1997; 277(5327)∶818.
7. 僧靖静，张云汉，高冬玲. TRAIL、 Survivin mRNA表达与胃癌凋亡发生的相关关系 [J]. 河南大学学报(医学科学版)， 2005; 24(1)∶25.
8. Yoo NJ, Kim HS, Kim SY, et al. Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas [J]. APMIS， 2003; 111(3)∶382.
9. Sinicrope FA, Penington RC, Tang XM. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells [J]. Clin Cancer Res， 2004; 10(24)∶8284.
10. Koyama S, Koike N, Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor [J]. J Cancer Res Clin Oncol， 2002; 128(2)∶73.
11. 张淑红, 周世庆, 真岩波, 等. 胃癌细胞Trail表达与细胞凋亡检测结果分析 [J]. 山东医药, 2002; 42(21)∶27.
12. 刘胜雄, 汤明, 吴飞跃. TRAIL在胃癌中的表达及其意义 [J]. 中国普通外科杂志, 2005; 14(10)∶789.
13. 程文芳, 易粹琼. 肿瘤坏死因子相关凋亡诱导配体的受体在胃癌中的表达 [J]. 中华内科杂志, 2003; 42(2)∶118.
14. Kuraoka K, Matsumura S, Sanada Y, et al. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan [J]. Oncol Rep， 2005; 14(2)∶465.
15. Park WS, Lee JH, Shin MS, et al. Inactivating mutations of KILLER/DR5 gene in gastric cancers [J]. Gastroenterology， 2001; 121(5)∶1219.
16. 张汝钢, 房殿春, 杨柳芹, 等. 5-Aza-CdR增强TRAIL对胃癌细胞的抗瘤活性与caspase-8表达的关系 [J]. 第三军医大学学报, 2005; 27(2)∶95.
17. Harada K, Toyooka S, Shivapurkar N, et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines [J]. Cancer Res， 2002; 62(20)∶5897.
18. Zuzak TJ, Steinhoff DF, Sutton LN, et al. Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma [J]. Eur J Cancer， 2002; 38(1)∶83.
19. Fulda S, Kufer MU, Meyer E, et al. Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer [J]. Oncogene， 2001; 20(41)∶5865.
20. 张汝钢, 房殿春, 杨柳芹, 等. 5-Aza-CdR可提高TRAIL对胃癌细胞Kato3的抗瘤活性 [J]. 重庆医学, 2003; 32(9)∶1141.
21. 张汝钢, 房殿春, 杨柳芹, 等. 胃癌细胞对TRAIL的敏感性与caspase-8基因甲基化状态的关系 [J]. 第三军医大学学报, 2004; 26(2)∶95.
22. Kanehara I, Nakata B, Hirakawa K. Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells [J]. Oncol Rep， 2005; 14(5)∶1249.
23. 杨柳芹, 房殿春, 张汝钢, 等. 胃癌细胞bcl-2和Caspase3的表达对TRAIL抗瘤作用的影响 [J]. 重庆医学, 2003; 32(9)∶1132.
24. Yang LQ, Fang DC, Wang RQ, et al. Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand [J]. World J Gastroenterol， 2004; 10(1)∶22.
25. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med， 1997; 3(8)∶917.
26. 杨柳芹, 房殿春. 胃癌细胞NF-κB和survivin的表达对TRAIL抗瘤作用的影响 [J]. 第三军医大学学报, 2004; 26(7)∶584.
27. 程文芳, 易粹琼. 死亡配体TRAIL诱导胃癌细胞凋亡的研究 [J]. 中华消化内镜杂志, 2002; 19(4)∶229.
28. 程文芳, 易粹琼. 肿瘤坏死因子相关凋亡诱导配体诱导人胃癌耐药细胞凋亡的研究 [J]. 中华消化杂志, 2003; 23(10)∶590.
29. Nam SY, Jung GA, Hur GC, et al. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers [J]. Cancer Sci， 2003; 94(12)∶1066.
30. 僧靖静, 张云汉, 高冬玲. TRAIL联合化疗药物诱导人胃癌细胞系BGC-823凋亡观察 [J]. 郑州大学学报(医学版), 2005; 40(3)∶442.
31. Anderson K, Simmons-Menchaca M, Lawson KA, et al. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA [J]. Cancer Res， 2004; 64(12)∶4263.
32. Tomasetti M, Rippo MR, Alleva R, et al. Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells [J]. Br J Cancer， 2004; 90(8)∶1644.
33. 杨柳芹, 房殿春. α-生育酚对TRAIL诱导胃癌细胞凋亡的影响及机制 [J]. 　解放军医学杂志, 2005; 30(9)∶779.
34. Hamasu T, Inanami O, Asanuma T, et al. Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists [J]. J Radiat Res, 2005; 46(1)∶103.
35. 王正兵, 贾筱琴, 陈兵, 等. TRAIL真核表达质粒的构建及抑制肝癌生长的实验研究 [J]. 中国普外基础与临床杂志, 2005; 12（3）∶261.
36. 公伟，刘军，梁飞，等. TRAIL受体在胰腺癌中的表达 [J]. 中国普外基础与临床杂志, 2006; 13(5)∶521.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Review of Signal Pathway of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Gastric Carcinoma

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