Comparative observation of choroidal osteoma by multimodal fundus imaging methods_Chinese Journal of Ocular Fundus Diseases

Authors：

 LiJuanjuan , LiHua , WangPing

Department of Ophthalmology, The Second People's Hospital of Yunnan Province, Kunming 650021, China;

Corresponding author：

LiJuanjuan, Email: ljj800502@163.com

Keywords：

Choroid neoplasms/diagnosis; Fluorescein angiography; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2016.03.013

Video：

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Objective To comparatively observe features of choroidal osteoma by multimodal fundus imaging methods. Methods This is a retrospective case study. Sixteen patients (16 eyes) with choroidal osteoma were enrolled in this study. The patients included 6 males (6 eyes) and 10 females (10 eyes), with an average age of (30.5±2.4) years. All patients received examination of best-corrected visual acuity, slit lamp microscope, indirect ophthalmoscopy, fundus color photography, fundus autofluorescence (AF), fundus fluorescein angiography (FFA) and spectral domain optical coherence tomography (SD-OCT). The tumors were classified as fresh lesion (clear boundary and rosy tumor with smooth surface) and obsolete lesions (pale and flat tumor with obvious patches). The tumor features of color fundus photography, AF, FFA and SD-OCT were comparatively observed. Results There were 5 fresh lesions and 11 obsolete lesions. Color fundus photography showed the tumor color was orange-red or yellow-white with clear boundary and retinal blood vessels on the surface of the tumor. The color of fresh lesion was rosy. In general, choroidal osteoma shown weak AF, however AF of fresh tumor was slightly stronger than the obsolete tumor, and retinal detachment region showed relatively stronger AF. FFA of fresh tumor indicated uniform intense fluorescence with clear boundary at late stage, much stronger than obsolete tumor. SD-OCT showed mesh-like reflected signal in the choroidal layer, but different from the surrounding choroidal vascular structures. Conclusions The tumor color is orange-red or yellow-white in color funds photography, which shown weak AF. FFA showed mottled hyperfluorescence in the early stage and tissue staining at the late stage. SD-OCT showed mesh-like reflected signal in the choroidal layer.

Citation： LiJuanjuan, LiHua, WangPing. Comparative observation of choroidal osteoma by multimodal fundus imaging methods. Chinese Journal of Ocular Fundus Diseases, 2016, 32(3): 283-286. doi: 10.3760/cma.j.issn.1005-1015.2016.03.013 Copy

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6.	Shields CL, Manalac J, Das C, et al. Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid[J]. Indian J Ophthalmol, 2015, 63(2):117-121.DOI:10.4103/0301-4738.154377.
7.	Empeslidis T, Imrani U, Konidaris V, et al. Diagnosis and monitoring of choroidal osteoma through multimodal imaging. Case Rep Med, 2014, 2014:393804.http://dx.doi.org/10.1155/2014/393804.DOI:10.1155/2014/393804.
8.	Munteanu M, Munteanu G, Giuri S, et al. Ossification of the choroid:three clinical cases and literature review of the pathogenesis of intraocular ossification[J]. Rom J Morphol Embryol, 2013, 54(3 Suppl):S871-877.
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10.	Yoshikawa T, Takahashi K. Decalcified choroidal osteoma found in the retina[J]. Clin Ophthalmol, 2012, 6:1823-1825.DOI:10.2147/OPTH.S37952.
11.	Kubota-Taniai M, Oshitari T, et al. Long-term success of intravitreal bevacizumab for choroidal neovascularization associated with choroidal osteoma[J]. Clin Ophthalmol, 2011, 5:1051-1055. DOI:10.2147/OPTH.S22219.
12.	Hussain R, Anantharaman G, Rajesh B, et al. Real-time in vivo micromorphology and histopathology of choroidal osteoma using enhanced depth imaging[J]. Indian J Ophthalmol, 2015, 63(5):453-455. DOI:10.4103/0301-4738.159887.
13.	Hasanreisoglu M, Shields JA, Mashayekhi A, et al. Bilateral choroidal osteoma:visual acuity at 45-year follow-up[J]. Retin Cases Brief Rep, 2015, 9(3):239-241. DOI:10.1097/ICB.0000000000000148.
14.	Lekha T, Renuka NS, Prasad HN. Anti-vascular endothelial growth factors for choroidal neovascularization secondary to choroidal osteoma:Long-term results[J]. Oman J Ophthalmol, 2015, 8(3):185-187. DOI:10.4103/0974-620X.169908.

