Effect of Preoperative Gastric Arterial Chemoembolization on Apoptosis of Lymph Node Metastasis of Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

PU Qingfan ¹ , SUN Suikang ¹ , LIU Zhanpei ² , YAN Lnan ² , CHAI Yu ¹ , CAO Gaojian ¹ , WU Wenzhen ¹ , YU Xixiang. ¹

Department of General Surgery, The Third Hospital, Wenzhou Medical College， Wenzhou 325200, China;

Corresponding author：

Keywords：

Gastric cancer Metastasis Chemoembolization Cell apoptosis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】ObjectiveTo study the effect of preoperative gastric arterial chemoembolization on apoptosis of lymph node metastasis of gastric cancer.
MethodsForty patients with gastric cancer and lymph node metastasis underwent curative resection, among which there were 20 patients who received the preoperative gastric arterial chemoembolization, and they constituted the treatment group. The rest of the patients were included in the control group. The expressions of p53, CD95 and bcl-2 were examined by immunohistochemistry and apoptosis in the lymph node metastasis was examined by in situ terminal transferasemediated dUTP nick end labeling （TUNEL）.
ResultsThe expression intensity of p53 and CD95 in lymph node metastasis of treatment group increased more significantly than that of control group, whereas the expression intensity of bcl-2 decreased in treatment group. There was a significantly positive correlation between the expressions of p53 and CD95 and the apoptosis.
ConclusionPreoperative gastric arterial chemoembolization may affect the expressions of p53, CD95 and bcl-2 and may induce the apoptosis of lymph node metastasis. It may be helpful to improve the effect of curative resection of gastric cancer.

Citation： PU Qingfan,SUN Suikang,LIU Zhanpei,YAN Lnan,CHAI Yu,CAO Gaojian,WU Wenzhen,YU Xixiang.. Effect of Preoperative Gastric Arterial Chemoembolization on Apoptosis of Lymph Node Metastasis of Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 427-430. doi: Copy

1.	Cancer, 1999; 86(9)∶ 1657.
2.	Surgery, 2004; 135(3)∶ 266.
3.	Blood, 1997; 89(6)∶ 1845.
4.	J Natl Cancer Inst, 1997; 89(11)∶ 783.
5.	Shimada K, Ajani JA. Adjuvant therapy for gastric carcinoma patients in the past 15 years: a review of western and oriental trials [Ｊ].
6.	Koike H, Ichikawa D, Kitamura K, et al. Perinodal involvement of cancer cells in gastric cancer patients [Ｊ].
7.	Hannun YA. Apoptosis and the dilemma of cancer chemotherapy [Ｊ].
8.	Micheau O, Solary E, Hammann A, et al. Sensitization of cancer cells treated with cytotoxic drugs to fasmediated cytotoxicity [Ｊ].
9.	Muller BM, Wilder S, Bannasch D, et al. p53 activates the CD95(APO1/Fas) gene in response to DNA damage by anticancer drugs [Ｊ]. J Exp Med, 1998; 188(11)∶2033.
10.	孙碎康, 蒲青凡, 严律南, 等. 胃癌病人术前选择性动脉栓塞化疗对肿瘤血管的影响 [Ｊ]. 中国普通外科杂志， 2002; 11（4）∶202.
11.	杨秀超, 崔振玉, 李正华. 经动脉插管灌注抗癌药提高胃癌手术疗效 [Ｊ]. 中华外科杂志， 1994; 32（7）∶ 403.
12.	徐工学, 李志霞, 陈佛来, 等. 术前区域性动脉灌注化疗对大肠癌细胞凋亡相关基因的影响 [Ｊ]. 中华外科杂志， 2001; 39（6）∶436.

1. Cancer, 1999; 86(9)∶ 1657.
2. Surgery, 2004; 135(3)∶ 266.
3. Blood, 1997; 89(6)∶ 1845.
4. J Natl Cancer Inst, 1997; 89(11)∶ 783.
5. Shimada K, Ajani JA. Adjuvant therapy for gastric carcinoma patients in the past 15 years: a review of western and oriental trials [Ｊ].
6. Koike H, Ichikawa D, Kitamura K, et al. Perinodal involvement of cancer cells in gastric cancer patients [Ｊ].
7. Hannun YA. Apoptosis and the dilemma of cancer chemotherapy [Ｊ].
8. Micheau O, Solary E, Hammann A, et al. Sensitization of cancer cells treated with cytotoxic drugs to fasmediated cytotoxicity [Ｊ].
9. Muller BM, Wilder S, Bannasch D, et al. p53 activates the CD95(APO1/Fas) gene in response to DNA damage by anticancer drugs [Ｊ]. J Exp Med, 1998; 188(11)∶2033.
10. 孙碎康, 蒲青凡, 严律南, 等. 胃癌病人术前选择性动脉栓塞化疗对肿瘤血管的影响 [Ｊ]. 中国普通外科杂志， 2002; 11（4）∶202.
11. 杨秀超, 崔振玉, 李正华. 经动脉插管灌注抗癌药提高胃癌手术疗效 [Ｊ]. 中华外科杂志， 1994; 32（7）∶ 403.
12. 徐工学, 李志霞, 陈佛来, 等. 术前区域性动脉灌注化疗对大肠癌细胞凋亡相关基因的影响 [Ｊ]. 中华外科杂志， 2001; 39（6）∶436.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Preoperative Gastric Arterial Chemoembolization on Apoptosis of Lymph Node Metastasis of Gastric Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content