Recent advances in foveal development after treatment for retinopathy of prematurity_Chinese Journal of Ocular Fundus Diseases

Authors：

Chen Shuangshuang , Zhang Qi , Ren Jianing , Peng Jie ,  Zhao Peiquan

Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;

Corresponding author：

Zhao Peiquan, Email: zhaopeiquan@126.com

Keywords：

Retinopathy of prematurity; Macula lutea; Therapy; Review

DOI：

10.3760/cma.j.cn511434-20200114-00016

Video：

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Abstract Full text Figures/Tables Video References Cited by

Retinopathy of prematurity (ROP) is a proliferative vascular retinal disease. Cryotherapy, laser photocoagulation, intravitreal injection of anti-vascular endothelial growth factor, scleral buckling surgery and vitrectomy are the main treatments. Treated with cryotherapy or laser photocoagulation or intravitreal injection of anti-vascular endothelial growth factor, patients with a history of ROP have thicker foveas, and the morphology of the fovea and the development of the retinal vessels in the macular area are affected, resulting in abnormal vision development. However, the specific mechanisms by which different treatments of ROP affecting the development of the macula are not yet clear. It still need further study with large samples to verify and explore, whether changes in the levels of intraocular vascular endothelial growth factor changing the process of normal macular development and how the abnormal development of the macula affects visual function.

Citation： Chen Shuangshuang, Zhang Qi, Ren Jianing, Peng Jie, Zhao Peiquan. Recent advances in foveal development after treatment for retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2021, 37(5): 394-398. doi: 10.3760/cma.j.cn511434-20200114-00016 Copy

