Objective To explore the feasibility and clinical effect of the nano-carbon particles in laparoscopic operation for adenocarcinoma of esophagogastric junction.
Methods From 2008 to 2011, 119 patients with adenocar-cinoma of esophagogastric junction who underwent the laparoscopic operation were divided into study group (n=56) and control group (n=63). The nano-carbon particle was injected into the subserosa around the tumor using the injection needle made by ourselves for lymphatic tracing before the laparoscopic operation in the study group, while no tracer was given in the control group. The indexes of lymph nodes, operation time, intraoperative blood loss, and postoperative hospital stay were compared in two groups.
Results The nano-carbon particle was injected into the subserosa around the tumor successfully in the study group. The numbers of dissected lymph nodes and metastatic lymph nodes in the study group were significantly more than those in the control group (dissected lymph nodes:20.52±4.51 versus 16.44±3.80, t=5.341,P=0.000;metastatic lymph nodes:8.88±3.15 versus 6.49±2.49, t=4.602, P=0.000). There were no statistical diff-erences in the intraoperative blood loss, operation time, and postoperative hospital stay in two groups 〔intraoperative blood loss:(97.50±27.52) ml versus (96.03±22.83) ml, t=0.318, P=0.751;operation time:(221.07±24.25) min versus (230.48±38.54) min, t=-1.570, P=0.119;postoperative hospital stay (10.82±1.67) d versus (10.29±1.33) d, t=1.945, P=0.054〕.
Conclusions Injection of the nano-carbon particles using the injection needle made by ourselves is feasible in laparoscopic operation for adenocarcinoma of esophagogastric junction. It can increase number of dissected lymph nodes without increasing operation time, intraoperative blood loss, and postoperative hospital stay.
Citation:
PU Min,HUANG Bin,REN Mingyang,DENG Sihan. Application of Nano-Carbon Particles in Laparoscopic Operation for Adenocarcinoma of Esophagogastric Junction. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(2): 147-151. doi:
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黄允宁, 王炜, 苏刚, 等. 微粒子活性炭在胃癌淋巴结清扫术中的应用价值[J]. 中华普通外科杂志, 2002, 17(6):354-355.
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黄广建, 陈忠清, 刘懿, 等. 活性炭纳米粒对胃癌淋巴清扫的指导作用[J]. 中国现代医学杂志, 2005, 15(2):233-235.
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邵丽玮, 温艳惠, 李慧运, 等. 内镜下淋巴化疗对胃癌淋巴转移的疗效研究[J]. 现代肿瘤医学, 2011, 19(6):1153-1156.
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, 14(2):115-122.
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- 1. Wijnhoven BP, Louwman MW, Tilanus HW, et al. Increased incidence of adenocarcinomas at the gastro-oesophageal junction in Dutch males since the 1990s[J]. Eur J Gastroenterol Hepatol,.
- 2. Sihvo EI, Salminen JT, Rämö OJ, et al. The epidemiology of oesophageal adenocarcinoma:has the cancer of gastric cardia an influence on the rising incidence of oesophageal adenocarcinoma?[J]. Scand J Gastroenterol, 2000, 35(10):1082-1086.
- 3. 荆晓岳, 王建国, 周兵, 等. 近10年豫北地区胃癌临床流行病学特征[J]. 中国普外基础与临床杂志, 2010, 17(1):29-33.
- 4. 王自强, 张元川, 张倩, 等. 腹腔镜下经膈肌裂孔食管胃切除治疗食管胃交界癌55例[J]. 中华胃肠外科杂志, 2010, 13(9):652-655.
- 5. 任明扬, 张军, 黄斌, 等. 三吻合器技术在腹腔镜下贲门癌切除22例分析[J/CD]. 中华普外科手术学杂志:电子版, 2010, 4(2):155-159.
- 6. 任明扬, 张军, 黄斌, 等. 腹腔镜胃癌手术107例体会[J/CD].中华临床医师杂志:电子版, 2011, 5(22):6795-6796.
- 7. 陈海宁, 张波, 陈秀峰, 等. 纳米炭在胃癌根治术中的临床应用研究[J]. 中国普外基础与临床杂志, 2011, 18(2):149-152.
- 8. 李松岩, 杜晓辉, 陈凛, 等. 淋巴示踪剂导引腹腔镜辅助下远端胃癌根治术的临床研究[J]. 中国普通外科杂志, 2010, 19(4):383-385.
- 9. 车红缨, 曾玉剑, 程中. 纳米炭淋巴示踪剂在胃癌淋巴结清扫和病理检查中的价值[J]. 重庆医学, 2009, 38(20):2571-2572.
- 10. 黄斌, 任明扬, 邓思寒, 等. 管状胃-食管吻合对近侧胃切除术后胃食管反流的影响[J/CD]. 中华普外科手术学杂志:电子版, 2011, 5(3):278-284.
- 11. Hulscher JB, van Sandick JW, de Boer AG, et al. Extended trans-thoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus[J]. N Engl J Med, 2002, 347(21):1662-1669.
- 12. 李德周, 赵玉亭, 宋展. 食管胃交界部癌的外科治疗进展[J]. 医学信息手术学分册, 2008, 21(1):43-45.
- 13. 任明扬, 张军, 黄斌, 等. 贲门癌经腹淋巴结清扫的临床价值[J]. 西部医学, 2009, 21(11):1954-1956.
- 14. Giuliani A, Caporale A, Corona M, et al. Lymph adenectomy in gastric cancer:influence on prognosis of lymph node count[J]. J Exp Clin Cancer Res, 2004, 23(2):215-224.
- 15. 蔡长茂. 纳米炭在普外科恶性肿瘤诊治中的应用[J]. 中华实用诊断与治疗杂志, 2010, 24(9):833-834.
- 16. 于永扬, 王存, 郑阳春, 等. 比较研究纳米炭示踪剂在低位直肠癌淋巴结清扫及病理检查中的价值[J]. 中国普外基础与临床杂志, 2008, 15(5):358-361.
- 17. Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH40:a new method for axillary lymph-node dissection in breast cancer[J]. Can J Surg, 2000, 43(3):191-196.
- 18. 李伟, 徐亮. 纳米炭在胃癌淋巴靶向化疗中的应用研究进展[J]. 泸州医学院学报, 2009, 32(4):439-441.
- 19. 郑春雷, 许军. 国产纳米活性炭在胃癌根治术中的应用[J]. 齐齐哈尔医学院学报, 2008, 29(3):275-277.
- 20. 黄允宁, 王炜, 苏刚, 等. 微粒子活性炭在胃癌淋巴结清扫术中的应用价值[J]. 中华普通外科杂志, 2002, 17(6):354-355.
- 21. 黄广建, 陈忠清, 刘懿, 等. 活性炭纳米粒对胃癌淋巴清扫的指导作用[J]. 中国现代医学杂志, 2005, 15(2):233-235.
- 22. Hagiwara A, Takahashi T, Ueda T, et al. Pre-operative endoscopicinfusions of an adsorbent containing mitomycin C (MMC-CH44) in stomach cancer[J]. Gan To Kagaku Ryoho, 1983, 10(12):2558-2564.
- 23. 邵丽玮, 温艳惠, 李慧运, 等. 内镜下淋巴化疗对胃癌淋巴转移的疗效研究[J]. 现代肿瘤医学, 2011, 19(6):1153-1156.
- 24. , 14(2):115-122.