HEAT SHOCK PROTEIN AND HEPATIC ISCHEMIA REPERFUSIOIN INJURY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUA Yunpeng , LIANG Lijian

Department of Hapatobiliary Surgery, The First Affiliated Hospital, SUN Yat-sen University of Medical Sciences, Guangzhou 510080;

Corresponding author：

Keywords：

Heat shock protein Liver Ischemic reperfusion

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Abstract Full text Figures/Tables Video References Cited by

Objective To study the effects of heat shock proteins (HSPs) in the course of hepatic ischemia reperfusion injury (HIRI), and analyze its mechanism.
Methods The relationship between HSPs and HIRI was studied by reviewing literatures.
Results HSPs was a kind of stress protein induced after cell was sitmulated by the stress. It could improve body′s tolerance to tough situation. Though hepatic ischemia reperfusion usually results in serious hepatic injury, at the same time it could induce can increase the production of HSPs that can protect liver from and lessen ischemia reperfusion injury.
Conclusion HSPs can improve the tolerance to HIRI and lessen injury. In addition, HSPs is thought to be markers of HIRI, and can be used as a efficient indicator to test the level of hepatic injury and assess prognosis.

Citation： HUA Yunpeng,LIANG Lijian,HUANG Jiefu.. HEAT SHOCK PROTEIN AND HEPATIC ISCHEMIA REPERFUSIOIN INJURY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(4): 269-271. doi: Copy

1.	William J. Mammalian stress reperfusion: cell physiology, structure/function of stress proteins, and implications for medicine and disease 〔Ｊ〕. Physiol Rev, 1992; 72(4)∶1063.
2.	Lindquit S, Craig EA. The heat shock proteins 〔Ｊ〕. Ann Rev Genet, 1988; 22∶631.
3.	Takahashi Y, Tamaki T, Tanaka M, et al. Efficacy of heat shock proteins induced by severe fasting to protect rat livers preserved for 72 hours from cold ischemia/reperfusion injury 〔Ｊ〕. Transplant Proc, 1998; 30(7)∶3700.
4.	Kobayashi J, Takeyoshi I, Ohwada S, et al. The effects of FR167653 in extended liver resection with ischemia in dogs 〔Ｊ〕. Hepatology, 1998; 28(2)∶459.
5.	Pannen BH, Maeda K, Ayuse T, et al. Hepatic heat shock and acutephase gene expression are induced simultaneously after celiotomy in the anesthetized pig 〔Ｊ〕. Anesthesiology, 1995; 83(4)∶850.
6.	Lille S, Su CY, Schoeller T, et al. Induction of heat shock protein 72 in rat skeletal muscle does not increase tolerance to ischemic reperfusion injury 〔Ｊ〕. Muscle Nerve, 1999; 22(3)∶390.
7.	Shimabukuro T, Yamamoto Y, Kume M, et al. Induction of heat shock response effect on the rat liver with carbon tetrachlorideinduced fibrosis from ischemiareperfusion injury 〔Ｊ〕. World J Surg, 1998; 22(5)∶464.
8.	Saad S, Kanai M, Awane M, et al. Protective effect of heat shock pretreatment with heat shock protein induction before hepatic warm ischemia injury caused by pringle maneuver 〔Ｊ〕. Surgery, 1995; 118(3)∶510.
9.	Kim YM, Watkins SC, Billiar TR, et al. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factorα reduced apoptosis by inducing heat shock protein 70 expression 〔Ｊ〕. J Biol Chem, 1997; 272(2)∶1402.
10.	Tsuruman T, Yagihashi A, Watanabe N, et al. Heat shock protein73 protects against small intestinal warm ischemiareperfusion injury in the rat 〔Ｊ〕. Surgery, 1999; 125(4)∶385.
11.	Yamamoto Y, Kume M, Yamaoka Y, et al. Implications of heat shock proteins during liver surgery and liver perfusion 〔Ｊ〕. Recent Results Cancer Res, 1998; 147∶157.
12.	Morimoto RI. Cell in stress: transcriptional activation of heat shock genes 〔Ｊ〕. Science, 1993; 259(5100)∶1409.
13.	Yamagami K, Yamamoto Y, Kume M, et al. Heat shock preconditioning ameliorates liver injury following normathermic ischemia reperfusion in steatotic rat liver 〔Ｊ〕. J Surg Res, 1998; 79(1)∶47.
14.	Van Why SK, Hildelrandt F, Ardito T, et al. Induction and intracellular location of HSP72 after renal ischemia 〔Ｊ〕. Am J Physiol, 1992; 263(5 pt 2)∶F769.
15.	Nishihara M, Sumimoto R, Fukude Y, et al. TNFα and heatshock protein gene expression in ischemic injured liver from fasted and nonfasted rats, role of donor fasting in the prevention of reperfusion injury following liver transplantation 〔Ｊ〕. Transpl Int, 1998; 11(Suppl 1)∶S417.
16.	Mehlen P, Schulze OK, Arrigo AP, et al. Small stress proteins as novel regulators apoptosis. Heat shock protein 27 blocks Fas/Apo1 and staurosporineinduced cell death 〔Ｊ〕. J Biol Chem, 1996; 271(28)∶16510.
17.	Gabai VL, Meriin AB, Mosser DD, et al. HSP70 prevents activation of stress kinases, a novel pathway of cellular thermotolerance 〔Ｊ〕. J Biol Chem, 1997; 272(29)∶18033.
18.	Sepehrnia B, Paz B, Dasgupta G, et al. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell 〔Ｊ〕. J Biol Chem, 1996; 271(25)∶15084.
19.	DAI CL, Kume M, Yamamoto Y, et al. Heat shock protein 72 production in liver tissue after experimental total hepatic inflow occlusion 〔Ｊ〕. Br J Surg, 1998; 85(8)∶1061.

