Research progress on the role of microglial glucose metabolism reprogramming in age-related macular degeneration_Chinese Journal of Ocular Fundus Diseases

Authors：

Zou Yue ^1,2,3 , Tan Xin ¹ ,  Li Yunqin ^1,2,3

1. Department of Ophthalmology, Affiliated Hospital of Yunnan University, Kunming 650021, China;
2. Yunnan Provincial Clinical Medical Center for Ophthalmic Diseases, Kunming 650021, China;
3. Yunnan Provincial Clinical Research Center for Eye Diseases, Kunming 650021, China;

Corresponding author：

Li Yunqin, Email: Liyunqin2004@126.com

Keywords：

Age-related macular degeneration; Microglial; Glucose metabolism reprogramming; Review

DOI：

10.3760/cma.j.cn511434-20240408-00147

Video：

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[Abstract]Age-related macular degeneration (AMD) involves dysregulation of the innate immune response of complement and mononuclear phagocytes and abnormalities of local microglia. When microglia transition from a resting state to an active state, their metabolic pathway also changes, known as "metabolic reprogramming", and their glucose metabolic reprogramming is a key factor in the pathogenesis of AMD, involving multiple signaling pathways. Including phosphatidylinositol 3-kinase-serine threonine kinase-rapamycin target, adenylate activated protein kinase and hypoxia-inducing factor 1 pathway. These metabolic changes regulate the inflammatory response, energy supply, and neuroprotective functions of microglia. Therapeutic strategies to regulate the reprogramming of glucose metabolism in microglia have achieved initial results. Future studies should further explore the mechanisms of microglia metabolic regulation to develop new targeted drugs and intervene in the treatment of AMD through anti-cellular aging pathways.

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33. Lauro C, Limatola C. Metabolic reprograming of microglia in the regulation of the innate inflammatory response[J/OL]. Front Immunol, 2020, 11: 493[2020-03-20]. https://pubmed.ncbi.nlm.nih.gov/32265936/. DOI: 10.3389/fimmu.2020.00493.
34. Lauro C, Chece G, Monaco L, et al. Fractalkine modulates microglia metabolism in brain ischemia[J/OL]. Front Cell Neurosci, 2019, 13: 414. DOI: 10.3389/fncel.2019.00414.
35. Voloboueva LA, Emery JF, Sun X, et al. Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin[J]. FEBS Lett, 2013, 587(6): 756-762. DOI: 10.1016/j.febslet.2013.01.067.
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