Research progress of hyperbaric oxygen therapy for cognitive impairment in cerebral small vessel disease_West China Medical Journal

Authors：

QU Zhixuan ,  ZENG Xianrong

Department of Neurology, Medical School of University of Electronic Science and Technology of China, Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610000, P. R. China;

Corresponding author：

ZENG Xianrong, Email: 570574804@qq.com

Keywords：

Cerebral small vessel disease; hyperbaric oxygen therapy; cognitive impairment; hypoxia; mechanism

DOI：

10.7507/1002-0179.202404127

Video：

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Abstract Full text Figures/Tables Video References Cited by

Cerebral small vessel disease refers to a series of clinical, imaging, and pathological syndromes caused by various factors affecting small blood vessels in the brain. Cognitive impairment is one of the most common complications of cerebral small vessel disease. Current researches have found that cognitive impairment is related to various factors such as hypoxia. Hyperbaric oxygen therapy can achieve certain therapeutic effects by improving hypoxia. This article reviews the pathogenesis of cerebral small vessel disease, biomarkers of cerebral small vessel disease, research progress on hyperbaric oxygen therapy for cognitive impairment, and focuses on the research progress of hyperbaric oxygen therapy for mild cognitive impairment and dementia, providing more references for clinical treatment.

Citation： QU Zhixuan, ZENG Xianrong. Research progress of hyperbaric oxygen therapy for cognitive impairment in cerebral small vessel disease. West China Medical Journal, 2024, 39(7): 1151-1155. doi: 10.7507/1002-0179.202404127 Copy

