Biocharacters of Keratin Family and Their Relationships with Malignant Tumors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HAN Qianfeng ¹ , ZHOU Zongguang ¹ , CHEN Yao. ²

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Keywords：

Keratin Rectal cancer Malignant tumor Early diagnosis

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【Abstract】Objective To investigate the recent studies on the biocharacters of keratin family (e.g. genetic mutations and abnormal expressions) and their relationships with the malignant tumors.
Methods The literatures of recent years on the biocharacters of keratin family (e.g. genetic mutations and abnormal expressions) and their relationships with the malignant tumors were reviewed.
Results Keratin family is a kind of structural proteins in cell which plays an important role in cytomechanics and regulates cell-cycle. The mutations of keratin genes (mRNA) or the overexpression of keratin proteins would interfere with the order of cell-cycle or the integrity of cytomechanics, and lead to some diseases and malignant tumors finally.
Conclusion The studies on biocharaters of keratin family (e.g. genetic mutations and abnormal expressions) are helpful in the diagnosis, staging and the evaluation of prognosis of some diseases and cancers, e.g. liver cirrhosis, breast cancer, rectum carcinoma, etc.

Citation： HAN Qianfeng,ZHOU Zongguang,CHEN Yao.. Biocharacters of Keratin Family and Their Relationships with Malignant Tumors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(5): 527-529. doi: Copy

1.	Fuchs E, Clevaland DW. A structural scaffolding of intermediate filaments in health and disease [J]. Science, 1998; 279(5350)∶514.
2.	Williams GR, Talbot IC, Leigh IM. Keratin expression in anal carcinoma: an immunohistochemical study [J]. Hispopathology, 1997; 30(5)∶443.
3.	Zhou X, Liao J, Hu L, et al. Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization [J]. J Biol Chem, 1999; 274(18)∶12861.
4.	Croxtall JD, Wu HL, Yang HY, et al. Lipocortin 1 coassociates with cytokeratins 8 and 18 in A549 cells via the Nterminal domain [J]. Biochim Biophys Acta, 1998; 1401(1)∶39.
5.	Sprecher E, IshidaYamamoto A, Becker OM, et al. Evidence for novel functions of the keratin tail emerging from a mutation causing ichthyosis hystrix [J]. J Invest Dermatol, 2001; 116(4)∶511.
6.	Magin TM, Schroder R, Leitgeb S, et al. Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liverspecific keratin 8positive aggregates [J]. J Cell Biol, 1998; 140(6)∶1441.
7.	Ku NO, Wright TL, Terrault NA, et al. Mutation of human keratin 18 in association with cryptogenic cirrhosis [J]. J Clin Invest, 1997; 99(1)∶19.
8.	McLean WH, Lane EB. Intermediate filaments in disease [J]. Curr Opin Cell Biol, 1995; 7(1)∶118.
9.	Ku NO, Liao J, Omary MB. Phosphorylation of human keratin 18 serine 33 regulates binding to 1433 proteins [J]. EMBO J, 1998; 17(7)∶1892.
10.	Fujisaki J, Shimoda T. Expression of cytokeratin subtypes in colorectal mucosa, adenoma, and carcinoma [J]. Gastroenterol Jpn, 1993; 28(5)∶647.
11.	Prochasson P, Gunther M, Laithier M, et al. Transcriptional mechanisms responsible for the overexpression of the keratin 18 gene in cells of a human colon carcinoma cell line [J]. Exp Cell Res, 1999; 248(1)∶243.
12.	Kwaspen FH, Smedts FM, Broos A, et al. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis [J]. Histopathology， 1997; 31(6)∶503.
13.	Shimoyama M, Yamazaki T, Suda T, et al. Prognostic significance of lateral lymph node micrometastases in lower rectal cancer: an immunohistochemical study with CAM5.2 [J]. Dis Colon Rectum, 2003; 46(3)∶333.
14.	Kriho VK, Yang HY, Moskal JR, et al. Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment [J]. Virchows Arch， 1997; 431(2)∶139.
15.	van Dorst EB, van Muijen GN, Litvinov SV, et al. The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells [J]. J Clin Pathol, 1998; 51(9)∶679.
16.	Jung YS, Lee KJ, Kim HJ, et al. Clinical significance of bone marrow micrometastasis detected by nested rtPCR for keratin19 in breast cancer patients [J]. Jpn J Clin Oncol, 2003; 33(4)∶167.
17.	Liao J, Omary MB. 1433 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor [J]. J Cell Biol, 1996; 133(2)∶346.
18.	Ueno T, Hoshii Y, Cui D, et al. Immunohistochemical study of cytokeratins in amyloid deposits associated with squamous cell carcinoma and dysplasia in the oral cavity, pharynx and larynx [J]. Pathol Int, 2003; 53(5)∶265.
19.	Jensen K, Kohler S, Rouse RV. Cytokeratin staining in Merkel cell carcinoma: an immunohistochemical study of cytokeratins 5/6, 7, 17, and 20 [J]. Appl Immunohistochem Mol Morphol, 2000; 8(4)∶310.
20.	Albers KM, Davis FE, Perrone TN， et al. Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities [J]. J Cell Biol, 1995; 28(1-2)∶157.

