Optical coherence tomography angiography in anterior ischemic optic neuropathy_Chinese Journal of Ocular Fundus Diseases

Authors：

HuLiying ,  LiZhiqing , LiXiaorong , YuRongguo , WangLinni , YangJin

Tianjin Medical University Hospital, Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin 300384, China;

Corresponding author：

LiZhiqing, Email: lzhqyk@163.com

Keywords：

Optic neuropathy, ischemic/diagnosis; Regional blood flow; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2016.03.011

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To observe the optic disc perfusion in anterior ischemic optic neuropathy (AION) patients. Methods Forty eyes of 40 AION patients and 30 eyes of 30 normal subjects were included. The stage of the diseases was defined based on the course of the disease, including acute stage (less than 3 weeks) and recovery stage (more than 3 months). Optic disc blood flow area, outer vascular density and blood flow index were measured by optical coherence tomography angiography in all the subjects. Optic disc perfusion was observed in acute and recovery stage of disease. Results The optic disc blood flow area, outer vascular density and blood flow index were decreased of AION eyes in acute stage compared with the normal subjects, the difference was statistically significant (P < 0.05); while the optic disc blood flow area, outer vascular density and blood flow index of AION eyes in the recovery stage showed no significant difference compared with normal subjects (P > 0.05). Conclusion Disc perfusion is reduced in AION at the acute stage, but recovered at the recovery stage.

Citation： HuLiying, LiZhiqing, LiXiaorong, YuRongguo, WangLinni, YangJin. Optical coherence tomography angiography in anterior ischemic optic neuropathy. Chinese Journal of Ocular Fundus Diseases, 2016, 32(3): 275-277. doi: 10.3760/cma.j.issn.1005-1015.2016.03.011 Copy

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11.	Yeung L, Lima VC, Garcia P, et al. Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema[J].Ophthalmology, 2009, 116(6):1158-1167. DOI:10.1016/j.ophtha.2008.12.063.
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14.	Hayreh SS, Podhajsky PA, Zimmerman B.Ipsilateral recurrence of nonarteritic anterior ischemic optic neuropathy[J].Am J Ophthalmol, 2001, 132(5):734-742.
15.	Hayreh SS, Podhajsky P, Zimmerman MB. Role of nocturnal arterial hypotension in optic nerve head ischemic disorders[J]. Ophthalmologica, 1999, 213(2):76-96.
16.	杜力, 宋琛, 徐玉华, 等.前部缺血性视神经病变的眼底荧光血管造影[J].中国人民解放军军医进修学院学报, 1987, 8(2):136-139.Du L, Song C, Xu YH, et al.Characteritics of fundus fluorescein angiography in anterior ischemic optic neuropathy[J].Journal of PLA Postgraduated Medical School, 1987, 8(2):136-139.

1. Hayreh SS. Anterior ischaemic optic neuropathy.Ⅱ. Fundus on ophthalmoscopy and fluorescein angiography[J]. Br J Ophthalmol, 1974, 58(12):964-980.
2. Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma[J].Ophthalmology, 2014, 121(7):1322-1332. DOI:10.1016/j.Ophtha.2014.01.021.
3. Wang X, Jia Y, Spain R, et al. Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis[J].Br J ophthalmol, 2014, 98(10):1368-1373. DOI:10.1136/bjophthalmol-2013-304547.
4. Kupersmith MJ, Anderson S, Durbin M, et al.Scanning laser polarimetry, but not optical coherence tomography predicts permanent visual field loss in acute nonarteritic anterior ischemic optic neuropathy[J].Invest Ophthalmol Vis Sci, 2013, 54(8):5514-5519. DOI:10.1167/iovs.13-12253.
5. The Ischemic Optic Neuropathy Decompression Trial Group. The ischemic optic neuropathy decompression trial (IONDT):design and methods[J]. Control Clin Trials, 1998, 19(3):276-296.
6. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography[J]. JAMA Ophthalmol, 2015, 133(1):66-73. DOI:10.1001/jamaophthalmol.2014.3950.
7. Huang Y, Zhang Q, Thorell MR, et al. Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5):382-389.DOI:10.3928/23258160-20140909-08.
8. Matsunaga D, Yi J, Puliafito CA, et al. OCT Angiography in healthy human subjects[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(6):510-515. DOI:10.3928/23258160-20141118-04.
9. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(1):45-50.DOI:10.1001/jamaophthalmol.2014.3616.
10. Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma[J]. Ophthalmology, 2014, 121(7):1322-1332.DOI:10.1016/j.ophtha.2014.01.021.
11. Yeung L, Lima VC, Garcia P, et al. Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema[J].Ophthalmology, 2009, 116(6):1158-1167. DOI:10.1016/j.ophtha.2008.12.063.
12. Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration[J]. Ophthalmology, 2014, 121(7):1435-1444.DOI:10.1016/j.ophtha.2014.01.034.
13. Hayreh SS.Ischemic optic neuropathy[J].Prog Retin Eye Res, 2009, 28(1):34-62. DOI:10.1016/j.preteyeres.2008.11.002.
14. Hayreh SS, Podhajsky PA, Zimmerman B.Ipsilateral recurrence of nonarteritic anterior ischemic optic neuropathy[J].Am J Ophthalmol, 2001, 132(5):734-742.
15. Hayreh SS, Podhajsky P, Zimmerman MB. Role of nocturnal arterial hypotension in optic nerve head ischemic disorders[J]. Ophthalmologica, 1999, 213(2):76-96.
16. 杜力, 宋琛, 徐玉华, 等.前部缺血性视神经病变的眼底荧光血管造影[J].中国人民解放军军医进修学院学报, 1987, 8(2):136-139.Du L, Song C, Xu YH, et al.Characteritics of fundus fluorescein angiography in anterior ischemic optic neuropathy[J].Journal of PLA Postgraduated Medical School, 1987, 8(2):136-139.

Chinese Journal of Ocular Fundus Diseases

Optical coherence tomography angiography in anterior ischemic optic neuropathy

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