Research progress on the mechanism and potential treatment of oxidative stress in diabetic retinal neurodegeneration_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Jiapeng ¹ ,  Luo Xiangxia ² , Zhuang Jiayuan ¹ , Guo Wanying ¹ , Wu Yutong ¹ , Dai Mingli ¹

1. Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;
2. Department of Ophthalmology, Gansu Provincial Hospital of Chinese Medicine, Lanzhou 730050, China;

Corresponding author：

Luo Xiangxia, Email: jessica_lxx@163.com

Keywords：

Diabetic retinopathy; Diabetic retinal neurodegeneration; Oxidative stress; Retinal neurovascular unit; Review

DOI：

10.3760/cma.j.cn511434-20240422-00162

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Diabetic retinal neurodegeneration is a serious complication of diabetes mellitus, manifested by apoptosis and gliosis, and its pathogenesis is closely related to the oxidative stress induced by high glucose levels. The increase in blood glucose in the body leads to excessive production of reactive oxygen species and the downregulation of antioxidant defense signaling pathways, which leads to oxidative stress in the body, which in turn induces apoptosis, mitochondrial damage and autophagy, resulting in diabetic retinal neurodegeneration. Antioxidant stress therapy with gene therapy, flavonoids, recombinant Ad-β-catenin carriers, and autophagy inducers to exert neuroprotective effects. In the future, more clinical trials are needed to explore the effective dosage and side effects of drugs, and to develop new drugs and treatment strategies for oxidative stress to prevent and treat diabetic retinal neurodegeneration and protect retinal nerve function.

Citation： Wang Jiapeng, Luo Xiangxia, Zhuang Jiayuan, Guo Wanying, Wu Yutong, Dai Mingli. Research progress on the mechanism and potential treatment of oxidative stress in diabetic retinal neurodegeneration. Chinese Journal of Ocular Fundus Diseases, 2024, 40(10): 813-818. doi: 10.3760/cma.j.cn511434-20240422-00162 Copy

