Objective To evaluate the clinical curative effect of early enteral nutrition (EN) in gastric cancer patients after operation and its safety.
Methods One hundred and eighty patients with gastric cancer diagnosed and underwent surgical treatment in gastrointestinal surgery center, West China Hospital from February 2011 to December 2011 were studied prospectively, who were randomly divided into EN group (n=91) and parenteral nutrition (PN) group (n=89). The nutrition state, rehabilitation, hospital stay, cost of nutrition in hospital, and complications were observed.
Results ①According to the postoperative serum nutrition index, there were no significant differences in the prealbumin, hemoglobin, and ratio of albumin to globulin in two groups (P>0.05), but the albumin level in the EN group was significantly
higher than that in the PN group (P=0.047). ②According to the postoperative rehabilitation index, the first ambulation time (P=0.011), first intake time (P=0.000), first nasogastric tube away time (P=0.013), first drainage tube away time (P=0.021), and first urinary catheter away time (P=0.002) in the EN group were significantly shorter than those in the PN group. The difference of the first anus exhaust time was not statistically significant in two groups (P=0.083). ③The cost of nutrition in hospital in the EN group was significantly less than that in the PN group (P=0.017). The postoperative hospital stay and total complication rate were not significant differences in two groups (P>0.05).
Conclusion Early postoperative EN is effective, economic, practical, which might be superior to PN.
Citation:
LI Ka,XIAO Xueling,LIU Shuang,HU Qiulan,HUANG Mingjun.. Curative Effect of Early Enteral Nutrition in Gastric Cancer Patients after Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(2): 174-177. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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徐正平, 陈海军. 胃肠癌术后肠内营养治疗54例疗效观察[J]. 中国煤炭工业医学杂志, 2009, 12(2):230.
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Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery:a systematic review and meta-analysis of randomized controlled trials in the English literature[J]. J Gastrointest Surg, 2008, 12(4):739-755.
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Hu QG, Zheng QC. The influence of enteral nutrition in postoperative patients with poor liver function[J]. World J Gastroenterol, 2003, 9(4):843-846.
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薛平慧, 林松, 刘君. 胃癌术后早期应用肠内营养液临床观察[J]. 药物流行病学杂志, 2011, 20(6):283-285.
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郑晓君. 老年胃癌患者手术后早期肠内营养对预后的影响研究[J]. 中国医药科学, 2011, 1(6):74, 78.
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Kudsk KA. Current aspects of mucosal immunology and its influence by nutrition[J]. Am J Surg, 2002, 183(4):390-398.
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袁琮韦华,李俊生, 嵇振岭, 等. 全肠外营养及早期肠内营养在胃癌全胃切除术后患者中的对比研究[J]. 中国普外基础与临床杂志, 2010, 17(4):357-362.
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陈运龙. 术后动力性胃排空障碍36例诊治体会[J]. 西部医学, 2009, 21(8):1311-1312.
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Huckleberry Y. Nutritional support and the surgical patient[J]. Am J Health Syst Pharm, 2004, 61(7):671-682.
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李长春, 王子云. 胃癌根治术后肠内营养与全肠外营养应用疗效的对比研究[J]. 中国实用医药, 2011, 6(28):45-46.
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宋金明, 苏治国, 马敏, 等. 住院药房肠内营养药物的应用情况分析[J]. 肠外与肠内营养, 2011, 18(6):355-357.
|
22. |
牟景敏, 赵莹, 张雪媛, 等. 心理干预对胃肠癌术后患者的影响[J]. 中国康复, 2011, 26(4):304-305.
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23. |
傅少华, 朱剑飞, 孙庆宇. 66例老年胃癌患者全胃切除术后的营养支持[J]. 苏州大学学报:医学版, 2007, 27(1):147-148,150.
|
24. |
罗世成, 郭建辉, 朱军, 等. 胃肠道肿瘤患者术后早期肠内营养与肠外营养支持的随机对照研究[J]. 中国普外基础与临床杂志, 2007, 14(3):324-328.
|
- 1. 王结实. 胃肠癌术后肠内营养治疗的疗效观察[J] . 当代医学, 2011, 17(18):103-104.