1.	储昭节, 王雨生. 我国大陆地区近20年早产儿视网膜病变发病概况[J]. 中华眼科杂志, 2012, 48(2): 179-183. DOI: 10.3760/cma.j.issn.0412-4081.2012.02.020.Chu ZJ, Wang YS. Incidence of retinopathy of prematurity in mainland of China over the last 20 years[J]. Chin J Ophthalmol, 2012, 48(2): 179-183. DOI: 10.3760/cma.j.issn.0412-4081.2012.02.020.
2.	Quinn GE, Gilbert C, Darlow BA, et al. Retinopathy of prematurity: an epidemic in the making[J]. Chin Med J (Engl), 2010, 123(20): 2929-2937.
3.	Wheeler DT, Dobson V, Chiang MF, et al. Retinopathy of prematurity in infants weighing less than 500 grams at birth enrolled in the early treatment for retinopathy of prematurity study[J]. Ophthalmology, 2011, 118(6): 1145-1151. DOI: 10.1016/j.ophtha.2010.09.031.
4.	Lee GA, Lee LR, Gole GA. Angle-closure glaucoma after laser treatment for retinopathy of prematurity[J]. J AAPOS, 1998, 2(6): 383-384. DOI: 10.1016/S1091-8531(98)90042-8.
5.	Lee RW, Mayer EJ, Markham RH. The aetiology of paediatric rhegmatogenous retinal detachment: 15 years experience[J]. Eye (Lond), 2008, 22(5): 636-640. DOI: 10.1038/sj.eye.6702724.
6.	Krolicki TJ, Tasman W. Cataract extraction in adults with retinopathy of prematurity[J]. Arch Ophthalmol, 1995, 113(2): 173-177. DOI: 10.1001/archopht.1995.01100020057028.
7.	欧阳丽娟, 皮练鸿. 早产儿视网膜病变治疗研究进展[J]. 激光杂志, 2015, 36(2): 135-138. DOI: 10.14016/j.cnki.jgzz.2015.02.135.Ouyang LJ, Pi LH. Research progress in treatment of retinopathy of prematurity[J]. Laser Journal, 2015, 36(2): 135-138. DOI: 10.14016/j.cnki.jgzz.2015.02.135.
8.	罗慧敏, 葛胜利, 王理论. ROP治疗的研究进展[J]. 世界最新医学信息文摘, 2019, 19(30): 124-125, 127. DOI: 10.19613/j.cnki.1671-3141.2019.30.057.Luo HM, Ge SL, Wang LL. Research progress of ROP treatment[J]. World Latest Medicine Information, 2019, 19(30): 124-125, 127. DOI: 10.19613/j.cnki.1671-3141.2019.30.057.
9.	Dogra MR, Katoch D, Dogra M. An update on retinopathy of prematurity (ROP)[J]. Indian J Pediatr, 2017, 84(12): 930-936. DOI: 10.1007/s12098-017-2404-3.
10.	易佐慧子, 陈长征. 玻璃体腔注射抗血管内皮生长因子药物治疗早产儿视网膜病变的研究现状[J]. 中华眼底病杂志, 2014, 30(1): 103-106. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.030.Yi ZHZ, Chen CZ. The advances of retinopathy of prematurity treated with intravitreal injection of anti-vascular endothelial growth factor[J]. Chin J Ocul Fundus Dis, 2014, 30(1): 103-106. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.030.
11.	许宇, 张琦, 季迅达, 等. 玻璃体腔注射抗血管内皮生长因子单克隆抗体ranibizumab联合激光光凝治疗急进性后部型早产儿视网膜病变的疗效观察[J]. 中华眼底病杂志, 2014, 30(1): 28-32. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.008.Xu Y, Zhang Q, Ji XD, et al. Combination of intravitreal injection of ranibizumab and laser photocoagulation for the treatment of aggressive posterior retinopathy of prematurity[J]. Chin J Ocul Fundus Dis, 2014, 30(1): 28-32. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.008.
12.	田汝银, 张国明, 唐松, 等. 玻璃体腔注射雷珠单克隆抗体治疗急进型后极部早产儿视网膜病变的临床疗效观察[J]. 中华眼科杂志, 2015, 51(11): 822-825. DOI: 10.3760/cma.j.issn.0412-4081.2015.11.006.Tian RY, Zhang GM, Tang S, et al. The clinical study on intravitreous injection of ranibizumab for aggressive posterior retinopathy of prematurity[J]. Chin J Ophthalmol, 2015, 51(11): 822-825. DOI: 10.3760/cma.j.issn.0412-4081.2015.11.006.
13.	程湧, 梁建宏, 黎晓新. 康柏西普玻璃体腔注射治疗急进性后极部早产儿视网膜病变的疗效观察[J]. 中华眼底病杂志, 2017, 33(2): 144-147. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.008.Cheng Y, Liang JH, Li XX. Intravitreal injection of conbercept for aggressive posterior retinopathy of prematurity[J]. Chin J Ocul Fundus Dis, 2017, 33(2): 144-147. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.008.
14.	Hwang CK, Hubbard GB, Hutchinson AK, et al. Outcomes after intravitreal bevacizumab versus laser photocoagulation for retinopathy of prematurity: a 5-year retrospective analysis[J]. Ophthalmology, 2015, 122(5): 1008-1015. DOI: 10.1016/j.ophtha.2014.12.017.
15.	Quinn GE, Dobson V, Davitt BV, et al. Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age[J]. Ophthalmology, 2008, 115(6): 1058-1064. DOI: 10.1016/j.ophtha.2007.07.028.
16.	Geloneck MM, Chuang AZ, Clark WL, et al. Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial[J]. JAMA Ophthalmol, 2014, 132(11): 1327-1333. DOI: 10.1001/jamaophthalmol.2014.2772.
17.	Shalev B, Farr AK, Repka MX. Randomized comparison of diode laser photocoagulation versus cryotherapy for threshold retinopathy of prematurity: seven-year outcome[J]. Am J Ophthalmol, 2001, 132(1): 76-80. DOI: 10.1016/S0002-9394(01)00956-4.
18.	Yang CS, Wang AG, Sung CS, et al. Long-term visual outcomes of laser-treated threshold retinopathy of prematurity: a study of refractive status at 7 years[J]. Eye (Lond), 2010, 24(1): 14-20. DOI: 10.1038/eye.2009.63.
19.	Quinn GE, Dobson V, Siatkowski R, et al. Does cryotherapy affect refractive error? Results from treated versus control eyes in the cryotherapy for retinopathy of prematurity trial[J]. Ophthalmology, 2001, 108(2): 343-347. DOI: 10.1016/S0161-6420(00)00527-3.
