Research progress of circRNA in retinoblastoma_Chinese Journal of Ocular Fundus Diseases

Authors：

Wei Pengxue ^1,2 , Liang Jia ² , Wang Shijing ² , Fang Dong ² ,  Zhang Shaochong ^1,2

1. The Second Clinical Medical College, Jinan University, Shenzhen 518020, China;
2. Shenzhen Institute of Eye Disease Control, Shenzhen 518040, China;

Corresponding author：

Zhang Shaochong, Email: zhangshaochong@gzzoc.com

Keywords：

Retinoblastoma; circRNA; Cancer biomarker; Molecular targeting treatment; Review

DOI：

10.3760/cma.j.cn511434-20231120-00465

Video：

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Abstract Full text Figures/Tables Video References Cited by

Retinoblastoma (RB), the most common primary intraocular malignancy in infants and young children, poses a serious threat to visual function and the life of children when systemic metastasis occurs. Circular RNA (circRNA) is a recently discovered class of non-coding RNA that mainly functions as competitive endogenous RNA by regulating gene expression through competing with microRNA. circRNA can function as oncogenes or tumor suppressors, regulating various biological processes in RB cells, such as proliferation, migration, apoptosis, autophagy, and drug resistance, thereby providing new therapeutic targets for RB. In addition, the differential expression of circRNA in tumor tissues or exosomes is expected to be a potential biomarker for RB. Further studies and explorations are still needed for the functions and regulatory mechanisms of circRNA in RB to reveal their precise roles in organisms and potential clinical applications.

Citation： Wei Pengxue, Liang Jia, Wang Shijing, Fang Dong, Zhang Shaochong. Research progress of circRNA in retinoblastoma. Chinese Journal of Ocular Fundus Diseases, 2024, 40(6): 478-484. doi: 10.3760/cma.j.cn511434-20231120-00465 Copy

