Features of full field electroretinogram responses in children with early type 1 diabetes_Chinese Journal of Ocular Fundus Diseases

Authors：

BaiXueqing , YuJifeng , ShiWei , CuiYanhui , LiuWen , TianLirong ,  LiLi

Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China;

Corresponding author：

LiLi, Email: liliyk1@163.com

Keywords：

Diabetes mellitus, type 1; Child; Electroretinography

DOI：

10.3760/cma.j.issn.1005-1015.2016.03.014

Video：

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Objective To observe the features of the full field electroretinogram (FF-ERG) in type 1 diabetes (T1D) children without diabetic retinopathy (DR). Methods Retrospective case study. Forty-one T1D children and 25 age-matched normal controls underwent a complete ophthalmic examination, including best-corrected visual acuity, refraction, intraocular pressure, slit lamp, fundus photography, indirect ophthalmoscopy, and spectral domain optical coherence tomography to exclude DR. All FF-ERG tests were performed by an experienced technician. The ERG series includes six protocols: dark-adapted 0.01 ERG (r-b 0.01); dark-adapted 3 ERG (mix-a 3.0, mix-b 3.0); dark-adapted 10 ERG (mix-a 10.0, mix-b 10.0); dark-adapted oscillatory potentials (OPS); light-adapted 3 ERG (c-a 3.0, c-b 3.0); light-adapted 30 Hz flicker (30 Hz FP) ERG. To compare the amplitudes and implicit times of the FF-ERG between the T1D and control group children. Results Compared with the control subjects, the FF-ERG amplitudes decreased and the implicit times increased in T1D. Except for r-b 0.01 (t=-0.228, P > 0.05), the amplitudes of other FF-ERGs were all significantly attenuated (t=-1.664, -3.645, -4.324, -6.123, -5.846, -12.9, -14.4, -5.23; P < 0.05) in T1D children. The implicit times of mix-b 3.0, mix-b 10.0, c-b 3.0 and OP2 significantly increased (t=5.242, 2.879, 5.378, 3.506; P < 0.05). The implicit times of r-b 0.01, mix-a 3.0, mix-a 10.0, c-a 3.0 and 30Hz FP changes were not significantly (t=2.331, 1.677, 0.557, 0.84, 0.064; P > 0.05). Conclusion The FF-ERG amplitudes decreased and implicit times increased in T1D children compared with the control normal subjects.

Citation： BaiXueqing, YuJifeng, ShiWei, CuiYanhui, LiuWen, TianLirong, LiLi. Features of full field electroretinogram responses in children with early type 1 diabetes. Chinese Journal of Ocular Fundus Diseases, 2016, 32(3): 287-290. doi: 10.3760/cma.j.issn.1005-1015.2016.03.014 Copy

1.	Klein R, Knudtson M, Lee K. The Wisconsin Epidemiologic Study of Diabetic Retinopathy:ⅩⅫthe twenty-five-year progression of retinopathy in persons with type 1 diabetes[J]. Ophthalmology, 2008, 115(11):1859-1868. DOI:10.1016/j.ophtha.2008.08.023.
2.	Rajalakshmi R, Amutha A, Ranjani H. Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes[J]. J Diabetes Complications, 2014, 28(3):291-297. DOI:10.1016/j.jdiacomp.2013.12.008.
3.	Wang NK, Lai CC, Wang JP, et al. Risk factors associated with the development of retinopathy 10yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan:a cohort study from the CGJDES[J].Pediatr Diabetes, 2015, 2015:E1. http://dx.doi.org/10.1111/pedi.12312. DOI:10.1111/pedi.12312..
4.	Parisi V, Uccioli L. Visual electrophysiological responses in persons with type 1 diabetes[J]. Diabetes Metab Res Rev, 2001, 17(1):12-18.
5.	阴正勤.应重视全视野视网膜电图在眼科临床的应用[J].中华眼底病杂志, 2009, 25(6):409-412. DOI:10.3760/cma.j.issn.1005-1015.2009.06.001.Yin ZQ. The importance of clinical application of full-field electroretinography in ophthalmology[J]. Chin J Ocul Fundus Dis, 2009, 25(6):409-412. DOI:10.3760/cma.j.issn.1005-1015.2009.06.001.
6.	Imagawa A, Hanafusa T. Fulminant type 1 diabetes mellitus[J]. Endocr J, 2006, 53(5):577-584.
7.	Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10[J]. Ophthalmology, 1991, 98(Suppl 5):S786-806.
8.	Chen H, Zhang M, Huang S, et al. The photopic negative response of flash ERG in nonproliferative diabetic retinopathy[J]. Doc Ophthalmol, 2008, 117(2):129-135. DOI:10.1007/s10633-008-9114-0.
9.	McCulloch DL, Marmor MF, Brigell MG. ISCEV Standard for full-field clinical electroretinography (2015 update)[J]. Doc Ophthalmol, 2015, 130(1):1-12. DOI:10.1007/s10633-014-9473-7.
10.	方晏红, 张学东, 雷博.视网膜电图震荡电位的研究进展及其在糖尿病视网膜病变中的应用[J].中华眼底病杂志, 2013, 29(1):106-108. DOI:10.3760/cma.j.issn.1005-1015.2013.01.032.Fang YH, Zhang XD, Lei B. The advances of electroretinogram oscillatory potentials and its application in diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2013, 29(1):106-108.DOI:10.3760/cma.j.issn.1005-1015.2013.01.032.
11.	戴加满, 李世迎, 阴正勤.锥杆通路对人视网膜电图振荡电位时频域贡献的分析[J].中华眼科杂志, 2015, 51(5):369-373. DOI:10.3760/cma.j.issn.0412-4081.2015.05.013.Dai JM, Li SY, Yin ZQ. Contributions of human rods and cones pathway to different conponents of oscillatory patential in time and frequency domain[J]. Chin J Ophthalmol, 2015, 51(5):369-373. DOI:10.3760/cma.j.issn.0412-4081.2015.05.013.
12.	Jansson RW, Raeder MB. Photopic full-field electroretinography and optical coherence tomography in type 1 diabetic retinopathy[J]. Graefe's Arch Clin Exp Ophthalmol, 2015, 253(7):989-997. DOI:10.1007/s00417-015-3034-y.
13.	Kuze M, Uji Y. Comparison between Dawson, Trick, and Litzkow electrode and contact lens electrodes used in clinical electroretinography[J]. Jpn J Ophthalmol, 2000, 44(4):374-380.

