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find Author "WANG Zhuoren" 1 results
  • THE RELATION BETWEEN RETINOBLASTOMA GENE EXPRESSION AND BIOLOGICAL CHARACTERISTICS OF GALLBLADDER CARCINOMA

    Objective To study the relation between retinoblastoma (Rb) gene expression and biological characteristics of gallbladder carcinoma. Methods The expression of Rb protein in tissues of 41 cases of gallbladder carcinoma, 7 cases of gallbladder papilloma, and 14 cases of cholecystitis were detected by immunohistochemical staining of SP with polyclonal antibody. Results The rate of positive staining was 58.7% in gallbladder carcinoma which was significantly lower than that in cholecystitis and gallbladder papilloma (100%). There was a significant difference of Rb protein expression among the low, moderate and high differentiations and so was between S5, S4, S1, S2 and S3 stage (P<0.05). Conclusion It sugests that expression or non-expression of Rb gene is closely related to the malignant potential invasiveness and prognosis of gallbladder carcinoma.

    Release date:2016-09-08 01:59 Export PDF Favorites Scan
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