1.	Stacey AW, Bowman R, Foster A, et al. Incidence of retinoblastoma has increased: results from 40 European countries[J]. Ophthalmology, 2021, 128(9): 1369-1371. DOI: 10.1016/j.ophtha.2021.01.024.
2.	Global Retinoblastoma Study Group. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries[J/OL]. Lancet Global Health, 2022, 10(8): e1128-e1140[2022-08-01]. https://pubmed.ncbi.nlm.nih.gov/35839812/. DOI: 10.1016/S2214-109X(22)00250-9.
3.	Singh G, Daniels AB. Disparities in retinoblastoma presentation, treatment, and outcomes in developed and less-developed countries[J]. Semin Ophthalmol, 2016, 31(4): 310-316. DOI: 10.3109/08820538.2016.1154177.
4.	Marković L, Bukovac A, Varošanec AM, et al. Genetics in ophthalmology: molecular blueprints of retinoblastoma[J]. Hum Genomics, 2023, 17(1): 82. DOI: 10.1186/s40246-023-00529-w.
5.	Zhang L, Wu J, Li YJ, et al. Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis[J]. Cancer Cell Int, 2020, 20: 301. DOI: 10.1186/s12935-020-01396-4.
6.	Xu L, Long H, Zhou B, et al. CircMKLN1 suppresses the progression of human retinoblastoma by modulation of miR-425-5p/PDCD4 axis[J]. Curr Eye Res, 2021, 46(11): 1751-1761. DOI: 10.1080/02713683.2021.1927110.
7.	Qu S, Yang X, Li X, et al. Circular RNA: a new star of noncoding RNAs[J]. Cancer Lett, 2015, 365(2): 141-148. DOI: 10.1016/j.canlet.2015.06.003.
8.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015, 22(3): 256-264. DOI: 10.1038/nsmb.2959.
9.	Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency[J]. Nature, 2013, 495(7441): 333-338. DOI: 10.1038/nature11928.
10.	Li Q, Zhao YH, Xu C, et al. Chemotherapy-induced senescence reprogramming promotes nasopharyngeal carcinoma metastasis by circRNA-mediated PKR activation[J/OL]. Adv Sci (Weinh), 2023, 10(8): e2205668[2023-01-22]. https://pubmed.ncbi.nlm.nih.gov/36683218/. DOI: 10.1002/advs.202205668.
11.	Chen N, Zhao G, Yan X, et al. A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1[J]. Genome Biol, 2018, 19(1): 218. DOI: 10.1186/s13059-018-1594-y.
12.	Li K, Peng ZY, Wang R, et al. Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7[J]. Mol Cancer, 2023, 22(1): 103. DOI: 10.1186/s12943-023-01811-0.
13.	Li S, Weng J, Song F, et al. Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression[J]. Cell Death Dis, 2020, 11(6): 452. DOI: 10.1038/s41419-020-2616-8.
14.	Zhang HD, Jiang LH, Hou JC, et al. Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer[J]. Biomed Pharmacother, 2018, 107: 1342-1353. DOI: 10.1016/j.biopha.2018.08.030.
15.	Chen NN, Chao DL, Li XG. Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis[J]. Cell Biochem Funct, 2020, 38(8): 1036-1046. DOI: 10.1002/cbf.3535.
16.	Zuo X, Fu C, Xie J, et al. Hsa_circ_0000527 downregulation suppresses the development of retinoblastoma by modulating the miR-27a-3p/HDAC9 pathway[J]. Curr Eye Res, 2022, 47(1): 115-126. DOI: 10.1080/02713683.2021.1925697.
17.	Liang T, Fan M, Meng Z, et al. Circ_0000527 drives retinoblastoma progression by regulating miR-1236-3p/SMAD2 pathway[J]. Curr Eye Res, 2022, 47(4): 624-633. DOI: 10.1080/02713683.2021.2007535.
