【摘要】 目的 探讨炎性标志物高敏C反应蛋白(highsensitivity creaction protein ,hsCRP)、纤维蛋白原(fibrinogen, FIB)与P波离散度(P wave dispersion, PWD)的关系。 方法 回顾分析2005年1〖CD3/5〗8月收治的102例心脏病住院患者的临床资料,分别测量PWD和获得hsCRP、FIB血浓度,对比分析炎性标志物和PWD之间的关系。 结果 心脏病住院患者的PWD (408±93) ms、hsCRP (368±317) mg/L和FIB (411±294) g/L均较正常值高。PWD异常组和正常组的血hsCRP分别为(482±211)、(193±093) mg/L,差异有统计学意义(Plt;001)；血FIB分别为(510±348)、(251±129) g/L,差异有统计学意义(Plt;005)。血hsCRP增高组PWD(549±96) ms，较正常组(285±74) ms显著增大(Plt;001),血FIB增高组PWD(479±68) ms，较正常组(359±87) ms显著增大(Plt;005)。PWD与血hsCRP成正相关(相关系数R=0418,Plt;005)；PWD与血FIB成正相关(相关系数R=0292,Plt;005)。 结论 PWD与血炎性标志物密切相关,血炎性标志物增高的患者PWD增大。【Abstract】〓Objective〓〖WT5”BZ〗To investigate the relationship between P wave dispersion (PWD) and inflammatory marker (serum highsensitivity creaction protein, hsCRP and fibronogen,FIB). Methods Retrospectively measure PWD of 102 inpatients with heart diseases,and get the results of the hsCRP and FIB. Results The average PWD (408±93) ms of 102 inpatients is higher than normal value,the average hsCRP (368±317) mg/L and FIB (411±294) g/L are higher than normal value. The serum concentration of the hsCRP and FIB increase significantly in abnormal PWD subgroup than normal PWD subgroup, respectively [(482±211) mg/L vs (193±093) mg/L, Plt;001 and (510±348) g/L vs (251±129) g/L, Plt;005)]. The PWD of the serum highconcentration hsCRP and FIB subgroup increase than normalconcentration subgroup significantly, respectively [(549±96) ms vs (285±74) ms, Plt;001 and (479±68) ms vs (359±87) ms,Plt;005] PWD has positive relationship with hsCRP(R=08,Plt;005)and FIB (R=0292,Plt;005). Conclusions PWD has good relationship with serum inflammtory makers, PWD increases with the ascending of concentration of the serum hsCRP and FIB.
目的:探讨血管紧张素Ⅱ受体拮抗剂(ARB)对PAF患者P波离散度的影响。方法:观察48 例阵发性AF患者的最宽P 波和P 波离散度,并与ARB干预治疗3 个月后进行对比分析。结果:ARB治疗3个月后最宽P波、P 波离散度及P 波离散度≥40 ms的例数与治疗前比较差异有统计学意义 (Plt;0.05或lt;0.01)。结论:ARB能减轻PAF患者心房结构重构及电重构,减少AF的发生。
ObjectiveTo investigate the effects of a new anti-anxiety-depression drug tandospirone on heart rate variability (HRV) and QT-dispersion in patients with anxiety and depression after intracoronary stent implantation. MethodsEighty-six anxious and depressive patients after intracoronary stent implantation during May 2011 and May 2013 were treated by tandospirone for 6 weeks. We evaluated the changes of HRV and QT dispersion before and after anti-anxiety-depression treatment. ResultsAfter six weeks of treatment, the HRV was increased obviously (P<0.05) and the QT dispersion was decreased significantly (P<0.01). ConclusionThe new anti-anxiety-depression drug tandospirone is effective on cardiac autonomic nervous system in patients with anxiety and depression after intracoronary stent implantation. And the drug is secure with a low rate of adverse reactions.
Diffusion tensor imaging technology can provide information on the white matter of the brain, which can be used to explore changes in brain tissue structure, but it lacks the specific description of the microstructure information of brain tissue. The neurite orientation dispersion and density imaging make up for its shortcomings. But in order to accurately estimate the brain microstructure, a large number of diffusion gradients are needed, and the calculation is complex and time-consuming through maximum likelihood fitting. Therefore, this paper proposes a kind of microstructure parameters estimation method based on the proximal gradient network, which further avoids the classic fitting paradigm. The method can accurately estimate the parameters while reducing the number of diffusion gradients, and achieve the purpose of imaging quality better than the neurite orientation dispersion and density imaging model and accelerated microstructure imaging via convex optimization model.