Hemocompatibility of Polyoxymethylene Used for Bileaflet Heart Valve_Journal of Biomedical Engineering

Authors：

WULiangliang ¹ , SONGQiang ¹ , LIUTao ¹ ,  LIULi ² , HUANGNan ¹

1. Key Lab of Advanced Technology of Materials, Southwest Jiaotong University, Chengdu 610031, China;
2. National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China;

Corresponding author：

LIULi, Email: liuli_7823@163.com

Keywords：

hemocompatibility; polyoxymethylene; artificial heart valve

DOI：

10.7507/1001-5515.20140065

Video：

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The possibility of polyoxymethylene (POM) as heart valve leaflet material was investigated by comparing the hemocompatibility with that of 316L stainless steel and low-temperature isotropic pyrolytic carbon (LTIC). Surface hydrophobicity was characterized by water contact angle measurement.Platelet adhesion, APTT/PT/TT and hemolysis rate tests were applied for evaluating hemocompatibility. The results showed that POM was hydrophobic and had a low hemolytic rate, adhesion amount and activation degree of platelets on POM surface were less than 316L stainless steel, and was similar to LTIC. This research pointed out potential application of POM as heart valve leaflets.

Citation： WULiangliang, SONGQiang, LIUTao, LIULi, HUANGNan. Hemocompatibility of Polyoxymethylene Used for Bileaflet Heart Valve. Journal of Biomedical Engineering, 2014, 31(2): 347-351. doi: 10.7507/1001-5515.20140065 Copy

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1. MOHAMMADI H,MEQUANINT K.Prosthetic aortic heart valves:modeling and design[J].Med Eng Phys,2011,33(2):131-147.
2. TOKUNAGA S,TOMINAGA R.Artificial valves "up to date" in Japan[J].J Artif Organs,2010,13(2):77-87.
3. 陈晓伟,池一凡,牛兆倬,等.不同类型生物材料的心脏瓣膜应用及安全性评价[J].中国组织工程研究与临床康复,2011,15(12):2257-2260.
4. ZHOU D J,YOU B,WU G B,et al.Mechanical properties and surface morphology of photodegraded polyoxymethylene modified by a core-shell acrylate elastomer with UV stabilization[J].Polym Int,2012,61(6):971-981.
5. OHLIN A,LINDER L.Biocompatibility of polyoxymethylene (Delrin^®) in bone[J].Biomaterials,1993,14(4):285-289.
6. FISTER J S,MEMOLI V A,GALANTE J O,et al.Biocompatibility of Delrin 150:a creep-resistant polymer for total joint prostheses[J].J Biomed Mater Res,1985,19(5):519-533.
7. CLARK R E,SWANSON W M,KARDOS J L,et al.Durability of prosthetic heart valves[J].Ann Thorac Surg,1978,26(4):323-335.
8. GRIGIONI M,DANIELE C,D'AVENIO G,et al.Wear patterns from fatigue life testing of a prosthetic heart valve[J].Wear,1999,225-229(Part 2):743-748.
9. CHEN J Y,CAO Y,LI H L.Investigation of the friction and wear behaviors of polyoxymethylene/linear low-density polyethylene/ethylene-acrylic-acid blends[J].Wear,2006,260(11-12):1342-1348.
10. ZHAO X W,YE L.Structure and mechanical properties of polyoxymethylene/multi-walled carbon nanotube composites[J].Composites Part B:Engineering,2011,42(4):926-933.
11. 陈卓玥.钛表面固定特异性识别内皮祖细胞多肽适配子的研究[D].成都:西南交通大学,2012.
12. 王向晖.改善热解碳人工心脏瓣膜材料血液相容性的研究[D].上海:中国科学院上海冶金研究所,2000.
13. DAS A,SATAPATHY B K.Structural,thermal,mechanical and dynamic mechanical properties of cenosphere filled polypropylene composites[J].Materials&Design,2011,32(3):1477-1484.
14. GKANIS V,HOUSIADAS C.Dynamics of flow in a mechanical heart valve:the role of leaflet inertia and leaflet compliance[J].J Biomech Eng,2011,133(4):041009.
15. 陈宝林,王东安.血液相容性抗凝血生物医用高分子材料的制备及其机制(英文)[J].中国组织工程研究与临床康复,2011,15(29):5507-5510.

Journal of Biomedical Engineering

Hemocompatibility of Polyoxymethylene Used for Bileaflet Heart Valve

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