Objective To investigate the activation and significance of nuclear transcription factorκB (NFκB) in primary breast carcinoma. MethodsImmunohistochemical staining method was used to detect expression of NFκB in 28 cases of primary breast carcinoma and 21 cases of breast tissues closely adjacent to carcinoma tissues. ResultsIt showed that there was expression of NFκB in 28 cases of breast carcinoma tissues and 21 cases of breast tissues closely adjacent to carcinoma. In 21 cases of breast tissues closely adjacent to carcinoma, NFκB was localized mainly in cytoplasm of epithelium cells of ducts and lobular acini. In 28 cases of breast carcinoma NFκB was mainly expressed in cytoplasm and /or nuclei of breast carcinoma cells. Conclusion NFκB is expressed in breast tissues closely adjacent to carcinoma and primary breast carcinoma tissues, and the expression style in the two situation was different. In the breast tissues closely adjacent to carcinoma, NFκB is localized in cytoplasm of epithelium cells of breast acini and duct in an inactive state. In breast carcinoma tissues, NFκB is localized in both cytoplasm and nuclei of carcinoma cells. This study suggests that NFκB is activated in breast carcinoma and plays a significant role in its tumorigenesis and development.
Citation：
GUO Shuangping,WANG Wenliang,ZHAI Yuqiang,et al.. Activation and Significance of Nuclear Transcription FactorκB in Primary Breast Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 306-309. doi:
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- 1. 郭双平, 王文亮, 翟宇强. 核转录因子NFκB的研究进展 [J].中华病理学杂志, 2000； 29（5）∶379.
- 2. Baeuerle PA， Baltimore D.NFkappa B: ten years after [J]. Cell,1996； 87(1)∶13.
- 3. Mayo MW， Baldwin AS. The transcription factor NFkappa B: control of oncogenesis and cancer therapy resistance [J]. Biochim Biophy Acta,2000； 1470(2)∶M55.
- 4. Burow ME, Weldon CB, Melnik LI, et al. PI3K/AKT regulation of NFkappa B signaling events in suppression of TNFinduced apoptosis [J]. Biochem Biophys Res Commun, 2000; 271(2)∶342.
- 5. Baeuerle PA. Ikappa BNFkappa B structures: at the interface of inflammation control [J]. Cell, 1998； 95(6)∶729.
- 6. Baeuerle PA, Henkel T. Function and activation of NFkappa B in the immune system [J]. Annu Rev Immunol,1994; 12(1)∶141.
- 7. Beg AA, Sha W, Bronson RT, et al. Embryonic lethality and liver degeneration in mice lacking the Rel A component of NF kappa B [J]. Nature,1995； 376(6536)∶167.
- 8. Bellas RE, FitzGerald MJ,Fausto N, et al. Inhibition of NFkappa B activity induces apoptosis in murine hepatocytes [J]. Am J Pathol,1997； 151(4)∶891.
- 9. Beg AA， Baltimore D. An essential role for NFkappa B in preventing TNFalphainduced cell death [J].Science, 1996； 274(5288)∶782.
- 10. Wang W, Abbruzzese JL, Evans DB,et al. The nuclear factorkappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells [J]. Clin Cancer Res, 1999； 5(1)∶119.
- 11. Jo H, Zhang R, Zhang H, et al. NFkappa B is required for Hras oncogene induced abnormal cell proliferation and tumorigenesis [J].Oncogene, 2000; 19(7)∶841.
- 12. Norris JL， Baldwin AS Jr. Oncogenic Ras enhances NFkappa B transcriptional activity through Rafdependent and Rafindependent mitogenactivated protein kinase signaling pathways [J]. J Biol Chem, 1999; 274(20)∶13841.
- 13. Hinz M, Krappmann D, Eichten A, et al. NFkappa B function in growth control: regulation of cyclin D1 expression and G0/G1to Sphase transition [J]. Mol Cell Bio,1999； 19(4)∶2690.
