Clinical Study in Applying Molecular Adsorbent Recycling System in Perioperative Period with Orthotopic Liver Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MING Yingzi , YE Qifa , YUAN Jinzhong.

The Organ Transplantation Institute，The Third Xiangya Hospital of Central South University, Changsha 410013,China;

Corresponding author：

Keywords：

Liver transplantation; Artificial liver

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ObjectiveTo summerize the experiences of using molecular adsorbent recycling system(MARS) in perioperative period of orthotopic liver transplantation (OLT). MethodsThe effects of MARS-artificial liver treatments in 19 cases were reviewed. ResultsThe levels of serum total bilirubin, BUN, Cr, urine acid and blood ammonia were greatly reduced by using MARS. Fifteen patients were bridged to transplantation, 1 patient was relieved in symptoms of hepatic encephalopathy after MARS treatment, died 2 weeks after leaving hospital, 1 patient died of severe gastrointestinal bleeding before transplantation. The survival rate is 89.5%.ConclusionMARS artificial liver now is a safe and effective assistant device. It can help to gain more chance of undergoing OLT for the patients.

Citation： MING Yingzi,YE Qifa,YUAN Jinzhong.. Clinical Study in Applying Molecular Adsorbent Recycling System in Perioperative Period with Orthotopic Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(2): 127-129下转134. doi: Copy

1.	Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol， 2001; 12(Suppl 17)∶S75.
2.	Stange J, Mitzner S, Ramlow W, et al. A new procedure for the removal of protein bound drugs and toxins [Ｊ]. ASAIO J, 1993; 39(3)∶M621.
3.	Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol, 2001; 12(Suppl 17)∶S75.
4.	Schmidt LE, Sorensen VR, Svendsen LB, et al. Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acuteonchronic liver failure [Ｊ]. Liver Transpl, 2001; 7(12)∶1034.
5.	Schmidt LE, Svendsen LB, Sorensen VR, et al. Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure [Ｊ]. Liver Transpl, 2001; 7(8)∶709.
6.	Sorkine P, Ben Abraham R, Szold O, et al. Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure [Ｊ]. Crit Care Med, 2001; 29(7)∶1332.

1. Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol， 2001; 12(Suppl 17)∶S75.
2. Stange J, Mitzner S, Ramlow W, et al. A new procedure for the removal of protein bound drugs and toxins [Ｊ]. ASAIO J, 1993; 39(3)∶M621.
3. Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol, 2001; 12(Suppl 17)∶S75.
4. Schmidt LE, Sorensen VR, Svendsen LB, et al. Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acuteonchronic liver failure [Ｊ]. Liver Transpl, 2001; 7(12)∶1034.
5. Schmidt LE, Svendsen LB, Sorensen VR, et al. Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure [Ｊ]. Liver Transpl, 2001; 7(8)∶709.
6. Sorkine P, Ben Abraham R, Szold O, et al. Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure [Ｊ]. Crit Care Med, 2001; 29(7)∶1332.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Study in Applying Molecular Adsorbent Recycling System in Perioperative Period with Orthotopic Liver Transplantation

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