RELATION BETWEEN CHANGES OF THE HEPATIC ENERGY METABOLISM AND ALLOGRAFT VIABILITY IN EARLY PHASE AFTER ORTHOTOPIC LIVER TRANSPLANTATION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepato-Ｂiliary-Pancreas Surgery, The Second Affiliated Hospital, Kunming Medical College, Kunming 650101;

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Keywords：

Liver transplantation Early phase after transplantation Allograft viability Arterial ketone body ration

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Objective To study the relation between changes of the hepatic energy metabolism and allograft viability in early phase after orthotopic liver transplantation, arterial blood ketone body ratio (AKBR) was measured in pre- intra and post-operative phase.
Methods The monkeys were divided into two groups in accordance with survived times. A group (＞24h), 5 monkeys survived 29—168 postoperative hours; B group (＜24h), 9 monkeys survived only 5—22 hours.
Results AKBR in all models immediately decreased to extraordinarily low state in anhepatic-phase (versus preanhepatic phase, Ｐ＜0.01), and A group recovered rapidly to the normal levels, and maintained continuously for 12 postoperative hours above the level of 0.7. In contrast in B group, AKBR decreased below 0.7 rapidly and failed to restore to the normal level. Within 12 hours postoperatively, in B group, AKBR was lower than 0.4. Conclusion AKBR is a sensitve indicator to the allograft viability in the early phase after hepatic transplantation.

Citation： ZHANG Bingyan,ZHANG Jie,TAN Jing,et al.. RELATION BETWEEN CHANGES OF THE HEPATIC ENERGY METABOLISM AND ALLOGRAFT VIABILITY IN EARLY PHASE AFTER ORTHOTOPIC LIVER TRANSPLANTATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(4): 211-213. doi: Copy

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2.	St Cyr JA, Elick B, Freese D, et al. Use of triple therapy and percutaneous needle diopsyto minimize graft failure following liver transplant 〔Ｊ〕. Transplant Proc, 1987; 19(1)∶2451.
3.	Shaw SW, Gordon RD, Iwatsuki S, et al. TE.hepatic retransplantation 〔Ｊ〕. Transplant Proc, 1985; 17(2)∶264.
4.	Konishi Y, Shaked A, Egawa H, et al. Correlation of hepatic injury, synthertic function and mitochondria energy level in orthotopic liver transplantation 〔Ｊ〕. J Surg Res, 1992; 52(5)∶446.
5.	严律南，吴言涛，周勇等. 肝脏能量代谢与手术后多器官衰竭的关系〔Ｊ〕. 普外基础与临床杂志， 1994； 1(1)∶28.
6.	Ozawa K, Fajimoto T, Nakatni T, et al. Changes in hepatic energy charge, blood ketone body ratio, and indocyanine green clearance in relation to DNA synthesis after hepatectomy 〔Ｊ〕. Life Sci, 1982; 31(7)∶647.
7.	Kazue Ozawa著，严律南主译. 氧化还原理论与现代肝脏外科〔M〕. 第1版. 北京：北京医科大学中国协和医科大学联合出版社， 1995∶74～77.
8.	Ozawa K, Aoyama H, Yasuda K, et al. Metabolic abnormalities associated with postoperative organ failurea redox theory 〔Ｊ〕. Arch Surg, 1983; 118(11)∶1245.
9.	Asonuma K, Takaya S, Selby R, et al. The clinical significance of the arterial ketone body ratio as an early indicator of graft viability in human liver transplantation 〔Ｊ〕. Transplant, 1991; 51(1)∶164.
10.	Taki Y, Ukikusa Y, Morimoto T, et al. Shortterm changes in blood ketone body ratio in the phase immediately after liver transplantation 〔Ｊ〕. Transplantation, 1987; 43(3)∶350.

1. Greig PD, Wodlf GM, Sinclair SB, et al. Treatment of primary liver graft nonfunction with prostaglandin E1 〔Ｊ〕. Transplantation, 1989; 48(3)∶447.
2. St Cyr JA, Elick B, Freese D, et al. Use of triple therapy and percutaneous needle diopsyto minimize graft failure following liver transplant 〔Ｊ〕. Transplant Proc, 1987; 19(1)∶2451.
3. Shaw SW, Gordon RD, Iwatsuki S, et al. TE.hepatic retransplantation 〔Ｊ〕. Transplant Proc, 1985; 17(2)∶264.
4. Konishi Y, Shaked A, Egawa H, et al. Correlation of hepatic injury, synthertic function and mitochondria energy level in orthotopic liver transplantation 〔Ｊ〕. J Surg Res, 1992; 52(5)∶446.
5. 严律南，吴言涛，周勇等. 肝脏能量代谢与手术后多器官衰竭的关系〔Ｊ〕. 普外基础与临床杂志， 1994； 1(1)∶28.
6. Ozawa K, Fajimoto T, Nakatni T, et al. Changes in hepatic energy charge, blood ketone body ratio, and indocyanine green clearance in relation to DNA synthesis after hepatectomy 〔Ｊ〕. Life Sci, 1982; 31(7)∶647.
7. Kazue Ozawa著，严律南主译. 氧化还原理论与现代肝脏外科〔M〕. 第1版. 北京：北京医科大学中国协和医科大学联合出版社， 1995∶74～77.
8. Ozawa K, Aoyama H, Yasuda K, et al. Metabolic abnormalities associated with postoperative organ failurea redox theory 〔Ｊ〕. Arch Surg, 1983; 118(11)∶1245.
9. Asonuma K, Takaya S, Selby R, et al. The clinical significance of the arterial ketone body ratio as an early indicator of graft viability in human liver transplantation 〔Ｊ〕. Transplant, 1991; 51(1)∶164.
10. Taki Y, Ukikusa Y, Morimoto T, et al. Shortterm changes in blood ketone body ratio in the phase immediately after liver transplantation 〔Ｊ〕. Transplantation, 1987; 43(3)∶350.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RELATION BETWEEN CHANGES OF THE HEPATIC ENERGY METABOLISM AND ALLOGRAFT VIABILITY IN EARLY PHASE AFTER ORTHOTOPIC LIVER TRANSPLANTATION

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