Advance of new dressings for promoting skin wound healing_Journal of Biomedical Engineering

Authors：

ZHANG Tianwei ^1,2 , LIU Fang ¹ ,  TIAN Weiqun ¹

1. Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, P.R.China;
2. PLA 96829 Troops, Dalian 116200, P.R.China;

Corresponding author：

Keywords：

wound healing; modern dressings; nanomaterials; integration; three-dimensional bio-printing

DOI：

10.7507/1001-5515.201811023

Video：

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As a temporary skin substitute, the dressings can protect the wound, stop bleeding, prevent infection and contribute to wound healing. According to the characteristics of the materials, wound dressings can be classified into traditional wound dressings, interactive dressings, bioactive dressings, tissue engineering dressings and smart dressings, etc. Different dressings have different characteristics, and some products have been widely used in clinic. Recently nanomaterials and three-dimensional bio-printing technology have significantly improved the performance of wound dressings. Future dressings will be developed from single function to multi-function composite, and integrated into an intelligent one. This paper reviews the current research progress and future development prospects of wound dressings.

Citation： ZHANG Tianwei, LIU Fang, TIAN Weiqun. Advance of new dressings for promoting skin wound healing. Journal of Biomedical Engineering, 2019, 36(6): 1055-1059. doi: 10.7507/1001-5515.201811023 Copy