18.	Yu B, Zhao J, Dong Y. Circ_0000527 promotes retinoblastoma progression through modulating miR-98-5p/XIAP pathway[J]. Curr Eye Res, 2021, 46(9): 1414-1423. DOI: 10.1080/02713683.2021.1891255.
19.	Zheng T, Chen W, Wang X, et al. Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis[J/OL]. Exp Eye Res, 2021, 211: 108650[2021-06-05]. https://pubmed.ncbi.nlm.nih.gov/34102206/. DOI: 10.1016/j.exer.2021.108650.
20.	Sun Z, Zhang A, Hou M, et al. Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p[J]. Bioengineered, 2020, 11(1): 949-957. DOI: 10.1080/21655979.2020.1814670.
21.	Wang HJ, Li MZ, Cui HB, et al. CircDHDDS/miR-361-3p/WNT3A axis promotes the development of retinoblastoma by regulating proliferation, cell cycle, migration, and invasion of retinoblastoma cells[J]. Neurochem Res, 2020, 45(11): 2691-2702. DOI: 10.1007/s11064-020-03112-0.
22.	Jiang YH, Xiao F, Wang L, et al. Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis[J]. Mol Cell Biochem, 2021, 476(1): 69-80. DOI: 10.1007/s11010-020-03886-5.
23.	Liu H, Yuan HF, Xu D, et al. Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p[J]. Eur Rev Med Pharmacol Sci, 2020, 24(23): 12080-12092. DOI: 10.26355/eurrev_ 202012_23997.
24.	Zhao W, Wang S, Qin T, et al. Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3[J]. J Cell Biochem, 2020, 121(7): 3516-3525. DOI: 10.1002/jcb.29631.
25.	Huang YL, Xue BG, Pan JH, et al. Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblasto ma by regulating ROCK1 expression[J/OL]. Exp Mol Pathol, 120: 104637[2021-04-18]. https://pubmed.ncbi.nlm.nih.gov/33844975/. DOI: 10.1016/j.yexmp.2021.104637.
26.	Zhang Y, Dou X, Kong Q, et al. Circ_0075804 promotes the malignant behaviors of retinoblastoma cells by binding to miR-138-5p to induce PEG10 expression[J]. Int Ophthalmol, 2022, 42(2): 509-523. DOI: 10.1007/s10792-021-02067-7.
27.	Han Q, Ma L, Shao L, et al. Circ_0075804 regulates the expression of LASP1 by targeting miR-1287-5p and thus affects the biological process of retinoblastoma[J]. Curr Eye Res, 2022, 47(7): 1077-1086. DOI: 10.1080/02713683.2022.2053164.
28.	An DX, Yang J, Ma LL. circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis[J]. Open Med, 2022, 17(1): 955-968. DOI: 10.1515/med-2022-0483.
29.	Du SS, Wang S, Zhang FY, et al. SKP2, positively regulated by circ_ODC1/miR-422a axis, promotes the proliferation of retinoblastoma[J]. J Cell Biochem, 2020, 121(1): 322-331. DOI: 10.1002/jcb.29177.
30.	Jiang Y, Xiao F, Wang L, et al. Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis[J/OL]. Exp Eye Res, 2021, 206: 108529[2021-04-04]. https://pubmed.ncbi.nlm.nih.gov/33676964/. DOI: 10.1016/j.exer.2021.108529.
31.	刘越峰, 张勇, 李欣, 等. CircROBO1对视网膜母细胞瘤细胞增殖的影响及其机制[J]. 山东医药, 2023, 63(13): 44-47. DOI: 10.3969/j.issn.1002-266X.2023.13.010.Liu YF, Zhang Y, Li X, et al. Effect of circROBO1 on proliferation of retinoblastoma cells and its mechanism[J]. Shandong Medical Journal, 2023, 63(13): 44-47. DOI: 10.3969/j.issn.1002-266X.2023.13.010.
32.	李磊, 黄赟, 黄明杰. Circ_0000989通过调控miR-183-5 p/LRP6轴促进视网膜母细胞瘤细胞增殖、迁移和侵袭[J]. 现代肿瘤医学, 2021, 29(22): 3914-3919. DOI: 10.3969/j.issn.1672-4992.2021.22.006.Li L, Huang Y, Huang MJ. circ_0000989 promotes the proliferation, migration and invasion of retinoblastoma cells by regulating miR-183-5 p/LRP6[J]. Modern Oncology, 2021, 29(22): 3914-3919. DOI: 10.3969/j.issn.1672-4992.2021.22.006.
