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find Keyword "阿尔兹海默病" 3 results
  • 老年轻度认知功能障碍的危险因素

    轻度认知功能障碍(MCI)是介于正常老化与老年期痴呆的一种过渡状态,其进展为痴呆的风险较高,而一旦进展为痴呆,其预后极差,将带来一系列的家庭和社会问题。因此,对MCI的早期诊断和干预将减少痴呆的发病率,而提高老年人的生活质量,减轻社会负担。现从MCI的概念、分类、流行病学及其危险因素等方面作一综述,以期能够早期识别相关危险因素,早期防治。

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  • Research progress about different levels of cognitive recession using resting state functional connectivity network methods

    Normal brain aging and a serious of neurodegenerative diseases may lead to decline in memory, attention and executive ability and poorer quality of life. The mechanism of the decline is not clear now and is still a hot issue in the fields of neuroscience and medicine. A large number of researches showed that resting state functional brain networks based functional magnetic resonance imaging (fMRI) are sensitive and susceptive to the change of cognitive function. In this paper, the researches of brain functional connectivity based on resting fMRI in recent years were compared, and the results of subjects with different levels of cognitive decline including normal brain aging, mild cognitive impairment (MCI) and Alzheimer’s disease (AD) were reviewed. And the changes of brain functional networks under three different levels of cognitive decline are introduced in this paper, which will provide the basis for the detection of normal brain aging and clinical diseases.

    Release date:2017-08-21 04:00 Export PDF Favorites Scan
  • Research progress on the role of Krüppel-like factor 4 in neurological diseases

    Krüppel-like factor 4 (KLF4) is a member of the sample Kruppel transcription factor protein family, is an evolutionary conservative contain zinc finger transcription factors, involved in regulating many cellular processes, such as cell growth, proliferation, differentiation and invasion, KLF4 expression in a variety of tissues and cells in the body, has widely in many physiological and pathological conditions. Many studies have shown that KLF4 is involved in neurobiological processes such as neuroinflammation, oxidative stress, apoptosis and axon regeneration, and is closely related to a variety of nervous system diseases such as epilepsy, stroke, and Alzheimer’s disease. Now KLF4 in its role in the development of nervous system diseases were reviewed, help to understand the pathogenesis of the disease and clinical treatment for diseases of the nervous system to provide potential targets.

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