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find Keyword "药物代谢" 9 results
  • Pharmacokinetic and Bioavailability of Donepezil Orally Disintegrating Tablet in Healthy Volunteers

    目的 采用高效液相色谱-质谱联用法研究盐酸多奈哌齐口腔崩解片的人体药物代谢动力学,并评价其生物等效性。 方法 2009年9月-11月对22例健康男性受试志愿者单次交叉口服盐酸多奈哌齐口腔崩解片(试验制剂)和盐酸多奈哌齐普通片(参比制剂),测定给药后不同时间点血浆中多奈哌齐经时血药浓度,采用DAS 2.0软件进行药物代谢动力学参数计算和生物等效性评价。 结果 受试者单次口服试验制剂与参比制剂后,达峰时间分别为(2.95 ± 1.16)、(3.19 ± 0.98) h,峰浓度分别为(9.98 ± 2.93)、(9.13 ± 2.05) ng/mL,药时曲线下面积(0-t)分别为(470.76± 142.64)、(446.57 ± 137.30)ng/mL·h;药时曲线下面积(0-∞)分别为(517.74 ± 169.79)、(489.47 ± 162.13)ng/mL·h。试验制剂与参比制剂的生物等效性结果为104.7%,其90%置信区间为(98.4%,111.4%)。结论 盐酸多奈哌齐口腔崩解片与普通片生物等效。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • 抗菌药物与细胞色素P450的相关研究

    抗菌药物广泛地应用于临床各个科室,常常与多种药物联合应用而产生药物相互作用。肝微粒体细胞色素P450是药物代谢最重要的酶系之一,药物作用影响其活性是发生药物相互作用的重要分子机制。了解抗菌药物与细胞色素P450的相关关系,有助于明确药物相互作用的分子基础,有助于指导临床合理联合用药,保障临床治疗更加安全有效。现就抗菌药物与细胞色素P450的相关研究作一综述。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • Pharmacokinetics of Single-dose Probucol Tablet in Healthy Volunteers

    目的 采用高效液相色谱-质谱联用法(HPLC-MS/MS)研究普罗布考片的人体药物代谢动力学变化规律。 方法 2010年10月-11月,24例健康男性受试者单次口服普罗布考片0.5 g,采用HPLC-MS/MS法测定给药后不同时间点血浆中普罗布考的经时血药浓度,采用DAS 2.0软件进行药动学参数计算。 结果 受试者单次口服普罗布考片,达峰时间为(11.50 ± 6.66)h,峰浓度为(2 894.72 ± 1 320.53)ng/mL,药-时曲线下面积(AUC)0-t为(238 876.96 ± 131 873.67) ng/mL· h,AUC0-∞为(259 989.08 ± 146 112.88)ng/mL· h,半衰期为(278.52 ± 164.72) h。结论 普罗布考片体内过程符合二室模型,单次口服具有较好的安全性。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • 经口腔吸入及鼻腔给药人体药物代谢动力学研究实施体会

    经口腔吸入及鼻腔给药的药物制剂日趋增多,通常具有血药浓度低,容易发生沾染,药物吸收入血迅速等特点,根据口、鼻腔给药的特点及影响因素,确保给药剂量的标准化,防止药物沾染是实现此类方式给药的重要问题。结合工作实践,现就经口、鼻腔给药制剂人体药物代谢动力学研究过程中的注意事项予以讨论交流,以供参考。

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  • Pharmacokinetic Study of Lovastatin/niacin Sustained-release Tablets in Healthy Chinese Volunteers

    ObjectiveTo study the pharmacokinetics of lovastatin/niacin sustained-release tablets in healthy Chinese volunteers. MethodsEligible subjects were enrolled to receive a single dose of 20/500, 20/750 and 20/1 000 mg lovastatin/niacin sustained-release tablets and multiple dose of 20/1 000 mg lovastatin/niacin sustainedrelease tablets, one time per day, sustained for 5 days, respectively. Blood samples were obtained before dosing and up to 10, 20, 30, and 45 minutes, and 1 hour, 1.5, 2, 2.5, 3, 3.5, 4, 5, 7, 9, 12, and 15 hours after dosing. Niacin, niacinamide, nicotinuric acid and lovastatin were detected by high performance liquid chromatography-tandem mass spectrometry method. ResultsThe peak concertration and the area under the plasma concentration-time curve (0-t) of nicotinuric acid had linear dynamics characteristics with the dosage when the dose of niacin was between 500 and 1 000 mg. After multiple dosing, pharmacokinetics parameters of nicotinuric acid and lovastatin were close. No significant diTherence was found between male and female subjects. ConclusionLovastatin/niacin sustained-release tablets possess linear kinetics. Accumulation is not significant after multiple dosing. Gender doesn't affect the pharmacokinetics parameters.