33.	Jiang G, Qu M, Kong L, et al. Hsa_circ_0084811 regulates cell proliferation and apoptosis in retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 axis[J/OL]. Biomed Res Int, 2022, 2022: 6918396[2022-07-19]. https://pubmed.ncbi.nlm.nih.gov/35909488/. DOI: 10.1155/2022/6918396.
34.	Lv X, Yang H, Zhong H, et al. Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis[J]. Pharm Biol, 2022, 60(1): 417-426. DOI: 10.1080/13880209.2022.2032206.
35.	储明慧, 陈海银, 张晓力. Circ_0000144靶向miR-502-5p调控人视网膜母细胞瘤Y79细胞增殖和凋亡及迁移侵袭[J]. 国际眼科杂志, 2021, 21(10): 1686-1692. DOI 10.3980/j.issn.1672-5123.2021.10.04.Chu MH, Chen HY, Zhang XL. Circ_0000144 targeting miR-502-5p to regulate the proliferation, apoptosis, migration and invasion of human retinoblastoma Y79 cells[J]. Int Eye Sci, 2021, 21(10): 1686-1692. DOI 10.3980/j.issn.1672-5123.2021.10.04.
36.	周鹏翔, 信波, 宋晓鹏, 等. CircAKT3对视网膜母细胞瘤细胞SO-Rb50增殖和凋亡的影响[J]. 陕西医学杂志, 2020, 49(8): 932-935. DOI: 10.3969/j.issn.1000-7377.2020.08.005.Zhou PX, Xin B, Song XP, et al. Effect of CircAKT3 on the proliferation and apoptosis of retinoblastoma SO-Rb50 cells[J]. Shaanxi Medical Journal, 2020, 49(8): 932-935. DOI: 10.3969/j.issn.1000-7377.2020.08.005.
37.	Xing L, Zhang L, Feng Y, et al. Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway[J]. Biomed Pharmacother, 2018, 105: 326-333. DOI: 10.1016/j.biopha.2018.05.141.
38.	Fu CB, Wang SC, Jin L, et al. CircTET1 inhibits retinoblastoma progression via targeting miR-492 and miR-494-3p through Wnt/beta-catenin signaling pathway[J]. Curr Eye Res, 2021, 46(7): 978-987. DOI: 10.1080/02713683.2020.1843685.
39.	Zhang H, Qiu X, Song Z, et al. CircCUL2 suppresses retinoblastoma cells by regulating miR-214-5p/E2F2 Axis[J/OL]. Anticancer Drugs, 2022, 33(1): e218-e227[2022-01-01]. https://pubmed.ncbi.nlm.nih.gov/34387590/. DOI: 10.1097/cad.0000000000001190.
40.	Singh L, Pushker N, Saini N, et al. Expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in human retinoblastoma[J]. Clin Exp Ophthalmol, 2015, 43(3): 259-267. DOI: 10.1111/ceo.12397.
41.	Alrefaei AF, Abu-Elmagd M. LRP6 receptor plays essential functions in development and human diseases[J]. Genes (Basel), 2022, 13(1): 120. DOI: 10.3390/genes13010120.
42.	Nguyen MN, Chakraborty D, Rao SR, et al. A Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission[J]. Cell Death Dis, 2023, 14(7): 420. DOI: 10.1038/s41419-023-05936-4.
43.	Zhao D, Cui Z. MicroRNA-361-3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling[J]. Exp Ther Med, 2019, 17(2): 1154-1162. DOI: 10.3892/etm.2018.7062.
44.	Tu J, Huo Z, Yu Y, et al. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies[J/OL]. Proc Natl Acad Sci USA, 2022, 119(16): e2117857119[2022-04-19]. https://pubmed.ncbi.nlm.nih.gov/35412907/. DOI: 10.1073/pnas.2117857119.
45.	Sambandam A, Storm E, Tauc H, et al. Obligate role for Rock1 and Rock2 in adult stem cell viability and function[J/OL]. Heliyon, 2023, 9(3): e14238[2023-03-09]. https://pubmed.ncbi.nlm.nih.gov/36950615/. DOI: 10.1016/j.heliyon.2023.e14238.
