- 1. Shanghai General Hospital, Shanghai Jiao Tong University School, National Eye Disease Clinical Medicine Research Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Research Center for Ophthalmology and Optic Medicine, Shanghai Key Clinical Specialties, Shanghai 200080, China;
- 2. Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai Visual Health Center (Shanghai Children and Adolescent Myopia Prevention and Treatment Technology Center), Shanghai 201103, China;
High myopia has a high genetic tendency, it not only shows in the excessive elongation of the axial length, but also lends to the formation and progression of various eye lesions, such as peripheral retinopathy, optic disc changes, posterior staphyloma, and myopic maculopathy, due to the mechanical stretching of the axial length to the ocular structure. In addition, high myopia increases the risk of several complications, such as glaucoma, cataract, and corneal disease. All these pathological changes will affect visual function and lead to irreversible vision impairment and blindness in the future. Therefore, it is important to pay attention to screening for optic disc abnormalities and posterior staphyloma, and regular monitor the changes of fundus, intraocular pressure, and lens. At the same time, high myopia has an impact on personal life such as study, psychology, sport, and work, and can reduce the quality of life as well as increase the cost of health care. The clinic should pay more attention to high myopia, prevent and control the development of high myopia from an early stage, in order to minimize its impact on ocular structure and visual function as well as its hazard to personal life and society.
Citation: Liu Shang, Xu Yupeng, Xu Xun. Research status and progress on the influence of high myopia on ocular structure and visual function. Chinese Journal of Ocular Fundus Diseases, 2023, 39(8): 690-695. doi: 10.3760/cma.j.cn511434-20211102-00624 Copy
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8. | 关国华, 詹宇坚, 余扬桂, 等. 儿童青少年高度近视眼轴长度屈光度、年龄及眼底损害的相关性[J]. 中国实用眼科杂志, 2000, 18(7): 409-411. DOI: 10.3760/cma.j.issn.1006-4443.2000.07.009.Guan GH, Zhan YJ, Yu YG, et al. Correlation of axial length, refraction, age and fundus lesions in children and adolescents with high myopia[J]. Chin J Pract Ophthalmol, 2000, 18(7): 409-411. DOI: 10.3760/cma.j.issn.1006-4443.2000.07.009. |
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- 1. Flitcroft DI, He M, Jonas JB, et al. IMI-defining and classifying myopia: a proposed set of standards for clinical and epidemiologic studies[J]. Invest Ophthalmol Vis Sci, 2019, 60(3): M20-M30. DOI: 10.1167/iovs.18-25957.
- 2. Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J]. Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/j.ophtha.2016.01.006.
- 3. Haarman AEG, Enthoven CA, Tideman JWL, et al. The complications of myopia: a review and meta-analysis[J]. Invest Ophthalmol Vis Sci, 2020, 61(4): 49. DOI: 10.1167/iovs.61.4.49.
- 4. Morgan IG, Ohno-Matsui K, Saw SM. Myopia[J]. Lancet (Lond), 2012, 379(9827): 1739-1748. DOI: 10.1016/s0140-6736(12)60272-4.
- 5. Tedja MS, Haarman AEG, Meester-Smoor MA, et al. IMI-myopia genetics report[J]. Invest Ophthalmol Vis Sci, 2019, 60(3): M89-M105. DOI: 10.1167/iovs.18-25965.
- 6. Ip JM, Huynh SC, Robaei D, et al. Ethnic differences in the impact of parental myopia: findings from a population-based study of 12-year-old Australian children[J]. Invest Ophthalmol Vis Sci, 2007, 48(6): 2520-2528. DOI: 10.1167/iovs.06-0716.
- 7. Guggenheim JA, Kirov G, Hodson SA. The heritability of high myopia: a reanalysis of Goldschmidt's data[J]. J Med Genet, 2000, 37(3): 227-231. DOI: 10.1136/jmg.37.3.227.
- 8. 关国华, 詹宇坚, 余扬桂, 等. 儿童青少年高度近视眼轴长度屈光度、年龄及眼底损害的相关性[J]. 中国实用眼科杂志, 2000, 18(7): 409-411. DOI: 10.3760/cma.j.issn.1006-4443.2000.07.009.Guan GH, Zhan YJ, Yu YG, et al. Correlation of axial length, refraction, age and fundus lesions in children and adolescents with high myopia[J]. Chin J Pract Ophthalmol, 2000, 18(7): 409-411. DOI: 10.3760/cma.j.issn.1006-4443.2000.07.009.
- 9. 王阳, 赵汝莲, 皮练鸿. 3~12岁儿童眼轴长度、晶状体屈光力与屈光不正的关系[J]. 中华眼视光学与视觉科学杂志, 2020, 22(3): 191-197. DOI: 10.3760/cma.j.cn115909-20190716-00197.Wang Y, Zhao RL, Pi LH. Relationship between axial length, lens power, and refractive error in children aged 3-12 years[J]. Chin J Optom Ophthalmol Vis Sci, 2020, 22(3): 191-197. DOI: 10.3760/cma.j.cn115909-20190716-00197.
- 10. Sanz Diez P, Yang LH, Lu MX, et al. Growth curves of myopia-related parameters to clinically monitor the refractive development in Chinese schoolchildren[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(5): 1045-1053. DOI: 10.1007/s00417-019-04290-6.
