1. |
Wolffe AP, Matzke MA. Epigenetics: regulation through repression [J]. Science, 1999; 286(5439)∶481.
|
2. |
Feinberg AP, Vogelstein B. Hypomethylation distinguishes ge-nes of some human cancers from their normal counterparts [J]. Nature, 1983; 301(5895)∶89.
|
3. |
Strahl BD, Allis CD. The language of covalent histone modifications [J]. Nature, 2000; 403(6765)∶41.
|
4. |
杨少辉, 戴冬秋. 肿瘤抑制基因甲基化与胃癌 [J]. 中国普外基础与临床杂志, 2006; 13(5)∶614.
|
5. |
Rea S, Eisenhaber F, O’Carroll D, et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases [J]. Nature, 2000; 406(6796)∶593.
|
6. |
Jenuwein T, Allis CD. Translating the histone code [J]. Science, 2001; 293(5532)∶1074.
|
7. |
Wang H, Cao R, Xia L, et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase [J]. Mol Cell, 2001; 8(6)∶1207.
|
8. |
Schubeler D, MacAlpine DM, Scalzo D, et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote [J]. Genes Dev, 2004; 18(11)∶1263.
|
9. |
Liang G, Lin JC, Wei V, et al. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome [J]. Proc Natl Acad Sci USA, 2004; 101(19)∶7357.
|
10. |
Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 [J]. Cell, 2004; 119(7)∶941.
|
11. |
Mahadevan LC, Willis AC, Barratt MJ. Rapid histone H3 ph-osphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors [J]. Cell, 1991; 65(5)∶775.
|
12. |
Nowak SJ, Corces VG. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation [J]. Trends Genet, 2004; 20(4)∶214.
|
13. |
Salvador LM, Park Y, Cottom J, et al. Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells [J]. J Biol Chem, 2001; 276(43)∶40146.
|
14. |
Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications [J]. Cell, 2000; 103(2)∶263.
|
15. |
Nowak SJ, Corces VG. Phosphorylation of histone H3 correlates with transcriptionally active loci [J]. Genes Dev, 2000; 14(23)∶3003.
|
16. |
Cameron EE, Bachman KE, Myohanen S, et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer [J]. Nat Genet, 1999; 21(1)∶103.
|
17. |
Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer [J]. Mol Cell Biol, 2003; 23(1)∶206.
|
18. |
Fahrner JA, Eguchi S, Herman JG, et al. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer [J]. Cancer Res, 2002; 62(24)∶7213.
|
19. |
Fuks F, Hurd PJ, Wolf D, et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation [J]. J Biol Chem, 2003; 278(6)∶4035.
|
20. |
Bachman KE, Park BH, Rhee I, et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene [J]. Cancer Cell, 2003; 3(1)∶89.
|
21. |
Cheung P, Tanner KG, Cheung WL, et al. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation [J]. Mol Cell, 2000; 5(6)∶905.
|
22. |
Lo WS, Trievel RC, Rojas JR, et al. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14 [J]. Mol Cell, 2000; 5(6)∶917.
|
23. |
Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails [J]. Genes Dev, 2001; 15(18)∶2343.
|
24. |
Wang H, Huang ZQ, Xia L, et al. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor [J]. Science, 2001; 293(5531)∶853.
|
25. |
Fang JY, Chen YX, Lu J, et al. Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116 [J]. Cell Res, 2004; 14(3)∶217.
|
26. |
Mitani Y, Oue N, Hamai Y, et al. Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma [J]. J Pathol, 2005; 205(1)∶65.
|
27. |
Hamai Y, Oue N, Mitani Y, et al. DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma [J]. Cancer Sci, 2003; 94(8)∶692.
|
28. |
Loprevite M, Tiseo M, Grossi F, et al. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines [J]. Oncol Res, 2005; 15(1)∶39.
|
29. |
Egger G, Liang G, Aparicio A, et al. Epigenetics in human disease and prospects for epigenetic therapy [J]. Nature, 2004; 429(6990)∶457.
|
30. |
Dobosy JR, Roberts JL, Fu VX, et al. The expanding role of epigenetics in the development, diagnosis and treatment of prostate cancer and benign prostatic hyperplasia [J]. J Urol, 2007; 177(3)∶822.
|
31. |
Kaminskas E, Farrell A, Abraham S, et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes [J]. Clin Cancer Res, 2005; 11(10)∶3604.
|