20.	McLoone EM, O'Keefe M, McLoone SF, et al. Long-term refractive and biometric outcomes following diode laser therapy for retinopathy of prematurity[J]. J AAPOS, 2006, 10(5): 454-459. DOI: 10.1016/j.jaapos.2006.05.005.
21.	Kaya M, Berk AT, Yaman A. Long-term evaluation of refractive changes in eyes of preterm children: a 6-year follow-up study[J]. Int Ophthalmol, 2018, 38(4): 1681-1688. DOI: 10.1007/s10792-017-0642-z.
22.	Kuo HK, Sun IT, Chung MY, et al. Refractive error in patients with retinopathy of prematurity after laser photocoagulation or bevacizumab monotherapy[J]. Ophthalmologica, 2015, 234(4): 211-217. DOI: 10.1159/000439182.
23.	姚昱欧, 尹虹, 黎晓新, 等. 激光光凝治疗对早产儿视网膜病变视野及屈光状态的影响[J]. 中华眼底病杂志, 2017, 33(2): 148-152. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.009.Yao YO, Yin H, Li XX, et al. Visual field outcomes and refractive status of retinopathy of prematurity after laser treatment[J]. Chin J Ocul Fundus Dis, 2017, 33(2): 148-152. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.009.
24.	Wu WC, Lin RI, Shih CP, et al. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity[J]. Ophthalmology, 2012, 119(9): 1907-1916. DOI: 10.1016/j.ophtha.2012.02.040.
25.	Vinekar A, Avadhani K, Sivakumar M, et al. Understanding clinically undetected macular changes in early retinopathy of prematurity on spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 5183-5188. DOI: 10.1167/iovs.10-7155.
26.	Diaz-Araya C, Provis JM. Evidence of photoreceptor migration during early foveal development: a quantitative analysis of human fetal retinae[J]. Vis Neurosci, 1992, 8(6): 505-514. DOI: 10.1017/S0952523800005605.
27.	Abramov I, Gordon J, Hendrickson A, et al. The retina of the newborn human infant[J]. Science, 1982, 217(4556): 265-267. DOI: 10.1126/science.6178160.
28.	Provis JM, Diaz CM, Dreher B. Ontogeny of the primate fovea: a central issue in retinal development[J]. Prog Neurobiol, 1998, 54(5): 549-580. DOI: 10.1016/S0301-0082(97)00079-8.
29.	Cornish EE, Madigan MC, Natoli R, et al. Gradients of cone differentiation and FGF expression during development of the foveal depression in macaque retina[J]. Vis Neurosci, 2005, 22(4): 447-459. DOI: 10.1017/S0952523805224069.
30.	Kozulin P, Natoli R, O' Brien KM, et al. Differential expression of anti-angiogenic factors and guidance genes in the developing macula[J/OL]. Mol Vis, 2009, 15: 45-59[2019-01-12]. https://pubmed.ncbi.nlm.nih.gov/19145251/.
31.	Kozulin P, Natoli R, Bumsted O' Brien KM, et al. The cellular expression of antiangiogenic factors in fetal primate macula[J]. Invest Ophthalmol Vis Sci, 2010, 51(8): 4298-4306. DOI: 10.1167/iovs.09-4905.
32.	Kozulin P, Natoli R, Madigan MC, et al. Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance[J]. Mol Vis, 2009, 15: 2649-2662.
33.	Hendrickson AE, Yuodelis C. The morphological development of the human fovea[J]. Ophthalmology, 1984, 91(6): 603-612. DOI: 10.1016/S0161-6420(84)34247-6.
34.	Maldonado RS, O' Connell RV, Sarin N, et al. Dynamics of human foveal development after premature birth[J]. Ophthalmology, 2011, 118(12): 2315-2325. DOI: 10.1016/j.ophtha.2011.05.028.
35.	Yuodelis C, Hendrickson A. A qualitative and quantitative analysis of the human fovea during development[J]. Vision Res, 1986, 26(6): 847-855. DOI: 10.1016/0042-6989(86)90143-4.
36.	Springer AD, Troilo D, Possin D, et al. Foveal cone density shows a rapid postnatal maturation in the marmoset monkey[J]. Vis Neurosci, 2011, 28(6): 473-484. DOI: 10.1017/S0952523811000332.
37.	郑璟, 柯晓云, 徐进, 等. 无ROP早产儿视盘周围视网膜神经纤维层及黄斑区视网膜和脉络膜厚度分析[J]. 眼科新进展, 2015, 35(9): 844-846. DOI: 10.13389/j.cnki.rao.2015.0230.Zheng J, Ke XY, Xu J, et al. Analysis of optic nerve fiber layer, macular foveal layer and choroidal thickness in prematurity children without ROP[J]. Rec Adv Ophthalmol, 2015, 35(9): 844-846. DOI: 10.13389/j.cnki.rao.2015.0230.
38.	Yanni SE, Wang J, Chan M, et al. Foveal avascular zone and foveal pit formation after preterm birth[J]. Br J Ophthalmol, 2012, 96(7): 961-966. DOI: 10.1136/bjophthalmol-2012-301612.
39.	Bowl W, Stieger K, Bokun M, et al. OCT-based macular structure–function correlation in dependence on birth weight and gestational age–the giessen long-term ROP study[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): OCT235-241. DOI: 10.1167/iovs.15-18843.
40.	Falavarjani KG, Iafe NA, Velez FG, et al. Optical coherence tomography angiography of the fovea in children borm preterm[J]. Retina, 2017, 37(12): 2289-2294. DOI: 10.1097/IAE.0000000000001471.
41.	Maldonado RS, O' Connell R, Ascher SB, et al. Spectral-domain optical coherence tomographic assessment of severity of cystoid macular edema in retinopathy of prematurity[J]. Arch Ophthalmol, 2012, 130(5): 569-578. DOI: 10.1001/archopthalmol.2011.1846.
42.	Chavala SH, Farsiu S, Maldonado R, et al. Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging[J]. Ophthalmology, 2009, 116(12): 2448-2456. DOI: 10.1016/j.ophtha.2009.06.003.
