The image characteristics of multispectral scanning laser imaging and optical coherence tomography in patients with pregnancy induced hypertension syndrome_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Lina ,  Liu Zengye , He Luning , Zhang Zhihui , Ma Cheng , Gao Chenming , Ma Yingxue

Department of Ophthalmology, Tianjin First Central Hospital, Tianjin 300192, China;

Corresponding author：

Liu Zengye, Email: lzydoc@163.com

Keywords：

Hypertension, pregnancy-induced; Hypertensive retinopathy/diagnosis; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2020.01.007

Video：

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Objective To observe the image characteristics of multispectral scanning laser imaging (MSLI) and OCT in patients with pregnancy induced hypertension syndrome (PIHS).Methods A total of 112 patients (224 eyes) of PIHS patients diagnosed in Obstetrics Department of Tianjin First Central Hospital from May 2016 to May 2017 were included in this study. The average age of the patients was 27.00±2.14 years. The average course of the disease was 15.00±8.27 days. There were 174 eyes in 87 patients of blurred vision, dazzling and visual fatigue consciously. All patients performed BCVA, direct ophthalmoscope, B ultrasound, confocal scanning laser Ophthalmoscope (cSLO) and spectral-domain OCT (SD-OCT). SD-OCT was performed with Spectralis HRA+OCT from Heidelberg Company in Germany to acquire tomographic images. Using Herdelberg's colorful program (MultiColor) based on cSLO and operating in accordance with standard methods, one scan simultaneously obtained blue light reflection based on 488 nm, green light reflection based on 515 nm, and infrared reflection based on 820 nm, synthesis to MSLI. Fundus abnormalities were classified into arterial spasm (stage Ⅰ), arteriosclerosis (stage Ⅱ), and retinopathy (stage Ⅲ). OCT examination was divided into normal and abnormal cases according to the abnormality of retinal morphology and thickness.Results Of the 224 eyes, 68 eyes (30.36%) showed normal fundus examination and 156 eyes (69.64%) showed abnormal fundus performance. Among them, 28 eyes were stage Ⅰ (17.95%); 40 eyes were stage Ⅱ (25.64%); 88 eyes were stage Ⅲ (56.41%). Thirty-six eyes (16.07%) showed normal fundus and 188 eyes (83.93%) showed abnormal performance with OCT. Of the 188 eyes with abnormal fundus performance, 86 eyes (45.74%) had retinal neuroepithelial serous detachment; 56 eyes (29.79%) had RPE detachment; optic disc edema, bulge, and local reflexes in the retinal nerve fiber layer were enhanced and/or the thickness increased in 46 eyes (24.47%). In MSLI, 48 eyes (21.43%) showed normal fundus; 176 eyes (78.57%) showed abnormal performance. Retinal edema was showed in green on MSLI, serous retinal neuroepithelial layer detachment, RPE layer detachment, retinal nerve fiber layer thickening, accompanied by changes in local retinal structure. The higher the degree of bulge, the darker the color. Consistent with the range of retinal edema revealed by SD-OCT.Conclusions MSLI and SD-OCT images show highly consistent lesions in PIHS patients. MSLI can more clearly show superficial and deep retinal lesions.

Citation： Wang Lina, Liu Zengye, He Luning, Zhang Zhihui, Ma Cheng, Gao Chenming, Ma Yingxue. The image characteristics of multispectral scanning laser imaging and optical coherence tomography in patients with pregnancy induced hypertension syndrome. Chinese Journal of Ocular Fundus Diseases, 2020, 36(1): 29-32. doi: 10.3760/cma.j.issn.1005-1015.2020.01.007 Copy

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13.	Espina MP, Arcinue CA, Ma F, et al. Analysis of a confocal scanning laser ophthalmoscope noncontact ultra-wide field lens system in retinal and choroidal disease[J]. Retina, 2015, 35(12): 2664-2668. DOI: 10.1097/IAE.0000000000000899.