46.	Tibrewal S, Ratna R, Gour A, et al. Clinical and molecular aspects of congenital aniridia-a review of current concepts[J]. Indian J Ophthalmol, 2022, 70(7): 2280-2292. DOI: 10.4103/ijo.IJO_ 2255_21.
47.	Ni W, Li Z, Ai K. lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis[J]. Bioengineered, 2022, 13(1): 1637-1649. DOI: 10.1080/21655979.2021.2021346.
48.	Lu X, Tu H, Tang D, et al. miR-130a-3p enhances the chemosensitivity of Y79 retinoblastoma cells to vincristine by targeting PAX6 expression[J]. Curr Eye Res, 2022, 47(3): 418-425. DOI: 10.1080/02713683.2021.1984537.
49.	Qiu L, Zhou R, Luo Z, et al. CDC27-ODC1 axis promotes metastasis, accelerates ferroptosis and predicts poor prognosis in neuroblastoma[J/OL]. Front Oncol, 2022, 12: 774458[2022-02-15]. https://pubmed.ncbi.nlm.nih.gov/35242701/. DOI: 10.3389/fonc.2022.774458.
50.	Niu J, Yan T, Guo W, et al. The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma[J]. Autophagy, 2023, 19(6): 1693-1710. DOI: 10.1080/15548627.2022.2150003.
51.	Yang J, Tan C, Wang Y, et al. The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy[J/OL]. Biochim Biophys Acta Mol Basis Dis, 2023, 1869(8): 166839[2023-08-06]. https://pubmed.ncbi.nlm.nih.gov/37549719/. DOI: 10.1016/j.bbadis.2023.166839.
52.	Xiong H, Huang G, Zhu Y, et al. Circ-SHPRH in human cancers: a systematic review and meta-analysis[J/OL]. Front Cell Dev Biol, 2023, 11: 1182900[2023-05-25]. https://pubmed.ncbi.nlm.nih.gov/37305675/. DOI: 10.3389/fcell.2023.1182900.
53.	Sun H, Wang Q, Yuan G, et al. Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a[J/OL]. J Clin Lab Anal, 2020, 34(6): e23235[2020-03-25]. https://pubmed.ncbi.nlm.nih.gov/32212290/. DOI: 10.1002/jcla.23235.
54.	Zhang X, Zhang Y, Wang C, et al. TET (Ten-eleven translocation) family proteins: structure, biological functions and applications[J]. Signal Transduct Target Ther, 2023, 8(1): 297. DOI: 10.1038/s41392-023-01537-x.
55.	Liu X, Zurlo G, Zhang Q. The roles of cullin-2 E3 ubiquitin ligase complex in cancer[J]. Adv Exp Med Biol, 2020, 1217: 173-186. DOI: 10.1007/978-981-15-1025-0_11.
56.	Raval V, Parulekar M, Singh AD. Emerging new therapeutics for retinoblastoma[J]. Ocul Oncol Pathol, 2022, 8(3): 149-155. DOI: 10.1159/000524919.
57.	Lyu J, Wang Y, Zheng QP, et al. Reduction of circular RNA expression associated with human retinoblastoma[J]. Exp Eye Res, 2019, 184: 278-285. DOI: 10.1016/j.exer.2019.03.017.
58.	Wang C, Xu M, Fan Q, et al. Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases[J/OL]. Asian J Pharm Sci, 2023, 18(1): 100772[2022-12-31]. https://pubmed.ncbi.nlm.nih.gov/36896446/. DOI: 10.1016/j.ajps.2022.100772.
59.	Wang J, Wang M, Jiang N, et al. Emerging chemical engineering of exosomes as "bioscaffolds" in diagnostics and therapeutics[J]. Genes Dis, 2023, 10(4): 1494-1512. DOI: 10.1016/j.gendis.2022.10.020.
60.	Turaka K, Shields CL, Meadows AT, et al. Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma[J]. Pediatr Blood Cancer, 2012, 59(1): 121-125. DOI: 10.1002/pbc.23278.
61.	Wen X, Fan J, Jin M, et al. Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial[J]. Lancet Child Adolesc Health, 2023, 7(9): 613-620. DOI: 10.1016/s2352-4642(23)00141-4.