43.	Cabrera MT, Maldonado RS, Toth CA, et al. Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2012, 153(1): 167-175. DOI: 10.1016/j.ajo.2011.06.017.
44.	Cabrera MT, O' Connell RV, Toth CA, et al. Macular findings in healthy full-term hispanic newborns observed by hand-held spectral-domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging Retina, 2013, 44(5): 448-454. DOI: 10.3928/23258160-20130801-01.
45.	Erol MK, Coban DT, Özdemir Ö, et al. Spectral-domain OCT analyses of macular changes after ranibizumab therapy for type 1 retinopathy of prematurity[J]. J Pediatr Ophthalmol Strabismus, 2015, 52(3): 152-158. DOI: 10.3928/01913913-20150326-12.
46.	Dubis AM, Costakos DM, Subramaniam CD, et al. Evaluation of normal human foveal development using optical coherence tomography and histologic examination[J]. Arch Ophthalmol, 2012, 130(10): 1291-1300. DOI: 10.1001/archophthalmol.2012.2270.
47.	Dubis AM, Subramaniam CD, Godara P, et al. Subclinical macular findings in infants screened for retinopathy of prematurity with spectral-domain optical coherence tomography[J]. Ophthalmology, 2013, 120(8): 1665-1671. DOI: 10.1016/j.ophtha.2013.01.028.
48.	冷云霞, 张柳, 张蒙, 等. 早产儿视网膜病变黄斑中心视网膜微血管形态特征: 基于光学相干断层扫描血管成像(OCTA)的观察[J]. 眼科新进展, 2018, 38(4): 357-360. DOI: 10.13389/j.cnki.rao.2018.0083.Leng YX, Zhang L, Zhang M, et al. Observation of central macular retinal microvascular network morphology of retinopathy of prematurity by optical coherence tomography angiography[J]. Rec Adv Ophthalmol, 2018, 38(4): 357-360. DOI: 10.13389/j.cnki.rao.2018.0083.
49.	Vogel RN, Strampe M, Fagbemi OE, et al. Foveal development in infants treated with bevacizumab or laser photocoagulation for retinopathy of prematurity[J]. Ophthalmology, 2018, 125(3): 444-452. DOI: 10.1016/j.ophtha.2017.09.020.
50.	Clark A, Wright T, Isaac M, et al. Macular morphology following unilateral bevacizumab injection for retinopathy of prematurity: an OCT study[J]. J AAPOS, 2017, 21(6): 499-501. DOI: 10.1016/j.jaapos.2017.06.024.
51.	Villegas VM, Capó H, Cavuoto K, et al. Foveal structure-function correlation in children with history of retinopathy of prematurity[J]. Am J Ophthalmol, 2014, 158(3): 508-512. DOI: 10.1016/j.ajo.2014.05.017.
52.	Marmor MF, Choi SS, Zawadzki RJ, et al. Visual insignificance of the foveal pit: reassessment of foveal hypoplasia as fovea plana[J]. Arch Ophthalmol, 2008, 126(7): 907-913. DOI: 10.1001/archopht.126.7.907.
53.	McAllister JT, Dubis AM, Tait DM, et al. Arrested development: high-resolution imaging of foveal morphology in albinism[J]. Vision Res, 2010, 50(8): 810-817. DOI: 10.1016/j.visres.2010.02.003.
54.	Saint-Geniez M, D' Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature[J]. Int J Dev Biol, 2004, 48(8-9): 1045-1058. DOI: 10.1387/ijdb.041895ms.
55.	Harder BC, Schlichtenbrede FC, Baltz SV, et al. Intravitreal bevacizumab for retinopathy of prematurity: refractive error results[J]. Am J Ophthalmol, 2013, 155(6): 1119-1124. DOI: 10.1016/j.ajo.2013.01.014.
56.	Mintz-Hittner HA, Geloneck MM. Review of effects of anti-VEGF treatment on refractive error[J]. Eye Brain, 2016, 8: 135-140. DOI: 10.2147/EB.S99306.
57.	Mintz-Hittner HA, Kennedy KA, Chuang AZ. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity[J]. N Engl J Med, 2011, 364(7): 603-615. DOI: 10.1056/NEJMoa1007374.
58.	Fernandez MP, Berrocal AM, Goff TC, et al. Histopathologic characterization of the expression of vascular endothelial growth factor in a case of retinopathy of prematurity treated with ranibizumab[J]. Am J Ophthalmol, 2017, 176: 134-140. DOI: 10.1016/j.ajo.2016.12.007.
59.	Young TL, Anthony DC, Pierce E, et al. Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity[J]. J AAPOS, 1997, 1(2): 105-110. DOI: 10.1016/S1091-8531(97)90008-2.
60.	Gursoy H, Bilgec MD, Erol N, et al. The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity[J]. Int Ophthalmol, 2016, 36(4): 591-600. DOI: 10.1007/s10792-016-0176-9.
61.	Lee AC, Maldonado RS, Sarin N, et al. Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity[J]. Retina, 2011, 31(8): 1470-1482. DOI: 10.1097/IAE.0b013e31821dfa6d.
62.	Vajzovic L, Rothman AL, Tran-Viet D, et al. Delay in retinal photoreceptor development in very preterm compared to term infants[J]. Invest Ophthalmol Vis Sci, 2015, 56(2): 908-913. DOI: 10.1167/iovs.14-16021.
63.	Bondalapati S, Milam RW Jr, Ulrich JN, et al. The characteristics and short-term refractive error outcomes of cystoid macular edema in premature neonates as detected by spectral-domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(8): 806-812. DOI: 10.3928/23258160-20150909-04.
64.	梁超群. 光相干断层扫描成像在早产儿视网膜病变中的应用[J]. 中华实验眼科杂志, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.Liang CQ. Progress of optical coherence tomography in retinopathy of prematurity[J]. Chin J Exp Ophthalmol, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.
65.	Chen YC, Chen YT, Chen SN. Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(1): 23-30. DOI: 10.1007/s00417-018-4162-y.