- 2. 赵晓雷, 彭俊生. 不同营养支持方法在胃癌病人术后的应用[J]. 肠外与肠内营养, 2007, 14(1):32-34, 38.
- 3. 李月春, 王东霞, 胡夏荣, 等. 结直肠癌术后早期肠内营养的应用体会[J]. 中国普外基础与临床杂志, 2008, 15(8):607-610.
- 4. 陈凤姣, 李淼, 李佳昕, 等. 大肠癌患者术前肠外营养支持对术后胃肠功能恢复的影响[J]. 护理学报, 2010, 17(5):47-48.
- 5. 孙霞. 直肠癌术后胃肠外营养的护理体会[J]. 齐齐哈尔医学院学报, 2011, 32(20):3401-3402.
- 6. 徐正平, 陈海军. 胃肠癌术后肠内营养治疗54例疗效观察[J]. 中国煤炭工业医学杂志, 2009, 12(2):230.
- 7. 叶仙珍. 42例胃癌根治术后早期肠内营养效果分析[J]. 现代医学, 2011, 11(8):78-79.
- 8. Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use[J]. JPEN J Parenter Enteral Nutr, 2006, 30(4):351-367.
- 9. 林伟, 陈金坤, 凃海健, 等. 全胃切除术后早期肠内营养对免疫状态的影响[J]. 齐齐哈尔医学院学报, 2007, 28(10):1178-1179.
- 10. Sedman PC, MacFie J, Palmer MD, et al. Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans[J]. Br J Surg, 1995, 82(12):1663-1667.
- 11. Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery:a systematic review and meta-analysis of randomized controlled trials in the English literature[J]. J Gastrointest Surg, 2008, 12(4):739-755.
- 12. Bowling TE. Does disorder of gastrointestinal motility affect food intake in the post-surgical patient?[J]. Proc Nutr Soc, 1994, 53(1):151-157.
- 13. Hu QG, Zheng QC. The influence of enteral nutrition in postoperative patients with poor liver function[J]. World J Gastroenterol, 2003, 9(4):843-846.
- 14. 薛平慧, 林松, 刘君. 胃癌术后早期应用肠内营养液临床观察[J]. 药物流行病学杂志, 2011, 20(6):283-285.
- 15. 郑晓君. 老年胃癌患者手术后早期肠内营养对预后的影响研究[J]. 中国医药科学, 2011, 1(6):74, 78.
- 16. Kudsk KA. Current aspects of mucosal immunology and its influence by nutrition[J]. Am J Surg, 2002, 183(4):390-398.
- 17. 袁琮韦华,李俊生, 嵇振岭, 等. 全肠外营养及早期肠内营养在胃癌全胃切除术后患者中的对比研究[J]. 中国普外基础与临床杂志, 2010, 17(4):357-362.
- 18. 陈运龙. 术后动力性胃排空障碍36例诊治体会[J]. 西部医学, 2009, 21(8):1311-1312.
- 19. Huckleberry Y. Nutritional support and the surgical patient[J]. Am J Health Syst Pharm, 2004, 61(7):671-682.
- 20. 李长春, 王子云. 胃癌根治术后肠内营养与全肠外营养应用疗效的对比研究[J]. 中国实用医药, 2011, 6(28):45-46.
- 21. 宋金明, 苏治国, 马敏, 等. 住院药房肠内营养药物的应用情况分析[J]. 肠外与肠内营养, 2011, 18(6):355-357.
- 22. 牟景敏, 赵莹, 张雪媛, 等. 心理干预对胃肠癌术后患者的影响[J]. 中国康复, 2011, 26(4):304-305.
- 23. 傅少华, 朱剑飞, 孙庆宇. 66例老年胃癌患者全胃切除术后的营养支持[J]. 苏州大学学报:医学版, 2007, 27(1):147-148,150.
- 24. 罗世成, 郭建辉, 朱军, 等. 胃肠道肿瘤患者术后早期肠内营养与肠外营养支持的随机对照研究[J]. 中国普外基础与临床杂志, 2007, 14(3):324-328.