1. Stacey AW, Bowman R, Foster A, et al. Incidence of retinoblastoma has increased: results from 40 European countries[J]. Ophthalmology, 2021, 128(9): 1369-1371. DOI: 10.1016/j.ophtha.2021.01.024.
2. Global Retinoblastoma Study Group. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries[J/OL]. Lancet Global Health, 2022, 10(8): e1128-e1140[2022-08-01]. https://pubmed.ncbi.nlm.nih.gov/35839812/. DOI: 10.1016/S2214-109X(22)00250-9.
3. Singh G, Daniels AB. Disparities in retinoblastoma presentation, treatment, and outcomes in developed and less-developed countries[J]. Semin Ophthalmol, 2016, 31(4): 310-316. DOI: 10.3109/08820538.2016.1154177.
4. Marković L, Bukovac A, Varošanec AM, et al. Genetics in ophthalmology: molecular blueprints of retinoblastoma[J]. Hum Genomics, 2023, 17(1): 82. DOI: 10.1186/s40246-023-00529-w.
5. Zhang L, Wu J, Li YJ, et al. Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis[J]. Cancer Cell Int, 2020, 20: 301. DOI: 10.1186/s12935-020-01396-4.
6. Xu L, Long H, Zhou B, et al. CircMKLN1 suppresses the progression of human retinoblastoma by modulation of miR-425-5p/PDCD4 axis[J]. Curr Eye Res, 2021, 46(11): 1751-1761. DOI: 10.1080/02713683.2021.1927110.
7. Qu S, Yang X, Li X, et al. Circular RNA: a new star of noncoding RNAs[J]. Cancer Lett, 2015, 365(2): 141-148. DOI: 10.1016/j.canlet.2015.06.003.
8. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015, 22(3): 256-264. DOI: 10.1038/nsmb.2959.
9. Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency[J]. Nature, 2013, 495(7441): 333-338. DOI: 10.1038/nature11928.
10. Li Q, Zhao YH, Xu C, et al. Chemotherapy-induced senescence reprogramming promotes nasopharyngeal carcinoma metastasis by circRNA-mediated PKR activation[J/OL]. Adv Sci (Weinh), 2023, 10(8): e2205668[2023-01-22]. https://pubmed.ncbi.nlm.nih.gov/36683218/. DOI: 10.1002/advs.202205668.
11. Chen N, Zhao G, Yan X, et al. A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1[J]. Genome Biol, 2018, 19(1): 218. DOI: 10.1186/s13059-018-1594-y.
12. Li K, Peng ZY, Wang R, et al. Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7[J]. Mol Cancer, 2023, 22(1): 103. DOI: 10.1186/s12943-023-01811-0.
13. Li S, Weng J, Song F, et al. Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression[J]. Cell Death Dis, 2020, 11(6): 452. DOI: 10.1038/s41419-020-2616-8.
14. Zhang HD, Jiang LH, Hou JC, et al. Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer[J]. Biomed Pharmacother, 2018, 107: 1342-1353. DOI: 10.1016/j.biopha.2018.08.030.
15. Chen NN, Chao DL, Li XG. Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis[J]. Cell Biochem Funct, 2020, 38(8): 1036-1046. DOI: 10.1002/cbf.3535.
16. Zuo X, Fu C, Xie J, et al. Hsa_circ_0000527 downregulation suppresses the development of retinoblastoma by modulating the miR-27a-3p/HDAC9 pathway[J]. Curr Eye Res, 2022, 47(1): 115-126. DOI: 10.1080/02713683.2021.1925697.
17. Liang T, Fan M, Meng Z, et al. Circ_0000527 drives retinoblastoma progression by regulating miR-1236-3p/SMAD2 pathway[J]. Curr Eye Res, 2022, 47(4): 624-633. DOI: 10.1080/02713683.2021.2007535.
18. Yu B, Zhao J, Dong Y. Circ_0000527 promotes retinoblastoma progression through modulating miR-98-5p/XIAP pathway[J]. Curr Eye Res, 2021, 46(9): 1414-1423. DOI: 10.1080/02713683.2021.1891255.
19. Zheng T, Chen W, Wang X, et al. Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis[J/OL]. Exp Eye Res, 2021, 211: 108650[2021-06-05]. https://pubmed.ncbi.nlm.nih.gov/34102206/. DOI: 10.1016/j.exer.2021.108650.
20. Sun Z, Zhang A, Hou M, et al. Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p[J]. Bioengineered, 2020, 11(1): 949-957. DOI: 10.1080/21655979.2020.1814670.
21. Wang HJ, Li MZ, Cui HB, et al. CircDHDDS/miR-361-3p/WNT3A axis promotes the development of retinoblastoma by regulating proliferation, cell cycle, migration, and invasion of retinoblastoma cells[J]. Neurochem Res, 2020, 45(11): 2691-2702. DOI: 10.1007/s11064-020-03112-0.
22. Jiang YH, Xiao F, Wang L, et al. Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis[J]. Mol Cell Biochem, 2021, 476(1): 69-80. DOI: 10.1007/s11010-020-03886-5.
23. Liu H, Yuan HF, Xu D, et al. Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p[J]. Eur Rev Med Pharmacol Sci, 2020, 24(23): 12080-12092. DOI: 10.26355/eurrev_ 202012_23997.
