Research progress of different types of stem cells in the application of diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Cao Bowen ,  Meng Xuxia

Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao 266650, China;

Corresponding author：

Meng Xuxia, Email: mengxuxia@163.com

Keywords：

Diabetic retinopathy/etiology; Diabetic retinopathy/therapy; Mesenchymal stem cells; Embryonic stem cells; Review

DOI：

10.3760/cma.j.issn.1005-1015.2018.04.026

Video：

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Abstract Full text Figures/Tables Video References Cited by

Diabetic retinopathy is a serious complication of diabetes and is the leading cause of blindness in people with diabetes. At present, there are many views on the pathogenesis of diabetic retinopathy, including the changes of retinal microenvironment caused by high glucose, the formation of advanced glycation end products, oxidative stress injury, inflammatory reaction and angiogenesis factor. These mechanisms produce a common pathway that leads to retinal degeneration and microvascular injury in the retina. In recent years, cell regeneration therapy plays an increasingly important role in the process of repairing diseases. Different types of stem cells have neurological and vascular protection for the retina, but the focus of the target is different. It has been reported that stem cells can regulate the retinal microenvironment and protect the retinal nerve cells by paracrine production, and can also reduce immune damage through potential immunoregulation, and can also differentiate into damaged cells by regenerative function. Combined with the above characteristics, stem cells show the potential for the repair of diabetic retinopathy, this stem cell-based regenerative therapy for clinical application provides a pre-based evident. However, in the process of stem cell transplantation, homogeneity of stem cells, cell delivery, effective homing and transplantation to damaged tissue is still a problem of cell therapy.

Citation： Cao Bowen, Meng Xuxia. Research progress of different types of stem cells in the application of diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2018, 34(4): 415-421. doi: 10.3760/cma.j.issn.1005-1015.2018.04.026 Copy

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26. Volarevic V, Arsenijevic N, Lukic ML, et al. Concise review: mesenchymal stem cell treatment of the complications of diabetes mellitus[J]. Stem Cells, 2011, 29(1): 5-10. DOI:10.1002/stem.556.
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28. Rajashekhar G, Ramadan A, Abburi C, et al. Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy[J/OL]. PLoS One, 2014, 9(1):84671[2014-01-09]. http://dx.plos.org/10.1371/journal.pone.0084671. DOI:10.1371/journal.pone.0084671.
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30. Nauta AJ, Fibbe WE. Hnmunomodulatory properties of mesenchymal stromal cells[J]. Blood, 2007, 110(10): 3499-3506. DOI:10.1182/blood-2007-02-069716.
31. Scalinci SZ, Scorolli L, Corradetti G, et al. Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous[J]. Clin Ophthalmol, 2011, 5: 691-696. DOI:10.2147/opth.s21161.
32. Liew A, O'Brien T. Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia[J]. Stem Cell Res Ther, 2012, 3(4):28.DOI:10.1186/scrt119.
33. Han JW, Choi D, Lee MY, et al. Bone marrow-derived mesenchymal stem cells improve diabetic neuropathy by direct modulation of both angiogenesis and myelination in peripheral nerves[J]. Cell Transplant, 2016, 25(2): 313-326.DOI:10.3727/096368915x688209.
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