Liu Lin 1 , Lu Hong 2,3
  • 1. The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China;
  • 2. Department of Ophthalmology, The First Hospital of Lanzhou University, Lanzhou 730000, China;
  • 3. Department of Ophthalmology, Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China;
Lu Hong, Email: honglucmu@outlook.com
Export PDF Favorites Scan Get Citation

Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis, typically as chronic anterior uveitis with insidious onset. Delayed and inadequate treatment may result in loss of patients' vision and even blindness. For refractory or severe uveitis related to juvenile idiopathic arthritis, systemic immunosuppressive agents should be used as early as possible. With the advantage of controlling ocular inflammation, avoiding ocular complications and reducing the use of traditional immunosuppressant drugs and glucocorticoid, tumor necrosis factor-α inhibitors have been new therapeutic options for uveitis associated with juvenile idiopathic arthritis, although methotrexate is known as the first-line approach. However, there are no internationally unified guidelines for clinical issues regarding the timing of application, reduction and withdrawal of tumor necrosis factor-α inhibitors, and no agreement on the application of tumor necrosis factor-α inhibitors in the management of ocular complications either. An in-depth understanding of the application status and progress of tumor necrosis factor alpha inhibitors in the treatment of juvenile idiopathic arthritis-associated uveitis has important clinical significance.

Citation: Liu Lin, Lu Hong. Advances of tumor necrosis factor-α inhibitor in the treatment of junior idiopathic arthritis associated uveitis. Chinese Journal of Ocular Fundus Diseases, 2021, 37(5): 399-403. doi: 10.3760/cma.j.cn511434-20200323-00125 Copy

  • Previous Article

    Recent advances in foveal development after treatment for retinopathy of prematurity
  • Next Article

    Systemic risk factors and epidemiology of cytomegalovirus retinitis status-post allogeneic bone marrow hematopoietic stem cell transplantation