1.	Kumar A, Wang Xiang, Nune K C, et al. Biodegradable hydrogel-based biomaterials with high absorbent properties for non-adherent wound dressing. Int Wound J, 2017, 14(6): 1076-1087.
2.	Aljghami M E, Saboor S, Amini-Nik S. Emerging innovative wound dressings. Ann Biomed Eng, 2019, 47(3): 659-675.
3.	Dhivya S, Padma V V, Santhini E. Wound dressings-a review. Biomedicine (Taipei), 2015, 5(4): 24-28.
4.	Francis N L, Hunger P M, Donius A E, et al. An ice-templated, linearly aligned chitosan-alginate scaffold for neural tissue engineering. J Biomed Mater Res A, 2013, 101(12): 3493-3503.
5.	Aderibigbe B A, Buyana B. Alginate in wound dressings. Pharmaceutics, 2018, 10(2): 1-19.
6.	Imran F H, Karim R, Maat N H. Managing burn wounds with SMARTPORE Technology polyurethane foam: two case reports. J Med Case Rep, 2016, 10(1): 120.
7.	Ashfaq M, Verma N, Khan S. Copper/zinc bimetal nanoparticles-dispersed carbon nanofibers: A novel potential antibiotic material. Mater Sci Eng C Mater Biol Appl, 2016, 59: 938-947.
8.	Mir M, Ali M N, Barakullah A, et al. Synthetic polymeric biomaterials for wound healing: a review. Prog Biomater, 2018, 7(1): 1-21.
9.	Sood A, Granick M S, Tomaselli N L. Wound dressings and comparative effectiveness data. Adv Wound Care (New Rochelle), 2014, 3(8): 511-529.
10.	Zhan Rixing, Wang Fan, Wu Ying, et al. Nitric oxide induces epidermal stem cell de-adhesion by targeting integrin beta 1 and Talin via the cGMP signalling pathway. Nitric Oxide-Biology and Chemistry, 2018, 78: 1-10.
11.	Fitzpatrick E, Holland O J, Vanderlelie J J. Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J, 2018, 15(4): 633-644.
12.	Cameron S J, Hosseinian F, Willmore W G. A current overview of the biological and cellular effects of nanosilver. Int J Mol Sci, 2018, 19(7). pii: E2030. DOI: 10.3390/ijms19072030.
13.	Sasaki Y, Sathi G A, Yamamoto O. In vivo evaluation of wound healing property of zinc smectite using a rat model. J Ceram Soc Jpn, 2016, 124(12): 1199-1204.
14.	Yan M, Hu Y G, Yao M, et al. GM-CSF ameliorates microvascular barrier integrity via pericyte-derived Ang-1 in wound healing. Wound Repair Regen, 2017, 25(6): 933-943.
15.	Schenck K, Schreurs O, Hayashi K, et al. The role of nerve growth factor (NGF) and its precursor forms in oral wound healing. Int J Mol Sci, 2017, 18(2): 12.
16.	Chen Jicai, Lin Beibei, Hu Houwen, et al. NGF accelerates cutaneous wound healing by promoting the migration of dermal fibroblasts via the PI3K/Akt-Rac1-JNK and ERK pathways. Biomed Res Int, 2014: 547187.
17.	Patrulea V, Ostafe V, Borchard G, et al. Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm, 2015, 97(B, SI): 417-426.
18.	Tran C D, Duri S, Harkins A L. Recyclable synthesis, characterization, and antimicrobial activity of chitosan-based polysaccharide composite materials. J Biomed Mater Res A, 2013, 101(8): 2248-2257.
19.	Ying H Y, Zhou J, Wang M Y, et al. In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing. Mat Sci Eng C, 2019, 101: 487-498.
20.	Abinaya M, Gayathri M. Biodegradable collagen from Scomberomorus lineolatus skin for wound healing dressings and its application on antibiofilm properties. J Cell Biochem, 2019, 120(9): 15572-15584.
21.	Chattopadhyay S, Raines R T. Collagen-based biomaterials for wound healing. Biopolymers, 2014, 101(8): 821-833.
22.	Stojkovska J, Djurdjevic Z, Jancic I, et al. Comparative in vivo evaluation of novel formulations based on alginate and silver nanoparticles for wound treatments. J Biomater Appl, 2018, 32(9): 1197-1211.
23.	Thakur A, Monga S, Wanchoo R K. Sorption and drug release studies from semi-interpenetrating polymer networks of chitosan and xanthan gum. Chem Biochem Eng Q, 2014, 28(1): 105-115.
