Expression of Thymidine Phosporylase and Counts of Lymph Vessels in Pancreatic Cancer and Chronic Pancreatitis Tissues_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Leping , YANG Zhulin , LIANG Shan , MIAO Xiongying , LI Qinglong

Research Laboratory of Hepatobiliary Disease, The Second Hospital of Central South University, Changsha 410011, China;

Corresponding author：

Keywords：

Pancreatic neoplasm; Chronic pancreatitis; Thymidine phosphorylase; Lymphoangiogenesis

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Objective 　To study the expression of thymidine phosporylase (TP) and the counts of lymph vessels in pancreatic cancer and chronic pancreatitis tissues, and to explore their clinicopathologic significances and correlation in the course of pancreatic cancer.
Methods 　SP immunohistochemical method was used to detetct the expression of TP and the locations of lymph vessels on the routinely paraffin-embedded sections of the specimens from 51 cases pancreatic cancer and 10 cases of chronic pancreatitis.
Results 　The positive rate of TP and the counts of lymph vessels were significantly higher (P＜0.05 and P＜0.01 respectively) in pancreatic cancer 〔54.9%, (12.5±4.3)/HP〕 than those in chronic pancreatitis 〔20.0%，(5.2±2.4)/HP〕. The positive rate of TP and the counts of lymph vessels were significantly lower （P＜0.05, P＜0.01） in well-differentiated adenocarcinoma cases and cases without metastasis compared with poor-differentiated adenocarcinoma cases and cases with metastasis. The counts of lymph vessels were significantly higher in the positive cases of TP than those in the negative ones in pancreatic cancer 〔(13.8±3.4)/HP vs (10.9±3.2)/HP〕, P＜0.01.
Conclusion 　The expression of TP and counts of lymph vessels might be important markers reflecting the progression, biological behaviors, metastatic status and prognosis of pancreatic cancer. TP might promote lympoangiogenesis in pancreatic cancer tissues.

Citation： YANG Leping,YANG Zhulin,LIANG Shan,MIAO Xiongying,LI Qinglong. Expression of Thymidine Phosporylase and Counts of Lymph Vessels in Pancreatic Cancer and Chronic Pancreatitis Tissues. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(4): 453-455. doi: Copy

1.	Takebayashi Y, Natsugoe S, Baba M, et al. Thymidine phosphorylase in human esophageal squamous cell carcinoma [Ｊ]. Cancer， 1999; 85(2)∶ 282.
2.	Toi M, Atiqur Rahman M, Bando H, et al. Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment [Ｊ]. Lancet Oncol, 2005; 6(3)　∶158.
3.	Terashima M, Fujiwara H, Takagane A, et al. Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients [Ｊ]. Eur J Cancer, 2002; 38(18)∶ 2375.
4.	Ciaparrone M, Quirino M, Schinzari G, et al. Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil [Ｊ]. Oncology, 2006; 70(5)∶366.
5.	Erkus M, Meteoglu I, Culhaci N, et al. Does thymidine phosphorylase correlate with angiogenesis in intraductal carcinoma of the breast? [Ｊ]. Saudi Med J, 2006; 27(9)∶1329.
6.	Kaiserling E. Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology [Ｊ]. Pathologe, 2004; 25(5)∶362.
7.	Van den Eynden GG, Van der Auwera I, Van Laere SJ, et al. Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study [Ｊ]. Br J Cancer, 2006; 94(11)∶1643.
8.	Takanami I. Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer [Ｊ]. Oncol Rep, 2006; 15(2)∶437.
9.	Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis [Ｊ]. Am J Pathol, 2007; 170(2)∶774.
10.	Sako A, Kitayama J, Ishikawa M, et al. Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer [Ｊ]. Gastric Cancer, 2006; 9(4)∶295.
11.	Osaki M, Sakatani T, Okamoto E, et al. Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel density in human gastric carcinomas [Ｊ]. Virchows Arch, 2000; 437(1)∶31.
12.	Shimabukuro T, Matsuyama H, Baba Y, et al. Expression of thymidine phosphorylase in human superficial bladder cancer [Ｊ]. Int J Urol, 2005; 12(1)∶29.
13.	Chujo M, Miura T, Kawano Y, et al. Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues [Ｊ]. Oncol Rep, 2006; 16(4)∶777.
14.	Marks A, Sutherland DR, Bailey D, et al. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours [Ｊ]. Br J Cancer, 1999; 80(3-4)∶569　.
15.	Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice [Ｊ]. EMBO J, 2001; 20(6)∶1223.
16.	Arigami T, Natsugoe S, Uenosono Y, et al. Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer [Ｊ]. Br J Cancer, 2005; 93(6)∶688.

1. 　Takebayashi Y, Natsugoe S, Baba M, et al. Thymidine phosphorylase in human esophageal squamous cell carcinoma [Ｊ]. Cancer， 1999; 85(2)∶ 282.
2. 　Toi M, Atiqur Rahman M, Bando H, et al. Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment [Ｊ]. Lancet Oncol, 2005; 6(3)　∶158.
3. 　Terashima M, Fujiwara H, Takagane A, et al. Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients [Ｊ]. Eur J Cancer, 2002; 38(18)∶ 2375.
4. 　Ciaparrone M, Quirino M, Schinzari G, et al. Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil [Ｊ]. Oncology, 2006; 70(5)∶366.
5. 　Erkus M, Meteoglu I, Culhaci N, et al. Does thymidine phosphorylase correlate with angiogenesis in intraductal carcinoma of the breast? [Ｊ]. Saudi Med J, 2006; 27(9)∶1329.
6. 　Kaiserling E. Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology [Ｊ]. Pathologe, 2004; 25(5)∶362.
7. 　Van den Eynden GG, Van der Auwera I, Van Laere SJ, et al. Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study [Ｊ]. Br J Cancer, 2006; 94(11)∶1643.
8. 　Takanami I. Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer [Ｊ]. Oncol Rep, 2006; 15(2)∶437.
9. 　Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis [Ｊ]. Am J Pathol, 2007; 170(2)∶774.
10. 　Sako A, Kitayama J, Ishikawa M, et al. Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer [Ｊ]. Gastric Cancer, 2006; 9(4)∶295.
11. 　Osaki M, Sakatani T, Okamoto E, et al. Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel density in human gastric carcinomas [Ｊ]. Virchows Arch, 2000; 437(1)∶31.
12. 　Shimabukuro T, Matsuyama H, Baba Y, et al. Expression of thymidine phosphorylase in human superficial bladder cancer [Ｊ]. Int J Urol, 2005; 12(1)∶29.
13. 　Chujo M, Miura T, Kawano Y, et al. Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues [Ｊ]. Oncol Rep, 2006; 16(4)∶777.
14. 　Marks A, Sutherland DR, Bailey D, et al. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours [Ｊ]. Br J Cancer, 1999; 80(3-4)∶569　.
15. 　Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice [Ｊ]. EMBO J, 2001; 20(6)∶1223.
16. 　Arigami T, Natsugoe S, Uenosono Y, et al. Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer [Ｊ]. Br J Cancer, 2005; 93(6)∶688.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Thymidine Phosporylase and Counts of Lymph Vessels in Pancreatic Cancer and Chronic Pancreatitis Tissues

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