STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUANG Jianhua , L Xinsheng.

Department of Surgery, Xiangya Affiliated Hospital, Hunan University of Medical Sciences, Changsha 410008;

Corresponding author：

Keywords：

Intrahepatic stone Etiology

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Objective To study the etiology of primary intrahepatic stones.
Methods The literatures in the recent years on the etiology of intrahepatic stone were revieved.
Results The formation of intrahepatic stone mainly caused by bacteria infection, parasitic infestation, bile stasis, congenital anatomic abnormalities and immunoreaction of bile tract. Further investigation found that metabolic, low protein diet, environment and ethnic factors and gene mutation were considered to play important roles in the formation of the intrahepatic stone.
Conclusion The formation of intrahepatic stone is complex and are result of multiple factors. It closely related to the infection and stasis of the bile duct.

Citation： HUANG Jianhua,L Xinsheng.. STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 125-127. doi: Copy

1.	Pitt HA, Venbrux AC, Coleman JA, et al. Intrahepatic stones: the transhepatic team approach 〔Ｊ〕. Ann Surg, 1994; 219(5)∶527.
2.	Suzuki N, Ise H, Shinya F, et al. The etiology of intrahepatic stones 〔Ｊ〕. Jpn J Clin Med, 1987; 45(2)∶163.
3.	顾倬云，黄志强. 中国人胆结石的特点全国11 342例胆结石手术病例临床调查，中华外科杂志， 1987； 25(3)∶321.
4.	Shibamoto Y, Shibata K, Tsukie E. Etiology of cholelithisais 〔Ｊ〕. Jpn J Clin Med, 1993; 5(1)∶33.
5.	Matsushiro T, Suzuki N, Sato T, et al. Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones 〔Ｊ〕. Gastroenterology, 1977; 71(4)∶630.
6.	Akiyama T, Nagakawa T, Kanno M, et al. A clinicopathologic study on intrahepatic cholesterol stones 〔Ｊ〕. Jpn J Surg, 1990; 20(5)∶530.
7.	Maki T. Pathogenesis of calcium bilirubinate gallstones: role of E coli βglucuronidase and coagulation by inorganic ions polyelectrocyte and agitation 〔Ｊ〕. Ann Surg, 1966; 164(1)∶90.
8.	Swidsinski A, Ludwig W, Pablig H, et al. Molecular genetic evidence of bacterial colonization of cholesterol gallstones 〔Ｊ〕. Gastroenterology, 1995; 108(3)∶860.
9.	Cetta F. The role of bactera in pigment gallstone diseases 〔Ｊ〕. Ann Surg, 1991; 213(4)∶315.
10.	Ohdan H, Oshiro H, Yamamoto Y, et al. Bactriological investigation of bile in patients with cholelithiasis 〔Ｊ〕. Surg Today, 1993; 23(5)∶390.