24.	Argin S, Kofinas P, Lo Y M. The cell release kinetics and the swelling behavior of physically crosslinked xanthan-chitosan hydrogels in simulated gastrointestinal conditions. Food Hydrocoll, 2014, 40: 138-144.
25.	Lopes S A, Veiga I G, Krause Bierhalz A C K, et al. Physicochemical properties and release behavior of indomethacin-loaded polysaccharide membranes. Int J Polym Mater Polym Biomater, 2018, 68(16): 956-964.
26.	Zhou S, Hokugo A, McClendon M, et al. Bioactive peptide amphiphile nanofiber gels enhance burn wound healing. Burns, 2019, 45(5): 1112-1121.
27.	Hong Lei, Shen Meiting, Fang Jiaxi, et al. Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration. J Mater Sci Mater Med, 2018, 29(9): 150.
28.	Priya S G, Gupta A, Jain E, et al. Bilayer cryogel wound dressing and skin regeneration grafts for the treatment of acute skin wounds. ACS Appl Mater Interfaces, 2016, 8(24): 15145-15159.
29.	Fluke L M, Restrepo R D, Patel S, et al. Strength and histology of a nanofiber scaffold in rats. J Surg Res, 2016, 205(2): 432-439.
30.	Lukanina K I, Grigoriev T E, Krasheninnikov S V, et al. Multi-hierarchical tissue-engineering ECM-like scaffolds based on cellulose acetate with collagen and chitosan fillers. Carbohydr Polym, 2018, 191: 119-126.
31.	Namazi M R, Fallahzadeh M K, Schwartz R A. Strategies for prevention of scars: what can we learn from fetal skin?. Int J Dermatol, 2011, 50(1): 85-93.
32.	Chantre C O, Campbell P H, Golecki H M, et al. Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model. Biomaterials, 2018, 166: 96-108.
33.	Tarassoli S P, Jessop Z M, Al-Sabah A, et al. Skin tissue engineering using 3D bioprinting: An evolving research field. J Plast Reconstr Aesthet Surg, 2018, 71(5): 615-623.
34.	Zhu Zhijie, Guo Shuangzhuang, Hirdler T, et al. 3D printed functional and biological materials on moving freeform surfaces. Adv Mater, 2018, 30(23): e1707495.
35.	Kim B S, Kwon Y W, Kong J S, et al. 3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering. Biomaterials, 2018, 168: 38-53.
36.	Zepon K M, Martins M M, Marques M S, et al. Smart wound dressing based on kappa-carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections. Carbohydr Polym, 2019, 206: 362-370.
37.	Mclister A, Mathur A, Davis J. Wound diagnostics: Deploying electroanalytical strategies for point of care sensors and smart dressings. Curr Opin Electrochem, 2017, 3(1): 40-45.
38.	Pinho E, Machado S, Soares G. Smart hydrogel for the pH-selective drug delivery of antimicrobial compounds. Macromol Symp, 2019, 385(1): 7.
39.	韩波, 李跃军. 智能无线传感敷料. 中华整形外科杂志, 2016, 32(5): 393-395.
40.	Hrga I. Wearable technologies: between fashion, art, performance, and science (Fiction). Tekstilec, 2019, 62(2): 124-136.
41.	Feng Yan, Chen Wenwen, Jia Yuexiao, et al. N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria. Nanoscale, 2016, 8(27): 13223-13227.
42.	Lu Bitao, Lu Fei, Ran Luoxiao, et al. Self-assembly of natural protein and imidazole molecules on gold nanoparticles: Applications in wound healing against multi-drug resistant bacteria. Int J Biol Macromol, 2018, 119: 505-516.
43.	Noori S, Kokabi M, Hassan Z M. Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing. J Appl Polym Sci, 2018, 135(21): 12.
44.	Yang Meirong, Wang Yejing, Cai Rui, et al. Preparation and characterization of silk sericin/glycerol films coated with silver nanoparticles for antibacterial application. Sci Adv Mater, 2018, 10(6): 761-768.
45.	Shi Rui, Niu Yuzhao, Gong Min, et al. Antimicrobial gelatin-based elastomer nanocomposite membrane loaded with ciprofloxacin and polymyxin B sulfate in halloysite nanotubes for wound dressing. Mater Sci Eng C Mater Biol Appl, 2018, 87: 128-138.