1. 储昭节, 王雨生. 我国大陆地区近20年早产儿视网膜病变发病概况[J]. 中华眼科杂志, 2012, 48(2): 179-183. DOI: 10.3760/cma.j.issn.0412-4081.2012.02.020.Chu ZJ, Wang YS. Incidence of retinopathy of prematurity in mainland of China over the last 20 years[J]. Chin J Ophthalmol, 2012, 48(2): 179-183. DOI: 10.3760/cma.j.issn.0412-4081.2012.02.020.
2. Quinn GE, Gilbert C, Darlow BA, et al. Retinopathy of prematurity: an epidemic in the making[J]. Chin Med J (Engl), 2010, 123(20): 2929-2937.
3. Wheeler DT, Dobson V, Chiang MF, et al. Retinopathy of prematurity in infants weighing less than 500 grams at birth enrolled in the early treatment for retinopathy of prematurity study[J]. Ophthalmology, 2011, 118(6): 1145-1151. DOI: 10.1016/j.ophtha.2010.09.031.
4. Lee GA, Lee LR, Gole GA. Angle-closure glaucoma after laser treatment for retinopathy of prematurity[J]. J AAPOS, 1998, 2(6): 383-384. DOI: 10.1016/S1091-8531(98)90042-8.
5. Lee RW, Mayer EJ, Markham RH. The aetiology of paediatric rhegmatogenous retinal detachment: 15 years experience[J]. Eye (Lond), 2008, 22(5): 636-640. DOI: 10.1038/sj.eye.6702724.
6. Krolicki TJ, Tasman W. Cataract extraction in adults with retinopathy of prematurity[J]. Arch Ophthalmol, 1995, 113(2): 173-177. DOI: 10.1001/archopht.1995.01100020057028.
7. 欧阳丽娟, 皮练鸿. 早产儿视网膜病变治疗研究进展[J]. 激光杂志, 2015, 36(2): 135-138. DOI: 10.14016/j.cnki.jgzz.2015.02.135.Ouyang LJ, Pi LH. Research progress in treatment of retinopathy of prematurity[J]. Laser Journal, 2015, 36(2): 135-138. DOI: 10.14016/j.cnki.jgzz.2015.02.135.
8. 罗慧敏, 葛胜利, 王理论. ROP治疗的研究进展[J]. 世界最新医学信息文摘, 2019, 19(30): 124-125, 127. DOI: 10.19613/j.cnki.1671-3141.2019.30.057.Luo HM, Ge SL, Wang LL. Research progress of ROP treatment[J]. World Latest Medicine Information, 2019, 19(30): 124-125, 127. DOI: 10.19613/j.cnki.1671-3141.2019.30.057.
9. Dogra MR, Katoch D, Dogra M. An update on retinopathy of prematurity (ROP)[J]. Indian J Pediatr, 2017, 84(12): 930-936. DOI: 10.1007/s12098-017-2404-3.
10. 易佐慧子, 陈长征. 玻璃体腔注射抗血管内皮生长因子药物治疗早产儿视网膜病变的研究现状[J]. 中华眼底病杂志, 2014, 30(1): 103-106. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.030.Yi ZHZ, Chen CZ. The advances of retinopathy of prematurity treated with intravitreal injection of anti-vascular endothelial growth factor[J]. Chin J Ocul Fundus Dis, 2014, 30(1): 103-106. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.030.
11. 许宇, 张琦, 季迅达, 等. 玻璃体腔注射抗血管内皮生长因子单克隆抗体ranibizumab联合激光光凝治疗急进性后部型早产儿视网膜病变的疗效观察[J]. 中华眼底病杂志, 2014, 30(1): 28-32. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.008.Xu Y, Zhang Q, Ji XD, et al. Combination of intravitreal injection of ranibizumab and laser photocoagulation for the treatment of aggressive posterior retinopathy of prematurity[J]. Chin J Ocul Fundus Dis, 2014, 30(1): 28-32. DOI: 10.3760/cma.j.issn.1005-1015.2014.01.008.
12. 田汝银, 张国明, 唐松, 等. 玻璃体腔注射雷珠单克隆抗体治疗急进型后极部早产儿视网膜病变的临床疗效观察[J]. 中华眼科杂志, 2015, 51(11): 822-825. DOI: 10.3760/cma.j.issn.0412-4081.2015.11.006.Tian RY, Zhang GM, Tang S, et al. The clinical study on intravitreous injection of ranibizumab for aggressive posterior retinopathy of prematurity[J]. Chin J Ophthalmol, 2015, 51(11): 822-825. DOI: 10.3760/cma.j.issn.0412-4081.2015.11.006.
13. 程湧, 梁建宏, 黎晓新. 康柏西普玻璃体腔注射治疗急进性后极部早产儿视网膜病变的疗效观察[J]. 中华眼底病杂志, 2017, 33(2): 144-147. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.008.Cheng Y, Liang JH, Li XX. Intravitreal injection of conbercept for aggressive posterior retinopathy of prematurity[J]. Chin J Ocul Fundus Dis, 2017, 33(2): 144-147. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.008.
14. Hwang CK, Hubbard GB, Hutchinson AK, et al. Outcomes after intravitreal bevacizumab versus laser photocoagulation for retinopathy of prematurity: a 5-year retrospective analysis[J]. Ophthalmology, 2015, 122(5): 1008-1015. DOI: 10.1016/j.ophtha.2014.12.017.
