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find Author "易成" 13 results
  • 肾脏癌肉瘤一例

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • 血管肌纤维母细胞瘤1例并文献复习

    目的:检索有关血管肌纤维母细胞瘤的文献。方法:检索中国期刊全文数据库、中文期刊全文数据库、万方数字化期刊全数据库。结果:检索的所有文献中血管肌纤维母细胞瘤均以个案报道,主要为女性,发病部位大多位于外阴,其次为阴道、宫颈、腹股沟,也有男性阴囊、腹股沟以及1例口底区的报告。结论:血管肌纤维母细胞瘤多为良性病变,彻底手术切除后无复发,但也有复发及恶变报道,应做长期随访观察。

    Release date:2016-09-08 10:00 Export PDF Favorites Scan
  • The effect of Pseudomonas aeruginosa injection on the prognosis of medullary thyroid carcinoma patients with abnormal serum calcitonin after surgery

    ObjectiveTo investigate the impact of postoperative application of Pseudomonas aeruginosa injection on recurrence free survival (RFS) and overall survival (OS) in patients with abnormal serum calcitonin levels following surgery for medullary thyroid carcinoma (MTC). MethodsA retrospective collection of data was conducted for 214 patients with abnormal serum calcitonin levels following MTC surgery at West China Hospital of Sichuan University from January 2015 to April 2024. Propensity score matching (1∶2) was utilized to match patients’ data to reduce confounding bias, comparing RFS and OS between patients who used (Pseudomonas group) and did not use (control group) Pseudomonas aeruginosa injection. ResultsAfter propensity score matching, 72 patients with abnormal postoperative calcitonin levels were included, with 24 in the Pseudomonas group and 48 in the control group. The median follow-up time for the 72 patients was 66 months (11–168 months). The 1-year RFS rates for the Pseudomonas group and the control group were 100% and 75.0%, respectively, and the 2-year RFS rates were 87.5% and 56.3%, respectively. The RFS in the Pseudomonas group was superior to that in the control group (χ2=4.791, P=0.029). The 5-year OS rates for the Pseudomonas group and the control group were 90.9% and 93.5%, respectively, with no significant difference between the two groups (χ2=0.469, P=0.491). The Cox proportional hazards regression model indicated that the median RFS was extended in the Pseudomonas group [25 months vs. 21 months, RR=0.350, 95%CI (0.135, 0.900), P=0.029], but there was no significant impact on OS [66 months vs. 69 months, RR=2.22, 95%CI (0.229, 21.444), P=0.503]. ConclusionPostoperative use of Pseudomonas aeruginosa injection in MTC patients with abnormal serum calcitonin level shows significant improvement in RFS, but no significant change in OS.

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  • 胰腺神经内分泌肿瘤的治疗进展

    胰腺神经内分泌肿瘤(PNET)是来源自胰腺多能神经内分泌干细胞的一种罕见的胰腺肿瘤,临床表现复杂多样,病程缓慢, 最终发生转移致死。PNET分为功能性和非功能性,目前治疗有手术、化学疗法、放射治疗、介入、生物治疗以及分子靶向药物治疗,近年生物治疗及分子靶向药物治疗在研究中显示出了良好疗效。根据国内外文献及最新临床试验研究进展,现就PNET治疗进展进行综述。

    Release date:2016-09-08 09:11 Export PDF Favorites Scan
  • 膀胱小细胞癌一例

    【摘要】 目的 总结膀胱小细胞癌的诊断及治疗。 方法 2009年8月1例行根治性膀胱切除、回肠代膀胱术患者经病理学、免疫组织化学检查确诊为膀胱小细胞癌。患者接受EP治疗方案治疗。 结果 治疗4周期后,复查CT未见转移,无Ⅲ~Ⅳ级毒副反应。 结论 膀胱小细胞癌需依靠病理学及免疫组织化学检查确诊,治疗目前参考小细胞肺癌治疗方案,以化学疗法为主,复习文献得出有无手术切除并不影响膀胱小细胞癌患者的预后,靶向药物的治疗尚需进一步研究。

    Release date:2016-09-08 09:24 Export PDF Favorites Scan
  • Clinical Observation of Oxaliplatin Combined With S1 Capsule for Advanced Gastric Cancer