1.	Kang Q, Yang C. Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications[J/OL]. Redox Biol, 2020, 37: 101799[2020-11-13]. https://pubmed.ncbi.nlm.nih.gov/33248932/. DOI: 10.1016/jredox.2020.101799.
2.
3.
4.	Sachdeva MM. Retinal neurodegeneration in diabetes: an emerging concept in diabetic retinopathy[J/OL]. Curr Diab Rep, 2021, 21(12): 65[2021-12-13]. https://pubmed.ncbi.nlm.nih.gov/34902066/. DOI: 10.1007/s11892-021-01428-x.
5.
6.	Tan TE, Wong TY. Diabetic retinopathy: looking forward to 2030[J/OL]. Front Endocrinol (Lausanne), 2022, 13: 1077669[2023-01-09]. https://pubmed.ncbi.nlm.nih.gov/36699020/. DOI: 10.3389/.fendo.2022.1077669.
7.
8.
9.
10.
11.	Zhou J, Chen B. Retinal cell damage in diabetic retinopathy[J/OL]. Cells, 2023, 12(9): 1342[2023-05-08]. https://pubmed.ncbi.nlm.nih.gov/37174742/. DOI: 10.3390/cells12091342.
12.
13.
14.
15.	Yang S, Zhang J, Chen L. The cells involved in the pathological process of diabetic retinopathy[J/OL]. Biomed Pharmacother, 2020, 132: 110818[2020-10-11]. https://pubmed.ncbi.nlm.nih.gov/33053509/. DOI: 10.1016/j.biopha.2020.110818.
16.
17.
18.
19.
20.
21.
22.
23.
24.	Downs KP, Nguyen H, Dorfleutner A, et al. An overview of the non-canonical inflammasome[J/OL]. Mol Aspects Med, 2020, 76: 100924[2020-11-11]. https://pubmed.ncbi.nlm.nih.gov/33187725/. DOI: 10.1016/j.mam.2020.100924.
25.
26.
27.
28.	Bugger H, Pfeil K. Mitochondrial ROS in myocardial ischemia reperfusion and remodeling[J/OL]. Biochim Biophys Acta Mol Basis Dis, 2020, 1866(7): 165768[2020-03-12]. https://pubmed.ncbi.nlm.nih.gov/32173461/. DOI: 10.1016/j.bbadis.2020.165768.
29.	Roy A, Kandettu A, Ray S, et al. Mitochondrial DNA replication and repair defects: clinical phenotypes and therapeutic interventions[J/OL]. Biochim Biophys Acta Bioenerg, 2022, 1863(5): 148554[2020-03-24]. https://pubmed.ncbi.nlm.nih.gov/35341749/. DOI: 10.1016/j.bbabio.2022.148554.
30.
31.	Rius-Pérez S, Torres-Cuevas I, Millán I, et al. PGC-1α, Inflammation, and oxidative stress: an integrative view in metabolism[J/OL]. Oxid Med Cell Longev, 2020, 2020: 1452696[2020-03-09]. https://pubmed.ncbi.nlm.nih.gov/32215168/. DOI: 10.1155/2020/1452696.
32.
33.
34.	Melentev PA, Ryabova EV, Surina NV, et al. Loss of swiss cheese in neurons contributes to neurodegeneration with mitochondria abnormalities, reactive oxygen species acceleration and accumulation of lipid droplets in drosophila brain[J/OL]. Int J Mol Sci, 2021, 22(15): 8275[2021-07-31]. https://pubmed.ncbi.nlm.nih.gov/34361042/. DOI: 10.3390/ijms22158275.
35.
36.	Piano I, Novelli E, Della Santina L, et al. Involvement of autophagic pathway in the progression of retinal degeneration in a mouse model of diabetes[J/OL]. Front Cell Neurosci, 2016, 10: 42[2016-02-19]. https://pubmed.ncbi.nlm.nih.gov/26924963/. DOI: 10.3389/fncel.2016.00042.
37.
38.	Sahu B, Leon LM, Zhang W, et al. Oxidative stress resistance 1 gene therapy retards neurodegeneration in the Rd1 mutant mouse model of retinopathy[J/OL]. Invest Ophthalmol Vis Sci, 2021, 62(12): 8[2021-09-02]. https://pubmed.ncbi.nlm.nih.gov/34505865/. DOI: 10.1167/iovs.62.12.8.
39.
40.	Volkert MR, Crowley DJ. Preventing neurodegeneration by controlling oxidative stress: the role of OXR1[J/OL]. Front Neurosci, 2020, 14: 611904[2020-12-15]. https://pubmed.ncbi.nlm.nih.gov/33384581/. DOI: 10.3389/fnins.2020.611904.
41.	Durand M, Kolpak A, Farrell T, et al. The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins[J/OL]. BMC Cell Biol, 2007, 8: 13[2007-03-28]. https://pubmed.ncbi.nlm.nih.gov/17391516/. DOI: 10.1186/1471-2121-8-13.
42.	Matos AL, Bruno DF, Ambrósio AF, et al. The benefits of flavonoids in diabetic retinopathy[J/OL]. Nutrients, 2020, 12(10): 3169[2020-10-16]. https://pubmed.ncbi.nlm.nih.gov/33081260/. DOI: 10.3390/nu12103169.
43.	Pan L, Cho KS, Yi I, et al. Baicalein, baicalin, and wogonin: protective effects against ischemia-induced neurodegeneration in the brain and retina[J/OL]. Oxid Med Cell Longev, 2021, 2021: 8377362[2021-06-29]. https://pubmed.ncbi.nlm.nih.gov/34306315/. DOI: 10.1155/2021/8377362.
44.
45.
46.
47.
48.	Ebrahim N, El-Halim HEA, Helal OK, et al. Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: implication of Wnt/ b-catenin signaling pathway[J/OL]. Biomed Pharmacother, 2022, 154: 113554[2022-08-17]. https://pubmed.ncbi.nlm.nih.gov/35987163/. DOI: 10.1016/j.biopha.2022.113554.
49.
50.
51.
52.	Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies[J/OL]. JCI Insight, 2017, 2(14): e93751[2017-07-20]. https://pubmed.ncbi.nlm.nih.gov/28724805/. DOI: 10.1172/jci.insight.93751.
53.	Amato R, Giannaccini M, Dal Monte M, et al. Association of the somatostatin analog octreotide with magnetic nanoparticles for intraocular delivery: a possible approach for the treatment of diabetic retinopathy[J/OL]. Front Bioeng Biotechnol, 2020, 8: 144[2020-02-25]. https://pubmed.ncbi.nlm.nih.gov/32158755/. DOI: 10.3389/fbioe.2020.00144.
54.	Fang Y, Shi K, Lu H, et al. Mingmu xiaomeng tablets restore autophagy and alleviate diabetic retinopathy by inhibiting PI3K/Akt/mTOR signaling[J/OL]. Front Pharmacol, 2021, 12: 632040[2021-04-13]. https://pubmed.ncbi.nlm.nih.gov/33927618/. DOI: 10.3389/fphar.2021.632040.
55.	Zeilbeck LF, Müller B, Knobloch V, et al. Differential angiogenic properties of lithium chloride in vitro and in vivo[J/OL]. PLoS One, 2014, 9(4): e95546[2014-04-21]. https://pubmed.ncbi.nlm.nih.gov/24751879/. DOI: 10.1371/journal.pone.0095546.
56.