24. Zhao W, Wang S, Qin T, et al. Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3[J]. J Cell Biochem, 2020, 121(7): 3516-3525. DOI: 10.1002/jcb.29631.
25. Huang YL, Xue BG, Pan JH, et al. Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblasto ma by regulating ROCK1 expression[J/OL]. Exp Mol Pathol, 120: 104637[2021-04-18]. https://pubmed.ncbi.nlm.nih.gov/33844975/. DOI: 10.1016/j.yexmp.2021.104637.
26. Zhang Y, Dou X, Kong Q, et al. Circ_0075804 promotes the malignant behaviors of retinoblastoma cells by binding to miR-138-5p to induce PEG10 expression[J]. Int Ophthalmol, 2022, 42(2): 509-523. DOI: 10.1007/s10792-021-02067-7.
27. Han Q, Ma L, Shao L, et al. Circ_0075804 regulates the expression of LASP1 by targeting miR-1287-5p and thus affects the biological process of retinoblastoma[J]. Curr Eye Res, 2022, 47(7): 1077-1086. DOI: 10.1080/02713683.2022.2053164.
28. An DX, Yang J, Ma LL. circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis[J]. Open Med, 2022, 17(1): 955-968. DOI: 10.1515/med-2022-0483.
29. Du SS, Wang S, Zhang FY, et al. SKP2, positively regulated by circ_ODC1/miR-422a axis, promotes the proliferation of retinoblastoma[J]. J Cell Biochem, 2020, 121(1): 322-331. DOI: 10.1002/jcb.29177.
30. Jiang Y, Xiao F, Wang L, et al. Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis[J/OL]. Exp Eye Res, 2021, 206: 108529[2021-04-04]. https://pubmed.ncbi.nlm.nih.gov/33676964/. DOI: 10.1016/j.exer.2021.108529.
31. 刘越峰, 张勇, 李欣, 等. CircROBO1对视网膜母细胞瘤细胞增殖的影响及其机制[J]. 山东医药, 2023, 63(13): 44-47. DOI: 10.3969/j.issn.1002-266X.2023.13.010.Liu YF, Zhang Y, Li X, et al. Effect of circROBO1 on proliferation of retinoblastoma cells and its mechanism[J]. Shandong Medical Journal, 2023, 63(13): 44-47. DOI: 10.3969/j.issn.1002-266X.2023.13.010.
32. 李磊, 黄赟, 黄明杰. Circ_0000989通过调控miR-183-5 p/LRP6轴促进视网膜母细胞瘤细胞增殖、迁移和侵袭[J]. 现代肿瘤医学, 2021, 29(22): 3914-3919. DOI: 10.3969/j.issn.1672-4992.2021.22.006.Li L, Huang Y, Huang MJ. circ_0000989 promotes the proliferation, migration and invasion of retinoblastoma cells by regulating miR-183-5 p/LRP6[J]. Modern Oncology, 2021, 29(22): 3914-3919. DOI: 10.3969/j.issn.1672-4992.2021.22.006.
33. Jiang G, Qu M, Kong L, et al. Hsa_circ_0084811 regulates cell proliferation and apoptosis in retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 axis[J/OL]. Biomed Res Int, 2022, 2022: 6918396[2022-07-19]. https://pubmed.ncbi.nlm.nih.gov/35909488/. DOI: 10.1155/2022/6918396.
34. Lv X, Yang H, Zhong H, et al. Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis[J]. Pharm Biol, 2022, 60(1): 417-426. DOI: 10.1080/13880209.2022.2032206.
35. 储明慧, 陈海银, 张晓力. Circ_0000144靶向miR-502-5p调控人视网膜母细胞瘤Y79细胞增殖和凋亡及迁移侵袭[J]. 国际眼科杂志, 2021, 21(10): 1686-1692. DOI 10.3980/j.issn.1672-5123.2021.10.04.Chu MH, Chen HY, Zhang XL. Circ_0000144 targeting miR-502-5p to regulate the proliferation, apoptosis, migration and invasion of human retinoblastoma Y79 cells[J]. Int Eye Sci, 2021, 21(10): 1686-1692. DOI 10.3980/j.issn.1672-5123.2021.10.04.
36. 周鹏翔, 信波, 宋晓鹏, 等. CircAKT3对视网膜母细胞瘤细胞SO-Rb50增殖和凋亡的影响[J]. 陕西医学杂志, 2020, 49(8): 932-935. DOI: 10.3969/j.issn.1000-7377.2020.08.005.Zhou PX, Xin B, Song XP, et al. Effect of CircAKT3 on the proliferation and apoptosis of retinoblastoma SO-Rb50 cells[J]. Shaanxi Medical Journal, 2020, 49(8): 932-935. DOI: 10.3969/j.issn.1000-7377.2020.08.005.
37. Xing L, Zhang L, Feng Y, et al. Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway[J]. Biomed Pharmacother, 2018, 105: 326-333. DOI: 10.1016/j.biopha.2018.05.141.
38. Fu CB, Wang SC, Jin L, et al. CircTET1 inhibits retinoblastoma progression via targeting miR-492 and miR-494-3p through Wnt/beta-catenin signaling pathway[J]. Curr Eye Res, 2021, 46(7): 978-987. DOI: 10.1080/02713683.2020.1843685.
39. Zhang H, Qiu X, Song Z, et al. CircCUL2 suppresses retinoblastoma cells by regulating miR-214-5p/E2F2 Axis[J/OL]. Anticancer Drugs, 2022, 33(1): e218-e227[2022-01-01]. https://pubmed.ncbi.nlm.nih.gov/34387590/. DOI: 10.1097/cad.0000000000001190.
40. Singh L, Pushker N, Saini N, et al. Expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in human retinoblastoma[J]. Clin Exp Ophthalmol, 2015, 43(3): 259-267. DOI: 10.1111/ceo.12397.