15. Quinn GE, Dobson V, Davitt BV, et al. Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age[J]. Ophthalmology, 2008, 115(6): 1058-1064. DOI: 10.1016/j.ophtha.2007.07.028.
16. Geloneck MM, Chuang AZ, Clark WL, et al. Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial[J]. JAMA Ophthalmol, 2014, 132(11): 1327-1333. DOI: 10.1001/jamaophthalmol.2014.2772.
17. Shalev B, Farr AK, Repka MX. Randomized comparison of diode laser photocoagulation versus cryotherapy for threshold retinopathy of prematurity: seven-year outcome[J]. Am J Ophthalmol, 2001, 132(1): 76-80. DOI: 10.1016/S0002-9394(01)00956-4.
18. Yang CS, Wang AG, Sung CS, et al. Long-term visual outcomes of laser-treated threshold retinopathy of prematurity: a study of refractive status at 7 years[J]. Eye (Lond), 2010, 24(1): 14-20. DOI: 10.1038/eye.2009.63.
19. Quinn GE, Dobson V, Siatkowski R, et al. Does cryotherapy affect refractive error? Results from treated versus control eyes in the cryotherapy for retinopathy of prematurity trial[J]. Ophthalmology, 2001, 108(2): 343-347. DOI: 10.1016/S0161-6420(00)00527-3.
20. McLoone EM, O'Keefe M, McLoone SF, et al. Long-term refractive and biometric outcomes following diode laser therapy for retinopathy of prematurity[J]. J AAPOS, 2006, 10(5): 454-459. DOI: 10.1016/j.jaapos.2006.05.005.
21. Kaya M, Berk AT, Yaman A. Long-term evaluation of refractive changes in eyes of preterm children: a 6-year follow-up study[J]. Int Ophthalmol, 2018, 38(4): 1681-1688. DOI: 10.1007/s10792-017-0642-z.
22. Kuo HK, Sun IT, Chung MY, et al. Refractive error in patients with retinopathy of prematurity after laser photocoagulation or bevacizumab monotherapy[J]. Ophthalmologica, 2015, 234(4): 211-217. DOI: 10.1159/000439182.
23. 姚昱欧, 尹虹, 黎晓新, 等. 激光光凝治疗对早产儿视网膜病变视野及屈光状态的影响[J]. 中华眼底病杂志, 2017, 33(2): 148-152. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.009.Yao YO, Yin H, Li XX, et al. Visual field outcomes and refractive status of retinopathy of prematurity after laser treatment[J]. Chin J Ocul Fundus Dis, 2017, 33(2): 148-152. DOI: 10.3760/cma.j.issn.1005-1015.2017.02.009.
24. Wu WC, Lin RI, Shih CP, et al. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity[J]. Ophthalmology, 2012, 119(9): 1907-1916. DOI: 10.1016/j.ophtha.2012.02.040.
25. Vinekar A, Avadhani K, Sivakumar M, et al. Understanding clinically undetected macular changes in early retinopathy of prematurity on spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 5183-5188. DOI: 10.1167/iovs.10-7155.
26. Diaz-Araya C, Provis JM. Evidence of photoreceptor migration during early foveal development: a quantitative analysis of human fetal retinae[J]. Vis Neurosci, 1992, 8(6): 505-514. DOI: 10.1017/S0952523800005605.
27. Abramov I, Gordon J, Hendrickson A, et al. The retina of the newborn human infant[J]. Science, 1982, 217(4556): 265-267. DOI: 10.1126/science.6178160.
28. Provis JM, Diaz CM, Dreher B. Ontogeny of the primate fovea: a central issue in retinal development[J]. Prog Neurobiol, 1998, 54(5): 549-580. DOI: 10.1016/S0301-0082(97)00079-8.
29. Cornish EE, Madigan MC, Natoli R, et al. Gradients of cone differentiation and FGF expression during development of the foveal depression in macaque retina[J]. Vis Neurosci, 2005, 22(4): 447-459. DOI: 10.1017/S0952523805224069.
30. Kozulin P, Natoli R, O' Brien KM, et al. Differential expression of anti-angiogenic factors and guidance genes in the developing macula[J/OL]. Mol Vis, 2009, 15: 45-59[2019-01-12]. https://pubmed.ncbi.nlm.nih.gov/19145251/.
31. Kozulin P, Natoli R, Bumsted O' Brien KM, et al. The cellular expression of antiangiogenic factors in fetal primate macula[J]. Invest Ophthalmol Vis Sci, 2010, 51(8): 4298-4306. DOI: 10.1167/iovs.09-4905.
