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find Author "李志" 16 results
  • Nine foveal hypoplasia patients in a family

    ObjectiveTo observe the clinical features of nine foveal hypoplasia (FVH) patients in a family. MethodsA retrospective clinical study. In August 2018, nine patients with FVH from a family diagnosed in Qilu Hospital of Shandong University (Qingdao) were included in this study. Detailed medical history of the proband was collected. Best corrected visual acuity (BCVA), slit-lamp, cycloplegic refraction, fundus color photography, optical coherence tomography (OCT) and OCT angiography (OCTA) were performed on the proband. The peripheral venous blood of V7 (family member), the proband and the proband's parents were collected for DNA extraction, and gene detection was performed. ResultsThe proband, a four-year-old girl, had poor vision with BCVA of 0.4 in both eyes. OCT showed absence of foveal pit, absence of outer segment lengthening, absence of outer nuclear layer widening and incursion of inner retinal layers. The proband's mother was 32 years old, and macular foveal reflection was not observed in her eyes. OCT and OCTA examination showed no foveal pit and foveal avascular zone in both eyes. Both eyes of the proband and her mother were diagnosed with Thomas grade 4 FVH. The other seven patients also had no foveal pit, and could be categorized into Thomas grade 3 or 4. No significant pathogenic genes and mutation sites were detected in the proband through whole genome sequencing, and no copy number variation or chromosomal abnormality associated with the phenotype of the proband was detected. After seven months of amblyopia treatment, the proband's BCVA had improved to 0.5 in the right eye and 0.6 in the left eye, while the BCVA did not change after 2 years of follow-up. ConclusionNine FVH patients in this family had no foveal pit with similar OCT images, and their visual acuity was affected from lightly to severely. Early amblyopia training is helpful to improve the visual acuity of child patients.

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  • RESEARCH PROGRESS IN REPAIR AND RECONSTRUCTION OF ISOLATED TRAUMATIC RADIAL HEAD DISLOCATION WITH ANNULAR LIGAMENT INJURY IN CHILDREN

    Objective To review the research progress in the repair and reconstruction of isolated traumatic radial head dislocation with annular l igament injury in children. Methods In recent years, the related l iterature concering isolated traumatic radial head dislocation with annular l igament injury in children was reviewed. Results For isolated traumatic radial head dislocation with annular l igament injury in children, the surgery should be chosen as the main treatment, includingopen reduction and annular l igament reconstruction surgery. Triceps aponeurosis is usually used as reconstruction materials of annular l igament, mainly because the position of taking material of annular l igament is at the operative incision with less surgery trauma and short operative time; aponeurosis is tough and thick with rigid fixation and low risk of re-dislocation. Artificial materials are paid attention to increasingly because they are easy to get, have rigid fixation, and can avoid operative injury caused by taking material of annular l igament. Conclusion Currently active annular l igament reconstruction surgery should be taken; triceps aponeurosis is widely adopted as reconstruction materials of annular l igament and artificial materials have come to be a new research trend.

    Release date:2016-08-31 05:42 Export PDF Favorites Scan
  • CLINICAL RESEARCH PROGRESS OF HETEROTOPIC OSSIFICATION OF ELBOW AFTER INJURY

    Objective To review the basic research and cl inical progress of elbow heterotopic ossification after injury. Methods The recent l iterature concerning heterotopic ossification of the elbow was reviewed. Results Heterotopic ossification was caused by variety of stimul i and conditions. The current methods of prevention and treatment were to improve surgical techniques, to reduce trauma and bleeding, to rinse the area with bone fragments with plenty of salt water, and to use non-steroidal anti-inflammatory drugs. Conclusion Once heterotopic ossification occurred, surgical treatment is unique treatment method, so emphasis is to prevent heterotopic ossification.

    Release date:2016-09-01 09:03 Export PDF Favorites Scan
  • 光动力疗法联合贝伐单抗治疗原发性视网膜血管增生性肿瘤一例

    Release date:2016-09-02 05:22 Export PDF Favorites Scan
  • 90 岁以上老龄股骨颈骨折患者死亡相关危险因素分析

    目的 对 90 岁以上老龄股骨颈骨折患者治疗后死亡的相关危险因素进行分析。 方法 回顾分析 2011 年 3 月—2016 年 3 月收治的 64 例 90 岁以上老龄股骨颈骨折患者资料,男 29 例,女 35 例;年龄 90~99 岁,平均 92.3 岁。骨折 Garden 分型:Ⅱ型 15 例,Ⅲ型 32 例,Ⅳ型 17 例。合并 3 种以上合并症者 37 例(57.8%)。受伤至入院时间 2 h~8 d,平均 65 h。入院后检测血红蛋白 86~152 g/L,平均 117 g/L;白蛋白 31.3~42.0 g/L,平均 36.2 g/L。术前美国麻醉医师协会(ASA)分级:Ⅱ级 28 例,Ⅲ级 23 例,Ⅳ级 13 例。谵妄患者 18 例(28.1%)。其中 40 例采用人工股骨头置换术治疗,24 例采用非手术治疗。所有患者随访至出院后 1 年,若患者死亡则以死亡为终点,观察记录患者出院后死亡率,单因素分析初步筛选死亡相关影响因素;进一步采用 logistics 回归行多因素分析,筛选死亡相关独立危险因素。 结果 患者住院时间 2~49 d,平均 19.4 d。所有患者均获随访,随访时间 1~12 个月,平均 10.1 个月。30 d 死亡率 10.9%(7/64),1 年死亡率 23.4%(15/64)。其中死于心力衰竭 5 例,呼吸衰竭 9 例,深静脉血栓形成 1 例。单因素分析显示,ASA 分级、合并症、入院后白蛋白及血红蛋白水平是老龄股骨颈骨折患者 1 年内死亡的影响因素(P<0.05);进一步多因素分析显示,ASA 分级Ⅲ、Ⅳ级、合并症≥3 种、血红蛋白<120 g/L 是老龄患者 1 年内死亡的独立危险因素(P<0.05)。 结论 积极治疗老龄股骨颈骨折患者合并症,纠正营养状况,加强多学科协作,可降低死亡率。

