3D Hemodynamic Numerical Simulation of Carotid Artery Aneurysm Before and after Surgery Based on CT Date_Journal of Biomedical Engineering

Authors：

RENGuorong ¹ , CAOXiaoqiang ² , WANGDongqing ² ,  JIANGPing ³ , LIYusheng ¹ , PEIBing ¹

1. Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang 212013, China;
2. Department of Radiology, the Affiliated Hospital, Jiangsu University, Zhenjiang 212013, China;
3. Department of Anatomy, School Medicine Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China;

Corresponding author：

JIANGPing, Email: jiangping1111@163.com

Keywords：

carotid artery aneurysm; hemodynamic; mimics; recurrence

DOI：

10.7507/1001-5515.20140064

Video：

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Hemodynamic situation is an important factor of recurrence of postoperative carotid artery aneurysm. In order to investigate the hemodynamic factors of postoperative carotid artery aneurysm affect carotid artery aneurysm recurrence, we established a 3D finite element carotid artery aneurysm for the preoperative and postoperative periods using the three-dimensional reconstruction techniques. And then we measured the hemodynamic factors of carotid artery aneurysm of preoperative and postoperative by the finite element method. The carotid artery aneurysm model has an accurate and realistic shape; the pressure of the recurrence of aneurysm was reduced significantly after surgery,wall shear stress increased significantly at residual neck, and blood flow velocity increased significantly, which will increase the risk of recurrence. The hemodynamic analysis provides a reference for development of aneurysm clinical treatment programs and prevention of recurrence.

Citation： RENGuorong, CAOXiaoqiang, WANGDongqing, JIANGPing, LIYusheng, PEIBing. 3D Hemodynamic Numerical Simulation of Carotid Artery Aneurysm Before and after Surgery Based on CT Date. Journal of Biomedical Engineering, 2014, 31(2): 341-346. doi: 10.7507/1001-5515.20140064 Copy

1.	于红玉,李海云,张莹,等.基于影像数据的三维颅内动脉瘤血流动力学数值:手术前后壁面切模拟对比[J].中国组织工程研究与临床康复,2010,14(39):7327-7330.
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4.	穆士卿,杨新建,张莹,等.颅内典型囊性动脉瘤的三维数值模拟及血液动力学分析[J].中国微侵袭神经外科杂志,2009,14(7):312-315.
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6.	顾兆勇,张宏斌,孟宪龙,等.支架植入颅内蜿蜒型动脉瘤的血液动力学仿真[J].医用生物力学,2009,24(1):64-69.
7.	黄清海,张星,施洋,等.不同类型脑动脉瘤内流体力学的三维数值模拟研究[J].中华神经外科疾病研究杂志,2009,8(1):69-72.
8.	王伟华.基于CT的脑动脉瘤三维模型重建及有限元分析[D].北京:北京工业大学,2009.
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19.	张炘,段传志,李铁林,等.切应力在血流动力学因素影响颅内动脉瘤形成和破裂中的作用[J].介入放射学杂志,2011,20(4):319-324.
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21.	王芙昱.基于计算流体力学技术的个体化颅内动脉瘤的血流动力学模型与试验[D].北京:中国人民解放军军医进修学院,2008.
22.	刘磊,许百男,王芙昱,等.颅内动脉瘤血流动力学的计算流体动力学数值模拟研究[J].临床神经外科杂志,2011,8(1):19-22.
23.	CHIEN A,CASTRO M A,TATESHIMA S,et al.Quantitative hemodynamic analysis of brain aneurysms at different locations[J].AJNR Am J Neuroradiol,2009,30(8):1507-1512.
24.	卢海涛,杨鹏飞,黄清海,等.颅内动脉瘤壁面压力分布的数值模拟研究[J].中华脑血管病杂志:电子版,2009,3(5):225-232.
25.	DOLAN J M,MENG H,SINGH S,et al.High fluid shear stress and spatial shear stress gradients affect endothelial proliferation,survival,and alignment[J].Ann Biomed Eng,2011,39(6):1620-1631.
26.	MUT F,LÖHNER R,CHIEN A,et al.Computational hemodynamics framework for the analysis of cerebral aneurysms[J].Int J Numer Method Biomed Eng,2011,27(6):822-839.