1. Kang Q, Yang C. Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications[J/OL]. Redox Biol, 2020, 37: 101799[2020-11-13]. https://pubmed.ncbi.nlm.nih.gov/33248932/. DOI: 10.1016/jredox.2020.101799.
2.
3.
4. Sachdeva MM. Retinal neurodegeneration in diabetes: an emerging concept in diabetic retinopathy[J/OL]. Curr Diab Rep, 2021, 21(12): 65[2021-12-13]. https://pubmed.ncbi.nlm.nih.gov/34902066/. DOI: 10.1007/s11892-021-01428-x.
5.
6. Tan TE, Wong TY. Diabetic retinopathy: looking forward to 2030[J/OL]. Front Endocrinol (Lausanne), 2022, 13: 1077669[2023-01-09]. https://pubmed.ncbi.nlm.nih.gov/36699020/. DOI: 10.3389/.fendo.2022.1077669.
7.
8.
9.
10.
11. Zhou J, Chen B. Retinal cell damage in diabetic retinopathy[J/OL]. Cells, 2023, 12(9): 1342[2023-05-08]. https://pubmed.ncbi.nlm.nih.gov/37174742/. DOI: 10.3390/cells12091342.
12.
13.
14.
15. Yang S, Zhang J, Chen L. The cells involved in the pathological process of diabetic retinopathy[J/OL]. Biomed Pharmacother, 2020, 132: 110818[2020-10-11]. https://pubmed.ncbi.nlm.nih.gov/33053509/. DOI: 10.1016/j.biopha.2020.110818.
16.
17.
18.
19.
20.
21.
22.
23.
24. Downs KP, Nguyen H, Dorfleutner A, et al. An overview of the non-canonical inflammasome[J/OL]. Mol Aspects Med, 2020, 76: 100924[2020-11-11]. https://pubmed.ncbi.nlm.nih.gov/33187725/. DOI: 10.1016/j.mam.2020.100924.
25.
26.
27.
28. Bugger H, Pfeil K. Mitochondrial ROS in myocardial ischemia reperfusion and remodeling[J/OL]. Biochim Biophys Acta Mol Basis Dis, 2020, 1866(7): 165768[2020-03-12]. https://pubmed.ncbi.nlm.nih.gov/32173461/. DOI: 10.1016/j.bbadis.2020.165768.
29. Roy A, Kandettu A, Ray S, et al. Mitochondrial DNA replication and repair defects: clinical phenotypes and therapeutic interventions[J/OL]. Biochim Biophys Acta Bioenerg, 2022, 1863(5): 148554[2020-03-24]. https://pubmed.ncbi.nlm.nih.gov/35341749/. DOI: 10.1016/j.bbabio.2022.148554.
30.
31. Rius-Pérez S, Torres-Cuevas I, Millán I, et al. PGC-1α, Inflammation, and oxidative stress: an integrative view in metabolism[J/OL]. Oxid Med Cell Longev, 2020, 2020: 1452696[2020-03-09]. https://pubmed.ncbi.nlm.nih.gov/32215168/. DOI: 10.1155/2020/1452696.
32.
33.
34. Melentev PA, Ryabova EV, Surina NV, et al. Loss of swiss cheese in neurons contributes to neurodegeneration with mitochondria abnormalities, reactive oxygen species acceleration and accumulation of lipid droplets in drosophila brain[J/OL]. Int J Mol Sci, 2021, 22(15): 8275[2021-07-31]. https://pubmed.ncbi.nlm.nih.gov/34361042/. DOI: 10.3390/ijms22158275.
35.
36. Piano I, Novelli E, Della Santina L, et al. Involvement of autophagic pathway in the progression of retinal degeneration in a mouse model of diabetes[J/OL]. Front Cell Neurosci, 2016, 10: 42[2016-02-19]. https://pubmed.ncbi.nlm.nih.gov/26924963/. DOI: 10.3389/fncel.2016.00042.
37.