    Release date:2018-07-30 05:33 Export PDF Favorites Scan
  • 双眼葡萄膜炎继发脉络膜骨瘤合并脉络膜新生血管1例

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  • 隐匿性脉络膜新生血管的吲哚青绿血管造影观察

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • Clinical characterisitics of choroidal excavation in the macula

    ObjectiveTo observe the clinical characterisitics of choroidal excavation in the macula. MethodsA total of 22 patients (22 eyes) with choroidal excavation diagnosed by spectral domain high definition optical coherence tomography (HD-OCT) were enrolled in this study. The patients included 12 males (54.50%) and 57 females (45.50%). The age was ranged from 21 to 82 years old, with an average of (41.44±13.17) years. All the patients were affected unilaterally, including 9 right eyes and 13 left eyes. The corrected vision, slit lamp microscope with preset lens, fundus photography, HD-OCT and fluorescence fundus angiography (FFA)were measured for all patients. The clinical characterisitics and concomitant diseases were observed. Seventeen eyes were followed for a period between 3 to 12 months. The lesions change were evaluated by HD-OCT. ResultsThere were 18 eyes (81.8%) with symptoms of micropsia and metamorphopsia, 4 eyes (18.2%) without symptoms. The corrected vision was ranged from 0.3 to 1.2, 12 eyes (54.54%) with moderate or high myopia. Fundus examination presents yellowish-white exudation in 12 eyes (54.54%), yellowish-white exudation accompanied with hemorrhage in 9 eyes (40.91%), grayish yellow reflex halo in 1 eye (4.55%). HD-OCT showed that the retinal pigment epithelium (RPE) layer was involved in the excavation, and the photoreceptor outer segment and pigment junction (OPR) layer was disappeared in all eyes. The external limiting membrane and the photoreceptor inner segment/outer segment junction layer were preserved in 13 eyes (59.09%) and disappeared in 9 eyes (40.91%). There were 10 eyes (18.18%) with a single lesion, 4 eyes (18.18%) with idiopathic choroidal neovascularization, 4 eyes (18.18%) with punctate inner choroidopathy, 1 eye (4.55%) with polypoidal choroidal vasculopathy, 1 eye (4.55%) with macular preretinal menbrance, 1 eye (4.55%) with central serous chorioretinopathy. FFA showed hypofluorescence in early phase, hyperfluorescence in late phase, without obvious leakage. There was no noticeable changes in size and morphological changes in the follow-up period. ConclusionsChoroidal excavation in the macula occurs mostly in middle-aged people with myopia. It can be associated with many fundus diseases. The excavation is located in RPE layer, and OPR layer disappeared. Choroidal excavation in the macula develops slowly.

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  • Effect of prolonged photodynamic therapy irradiation time combined with intravitreal injection of ranibizumab in the treatment of circumscribed choroidal hemangioma

    ObjectiveTo observe the clinical effect of prolonged photodynamic therapy (PDT) irradiation time combined with intravitreal injection of ranibizumab in the treatment of circumscribed choroidal hemangioma (CCH).MethodsA retrospective clinical study. From March 2012 to March 2018, 51 eyes of 51 patients diagnosed in Shenzhen Eye Hospital were included in the study. Among the patients, the tumor of 36 eyes were located in macular area, of 15 eyes were located outside macular area (near center or around optic disc). All patients underwent BCVA, color fundus photography, FFA, ocular B-scan ultrasonography and OCT examinations. The BCVA examination was performed using the international standard visual acuity chart, which was converted into logMAR visual acuity. OCT showed 48 eyes with macular serous retinal detachment. of 36 eyes with tumor located in macular area, the logMAR BCVA was 0.05±0.05, the tumor thickness was 4.5±2.2 mm, the diameter of tumor was 9.7±3.6 mm. Of 15 eyes with tumor located outside macular area, the logMAR BCVA was 0.32±0.15, the tumor thickness was 3.8±1.4 mm, the diameter of tumor was 7.7±1.9 mm. PDT was performed for all eyes with the irradiation time of 123 s. After 48 h, all patients received intravitreal injections of 0.5 mg ranibizumab (0.05 ml). At 1, 3 and 6 months after treatment, the same equipment and methods before treatment were used for related examination. BCVA, subretinal effusion (SRF), tumor leakage and size changes were observed. BCVA, tumor thickness and diameter before and after treatment were compared by t test.ResultsAt 6 months after treatment, the tumor was becoming smaller without scar formation. FFA showed that the blood vessels in the tumor were sparse compared with those before treatment, and the fluorescence leakage domain was reduced. OCT showed 43 eyes of macular serous detachment were treated after the combined treatment. The logMAR BCVA were 0.16±0.15 and 0.55±0.21 of the eyes with tumor located in or outside macular area, respectively. The difference of logMAR BCVA between before and after treatment was significant (t=-2.511, -2.676; P=0.036, 0.040). Both the tumor thickness (t=3.416, 3.055; P=0.011, 0.028) and diameter (t=4.385, 4.171; P=0.002, 0.009) of CCH patients were significantly reduced compared with that before treatment.ConclusionThe tumor of CCH can be reduced by prolonged PDT irradiation time combined with intravitreal injection of ranibizumab.

    Release date:2020-03-18 02:34 Export PDF Favorites Scan
  • 视路胶质瘤伴眼内浸润和眼球萎缩1例

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