Objective To evaluate the curative effectiveness and safety of transanal endoscopic microsurgery (TEM) vs. radical surgery (RS) for the patients with rectal malignant tumor, and to provide information for clinical research and practice. Methods Through computer searching The Cochrane Central Register of Controlled Trials, PubMed, OVID, CBM and CNKI from inception to April 2010, and hand searching relevant journals including Chinese Journal of Surgery and Chinese Journal of Evidence-Based Medicine, the randomized controlled trails (RCTs) and non-randomized controlled trails (NRCTs) comparing TEM with RS for rectal malignant tumor were collected. Data were extracted and evaluated by two reviewers independently according to the Cochrane Handbook for Systematic Reviews. Meta-analyses were conducted using the Cochrane collaboration’s software RevMan 5.0. Results One RCT and four NRCTs met the selection criteria, involving 929 patients. The methodological quality of all trials was low with possibility of bias. The meta-analyses showed that: a) Three studies reported local recurrence in T1 stage patients. There was a significant difference in local recurrence between the two groups (OR=12.61, 95%CI 2.59 to 61.29, P=0.002); b) Two studies reported disease-free survival in T1 stage patients. There was no significant difference between the two groups in disease-free survival (OR=1.12, 95%CI 0.31 to 4.12, P=0.86); c) Three studies reported overall survival in T1 stage patients. There was no significant difference between the two groups (OR=1.09, 95%CI 0.57 to 2.08, P=0.80); and d) Three studies reported postoperative complications in T1 stage patients. There was a significant difference between the two groups in terms of complications (OR=0.05, 95%CI 0.02 to 0.10, Plt;0.00001). Conclusion For T1 stage patients, TEM is associated with less injury of tissue, less operative bleeding, short duration of hospital stay, and low incidence of postoperative complications. The disease-free and overall survivals are comparable to those of RS, but the local recurrence rate is higher. The role of TEM in T2 stage patients is still under discussion. However, the trails available for this systematic review are of lower methodological quality, and bias may exist due to NRCTs. Therefore, more high quality RCTs are required.
目的：总结吻合器痔上黏膜环切术（PPH）治疗痔病的经验。探讨该术式的有关问题，以便提高疗效。方法：回顾性分析了2001～2006年8月收治痔病541例，其中PPH术42例的临床资料。本组均为Ⅲ度或Ⅳ度痔。局部合并症共22例次：血栓外痔愈合后遗留皮赘14例，肛裂2例。有关全身合并症：前列腺增生7例，慢性泌尿系统感染1例。结果:42例中，35例术后2～5天出院，6例自愿留院到7天，1例慢性尿路感染者术后2～7天多次便血，再次手术后28日痊愈出院。随访13～24个月：32例恢复满意，10例有肛门包块感及包块排粪时轻度脱出，其中3例经进一步处理缓解，另7例观察治疗。结论:(1)PPH手术简单易行，疼痛轻，住院时间短，效果好。(2)为了提高效果术中应注意：①禁忌症为单个痔块脱出和肛管皮肤不平滑并纤维化的Ⅳ度病变者外。我们还发现慢性泌尿系统感染未彻底治愈者也应视为相对禁忌。明显前列腺增生者也应慎重。②术中按经典PPH手术的要求进行操作，扩肛器插入前后，不宜扩肛和下牵痔块。③个别巨大痔块及皮赘性痔块（tag）宜先行切除，再行本术。④重度脱出者，黏膜切除应宽大，必要时切除部分肛垫。
目的：探讨物理治疗在新生儿经会阴肛门形成术中的治疗效果，提高护理质量。方法：将103例新生儿肛门直肠畸形患儿，随机分为实验组和对照组，对照组实施常规护理治疗。实验组在常规护理治疗基础上，实施物理治疗。结果：物理治疗实验组患儿肛周的局部红肿情况明显低于对照组（P＜0.05），实验组患儿的平均住院日较对照组明显缩短（P＜0.05）。结论：物理治疗能降低新生儿经会阴肛门成形术术后并发症的发生率，缩短住院天数，降低医疗费用，提高护理质量。
目的 探讨老年低位直肠癌经肛门局部切除后加放、化疗的临床意义。方法 对18例年龄≥65岁，肿瘤距肛缘≤6 cm且经病理证实但拒绝Miles术的直肠癌患者行经肛门局部切除； 于术后1个月给予放疗（总剂量50 Gy）； 化疗： 亚叶酸钙200 mg、5-FU 400 mg/m2，第1次于术后第1~5 d，每3~4周重复1次，共3~6次。结果 全部病例无手术死亡，术后均有良好的肛门功能。16例获随访，随访5年，其中3例局部复发，拒绝再次手术，给予放、化疗。死亡12例，其中2例死于远处转移，10例死于其他因素。本组患者1年生存率为77.8%（14/18），5年生存率为38.9%（7/18）。结论 对老年低位直肠癌拒绝Miles术的患者行经肛门局部切除加放、化疗，疗效确切，可提高患者生活质量，延长生存期。
目的 探讨直肠癌根治性切除后用臀大肌瓣与弹性金属环行肛门成形的疗效及其在肿瘤局部治疗中的意义。方法 对34例中下段直肠癌在根治性切除后，利用自体臀大肌瓣加弹性金属环行会阴肛门成形，以代替切除的括约肌，使患者仍保持术后由会阴部排便。结果 手术成功30例，失败4例。按患者术后排便感觉、排便次数及排便预感等主观感觉划分，术后效果优者10例（33．3%），良者16例（53.3%），差者4例（13.3%）。术后随访6个月～6年，其控制大便优良率为76.7%（23/30），术后1年生存率为100%，3年为82.4%（28／34），5年为58.8%（20／34）。结论 臀大肌瓣加弹性金属环行肛门成形术术式对部分患者，特别是不愿意行腹壁人工肛门的直肠癌患者具有一定实用价值，值得推广应用。
目的总结陈旧性会阴肛管缺损肛门不全失禁临床处理经验。方法回顾性分析我院1994年1月至2000年1月收治的7例陈旧性会阴肛管缺损肛门不全失禁患者的临床资料。结果7例患者均行手术治疗，术后全部随访，无一例复发。结论对于陈旧性会阴肛管缺损肛门不全失禁患者，明确找到断裂的外括约肌断端是手术成败的关键。
From this experiment we found that acetylcholine (Ach) was the agonist of the colonic smooth muscles, and noradrenaline (NA) the internal anal sphincter(IAS). The contractions of colonic smooth muscles were significantly inhibited under the calcium-free solution (Ｐ＜0.01), but the IAS was not affected. Ryanodine, which can exhaust the intracellular calcium, remarkably depressed the contractions of IAS (Ｐ＜0.01),but had no effect on the colonic smooth muscles. It can be concluded that the contractions of colonic smooth muscles are mainly related to the influx of extracellular calcium; the release of intracellular calcium plays an important role in the contractions of IAS.
目的 观察和评估一期手术治疗肛门直肠周围脓肿的临床疗效。方法 回顾性分析我院2001年1月至2006年10月期间107例实施一期手术的肛门直肠周围脓肿患者的临床资料。结果 所有患者均行一次性根治手术，术后切口换药。住院时间9～28 d，平均18.5 d。术后随访3～36个月，平均19.5个月，1例术后形成瘘管，2例术后脓肿复发，此3例经再次手术治愈，无复发； 术后一次性治愈率达97.2%（104/107）。结论 一期手术治疗肛门直肠周围脓肿较单纯切开引流手术能明显地缩短术后感染控制时间，降低术后脓肿的复发率和肛瘘的发生率，减轻患者的痛苦。