    【摘要】 目的 探讨替吉奥胶囊联合奥沙利铂治疗晚期胃癌的近期疗效和毒性反应。 方法 2010年1-7月,16例晚期胃癌患者根据体表面积来确定初始剂量,体表面积lt;1.25 m2,替吉奥胶囊40 mg/次,2次/d;体表面积1.25~1.5 m2,替吉奥胶囊50 mg/次,2次/d;体表面积gt;1.5 m2,替吉奥胶囊60 mg/次,2次/d,早、晚饭后分别口服1次,连续服用28 d,停药14 d。奥沙利铂注射液130 mg/m2加入5%葡萄糖注射液500 mL避光缓慢静gt;2 h,第1、21天重复,连用2周期。按RECIST 1.1标准评价客观疗效和不良反应。 结果 16例患者中PR 9例(56.3%),SD3例(18.8%),PD 4例(25%),总有效率为69.0%。不良反应主要是血液学毒性、胃肠道反应及外周神经毒性,且均在Ⅰ~Ⅱ。 结论 替吉奥胶囊联合奥沙利铂方案治疗晚期胃癌的近期疗效较好,不良反应可以耐受,值得进一步研究应用。【Abstract】 Objective To explore the early efficacy of Oxaliplatin combined with S1 capsule on advanced gastric cancer and observe the toxicity. Methods A total of 16 patients with advanced gastric cancer from January to July 2010 were treated with chemotherapy: oxaliplatin 130 mg/m2 mixed with 5% glucose injection 500 mL in the first day and repeated in the 21st day; Po after breakfast and dinner: S1 capsule with an initial dose according to the body surface area. Body surface lt;1.25 m2, 40 mg once, twice per day; body surface:1.25-1.5 m2,50 mg once, twice per day; body surface gt;1.5 m2, 60 mg once, twice per day. The medication lasted for 28 days, withdrew for 14 days. All of the patients underwent the treatment for two cycles. Efficacy and toxicities were evaluated according to the RECIST 1.1 standard. Results Of the 16 patients, partial remission (PR) was in nine (56.3%), stable disease was in three (18.8%) (SD), and progression disease was in four (PD). The total response rate was 69.0%. The major toxicities included leucopenia, nausea, vomiting and neurosensory abnormity. Conclusion Oxaliplatin combined with S1 capsule is effective on advanced gastric cancer, and the adverse effects are tolerable.

    Release date:2016-09-08 09:52 Export PDF Favorites Scan
  • 晚期结直肠癌中人类免疫缺陷病毒感染患者治疗两例

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  • Anticancer Effect of Ginsenoside Rg3 on Mice Colorectal Cancer

    ObjectiveTo observe the anticancer efficacy of ginsenoside Rg3 on colorectal cancer in vitro and in vivo. MethodsMice colorectal cell line (CT26) was incubated in 96-well plates (3×103-4×103 per well) with various concentrations of ginsenoside Rg3 (0, 5, 10, 15, 20 μg/mL) for 24 hours and 48 hours. 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-dipheny 1-2-H-tetrazolium bromide assay was used to detect the inhibitory rate of cells. Xenograft models were established by subcutaneous implantation of CT26 cells into BABL/c mice. Each mouse was injected with 1×107 cells suspended in serum-free medium. Xenograft mice were randomized into four groups: physiological saline group, ginsenoside Rg3 5 mg/kg group, ginsenoside Rg3 10 mg/kg group, and ginsenoside Rg3 20 mg/kg group. Ginsenoside Rg3 was administrated to mice by intragastric gavage. All animals were observed for activity, body weight, tumor size, survival time, mental state and adverse effect of ginsenoside Rg3. Hematoxylin-eosin stain was used for comparing necrosis rate among groups. ResultsThe inhibitory rates of cells were increasing following the elevating concentrations of ginsenoside Rg3. The anti-proliferation effect of ginsenoside Rg3 for 48 hours was weaker than the anti-proliferation effect for 24 hours. The decrease of mice body weight was slower than physiological saline group after administration of ginsenoside Rg3, and the number of mice with worse physiological state, lack of activity and loss of appetite in physiological saline group were more than that in ginsenoside Rg3 groups. However, these results among four groups were not significantly different (P>0.05). There were no obvious adverse effects of ginsenoside Rg3 found during the whole study. The necrosis rate of physiological saline group, Rg3 10 mg/kg group and Rg3 20 mg/kg group was 20%, 60% and 80% respectively. ConclusionGinsenoside Rg3, as a single agent, still has anticancer activity. The anticancer efficacy is increasing following the elevating concentrations of ginsenoside Rg3. Ginsenoside Rg3 is a dose dependent agent.

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  • 细胞因子风暴与病毒性肺炎

    Release date:2021-02-08 08:11 Export PDF Favorites Scan
  • 芬太尼缓释透皮贴剂联合心理暗示治疗中重度癌性疼痛

    目的 评价芬太尼透皮贴剂(TDF)联合积极心理暗示对中重度癌性疼痛治疗的效果。 方法 将2011年1月-8月40例中重度癌性疼痛患者随机分为对照组和观察组,每组各20例。对照组患者采用TDF 50 μg/h治疗,贴膜每3天更换一次;观察组患者在对照组治疗方法基础上,再联合积极心理暗示治疗。观察两组患者治疗前后疼痛改善情况及不良反应。 结果 观察组患者疼痛及生活质量均较对照组有明显改善。 结论 TDF联合积极的心理暗示可以减轻患者疼痛程度,并可提高其生活质量。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
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