Research progress on the mechanism and potential treatment of oxidative stress in diabetic retinal neurodegeneration_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Jiapeng ¹ ,  Luo Xiangxia ² , Zhuang Jiayuan ¹ , Guo Wanying ¹ , Wu Yutong ¹ , Dai Mingli ¹

1. Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;
2. Department of Ophthalmology, Gansu Provincial Hospital of Chinese Medicine, Lanzhou 730050, China;

Corresponding author：

Luo Xiangxia, Email: jessica_lxx@163.com

Keywords：

Diabetic retinopathy; Diabetic retinal neurodegeneration; Oxidative stress; Retinal neurovascular unit; Review

DOI：

10.3760/cma.j.cn511434-20240422-00162

Video：

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Abstract Full text Figures/Tables Video References Cited by

Diabetic retinal neurodegeneration is a serious complication of diabetes mellitus, manifested by apoptosis and gliosis, and its pathogenesis is closely related to the oxidative stress induced by high glucose levels. The increase in blood glucose in the body leads to excessive production of reactive oxygen species and the downregulation of antioxidant defense signaling pathways, which leads to oxidative stress in the body, which in turn induces apoptosis, mitochondrial damage and autophagy, resulting in diabetic retinal neurodegeneration. Antioxidant stress therapy with gene therapy, flavonoids, recombinant Ad-β-catenin carriers, and autophagy inducers to exert neuroprotective effects. In the future, more clinical trials are needed to explore the effective dosage and side effects of drugs, and to develop new drugs and treatment strategies for oxidative stress to prevent and treat diabetic retinal neurodegeneration and protect retinal nerve function.

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8. Soni D, Sagar P, Takkar B. Diabetic retinal neurodegeneration as a form of diabetic retinopathy[J]. Int Ophthalmol, 2021, 41(9): 3223-3248. DOI: 10.1007/s10792-021-01864-4.
9. Mrugacz M, Bryl A, Zorena K. Retinal vascular endothelial cell dysfunction and neuroretinal degeneration in diabetic patients[J]. J Clin Med, 2021, 10(3): 458. DOI: 10.3390/jcm10030458.
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11. Zhou J, Chen B. Retinal cell damage in diabetic retinopathy[J/OL]. Cells, 2023, 12(9): 1342[2023-05-08]. https://pubmed.ncbi.nlm.nih.gov/37174742/. DOI: 10.3390/cells12091342.
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13. Baudry M, Bi X. Calpain-1 and calpain-2: the yin and yang of yynaptic ylasticity and yeurodegeneration[J]. Trends Neurosci, 2016, 39(4): 235-245. DOI: 10.1016/j.tins.2016.01.007.
14. Nelson WB, Smuder AJ, Hudson MB, et al. Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation[J]. Crit Care Med, 2012, 40(6): 1857-1863. DOI: 10.1097/CCM.0b013e318246bb5d.
15. Yang S, Zhang J, Chen L. The cells involved in the pathological process of diabetic retinopathy[J/OL]. Biomed Pharmacother, 2020, 132: 110818[2020-10-11]. https://pubmed.ncbi.nlm.nih.gov/33053509/. DOI: 10.1016/j.biopha.2020.110818.
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18. Tang L, Xu GT, Zhang JF. Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy[J]. Neural Regen Res, 2023, 18(5): 976-982. DOI: 10.4103/1673-5374.355743.
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20. Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, et al. The role of GFAP and vimentin in learning and memory[J]. Biol Chem, 2019, 400(9): 1147-1156. DOI: 10.1515/hsz-2019-0199.
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22. Chakrabarty S, Verhelst SHL. Controlled inhibition of apoptosis by photoactivatable caspase inhibitors[J]. Cell Chem Biol, 2020, 27(11): 1434-1440. DOI: 10.1016/j.chembiol.2020.08.001.
23. Sahoo G, Samal D, Khandayataray P, et al. A review on caspases: key regulators of biological activities and apoptosis[J]. Mol Neurobiol, 2023, 60(10): 5805-5837. DOI: 10.1007/s12035-023-03433-5.
24. Downs KP, Nguyen H, Dorfleutner A, et al. An overview of the non-canonical inflammasome[J/OL]. Mol Aspects Med, 2020, 76: 100924[2020-11-11]. https://pubmed.ncbi.nlm.nih.gov/33187725/. DOI: 10.1016/j.mam.2020.100924.
25. Valverde AM, Miranda S, García-Ramírez M, et al. Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy[J]. Molecular Vision, 2013, 19(3): 47-53. DOI: 10.1016/j.cub.2012.10.032.
26. Matteucci A, Gaddini L, Villa M, et al. Neuroprotection by rat Müller glia against high glucose-induced neurodegeneration through a mechanism involving ERK1/2 activation[J]. Exp Eye Res, 2014, 125: 20-29. DOI: 10.1016/j.exer.2014.05.011.
27. 司俊康, 郭俊国, 王兴荣. 氧化应激诱导视网膜神经节细胞凋亡的研究进展[J]. 国际眼科杂志, 2013, 13(12): 2424-2426. DOI: 10.3980/j.issn.1672-5123.2013.12.17.Si JK, Guo JG, Wang XR. Research advances of oxidative stress-induced apoptosis of retinal ganglion cells[J]. Int Eye Sci, 2013, 13(12): 2424-2426. DOI: 10.3980/j.issn.1672-5123.2013.12.17.
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Chinese Journal of Ocular Fundus Diseases

Latest ArticlesResearch progress on the mechanism and potential treatment of oxidative stress in diabetic retinal neurodegeneration

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