1. 于红玉,李海云,张莹,等.基于影像数据的三维颅内动脉瘤血流动力学数值:手术前后壁面切模拟对比[J].中国组织工程研究与临床康复,2010,14(39):7327-7330.
2. POETHKE J,GOUBERGRITS L,KERTZSCHER U,et al.Impact of imaging modality for analysis of a cerebral aneurysm:comparison between CT,MRI and 3DRA[C]//IFMBE Proceedings,2009,22:1889-1893.
3. CASTRO M A,PUTMAN C M,CEBRAL J R.Computational fluid dynamics modeling of intracranial aneurysms:effects of parent artery segmentation on intra-aneurysmal hemodynamics[J].AJNR Am J Neuroradiol,2006,27(8):1703-1709.
4. 穆士卿,杨新建,张莹,等.颅内典型囊性动脉瘤的三维数值模拟及血液动力学分析[J].中国微侵袭神经外科杂志,2009,14(7):312-315.
5. 陈旭东,罗祺,罗毅男,等.顶端动脉瘤的血流动力学数值模拟切应力分析[J].吉林大学学报:医学版,2005,31(3):381-383.
6. 顾兆勇,张宏斌,孟宪龙,等.支架植入颅内蜿蜒型动脉瘤的血液动力学仿真[J].医用生物力学,2009,24(1):64-69.
7. 黄清海,张星,施洋,等.不同类型脑动脉瘤内流体力学的三维数值模拟研究[J].中华神经外科疾病研究杂志,2009,8(1):69-72.
8. 王伟华.基于CT的脑动脉瘤三维模型重建及有限元分析[D].北京:北京工业大学,2009.
9. 戴建华,丁光宏,龚剑秋,等.颅内动脉瘤的血液动力学二维数值模拟[J].复旦学报(自然科学版),2004,43(3):392-396.
10. LADISA J F,TAYLOR C A,FEINSTEIN J A.Aortic coarctation:recent developments in experimental and computational methods to assess treatments for this simple condition[J].Prog Pediatr Cardiol,2010,30(1):45-49.
11. 张星.支架对脑动脉瘤血液动力学影响的三维数值模拟研究[D].上海:第二军医大学,2008:1-64.
12. 邱晓宁,费智敏,王炜哲,等.颅内动脉瘤夹闭手术的血流动力学数值分析[J].生物医学工程学杂志,2012,29(1):102-106,111.
13. HASSAN T,TIMOFEEV E V,SAITO T,et al.Computational replicas:anatomic reconstructions of cerebral vessels as volume numerical grids at three-dimensional angiography[J].AJNR Am J Neuroradiol,2004,25(8):1356-1365.
14. SURDELL D L,HAGE Z,EDDLEMAN C S,et al.Revascularization for complex intracranial aneurysms[J].Neurosurg Focus,2008,24(2):16-21.
15. LAWTON M T,HAMILTON M G,MORCOS J J,et al.Revascularization and aneurysm surgery:current techniques,indications,and outcome[J].Neurosurgery,1996,38(1):83-92;discussion:92.
16. SEKHAR L N,NATARAJAN S K,ELLENBOGEN R G,et al.Cerebral revascularization for ischemia,aneurysms,and cranial base tumors[J].Neurosurgery,2008,62(6 Suppl 3):S1373-S1408.
17. ALI M J,BENDOK B R,TELLA M N,et al.Arterial reconstruction by direct surgical clipping of a basilar artery dissecting aneurysm after failed vertebral artery occlusion:technical case report and literature review[J].Neurosurgery,2003,52(6):1475-1480.
18. CANTÓN G,LEVY D I,LASHERAS J C,et al.Flow changes caused by the sequential placement of stents across the neck of sidewall cerebral aneurysms[J].J Neurosurg,2005,103(5):891-902.
19. 张炘,段传志,李铁林,等.切应力在血流动力学因素影响颅内动脉瘤形成和破裂中的作用[J].介入放射学杂志,2011,20(4):319-324.
20. 何旭英,段传志,李铁林,等,颈内动脉-后交通动脉瘤形成的形态学因素分析[J].国际脑血管病杂志,2007,15(6):460-463.
21. 王芙昱.基于计算流体力学技术的个体化颅内动脉瘤的血流动力学模型与试验[D].北京:中国人民解放军军医进修学院,2008.
22. 刘磊,许百男,王芙昱,等.颅内动脉瘤血流动力学的计算流体动力学数值模拟研究[J].临床神经外科杂志,2011,8(1):19-22.
23. CHIEN A,CASTRO M A,TATESHIMA S,et al.Quantitative hemodynamic analysis of brain aneurysms at different locations[J].AJNR Am J Neuroradiol,2009,30(8):1507-1512.
24. 卢海涛,杨鹏飞,黄清海,等.颅内动脉瘤壁面压力分布的数值模拟研究[J].中华脑血管病杂志:电子版,2009,3(5):225-232.
25. DOLAN J M,MENG H,SINGH S,et al.High fluid shear stress and spatial shear stress gradients affect endothelial proliferation,survival,and alignment[J].Ann Biomed Eng,2011,39(6):1620-1631.
26. MUT F,LÖHNER R,CHIEN A,et al.Computational hemodynamics framework for the analysis of cerebral aneurysms[J].Int J Numer Method Biomed Eng,2011,27(6):822-839.

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3D Hemodynamic Numerical Simulation of Carotid Artery Aneurysm Before and after Surgery Based on CT Date

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