41. Alrefaei AF, Abu-Elmagd M. LRP6 receptor plays essential functions in development and human diseases[J]. Genes (Basel), 2022, 13(1): 120. DOI: 10.3390/genes13010120.
42. Nguyen MN, Chakraborty D, Rao SR, et al. A Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission[J]. Cell Death Dis, 2023, 14(7): 420. DOI: 10.1038/s41419-023-05936-4.
43. Zhao D, Cui Z. MicroRNA-361-3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling[J]. Exp Ther Med, 2019, 17(2): 1154-1162. DOI: 10.3892/etm.2018.7062.
44. Tu J, Huo Z, Yu Y, et al. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies[J/OL]. Proc Natl Acad Sci USA, 2022, 119(16): e2117857119[2022-04-19]. https://pubmed.ncbi.nlm.nih.gov/35412907/. DOI: 10.1073/pnas.2117857119.
45. Sambandam A, Storm E, Tauc H, et al. Obligate role for Rock1 and Rock2 in adult stem cell viability and function[J/OL]. Heliyon, 2023, 9(3): e14238[2023-03-09]. https://pubmed.ncbi.nlm.nih.gov/36950615/. DOI: 10.1016/j.heliyon.2023.e14238.
46. Tibrewal S, Ratna R, Gour A, et al. Clinical and molecular aspects of congenital aniridia-a review of current concepts[J]. Indian J Ophthalmol, 2022, 70(7): 2280-2292. DOI: 10.4103/ijo.IJO_ 2255_21.
47. Ni W, Li Z, Ai K. lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis[J]. Bioengineered, 2022, 13(1): 1637-1649. DOI: 10.1080/21655979.2021.2021346.
48. Lu X, Tu H, Tang D, et al. miR-130a-3p enhances the chemosensitivity of Y79 retinoblastoma cells to vincristine by targeting PAX6 expression[J]. Curr Eye Res, 2022, 47(3): 418-425. DOI: 10.1080/02713683.2021.1984537.
49. Qiu L, Zhou R, Luo Z, et al. CDC27-ODC1 axis promotes metastasis, accelerates ferroptosis and predicts poor prognosis in neuroblastoma[J/OL]. Front Oncol, 2022, 12: 774458[2022-02-15]. https://pubmed.ncbi.nlm.nih.gov/35242701/. DOI: 10.3389/fonc.2022.774458.
50. Niu J, Yan T, Guo W, et al. The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma[J]. Autophagy, 2023, 19(6): 1693-1710. DOI: 10.1080/15548627.2022.2150003.
51. Yang J, Tan C, Wang Y, et al. The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy[J/OL]. Biochim Biophys Acta Mol Basis Dis, 2023, 1869(8): 166839[2023-08-06]. https://pubmed.ncbi.nlm.nih.gov/37549719/. DOI: 10.1016/j.bbadis.2023.166839.
52. Xiong H, Huang G, Zhu Y, et al. Circ-SHPRH in human cancers: a systematic review and meta-analysis[J/OL]. Front Cell Dev Biol, 2023, 11: 1182900[2023-05-25]. https://pubmed.ncbi.nlm.nih.gov/37305675/. DOI: 10.3389/fcell.2023.1182900.
53. Sun H, Wang Q, Yuan G, et al. Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a[J/OL]. J Clin Lab Anal, 2020, 34(6): e23235[2020-03-25]. https://pubmed.ncbi.nlm.nih.gov/32212290/. DOI: 10.1002/jcla.23235.
54. Zhang X, Zhang Y, Wang C, et al. TET (Ten-eleven translocation) family proteins: structure, biological functions and applications[J]. Signal Transduct Target Ther, 2023, 8(1): 297. DOI: 10.1038/s41392-023-01537-x.
55. Liu X, Zurlo G, Zhang Q. The roles of cullin-2 E3 ubiquitin ligase complex in cancer[J]. Adv Exp Med Biol, 2020, 1217: 173-186. DOI: 10.1007/978-981-15-1025-0_11.
56. Raval V, Parulekar M, Singh AD. Emerging new therapeutics for retinoblastoma[J]. Ocul Oncol Pathol, 2022, 8(3): 149-155. DOI: 10.1159/000524919.
57. Lyu J, Wang Y, Zheng QP, et al. Reduction of circular RNA expression associated with human retinoblastoma[J]. Exp Eye Res, 2019, 184: 278-285. DOI: 10.1016/j.exer.2019.03.017.
58. Wang C, Xu M, Fan Q, et al. Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases[J/OL]. Asian J Pharm Sci, 2023, 18(1): 100772[2022-12-31]. https://pubmed.ncbi.nlm.nih.gov/36896446/. DOI: 10.1016/j.ajps.2022.100772.
59. Wang J, Wang M, Jiang N, et al. Emerging chemical engineering of exosomes as "bioscaffolds" in diagnostics and therapeutics[J]. Genes Dis, 2023, 10(4): 1494-1512. DOI: 10.1016/j.gendis.2022.10.020.
60. Turaka K, Shields CL, Meadows AT, et al. Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma[J]. Pediatr Blood Cancer, 2012, 59(1): 121-125. DOI: 10.1002/pbc.23278.
61. Wen X, Fan J, Jin M, et al. Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial[J]. Lancet Child Adolesc Health, 2023, 7(9): 613-620. DOI: 10.1016/s2352-4642(23)00141-4.

Chinese Journal of Ocular Fundus Diseases

Research progress of circRNA in retinoblastoma

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