11.	Rehnberg O, Haglundu D. Gallstone diseases following or without vagotomy 〔Ｊ〕. Ann Surg, 1985; 201(3)∶315.
12.	Hawse RH, Cotton PB, Vallon AG. Follow up 6 to 11 years after duodenoscopic sphincterotomy for stones in patients with perior cholecystectomy 〔Ｊ〕. Gastroenterology, 1990; 98(4)∶1008.
13.	Leung JWC, Sung JY, Costerton JW, et al. Bacteriological and election microscopy examination of brown pigment stones 〔Ｊ〕. J Clin Microbiol, 1989; 27(5)∶915.
14.	Kim MH, Lee SK, Min YII, et al. Expandable metallic stents: in the benign strictures of intrahepatic ducts in patients with primary intrahepatic stones 〔Ｊ〕. Dig Endoscopy, 1993; 5(1)∶67.
15.	Imanoglu K, Yonehiro EG, Perry JF, et al. Formation of calculi following cholecystectomy attending partial occlusion of the common bile duct 〔Ｊ〕. Surg Forum, 1957; 8(2)∶225.
16.	Jan YY, Chen MF. Percutaneous transhepatic cholangioscopic lithotomy for hepatolithiasis: longterm result 〔Ｊ〕. Gastrointest Endosc, 1995; 42(1)∶1.
17.	Stock FE, Fung JHY. Oriental cholangiohepatitis 〔Ｊ〕. Arch Surg, 1962; 84(4)∶409.
18.	黄志强主编. 黄志强胆道外科学. 济南：山东科学技术出版社， 1998∶534～537.
19.	Nakayama Y, Koga A. Hepatolithiasis: present status 〔Ｊ〕. World J Surg, 1984; 8(1)∶9.
20.	Nakanuma Y, Yamaguchi K, Ohta K, et al. Pathology of hepatolithiasis in Japan 〔Ｊ〕. J Biliary Tract Pancreas, 1989; 10(6)∶1301.
21.	张圣道，韩天权. 胆结石研究的展望. 外科理论与实践， 1999； 4(1)∶5.
22.	Kano M, Shoda J, Irimura T, et al. Effects of longterm ursodeoxycholate administration on expression levels of secretory lowmolecularweight phospholopase A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones 〔Ｊ〕. Hepatology, 1998; 28(2)∶302.
23.	蒋兆彦，韩天权，所广军等. 胆囊结石病人Apo B基因Xba I多态性及其与血脂的关系. 外科理论与实践，1999； 4(1)∶18.
24.	宋坚，韩天权，陈胜等. 胆石病患者胆囊收缩素受体与胆囊动力关系的研究. 外科理论与实践， 1999； 4(1)∶24.
25.	Shoda J, Kano M, Asano T, et al. Secretory lowmolecularweight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis 〔Ｊ〕. Hepatology, 1999; 29(4)∶1026.
26.	冉崇福，杨可桢，韩本立等. 兔胆色素结石中Ag特异性IgG的检测及意义. 中华肝胆外科杂志， 1999； 5(2)∶114.
27.	Sheen Chen SM, Eng HL, Chou FF, et al. Serumsoluble interleukin2 receptor in patients with hepatolithiasis: a prelimary report 〔Ｊ〕. Hepatogastroenterology, 1998; 45(19)∶196.
28.	Shoda J, Tanada N, He BF, et al. Alterations of bile acid composition in gallstones, bile and liver of patients with hepatolithiasis and their etiological significance 〔Ｊ〕. Dig Dis Sci, 1993; 38(11)∶2130.