32. Kozulin P, Natoli R, Madigan MC, et al. Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance[J]. Mol Vis, 2009, 15: 2649-2662.
33. Hendrickson AE, Yuodelis C. The morphological development of the human fovea[J]. Ophthalmology, 1984, 91(6): 603-612. DOI: 10.1016/S0161-6420(84)34247-6.
34. Maldonado RS, O' Connell RV, Sarin N, et al. Dynamics of human foveal development after premature birth[J]. Ophthalmology, 2011, 118(12): 2315-2325. DOI: 10.1016/j.ophtha.2011.05.028.
35. Yuodelis C, Hendrickson A. A qualitative and quantitative analysis of the human fovea during development[J]. Vision Res, 1986, 26(6): 847-855. DOI: 10.1016/0042-6989(86)90143-4.
36. Springer AD, Troilo D, Possin D, et al. Foveal cone density shows a rapid postnatal maturation in the marmoset monkey[J]. Vis Neurosci, 2011, 28(6): 473-484. DOI: 10.1017/S0952523811000332.
37. 郑璟, 柯晓云, 徐进, 等. 无ROP早产儿视盘周围视网膜神经纤维层及黄斑区视网膜和脉络膜厚度分析[J]. 眼科新进展, 2015, 35(9): 844-846. DOI: 10.13389/j.cnki.rao.2015.0230.Zheng J, Ke XY, Xu J, et al. Analysis of optic nerve fiber layer, macular foveal layer and choroidal thickness in prematurity children without ROP[J]. Rec Adv Ophthalmol, 2015, 35(9): 844-846. DOI: 10.13389/j.cnki.rao.2015.0230.
38. Yanni SE, Wang J, Chan M, et al. Foveal avascular zone and foveal pit formation after preterm birth[J]. Br J Ophthalmol, 2012, 96(7): 961-966. DOI: 10.1136/bjophthalmol-2012-301612.
39. Bowl W, Stieger K, Bokun M, et al. OCT-based macular structure–function correlation in dependence on birth weight and gestational age–the giessen long-term ROP study[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): OCT235-241. DOI: 10.1167/iovs.15-18843.
40. Falavarjani KG, Iafe NA, Velez FG, et al. Optical coherence tomography angiography of the fovea in children borm preterm[J]. Retina, 2017, 37(12): 2289-2294. DOI: 10.1097/IAE.0000000000001471.
41. Maldonado RS, O' Connell R, Ascher SB, et al. Spectral-domain optical coherence tomographic assessment of severity of cystoid macular edema in retinopathy of prematurity[J]. Arch Ophthalmol, 2012, 130(5): 569-578. DOI: 10.1001/archopthalmol.2011.1846.
42. Chavala SH, Farsiu S, Maldonado R, et al. Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging[J]. Ophthalmology, 2009, 116(12): 2448-2456. DOI: 10.1016/j.ophtha.2009.06.003.
43. Cabrera MT, Maldonado RS, Toth CA, et al. Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2012, 153(1): 167-175. DOI: 10.1016/j.ajo.2011.06.017.
44. Cabrera MT, O' Connell RV, Toth CA, et al. Macular findings in healthy full-term hispanic newborns observed by hand-held spectral-domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging Retina, 2013, 44(5): 448-454. DOI: 10.3928/23258160-20130801-01.
45. Erol MK, Coban DT, Özdemir Ö, et al. Spectral-domain OCT analyses of macular changes after ranibizumab therapy for type 1 retinopathy of prematurity[J]. J Pediatr Ophthalmol Strabismus, 2015, 52(3): 152-158. DOI: 10.3928/01913913-20150326-12.
46. Dubis AM, Costakos DM, Subramaniam CD, et al. Evaluation of normal human foveal development using optical coherence tomography and histologic examination[J]. Arch Ophthalmol, 2012, 130(10): 1291-1300. DOI: 10.1001/archophthalmol.2012.2270.
47. Dubis AM, Subramaniam CD, Godara P, et al. Subclinical macular findings in infants screened for retinopathy of prematurity with spectral-domain optical coherence tomography[J]. Ophthalmology, 2013, 120(8): 1665-1671. DOI: 10.1016/j.ophtha.2013.01.028.