- 11. Ramamurthy D, Lin Chua SY, Saw SM. A review of environmental risk factors for myopia during early life, childhood and adolescence[J]. Clin Exp Optom, 2015, 98(6): 497-506. DOI: 10.1111/cxo.12346.
- 12. Verkicharla PK, Ohno-Matsui K, Saw SM. Current and predicted demographics of high myopia and an update of its associated pathological changes[J]. Ophthalmic Physiol Opt, 2015, 35(5): 465-475. DOI: 10.1111/opo.12238.
- 13. Liu HH, Xu L, Wang YX, et al. Prevalence and progression of myopic retinopathy in Chinese adults: the Beijing eye study[J]. Ophthalmology, 2010, 117(9): 1763-1768. DOI: 10.1016/j.ophtha.2010.01.020.
- 14. Gao LQ, Liu W, Liang YB, et al. Prevalence and characteristics of myopic retinopathy in a rural Chinese adult population: the Handan eye study[J]. Arch Ophthalmol, 2011, 129(9): 1199-1204. DOI: 10.1001/archophthalmol.2011.230.
- 15. Lai TY, Fan DS, Lai WW, et al. Peripheral and posterior pole retinal lesions in association with high myopia: a cross-sectional community-based study in Hong Kong[J]. Eye (Lond), 2008, 22(2): 209-213. DOI: 10.1038/sj.eye.6702573.
- 16. Cheng SC, Lam CS, Yap MK. Prevalence of myopia-related retinal changes among 12-18 year old Hong Kong Chinese high myopes[J]. Ophthalmic Physiol Opt, 2013, 33(6): 652-660. DOI: 10.1111/opo.12082.
- 17. Lam DS, Fan DS, Chan WM, et al. Prevalence and characteristics of peripheral retinal degeneration in Chinese adults with high myopia: a cross-sectional prevalence survey[J]. Optom Vis Sci, 2005, 82(4): 235-238. DOI: 10.1097/01.opx.0000159359.49457.b4.
- 18. Li Z, Guo C, Nie D, et al. A deep learning system for identifying lattice degeneration and retinal breaks using ultra-widefield fundus images[J]. Ann Transl Med, 2019, 7(22): 618. DOI: 10.21037/atm.2019.11.28.
- 19. Feltgen N, Walter P. Rhegmatogenous retinal detachment--an ophthalmologic emergency[J]. Dtsch Arztebl Int, 2014, 111(1-2): 12-21; quiz 22. DOI:10.3238/arztebl.2014.0012.
- 20. Li X. Incidence and epidemiological characteristics of rhegmatogenous retinal detachment in Beijing, China[J]. Ophthalmology, 2003, 110(12): 2413-2417. DOI: 10.1016/s0161-6420(03)00867-4.
- 21. Lewis H. Peripheral retinal degenerations and the risk of retinal detachment[J]. Am J Ophthalmol, 2003, 136(1): 155-160. DOI: 10.1016/s0002-9394(03)00144-2.
- 22. Han X, Ong JS, An J, et al. Association of myopia and intraocular pressure with retinal detachment in European descent participants of the UK biobank cohort: a mendelian randomization study[J]. JAMA Ophthalmol, 2020, 138(6): 671-678. DOI: 10.1001/jamaophthalmol.2020.1231.
- 23. Ohno-Matsui K, Jonas JB. Posterior staphyloma in pathologic myopia[J]. Prog Retin Eye Res, 2019, 70: 99-109. DOI: 10.1016/j.preteyeres.2018.12.001.
- 24. Zheng F, Wong CW, Sabanayagam C, et al. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia[J]. Acta Ophthalmol, 2020, 99(2): e144-e153. DOI: 10.1111/aos.14527.
- 25. Hsiang HW, Ohno-Matsui K, Shimada N, et al. Clinical characteristics of posterior staphyloma in eyes with pathologic myopia[J]. Am J Ophthalmol, 2008, 146(1): 102-110. DOI: 10.1016/j.ajo.2008.03.010.
- 26. Frisina R, Baldi A, Cesana BM, et al. Morphological and clinical characteristics of myopic posterior staphyloma in Caucasians[J]. Graefe's Arch Clin Exp Ophthalmol, 2016, 254(11): 2119-2129. DOI: 10.1007/s00417-016-3359-1.
- 27. Li Z, Liu R, Xiao O, et al. Progression of myopic maculopathy in highly myopic Chinese eyes[J]. Invest Ophthalmol Vis Sci, 2019, 60(4): 1096-1104. DOI: 10.1167/iovs.18-25800.
- 28. Ruiz-Medrano J, Montero JA, Flores-Moreno I, et al. Myopic maculopathy: current status and proposal for a new classification and grading system (ATN) [J]. Prog Retin Eye Res, 2019, 69: 80-115. DOI: 10.1016/j.preteyeres.2018.10.005.
- 29. Chang L, Pan CW, Ohno-Matsui K, et al. Myopia-related fundus changes in Singapore adults with high myopia[J]. Am J Ophthalmol, 2013, 155(6): 991-999. DOI: 10.1016/j.ajo.2013.01.016.
- 30. Chen SJ, Cheng CY, Li AF, et al. Prevalence and associated risk factors of myopic maculopathy in elderly Chinese: the Shihpai eye study[J]. Invest Ophthalmol Vis Sci, 2012, 53(8): 4868-4873. DOI: 10.1167/iovs.12-9919.
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