1. Klein R, Knudtson M, Lee K. The Wisconsin Epidemiologic Study of Diabetic Retinopathy:ⅩⅫthe twenty-five-year progression of retinopathy in persons with type 1 diabetes[J]. Ophthalmology, 2008, 115(11):1859-1868. DOI:10.1016/j.ophtha.2008.08.023.
2. Rajalakshmi R, Amutha A, Ranjani H. Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes[J]. J Diabetes Complications, 2014, 28(3):291-297. DOI:10.1016/j.jdiacomp.2013.12.008.
3. Wang NK, Lai CC, Wang JP, et al. Risk factors associated with the development of retinopathy 10yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan:a cohort study from the CGJDES[J].Pediatr Diabetes, 2015, 2015:E1. http://dx.doi.org/10.1111/pedi.12312. DOI:10.1111/pedi.12312..
4. Parisi V, Uccioli L. Visual electrophysiological responses in persons with type 1 diabetes[J]. Diabetes Metab Res Rev, 2001, 17(1):12-18.
5. 阴正勤.应重视全视野视网膜电图在眼科临床的应用[J].中华眼底病杂志, 2009, 25(6):409-412. DOI:10.3760/cma.j.issn.1005-1015.2009.06.001.Yin ZQ. The importance of clinical application of full-field electroretinography in ophthalmology[J]. Chin J Ocul Fundus Dis, 2009, 25(6):409-412. DOI:10.3760/cma.j.issn.1005-1015.2009.06.001.
6. Imagawa A, Hanafusa T. Fulminant type 1 diabetes mellitus[J]. Endocr J, 2006, 53(5):577-584.
7. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10[J]. Ophthalmology, 1991, 98(Suppl 5):S786-806.
8. Chen H, Zhang M, Huang S, et al. The photopic negative response of flash ERG in nonproliferative diabetic retinopathy[J]. Doc Ophthalmol, 2008, 117(2):129-135. DOI:10.1007/s10633-008-9114-0.
9. McCulloch DL, Marmor MF, Brigell MG. ISCEV Standard for full-field clinical electroretinography (2015 update)[J]. Doc Ophthalmol, 2015, 130(1):1-12. DOI:10.1007/s10633-014-9473-7.
10. 方晏红, 张学东, 雷博.视网膜电图震荡电位的研究进展及其在糖尿病视网膜病变中的应用[J].中华眼底病杂志, 2013, 29(1):106-108. DOI:10.3760/cma.j.issn.1005-1015.2013.01.032.Fang YH, Zhang XD, Lei B. The advances of electroretinogram oscillatory potentials and its application in diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2013, 29(1):106-108.DOI:10.3760/cma.j.issn.1005-1015.2013.01.032.
11. 戴加满, 李世迎, 阴正勤.锥杆通路对人视网膜电图振荡电位时频域贡献的分析[J].中华眼科杂志, 2015, 51(5):369-373. DOI:10.3760/cma.j.issn.0412-4081.2015.05.013.Dai JM, Li SY, Yin ZQ. Contributions of human rods and cones pathway to different conponents of oscillatory patential in time and frequency domain[J]. Chin J Ophthalmol, 2015, 51(5):369-373. DOI:10.3760/cma.j.issn.0412-4081.2015.05.013.
12. Jansson RW, Raeder MB. Photopic full-field electroretinography and optical coherence tomography in type 1 diabetic retinopathy[J]. Graefe's Arch Clin Exp Ophthalmol, 2015, 253(7):989-997. DOI:10.1007/s00417-015-3034-y.
13. Kuze M, Uji Y. Comparison between Dawson, Trick, and Litzkow electrode and contact lens electrodes used in clinical electroretinography[J]. Jpn J Ophthalmol, 2000, 44(4):374-380.

Chinese Journal of Ocular Fundus Diseases

Features of full field electroretinogram responses in children with early type 1 diabetes

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