48. 冷云霞, 张柳, 张蒙, 等. 早产儿视网膜病变黄斑中心视网膜微血管形态特征: 基于光学相干断层扫描血管成像(OCTA)的观察[J]. 眼科新进展, 2018, 38(4): 357-360. DOI: 10.13389/j.cnki.rao.2018.0083.Leng YX, Zhang L, Zhang M, et al. Observation of central macular retinal microvascular network morphology of retinopathy of prematurity by optical coherence tomography angiography[J]. Rec Adv Ophthalmol, 2018, 38(4): 357-360. DOI: 10.13389/j.cnki.rao.2018.0083.
49. Vogel RN, Strampe M, Fagbemi OE, et al. Foveal development in infants treated with bevacizumab or laser photocoagulation for retinopathy of prematurity[J]. Ophthalmology, 2018, 125(3): 444-452. DOI: 10.1016/j.ophtha.2017.09.020.
50. Clark A, Wright T, Isaac M, et al. Macular morphology following unilateral bevacizumab injection for retinopathy of prematurity: an OCT study[J]. J AAPOS, 2017, 21(6): 499-501. DOI: 10.1016/j.jaapos.2017.06.024.
51. Villegas VM, Capó H, Cavuoto K, et al. Foveal structure-function correlation in children with history of retinopathy of prematurity[J]. Am J Ophthalmol, 2014, 158(3): 508-512. DOI: 10.1016/j.ajo.2014.05.017.
52. Marmor MF, Choi SS, Zawadzki RJ, et al. Visual insignificance of the foveal pit: reassessment of foveal hypoplasia as fovea plana[J]. Arch Ophthalmol, 2008, 126(7): 907-913. DOI: 10.1001/archopht.126.7.907.
53. McAllister JT, Dubis AM, Tait DM, et al. Arrested development: high-resolution imaging of foveal morphology in albinism[J]. Vision Res, 2010, 50(8): 810-817. DOI: 10.1016/j.visres.2010.02.003.
54. Saint-Geniez M, D' Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature[J]. Int J Dev Biol, 2004, 48(8-9): 1045-1058. DOI: 10.1387/ijdb.041895ms.
55. Harder BC, Schlichtenbrede FC, Baltz SV, et al. Intravitreal bevacizumab for retinopathy of prematurity: refractive error results[J]. Am J Ophthalmol, 2013, 155(6): 1119-1124. DOI: 10.1016/j.ajo.2013.01.014.
56. Mintz-Hittner HA, Geloneck MM. Review of effects of anti-VEGF treatment on refractive error[J]. Eye Brain, 2016, 8: 135-140. DOI: 10.2147/EB.S99306.
57. Mintz-Hittner HA, Kennedy KA, Chuang AZ. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity[J]. N Engl J Med, 2011, 364(7): 603-615. DOI: 10.1056/NEJMoa1007374.
58. Fernandez MP, Berrocal AM, Goff TC, et al. Histopathologic characterization of the expression of vascular endothelial growth factor in a case of retinopathy of prematurity treated with ranibizumab[J]. Am J Ophthalmol, 2017, 176: 134-140. DOI: 10.1016/j.ajo.2016.12.007.
59. Young TL, Anthony DC, Pierce E, et al. Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity[J]. J AAPOS, 1997, 1(2): 105-110. DOI: 10.1016/S1091-8531(97)90008-2.
60. Gursoy H, Bilgec MD, Erol N, et al. The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity[J]. Int Ophthalmol, 2016, 36(4): 591-600. DOI: 10.1007/s10792-016-0176-9.
61. Lee AC, Maldonado RS, Sarin N, et al. Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity[J]. Retina, 2011, 31(8): 1470-1482. DOI: 10.1097/IAE.0b013e31821dfa6d.
62. Vajzovic L, Rothman AL, Tran-Viet D, et al. Delay in retinal photoreceptor development in very preterm compared to term infants[J]. Invest Ophthalmol Vis Sci, 2015, 56(2): 908-913. DOI: 10.1167/iovs.14-16021.
63. Bondalapati S, Milam RW Jr, Ulrich JN, et al. The characteristics and short-term refractive error outcomes of cystoid macular edema in premature neonates as detected by spectral-domain optical coherence tomography[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(8): 806-812. DOI: 10.3928/23258160-20150909-04.
64. 梁超群. 光相干断层扫描成像在早产儿视网膜病变中的应用[J]. 中华实验眼科杂志, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.Liang CQ. Progress of optical coherence tomography in retinopathy of prematurity[J]. Chin J Exp Ophthalmol, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.
65. Chen YC, Chen YT, Chen SN. Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(1): 23-30. DOI: 10.1007/s00417-018-4162-y.

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