1. Kumar A, Wang Xiang, Nune K C, et al. Biodegradable hydrogel-based biomaterials with high absorbent properties for non-adherent wound dressing. Int Wound J, 2017, 14(6): 1076-1087.
2. Aljghami M E, Saboor S, Amini-Nik S. Emerging innovative wound dressings. Ann Biomed Eng, 2019, 47(3): 659-675.
3. Dhivya S, Padma V V, Santhini E. Wound dressings-a review. Biomedicine (Taipei), 2015, 5(4): 24-28.
4. Francis N L, Hunger P M, Donius A E, et al. An ice-templated, linearly aligned chitosan-alginate scaffold for neural tissue engineering. J Biomed Mater Res A, 2013, 101(12): 3493-3503.
5. Aderibigbe B A, Buyana B. Alginate in wound dressings. Pharmaceutics, 2018, 10(2): 1-19.
6. Imran F H, Karim R, Maat N H. Managing burn wounds with SMARTPORE Technology polyurethane foam: two case reports. J Med Case Rep, 2016, 10(1): 120.
7. Ashfaq M, Verma N, Khan S. Copper/zinc bimetal nanoparticles-dispersed carbon nanofibers: A novel potential antibiotic material. Mater Sci Eng C Mater Biol Appl, 2016, 59: 938-947.
8. Mir M, Ali M N, Barakullah A, et al. Synthetic polymeric biomaterials for wound healing: a review. Prog Biomater, 2018, 7(1): 1-21.
9. Sood A, Granick M S, Tomaselli N L. Wound dressings and comparative effectiveness data. Adv Wound Care (New Rochelle), 2014, 3(8): 511-529.
10. Zhan Rixing, Wang Fan, Wu Ying, et al. Nitric oxide induces epidermal stem cell de-adhesion by targeting integrin beta 1 and Talin via the cGMP signalling pathway. Nitric Oxide-Biology and Chemistry, 2018, 78: 1-10.
11. Fitzpatrick E, Holland O J, Vanderlelie J J. Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J, 2018, 15(4): 633-644.
12. Cameron S J, Hosseinian F, Willmore W G. A current overview of the biological and cellular effects of nanosilver. Int J Mol Sci, 2018, 19(7). pii: E2030. DOI: 10.3390/ijms19072030.
13. Sasaki Y, Sathi G A, Yamamoto O. In vivo evaluation of wound healing property of zinc smectite using a rat model. J Ceram Soc Jpn, 2016, 124(12): 1199-1204.
14. Yan M, Hu Y G, Yao M, et al. GM-CSF ameliorates microvascular barrier integrity via pericyte-derived Ang-1 in wound healing. Wound Repair Regen, 2017, 25(6): 933-943.
15. Schenck K, Schreurs O, Hayashi K, et al. The role of nerve growth factor (NGF) and its precursor forms in oral wound healing. Int J Mol Sci, 2017, 18(2): 12.
16. Chen Jicai, Lin Beibei, Hu Houwen, et al. NGF accelerates cutaneous wound healing by promoting the migration of dermal fibroblasts via the PI3K/Akt-Rac1-JNK and ERK pathways. Biomed Res Int, 2014: 547187.
17. Patrulea V, Ostafe V, Borchard G, et al. Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm, 2015, 97(B, SI): 417-426.
18. Tran C D, Duri S, Harkins A L. Recyclable synthesis, characterization, and antimicrobial activity of chitosan-based polysaccharide composite materials. J Biomed Mater Res A, 2013, 101(8): 2248-2257.
19. Ying H Y, Zhou J, Wang M Y, et al. In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing. Mat Sci Eng C, 2019, 101: 487-498.
20. Abinaya M, Gayathri M. Biodegradable collagen from Scomberomorus lineolatus skin for wound healing dressings and its application on antibiofilm properties. J Cell Biochem, 2019, 120(9): 15572-15584.
21. Chattopadhyay S, Raines R T. Collagen-based biomaterials for wound healing. Biopolymers, 2014, 101(8): 821-833.
22. Stojkovska J, Djurdjevic Z, Jancic I, et al. Comparative in vivo evaluation of novel formulations based on alginate and silver nanoparticles for wound treatments. J Biomater Appl, 2018, 32(9): 1197-1211.
23. Thakur A, Monga S, Wanchoo R K. Sorption and drug release studies from semi-interpenetrating polymer networks of chitosan and xanthan gum. Chem Biochem Eng Q, 2014, 28(1): 105-115.
24. Argin S, Kofinas P, Lo Y M. The cell release kinetics and the swelling behavior of physically crosslinked xanthan-chitosan hydrogels in simulated gastrointestinal conditions. Food Hydrocoll, 2014, 40: 138-144.
25. Lopes S A, Veiga I G, Krause Bierhalz A C K, et al. Physicochemical properties and release behavior of indomethacin-loaded polysaccharide membranes. Int J Polym Mater Polym Biomater, 2018, 68(16): 956-964.
26. Zhou S, Hokugo A, McClendon M, et al. Bioactive peptide amphiphile nanofiber gels enhance burn wound healing. Burns, 2019, 45(5): 1112-1121.
27. Hong Lei, Shen Meiting, Fang Jiaxi, et al. Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration. J Mater Sci Mater Med, 2018, 29(9): 150.
28. Priya S G, Gupta A, Jain E, et al. Bilayer cryogel wound dressing and skin regeneration grafts for the treatment of acute skin wounds. ACS Appl Mater Interfaces, 2016, 8(24): 15145-15159.
29. Fluke L M, Restrepo R D, Patel S, et al. Strength and histology of a nanofiber scaffold in rats. J Surg Res, 2016, 205(2): 432-439.
30. Lukanina K I, Grigoriev T E, Krasheninnikov S V, et al. Multi-hierarchical tissue-engineering ECM-like scaffolds based on cellulose acetate with collagen and chitosan fillers. Carbohydr Polym, 2018, 191: 119-126.
31. Namazi M R, Fallahzadeh M K, Schwartz R A. Strategies for prevention of scars: what can we learn from fetal skin?. Int J Dermatol, 2011, 50(1): 85-93.
32. Chantre C O, Campbell P H, Golecki H M, et al. Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model. Biomaterials, 2018, 166: 96-108.
33. Tarassoli S P, Jessop Z M, Al-Sabah A, et al. Skin tissue engineering using 3D bioprinting: An evolving research field. J Plast Reconstr Aesthet Surg, 2018, 71(5): 615-623.
34. Zhu Zhijie, Guo Shuangzhuang, Hirdler T, et al. 3D printed functional and biological materials on moving freeform surfaces. Adv Mater, 2018, 30(23): e1707495.
35. Kim B S, Kwon Y W, Kong J S, et al. 3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering. Biomaterials, 2018, 168: 38-53.
36. Zepon K M, Martins M M, Marques M S, et al. Smart wound dressing based on kappa-carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections. Carbohydr Polym, 2019, 206: 362-370.
37. Mclister A, Mathur A, Davis J. Wound diagnostics: Deploying electroanalytical strategies for point of care sensors and smart dressings. Curr Opin Electrochem, 2017, 3(1): 40-45.
38. Pinho E, Machado S, Soares G. Smart hydrogel for the pH-selective drug delivery of antimicrobial compounds. Macromol Symp, 2019, 385(1): 7.
39. 韩波, 李跃军. 智能无线传感敷料. 中华整形外科杂志, 2016, 32(5): 393-395.
40. Hrga I. Wearable technologies: between fashion, art, performance, and science (Fiction). Tekstilec, 2019, 62(2): 124-136.
41. Feng Yan, Chen Wenwen, Jia Yuexiao, et al. N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria. Nanoscale, 2016, 8(27): 13223-13227.
42. Lu Bitao, Lu Fei, Ran Luoxiao, et al. Self-assembly of natural protein and imidazole molecules on gold nanoparticles: Applications in wound healing against multi-drug resistant bacteria. Int J Biol Macromol, 2018, 119: 505-516.
43. Noori S, Kokabi M, Hassan Z M. Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing. J Appl Polym Sci, 2018, 135(21): 12.
44. Yang Meirong, Wang Yejing, Cai Rui, et al. Preparation and characterization of silk sericin/glycerol films coated with silver nanoparticles for antibacterial application. Sci Adv Mater, 2018, 10(6): 761-768.
45. Shi Rui, Niu Yuzhao, Gong Min, et al. Antimicrobial gelatin-based elastomer nanocomposite membrane loaded with ciprofloxacin and polymyxin B sulfate in halloysite nanotubes for wound dressing. Mater Sci Eng C Mater Biol Appl, 2018, 87: 128-138.

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