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  • Pharmacological Mechanism of Tamoxifen and Its Influence on Ovary Function

    ObjectiveTo summarize the relevant studies of pharmacological mechanism of tamoxifen and its influence on ovary function in order to provide information and evidence for the therapy of breast cancer. MethodsPapers published from January 1950 to January 2014, were retrieved in MedLine, OVID, CBM, CNKI databases using the keywords on tamoxifen, drug metabolism, ovary, sex hormone, etc, 1286 papers were retrieved in English literatures, and 621 in Chinese literatures. Criteria of paper adoption:①The clinical and basic studies about metabolism of tamoxifen, metabolic effect of tamoxifen, and gene polymorphism of CYP2D6.②The role played by estrogen receptor and protein cofactors in tamoxifen effect.③The clinical and basic studies about tamoxifen induced ovulation, caused endometrial thickening, changed sex hormone levels. According to the above criteria, 152 papers were selected, and 77 papers out of them were finally analyzed and reviewed. Results①The tamoxifen metabolite 4-OH-N-tamoxifen was the main working component, the decreased levels could predict the poor prognosis.②The CYP2D6 gene polymorphism could affect the metabolic effect of tamoxifen and the therapeutic effect of patients with breast cancer.③The metabolic effect of tamoxifen needed the participation of the estrogen receptors and protein cofactors.④Tamoxifen could affect the reproductive system function through the estrogen receptor of H-P-O axis, ovary, and endometrium. ConclusionsMetabolic effect of tamoxifen is regulated by gene, it could affect reproductive system functions through estrogen receptor. the mechanism that tamoxifen cowld affect the hormone levels and wherther it could reflect the ovarian function by monitering the hormone levels continuously for patients with breast cancer need to be researched.

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  • 正常血糖-高胰岛素钳夹技术在胰岛素制剂药物代谢动力学研究中的应用进展

    正常血糖-高胰岛素钳夹技术是评价胰岛素敏感性的金标准技术。葡萄糖钳夹技术在糖尿病和胰岛素抵抗相关疾病的研究中具有独特的价值。近年来,随着胰岛素制剂及其类似物的迅速发展,该技术在其药物代谢动力学和药物效应动力学研究中的应用日益广泛。该文就正常血糖-高胰岛素钳夹技术在胰岛素制剂的药物代谢动力学及药物效应动力学研究中的发展历程和应用进展作一简要综述。

    Release date:2017-11-24 10:58 Export PDF Favorites Scan
  • Research progress of three-dimensional printing technology in liver surgery and hepatotoxicity evaluation

    Three-dimensional (3D) printing, an emerging rapid prototyping technology, has been widely used in biomedical field. 3D printing was originally used to construct the visualization models and molds in medicine. With the development of 3D printing in biomedical field, the technology was gradually applied in complex tissue regeneration and organ reconstruction. Artificial tissues and organs obtained by 3D printing are expected to be used for organ transplantation, new drug development and drug toxicity evaluation in the field of medicine and health care research. This paper describes the individualized application of 3D printing technology in liver surgery and introduces the research progress of 3D bioprinting technology in liver transplantation, drug metabolism and hepatotoxicity evaluation, and prospects its future development trend to provide a reference for further study.

    Release date:2018-08-23 05:06 Export PDF Favorites Scan
  • 耐药性癫痫及其分子遗传学机制研究

    尽管近年来,大量新型抗癫痫药物涌现,但仍有超过 1/3 的癫痫患者症状没有得到有效控制,发展成为耐药性癫痫。未经控制的癫痫可导致多种行为和精神障碍,造成患者的死亡率升高和生活质量降低。针对耐药性癫痫的特定生物学机制进行精准医疗,能够有效提高抗癫痫药物的有效性和耐受度。文章主要从分子遗传学的角度,对耐药性癫痫的研究进展作一综述。

    Release date:2020-01-09 08:49 Export PDF Favorites Scan
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