Retinoblastoma (RB) is the most common intraocular malignancy in childhood. In recent years, with the development of the comprehensive treatment concept based on chemical therapy and the improvement of diagnosis and treatment technology, the long-term survival rate of RB children has been greatly improved, and the treatment goal has gradually shifted from saving the lives of children to improving the quality of life of children. In large RB diagnosis and treatment centers in China, the survival rate of children is basically equivalent to that of developed countries. However, in some backward areas, RB still poses a great threat to the lives of children. Therefore, the necessary measures to improve the survival rate of children with RB and the quality of life of their families are to intensify the popularization of popular science, improve the public awareness of RB disease, improve the diagnostic efficiency, implement reasonable and standardized treatment plans, conduct genetic counseling and prenatal assessment for high-risk groups, and train professional and technical personnel.