1. 余铮, 王雨晴. 妊娠高血压综合征患者频域光相干断层扫描检查[J]. 中华眼底病杂志, 2014, 30(6): 621-622. DOI: 10.3760/cma.j.issn.1005-1015.2014.06.021.Yu Z, Wang YQ. Spectral domain optical coherence tomography in patients with pregnancy induced hypertension syndrome[J]. Chin J Ocul Fundus Dis, 2014, 30(6): 621-622. DOI: 10.3760/cma.j.issn.1005-1015.2014.06.021.
2. 郭建玲, 余凤慈, 梁淑贞. 妊娠期高血压综合征治疗中眼底观察的临床意义[J]. 国际眼科杂志, 2010, 5(10): 1021-1022. DOI: 10.3969/j.issn.1672-5123.2010.05.079.Guo JL, Yu FC, Liang SZ. Significance of fundus observation in the treatment of pregnancy induced hypertension syndrome[J]. Int Eye Sci, 2010, 5(10): 1021-1022. DOI: 10.3969/j.issn.1672-5123.2010.05.079.
3. 廖莹琳, 刘瑞英, 幸宜春, 等. 妊娠高血压综合征眼底改变临床观察[J]. 实用临床医学, 2006, 7(9): 126. DOI: 10.3969/j.issn.1009-8194.2006.09.073.Liao YL, Liu RY, Xing YC, et al. Clinical observation of fundus changes in pregnancy induced hypertension syndrome[J]. Practical Clinical Medicine, 2006, 7(9): 126. DOI: 10.3969/j.issn.1009-8194.2006.09.073.
4. Tan AC, Fleckenstein M, Schmitz-Valckenberg S, et al. Clinical application of multicolor imaging technology[J]. Ophthalmologica, 2016, 236(1): 8-18. DOI: 10.1159/000446857.
5. 苟文丽. 妊娠期高血压疾病[M]//乐杰. 妇产科学. 7版. 北京: 人民卫生出版社, 2008: 92-99.Gou WL. Hypertensive disorders complicating pregnancy[M]//Le J. Obstetrics gynecology. 7 ed. Beijing: People's Medical Publishing House, 2008: 92-99.
6. Kaizu Y, Nakao S, Wada I, et al. Imaging of retinal vascular layers: adaptive optics scanning laser ophthalmoscopy versus optical coherence tomography angiography[J/OL]. Transl Vis Sci Technol, 2017, 6(5): 2[2017-09-01]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580501/. DOI: 10.1167/tvst.6.5.2.
7. 张惠蓉. 妊娠高血压综合征的眼底改变[M]//刘家琦, 李凤鸣. 实用眼科学. 3版. 北京: 人民卫生出版社, 2010: 429-430.Zhang HR. Fundus changes in pregnancy induced hypertension syndrome[M]//Liu JQ, Li FM. Practical Ophthalmology. 3 ed. Beijing: People's Medical Publishing House, 2010: 429-430.
8. 庞燕, 张严卓, 李莹, 等. 妊娠高血压疾病与眼底检查的相关研究[J]. 中国现代医生, 2009, 47(15): 220-221. DOI: 10.3969/j.issn.1673-9701.2009.15.122.Pang Y, Zhang YZ, Liu Y, et al. Study on the relationship between hypertensive disorder complicating pregnancy and fundus examination[J]. China Modern Doctor, 2009, 47(15): 220-221. DOI: 10.3969/j.issn.1673-9701.2009.15.122.
9. 郭丽莉, 于文贞. 光学相干断层扫描在评估特发性黄斑前膜患者术后视力改善中的应用价值[J]. 中华实验眼科杂志, 2015, 33(1): 66-69. DOI: 10.3760/cma.j.issn.2095-0160.2015.01.014.Guo LL, Yu WZ. Application value of optical coherence tomography in predicting visual outcome after vitrectomy for idiopathic macular epiretinal membrane[J]. Chin J Exp Ophthalmol, 2015, 33(1): 66-69. DOI: 10.3760/cma.j.issn.2095-0160.2015.01.014.
10. 李淑婷, 王相宁, 杜新华, 等. 共焦激光扫描炫彩眼底成像与彩色眼底照相对糖尿病视网膜病变的检出比较[J]. 中华眼底病杂志, 2018, 34(4): 338-342. DOI: 10.3760/cma.j.issn.1005-1015.2018.04.006.Li ST, Wang XN, Du XH, et al. Comparison of confocal laser scanning colorful fundus imaging and color fudus photography for detection of diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2018, 34(4): 338-342. DOI: 10.3760/cma.j.issn.1005-1015.2018.04.006.
11. Yu S, Wang F, Pang CE, et al. Multimodal imaging findings in retinal deep capillary ischemia[J]. Retina, 2014, 34(4): 636-646. DOI: 10.1097/IAE.0000000000000048.
12. Spaide RF. Questioning optical coherence tomography[J]. Ophthalmology, 2012, 119(11): 2203-2204. DOI: 10.1016/j.ophtha.2012.09.009.
13. Espina MP, Arcinue CA, Ma F, et al. Analysis of a confocal scanning laser ophthalmoscope noncontact ultra-wide field lens system in retinal and choroidal disease[J]. Retina, 2015, 35(12): 2664-2668. DOI: 10.1097/IAE.0000000000000899.

Chinese Journal of Ocular Fundus Diseases

The image characteristics of multispectral scanning laser imaging and optical coherence tomography in patients with pregnancy induced hypertension syndrome

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