38. Sahu B, Leon LM, Zhang W, et al. Oxidative stress resistance 1 gene therapy retards neurodegeneration in the Rd1 mutant mouse model of retinopathy[J/OL]. Invest Ophthalmol Vis Sci, 2021, 62(12): 8[2021-09-02]. https://pubmed.ncbi.nlm.nih.gov/34505865/. DOI: 10.1167/iovs.62.12.8.
39.
40. Volkert MR, Crowley DJ. Preventing neurodegeneration by controlling oxidative stress: the role of OXR1[J/OL]. Front Neurosci, 2020, 14: 611904[2020-12-15]. https://pubmed.ncbi.nlm.nih.gov/33384581/. DOI: 10.3389/fnins.2020.611904.
41. Durand M, Kolpak A, Farrell T, et al. The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins[J/OL]. BMC Cell Biol, 2007, 8: 13[2007-03-28]. https://pubmed.ncbi.nlm.nih.gov/17391516/. DOI: 10.1186/1471-2121-8-13.
42. Matos AL, Bruno DF, Ambrósio AF, et al. The benefits of flavonoids in diabetic retinopathy[J/OL]. Nutrients, 2020, 12(10): 3169[2020-10-16]. https://pubmed.ncbi.nlm.nih.gov/33081260/. DOI: 10.3390/nu12103169.
43. Pan L, Cho KS, Yi I, et al. Baicalein, baicalin, and wogonin: protective effects against ischemia-induced neurodegeneration in the brain and retina[J/OL]. Oxid Med Cell Longev, 2021, 2021: 8377362[2021-06-29]. https://pubmed.ncbi.nlm.nih.gov/34306315/. DOI: 10.1155/2021/8377362.
44.
45.
46.
47.
48. Ebrahim N, El-Halim HEA, Helal OK, et al. Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: implication of Wnt/ b-catenin signaling pathway[J/OL]. Biomed Pharmacother, 2022, 154: 113554[2022-08-17]. https://pubmed.ncbi.nlm.nih.gov/35987163/. DOI: 10.1016/j.biopha.2022.113554.
49.
50.
51.
52. Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies[J/OL]. JCI Insight, 2017, 2(14): e93751[2017-07-20]. https://pubmed.ncbi.nlm.nih.gov/28724805/. DOI: 10.1172/jci.insight.93751.
53. Amato R, Giannaccini M, Dal Monte M, et al. Association of the somatostatin analog octreotide with magnetic nanoparticles for intraocular delivery: a possible approach for the treatment of diabetic retinopathy[J/OL]. Front Bioeng Biotechnol, 2020, 8: 144[2020-02-25]. https://pubmed.ncbi.nlm.nih.gov/32158755/. DOI: 10.3389/fbioe.2020.00144.
54. Fang Y, Shi K, Lu H, et al. Mingmu xiaomeng tablets restore autophagy and alleviate diabetic retinopathy by inhibiting PI3K/Akt/mTOR signaling[J/OL]. Front Pharmacol, 2021, 12: 632040[2021-04-13]. https://pubmed.ncbi.nlm.nih.gov/33927618/. DOI: 10.3389/fphar.2021.632040.
55. Zeilbeck LF, Müller B, Knobloch V, et al. Differential angiogenic properties of lithium chloride in vitro and in vivo[J/OL]. PLoS One, 2014, 9(4): e95546[2014-04-21]. https://pubmed.ncbi.nlm.nih.gov/24751879/. DOI: 10.1371/journal.pone.0095546.
56.

Chinese Journal of Ocular Fundus Diseases

Research progress on the mechanism and potential treatment of oxidative stress in diabetic retinal neurodegeneration

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content