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find Keyword "口腔黏膜炎" 4 results
  • 硫糖铝涂剂联合益口含漱液治疗化学疗法后口腔黏膜炎的疗效观察

    目的 观察硫糖铝涂剂联合益口含漱液治疗化学疗法(化疗)后口腔黏膜炎的疗效。 方法 将2011年1月-12月化疗后口腔黏膜炎患者63例, 随机分为治疗组32例和对照组31例。治疗组采用硫糖铝涂剂、益口含漱液治疗,对照组仅用益口含漱液常规治疗,观察两组疗效。 结果 治疗组的总有效率(93.8%)明显高于对照组(71.0%),两组经统计比较差异有统计学意义(P<0.05)。 结论 硫糖铝涂剂联合益口含漱液治疗化疗后口腔黏膜炎,与单纯使用益口含漱液相比,有较好的疗效。

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  • 放射及化学治疗所致口腔黏膜炎的护理

    口腔黏膜炎是放射及化学治疗常见的不良反应,而口腔黏膜炎引起的继发反应,是影响患者生活质量的重要原因,所以对于口腔黏膜炎的护理非常重要。本文对放射及化学治疗引起口腔黏膜炎的护理进行了总结,以便于临床工作中医护人员正确评估患者的口腔,同时能够及时给予患者最佳的护理措施,进而提高患者的生活质量。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • Efficacy of palifermin on oral mucositis and aGVHD for hematological malignancy patients undergoing hematopoietic stem cell transplantation: a meta-analysis

    ObjectivesTo systematically review the efficacy and safety of palifermin on oral mucositis (OM) and acute graft versus host disease (aGVHD) for hematological malignancy patients undergoing hematopoietic stem cell transplantation (HSCT).MethodsPubMed, The Cochrane Library, Web of Science, EMbase, Clinicaltrials.gov, CNKI and WanFang Data databases were electronically searched to collect randomized controlled trials (RCTs) of the efficacy of palifermin on OM and aGVHD for hematological malignancy patients undergoing HSCT from inception to September 30th, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 7 RCTs involving 904 patients were included. The results of meta-analysis showed that: palifermin could reduce the duration of OM grade 2 to 4 (MD=−4.21, 95%CI −7.83 to −0.58, P=0.02), OM grade 3 to 4 (MD=−2.54, 95%CI −4.61 to −0.46, P=0.02) significantly for hematological malignancy patients undergoing HSCT. However, no significant difference was found in the prevalence of aGVHD grade 2 to 4 (RR=1.29, 95%CI 0.95 to 1.75, P=0.11), aGVHD grade 3 to 4 (RR=0.99, 95%CI 0.55 to 1.77, P=0.97), OM grade 2 to 4 (RR=0.86, 95%CI 0.72 to 1.03, P=0.11) and OM grade 3 to 4 (RR=0.82, 95%CI 0.65 to 1.03, P=0.08) between palifermin group and placebo group. The prevalence of paresthesia (RR=4.24, 95%CI 1.24 to 14.56, P=0.02) and erythema (RR=1.49, 95%CI 1.06 to 2.09, P=0.02) were significantly higher in palifermin group.ConclusionsThe durations of OM grade 2 to 4, 3 to 4 are significantly reduce in patients receiving palifermin compared with those receiving a placebo, however, no statistically significant difference are found in the incidence of aGVHD grade 2 to 4, 3 to 4, OM grade 2 to 4, 3 to 4. Parethesia and erythema are more prevalent among patients using palifermin. Therefore, advantages and disadvantages of palifermin should be considered when used in clinical.

    Release date:2019-04-19 09:26 Export PDF Favorites Scan
  • Progress in the prevention and treatment of chemotherapy-induced mucositis

    Chemotherapy-induced mucositis, one of the most common complications of chemotherapy, can be subdivided in oral and gastrointestinal mucositis. The patients always suffer from oral pain and ulcers, nausea, vomiting, abdominal pain and diarrhea. 5-Fluorouracil- and irinotecan-based regimens are frequently associated with a higher risk and more severe grade of mucositis. The onset of mucositis is also influenced by the patient’s characteristics including age, sex, genetic polymorphisms, systemic comorbidities. At present, the diagnosis of chemotherapy-induced mucositis is mainly based on medical history, physical examination and gastroenteroscopy, lack of reliable biomarkers for early diagnosis. The principles of diagnosis and treatment mainly refer to the clinical practice guidelines issued. Therefore, this article will review the mechanism, diagnosis, latest preventive and treatment strategies of chemotherapy-induced mucositis for helping clinicians to further correctly understand and deal with the adverse reactions.

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