1. Behera M, Das MK. A case of choroidal osteoma in a 10-year-old child[J]. Int Med Case Rep J, 2015, 8:273-275.DOI:10.2147/IMCRJ.S92693.
2. Heichel J, Bredehorn-MayräT, Stuhlträger U, et al. Manifestation of bilateral choroidal osteoma in childhood:progressive myopia due to staphyloma posticum[J]. Ophthalmologe, 2016, 113(2):160-163. DOI:10.1007/s00347-015-0065-z.
3. Shields CL, Hasanreisoglu M, Saktanasate J, et al. Sclerochoroidal calcification:clinical features, outcomes, and relationship with hypercalcemia and parathyroid adenoma in 179 eyes[J].2015, 35(3):547-554.DOI:10.1097/IAE.0000000000000450.
4. Gass JDM. New observations concerning choroidal osteomas[J]. Int Ophthalmol, 1979, 1(2):71-84.
5. Gass JDM, Guerry RK, Jack RL, et al. Choroidal osteoma[J]. Arch Ophthalmol, 1978, 96(3):428-435.
6. Shields CL, Manalac J, Das C, et al. Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid[J]. Indian J Ophthalmol, 2015, 63(2):117-121.DOI:10.4103/0301-4738.154377.
7. Empeslidis T, Imrani U, Konidaris V, et al. Diagnosis and monitoring of choroidal osteoma through multimodal imaging. Case Rep Med, 2014, 2014:393804.http://dx.doi.org/10.1155/2014/393804.DOI:10.1155/2014/393804.
8. Munteanu M, Munteanu G, Giuri S, et al. Ossification of the choroid:three clinical cases and literature review of the pathogenesis of intraocular ossification[J]. Rom J Morphol Embryol, 2013, 54(3 Suppl):S871-877.
9. Narayanan R, Shah VA. Intravitreal bevacizumab in the management of choroidal neovascular membrane secondary to choroidal osteoma[J]. Eur J Ophthalmol, 2008, 18(3):466-468.
10. Yoshikawa T, Takahashi K. Decalcified choroidal osteoma found in the retina[J]. Clin Ophthalmol, 2012, 6:1823-1825.DOI:10.2147/OPTH.S37952.
11. Kubota-Taniai M, Oshitari T, et al. Long-term success of intravitreal bevacizumab for choroidal neovascularization associated with choroidal osteoma[J]. Clin Ophthalmol, 2011, 5:1051-1055. DOI:10.2147/OPTH.S22219.
12. Hussain R, Anantharaman G, Rajesh B, et al. Real-time in vivo micromorphology and histopathology of choroidal osteoma using enhanced depth imaging[J]. Indian J Ophthalmol, 2015, 63(5):453-455. DOI:10.4103/0301-4738.159887.
13. Hasanreisoglu M, Shields JA, Mashayekhi A, et al. Bilateral choroidal osteoma:visual acuity at 45-year follow-up[J]. Retin Cases Brief Rep, 2015, 9(3):239-241. DOI:10.1097/ICB.0000000000000148.
14. Lekha T, Renuka NS, Prasad HN. Anti-vascular endothelial growth factors for choroidal neovascularization secondary to choroidal osteoma:Long-term results[J]. Oman J Ophthalmol, 2015, 8(3):185-187. DOI:10.4103/0974-620X.169908.

Chinese Journal of Ocular Fundus Diseases

Comparative observation of choroidal osteoma by multimodal fundus imaging methods

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