1. William J. Mammalian stress reperfusion: cell physiology, structure/function of stress proteins, and implications for medicine and disease 〔Ｊ〕. Physiol Rev, 1992; 72(4)∶1063.
2. Lindquit S, Craig EA. The heat shock proteins 〔Ｊ〕. Ann Rev Genet, 1988; 22∶631.
3. Takahashi Y, Tamaki T, Tanaka M, et al. Efficacy of heat shock proteins induced by severe fasting to protect rat livers preserved for 72 hours from cold ischemia/reperfusion injury 〔Ｊ〕. Transplant Proc, 1998; 30(7)∶3700.
4. Kobayashi J, Takeyoshi I, Ohwada S, et al. The effects of FR167653 in extended liver resection with ischemia in dogs 〔Ｊ〕. Hepatology, 1998; 28(2)∶459.
5. Pannen BH, Maeda K, Ayuse T, et al. Hepatic heat shock and acutephase gene expression are induced simultaneously after celiotomy in the anesthetized pig 〔Ｊ〕. Anesthesiology, 1995; 83(4)∶850.
6. Lille S, Su CY, Schoeller T, et al. Induction of heat shock protein 72 in rat skeletal muscle does not increase tolerance to ischemic reperfusion injury 〔Ｊ〕. Muscle Nerve, 1999; 22(3)∶390.
7. Shimabukuro T, Yamamoto Y, Kume M, et al. Induction of heat shock response effect on the rat liver with carbon tetrachlorideinduced fibrosis from ischemiareperfusion injury 〔Ｊ〕. World J Surg, 1998; 22(5)∶464.
8. Saad S, Kanai M, Awane M, et al. Protective effect of heat shock pretreatment with heat shock protein induction before hepatic warm ischemia injury caused by pringle maneuver 〔Ｊ〕. Surgery, 1995; 118(3)∶510.
9. Kim YM, Watkins SC, Billiar TR, et al. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factorα reduced apoptosis by inducing heat shock protein 70 expression 〔Ｊ〕. J Biol Chem, 1997; 272(2)∶1402.
10. Tsuruman T, Yagihashi A, Watanabe N, et al. Heat shock protein73 protects against small intestinal warm ischemiareperfusion injury in the rat 〔Ｊ〕. Surgery, 1999; 125(4)∶385.
11. Yamamoto Y, Kume M, Yamaoka Y, et al. Implications of heat shock proteins during liver surgery and liver perfusion 〔Ｊ〕. Recent Results Cancer Res, 1998; 147∶157.
12. Morimoto RI. Cell in stress: transcriptional activation of heat shock genes 〔Ｊ〕. Science, 1993; 259(5100)∶1409.
13. Yamagami K, Yamamoto Y, Kume M, et al. Heat shock preconditioning ameliorates liver injury following normathermic ischemia reperfusion in steatotic rat liver 〔Ｊ〕. J Surg Res, 1998; 79(1)∶47.
14. Van Why SK, Hildelrandt F, Ardito T, et al. Induction and intracellular location of HSP72 after renal ischemia 〔Ｊ〕. Am J Physiol, 1992; 263(5 pt 2)∶F769.
15. Nishihara M, Sumimoto R, Fukude Y, et al. TNFα and heatshock protein gene expression in ischemic injured liver from fasted and nonfasted rats, role of donor fasting in the prevention of reperfusion injury following liver transplantation 〔Ｊ〕. Transpl Int, 1998; 11(Suppl 1)∶S417.
16. Mehlen P, Schulze OK, Arrigo AP, et al. Small stress proteins as novel regulators apoptosis. Heat shock protein 27 blocks Fas/Apo1 and staurosporineinduced cell death 〔Ｊ〕. J Biol Chem, 1996; 271(28)∶16510.
17. Gabai VL, Meriin AB, Mosser DD, et al. HSP70 prevents activation of stress kinases, a novel pathway of cellular thermotolerance 〔Ｊ〕. J Biol Chem, 1997; 272(29)∶18033.
18. Sepehrnia B, Paz B, Dasgupta G, et al. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell 〔Ｊ〕. J Biol Chem, 1996; 271(25)∶15084.
19. DAI CL, Kume M, Yamamoto Y, et al. Heat shock protein 72 production in liver tissue after experimental total hepatic inflow occlusion 〔Ｊ〕. Br J Surg, 1998; 85(8)∶1061.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

HEAT SHOCK PROTEIN AND HEPATIC ISCHEMIA REPERFUSIOIN INJURY

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