1. Pitt HA, Venbrux AC, Coleman JA, et al. Intrahepatic stones: the transhepatic team approach 〔Ｊ〕. Ann Surg, 1994; 219(5)∶527.
2. Suzuki N, Ise H, Shinya F, et al. The etiology of intrahepatic stones 〔Ｊ〕. Jpn J Clin Med, 1987; 45(2)∶163.
3. 顾倬云，黄志强. 中国人胆结石的特点全国11 342例胆结石手术病例临床调查，中华外科杂志， 1987； 25(3)∶321.
4. Shibamoto Y, Shibata K, Tsukie E. Etiology of cholelithisais 〔Ｊ〕. Jpn J Clin Med, 1993; 5(1)∶33.
5. Matsushiro T, Suzuki N, Sato T, et al. Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones 〔Ｊ〕. Gastroenterology, 1977; 71(4)∶630.
6. Akiyama T, Nagakawa T, Kanno M, et al. A clinicopathologic study on intrahepatic cholesterol stones 〔Ｊ〕. Jpn J Surg, 1990; 20(5)∶530.
7. Maki T. Pathogenesis of calcium bilirubinate gallstones: role of E coli βglucuronidase and coagulation by inorganic ions polyelectrocyte and agitation 〔Ｊ〕. Ann Surg, 1966; 164(1)∶90.
8. Swidsinski A, Ludwig W, Pablig H, et al. Molecular genetic evidence of bacterial colonization of cholesterol gallstones 〔Ｊ〕. Gastroenterology, 1995; 108(3)∶860.
9. Cetta F. The role of bactera in pigment gallstone diseases 〔Ｊ〕. Ann Surg, 1991; 213(4)∶315.
10. Ohdan H, Oshiro H, Yamamoto Y, et al. Bactriological investigation of bile in patients with cholelithiasis 〔Ｊ〕. Surg Today, 1993; 23(5)∶390.
11. Rehnberg O, Haglundu D. Gallstone diseases following or without vagotomy 〔Ｊ〕. Ann Surg, 1985; 201(3)∶315.
12. Hawse RH, Cotton PB, Vallon AG. Follow up 6 to 11 years after duodenoscopic sphincterotomy for stones in patients with perior cholecystectomy 〔Ｊ〕. Gastroenterology, 1990; 98(4)∶1008.
13. Leung JWC, Sung JY, Costerton JW, et al. Bacteriological and election microscopy examination of brown pigment stones 〔Ｊ〕. J Clin Microbiol, 1989; 27(5)∶915.
14. Kim MH, Lee SK, Min YII, et al. Expandable metallic stents: in the benign strictures of intrahepatic ducts in patients with primary intrahepatic stones 〔Ｊ〕. Dig Endoscopy, 1993; 5(1)∶67.
15. Imanoglu K, Yonehiro EG, Perry JF, et al. Formation of calculi following cholecystectomy attending partial occlusion of the common bile duct 〔Ｊ〕. Surg Forum, 1957; 8(2)∶225.
16. Jan YY, Chen MF. Percutaneous transhepatic cholangioscopic lithotomy for hepatolithiasis: longterm result 〔Ｊ〕. Gastrointest Endosc, 1995; 42(1)∶1.
17. Stock FE, Fung JHY. Oriental cholangiohepatitis 〔Ｊ〕. Arch Surg, 1962; 84(4)∶409.
18. 黄志强主编. 黄志强胆道外科学. 济南：山东科学技术出版社， 1998∶534～537.
19. Nakayama Y, Koga A. Hepatolithiasis: present status 〔Ｊ〕. World J Surg, 1984; 8(1)∶9.
20. Nakanuma Y, Yamaguchi K, Ohta K, et al. Pathology of hepatolithiasis in Japan 〔Ｊ〕. J Biliary Tract Pancreas, 1989; 10(6)∶1301.
21. 张圣道，韩天权. 胆结石研究的展望. 外科理论与实践， 1999； 4(1)∶5.
22. Kano M, Shoda J, Irimura T, et al. Effects of longterm ursodeoxycholate administration on expression levels of secretory lowmolecularweight phospholopase A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones 〔Ｊ〕. Hepatology, 1998; 28(2)∶302.
23. 蒋兆彦，韩天权，所广军等. 胆囊结石病人Apo B基因Xba I多态性及其与血脂的关系. 外科理论与实践，1999； 4(1)∶18.
24. 宋坚，韩天权，陈胜等. 胆石病患者胆囊收缩素受体与胆囊动力关系的研究. 外科理论与实践， 1999； 4(1)∶24.
25. Shoda J, Kano M, Asano T, et al. Secretory lowmolecularweight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis 〔Ｊ〕. Hepatology, 1999; 29(4)∶1026.
26. 冉崇福，杨可桢，韩本立等. 兔胆色素结石中Ag特异性IgG的检测及意义. 中华肝胆外科杂志， 1999； 5(2)∶114.
27. Sheen Chen SM, Eng HL, Chou FF, et al. Serumsoluble interleukin2 receptor in patients with hepatolithiasis: a prelimary report 〔Ｊ〕. Hepatogastroenterology, 1998; 45(19)∶196.
28. Shoda J, Tanada N, He BF, et al. Alterations of bile acid composition in gallstones, bile and liver of patients with hepatolithiasis and their etiological significance 〔Ｊ〕. Dig Dis Sci, 1993; 38(11)∶2130.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE

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