1. Fuchs E, Clevaland DW. A structural scaffolding of intermediate filaments in health and disease [J]. Science, 1998; 279(5350)∶514.
2. Williams GR, Talbot IC, Leigh IM. Keratin expression in anal carcinoma: an immunohistochemical study [J]. Hispopathology, 1997; 30(5)∶443.
3. Zhou X, Liao J, Hu L, et al. Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization [J]. J Biol Chem, 1999; 274(18)∶12861.
4. Croxtall JD, Wu HL, Yang HY, et al. Lipocortin 1 coassociates with cytokeratins 8 and 18 in A549 cells via the Nterminal domain [J]. Biochim Biophys Acta, 1998; 1401(1)∶39.
5. Sprecher E, IshidaYamamoto A, Becker OM, et al. Evidence for novel functions of the keratin tail emerging from a mutation causing ichthyosis hystrix [J]. J Invest Dermatol, 2001; 116(4)∶511.
6. Magin TM, Schroder R, Leitgeb S, et al. Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liverspecific keratin 8positive aggregates [J]. J Cell Biol, 1998; 140(6)∶1441.
7. Ku NO, Wright TL, Terrault NA, et al. Mutation of human keratin 18 in association with cryptogenic cirrhosis [J]. J Clin Invest, 1997; 99(1)∶19.
8. McLean WH, Lane EB. Intermediate filaments in disease [J]. Curr Opin Cell Biol, 1995; 7(1)∶118.
9. Ku NO, Liao J, Omary MB. Phosphorylation of human keratin 18 serine 33 regulates binding to 1433 proteins [J]. EMBO J, 1998; 17(7)∶1892.
10. Fujisaki J, Shimoda T. Expression of cytokeratin subtypes in colorectal mucosa, adenoma, and carcinoma [J]. Gastroenterol Jpn, 1993; 28(5)∶647.
11. Prochasson P, Gunther M, Laithier M, et al. Transcriptional mechanisms responsible for the overexpression of the keratin 18 gene in cells of a human colon carcinoma cell line [J]. Exp Cell Res, 1999; 248(1)∶243.
12. Kwaspen FH, Smedts FM, Broos A, et al. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis [J]. Histopathology， 1997; 31(6)∶503.
13. Shimoyama M, Yamazaki T, Suda T, et al. Prognostic significance of lateral lymph node micrometastases in lower rectal cancer: an immunohistochemical study with CAM5.2 [J]. Dis Colon Rectum, 2003; 46(3)∶333.
14. Kriho VK, Yang HY, Moskal JR, et al. Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment [J]. Virchows Arch， 1997; 431(2)∶139.
15. van Dorst EB, van Muijen GN, Litvinov SV, et al. The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells [J]. J Clin Pathol, 1998; 51(9)∶679.
16. Jung YS, Lee KJ, Kim HJ, et al. Clinical significance of bone marrow micrometastasis detected by nested rtPCR for keratin19 in breast cancer patients [J]. Jpn J Clin Oncol, 2003; 33(4)∶167.
17. Liao J, Omary MB. 1433 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor [J]. J Cell Biol, 1996; 133(2)∶346.
18. Ueno T, Hoshii Y, Cui D, et al. Immunohistochemical study of cytokeratins in amyloid deposits associated with squamous cell carcinoma and dysplasia in the oral cavity, pharynx and larynx [J]. Pathol Int, 2003; 53(5)∶265.
19. Jensen K, Kohler S, Rouse RV. Cytokeratin staining in Merkel cell carcinoma: an immunohistochemical study of cytokeratins 5/6, 7, 17, and 20 [J]. Appl Immunohistochem Mol Morphol, 2000; 8(4)∶310.
20. Albers KM, Davis FE, Perrone TN， et al. Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities [J]. J Cell Biol, 1995; 28(1-2)∶157.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Biocharacters of Keratin Family and Their Relationships with Malignant Tumors

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