• Department of General Surgery, Fuqing City Hospital, Fuqing 350300;
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Objective  To investigate the effect of the drug-resistance characteristic of neoplasm cell on the expression of Fas during the chemical medi-cure.
Methods  The adriamycin-resistance hepatic carcinoma cells (HepG2 cell lines) were estabilished by cell biology. Changes of expression of the HepG2 cell lines was determined by immunohistochemistry.
Results  When the HepG2 cell lines were not induced by adriamycin, the expression of Fas of them was weak and Fas mainly existed in cell membrane. When induced by adriamycin, the expression was enhanced and Fas mainly existed in cytochylema. Simultaneously, the death rate of the cell lines changed. The death rate of the drug-resistance cell lines in 0.1 μg/ml ADM was almost as same as that of non-drug-resistance cell lines without ADM (P>0.05) and was significantly different from that of non-drug-resistance cell lines in 0.1 μg/ml ADM (P<0.05). Conclusion  Changes of the expression of Fas may be one of the drug-resistance mechanisms of carcinoma cell.

Citation: XIANG Liangguang,LIN Xinlong,LI Weiqing,et al.. CHANGES OF EXPRESSION Fas OF THE ADRIAMYCIN-RESISTANCE HEPATIC CARCINOMA CELLS (HepG2 CELL LINES). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(4): 229-230. doi: Copy