1.	Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol, 2019, 18(7): 684-696.
2.	徐培丽, 杨一帆, 胡楠, 等. 脑小血管病与认知功能障碍相关性研究进展. 辽宁中医药大学学报, 2024, 26(3): 56-60.
3.	郑金萍, 谢乐, 方锐, 等. 脑小血管病生物标志物的研究进展. 世界科学技术-中医药现代化, 2021, 23(12): 4398-4405.
4.	Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol, 2010, 9(7): 689-701.
5.	Vila JF, Balcarce PE, Abiusi GR, et al. Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial. Undersea Hyperb Med, 2005, 32(5): 341-349.
6.	Brisset M, Boutouyrie P, Pico F, et al. Large-vessel correlates of cerebral small-vessel disease. Neurology, 2013, 80(7): 662-669.
7.	Nezu T, Hosomi N, Aoki S, et al. Endothelial dysfunction is associated with the severity of cerebral small vessel disease. Hypertens Res, 2015, 38(4): 291-297.
8.	Rajani RM, Quick S, Ruigrok SR, et al. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci Transl Med, 2018, 10(448): eaam9507.
9.	Li Y, Li M, Zhang X, et al. Higher blood-brain barrier permeability is associated with higher white matter hyperintensities burden. J Neurol, 2017, 264(7): 1474-1481.
10.	Zhang CE, Wong SM, Uiterwijk R, et al. Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging Behav, 2019, 13(2): 389-395.
11.	郝栋, 李孟文, 孔艳妮, 等. 脑小血管病患者血清 Hcy、VEGF 水平及意义. 神经损伤与功能重建, 2020, 15(7): 423-424.
12.	张微微. 脑小血管病的新进展. 中华脑血管病杂志(电子版), 2008, 2(4): 272-277.
13.	Shoamanesh A, Preis SR, Beiser AS, et al. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology, 2015, 84(8): 825-832.
14.	张贵强. 脑小血管病患者血浆血管内皮生长因子水平的变化及意义. 中国实用神经疾病杂志, 2018, 21(14): 1547-1551.
15.	王瑾, 赵建华, 刘昊, 等. 脑小血管病患者血清 VEGF 水平与脑白质高信号、认知功能障碍的相关性研究. 中华行为医学与脑科学杂志, 2022, 31(4): 333-340.
16.	何昕, 邓建中, 黄晓宇. 脑小血管病患者认知损害程度与高同型半胱氨酸及 hs-CRP 的相关性. 中国实用神经疾病杂志, 2017, 20(1): 59-61.
17.	黄淑云, 卢健聪, 章成国, 等. 血浆同型半胱氨酸水平与非高血压脑小血管病患者脑白质病变关系的研究. 中国老年保健医学, 2018, 16(4): 26-28.
18.	任玲, 何成奇. 高压氧治疗改善认知功能障碍的研究进展. 华西医学, 2023, 38(4): 597-602.
19.	Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci, 2017, 11: 25.
20.	Butterfield DA, Lauderback CM. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med, 2002, 32(11): 1050-1060.
21.	Schottlender N, Gottfried I, Ashery U. Hyperbaric oxygen treatment: effects on mitochondrial function and oxidative stress. Biomolecules, 2021, 11(12): 1827.
22.	Thom SR, Milovanova TN, Yang M, et al. Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. Wound Repair Regen, 2011, 19(2): 149-161.
23.	王晓莉, 杨于嘉, 谢岷, 等. 高压氧治疗促进 HIBD 新生大鼠内源性神经干细胞的迁移与分化. 中国当代儿科杂志, 2009, 11(9): 749-752.
24.	周磊, 应英, 范茂丹, 等. 高压氧治疗对慢性脑缺血大鼠认知功能的影响及其作用机制. 中国卒中杂志, 2020, 15(8): 836-841.
25.	Hu HQ, Shu MQ, Xue F, et al. Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. Physiol Behav, 2018, 195: 1-8.
26.	Gottfried I, Schottlender N, Ashery U. Hyperbaric oxygen treatment-from mechanisms to cognitive improvement. Biomolecules, 2021, 11(10): 1520.
27.	韩晓云, 解力, 李永安. 高压氧治疗脑小血管病患者对血清 hs-CRP、同型半胱氨酸水平及认知、抑郁相关指标的影响分析. 世界复合医学, 2023, 9(3): 153-155, 159.
28.	陈丹娜, 卢晓航, 陈晓洁, 等. 高压氧联合丁苯酞治疗脑梗死的效果及对血同型半胱氨酸的影响. 中国医药科学, 2022, 12(8): 147-150.
29.	姜如海. 高压氧治疗对脑小血管病患者血清急性时相反应蛋白及认知相关指标的影响研究. 中国医学创新, 2021, 18(22): 106-109.
30.	冼晓琪, 杨杰华, 区大明, 等. 心理干预联合高压氧对脑小血管病患者抑郁症状及认知功能的影响. 实用医技杂志, 2015(9): 922-925.
31.	杨杰华, 冼晓琪, 区大明, 等. 高压氧联合重复经颅磁刺激对脑小血管病伴抑郁患者躯体症状及认知功能的疗效研究. 中国康复医学杂志, 2015, 30(4): 362-365.
32.	秦艳霞, 刘再高, 郑杰, 等. 脑复康方联合高压氧治疗脑小血管病致认知功能障碍疗效及对血清 VEGF、BDNF、hs-CRP 的影响. 现代中西医结合杂志, 2018, 27(19): 2099-2102.
33.	杨杰华, 冼晓琪, 区大明, 等. 高压氧对脑小血管病大鼠学习记忆功能及脑源性神经生长因子、乙酰胆碱表达的影响. 中华物理医学与康复杂志, 2014, 36(7): 508-511.
34.	罗增媛, 李俊, 胡结林, 等. “智三针”联合高压氧对脑梗死后血管性认知障碍患者认知功能及日常生活活动能力的影响. 中国当代医药, 2024, 31(3): 92-95.
35.	边亚礼, 杨艳双, 巩江华. 高压氧联合丁苯肽及艾地苯醌治疗血管性痴呆的疗效及对氧化应激、认知功能的影响. 中华航海医学与高气压医学杂志, 2024, 31(1): 55-58.
36.	江玉英. 高压氧联合有氧运动治疗老年轻度血管性痴呆的疗效观察. 中国标准化, 2022(8): 200-202.
37.	蒋芳况, 王杨, 王丽, 等. 高压氧联合有氧运动治疗老年轻度血管性痴呆的疗效观察. 国际老年医学杂志, 2021, 42(5): 275-278.
38.	武卫周, 员丽娜, 田晋梅, 等. 养血清脑颗粒联合高压氧治疗血管性痴呆的临床研究. 武警后勤学院学报(医学版), 2020, 29(1): 25-28.
39.	刘莉莉, 陈艳芳, 王晓宇. 高压氧联合银杏叶提取物治疗老年血管性痴呆疗效观察. 新乡医学院学报, 2024, 41(5): 477-481.
40.	陈克龙, 宋成城, 陈凌. 益气活血法在脑小血管病认知障碍患者中的临床应用. 中华全科医学, 2023, 21(10): 1767-1769.
41.	石磊, 陈宁宁, 郭亚培, 等. 冬凌草甲素对脑小血管病大鼠认知功能及PERK/CHOP信号通路的影响. 中国药师, 2022, 25(6): 949-954, 980.

1. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol, 2019, 18(7): 684-696.
2. 徐培丽, 杨一帆, 胡楠, 等. 脑小血管病与认知功能障碍相关性研究进展. 辽宁中医药大学学报, 2024, 26(3): 56-60.
3. 郑金萍, 谢乐, 方锐, 等. 脑小血管病生物标志物的研究进展. 世界科学技术-中医药现代化, 2021, 23(12): 4398-4405.
4. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol, 2010, 9(7): 689-701.
5. Vila JF, Balcarce PE, Abiusi GR, et al. Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial. Undersea Hyperb Med, 2005, 32(5): 341-349.
6. Brisset M, Boutouyrie P, Pico F, et al. Large-vessel correlates of cerebral small-vessel disease. Neurology, 2013, 80(7): 662-669.
7. Nezu T, Hosomi N, Aoki S, et al. Endothelial dysfunction is associated with the severity of cerebral small vessel disease. Hypertens Res, 2015, 38(4): 291-297.
8. Rajani RM, Quick S, Ruigrok SR, et al. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci Transl Med, 2018, 10(448): eaam9507.
9. Li Y, Li M, Zhang X, et al. Higher blood-brain barrier permeability is associated with higher white matter hyperintensities burden. J Neurol, 2017, 264(7): 1474-1481.
10. Zhang CE, Wong SM, Uiterwijk R, et al. Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging Behav, 2019, 13(2): 389-395.
11. 郝栋, 李孟文, 孔艳妮, 等. 脑小血管病患者血清 Hcy、VEGF 水平及意义. 神经损伤与功能重建, 2020, 15(7): 423-424.
12. 张微微. 脑小血管病的新进展. 中华脑血管病杂志(电子版), 2008, 2(4): 272-277.
13. Shoamanesh A, Preis SR, Beiser AS, et al. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology, 2015, 84(8): 825-832.
14. 张贵强. 脑小血管病患者血浆血管内皮生长因子水平的变化及意义. 中国实用神经疾病杂志, 2018, 21(14): 1547-1551.
15. 王瑾, 赵建华, 刘昊, 等. 脑小血管病患者血清 VEGF 水平与脑白质高信号、认知功能障碍的相关性研究. 中华行为医学与脑科学杂志, 2022, 31(4): 333-340.
16. 何昕, 邓建中, 黄晓宇. 脑小血管病患者认知损害程度与高同型半胱氨酸及 hs-CRP 的相关性. 中国实用神经疾病杂志, 2017, 20(1): 59-61.
17. 黄淑云, 卢健聪, 章成国, 等. 血浆同型半胱氨酸水平与非高血压脑小血管病患者脑白质病变关系的研究. 中国老年保健医学, 2018, 16(4): 26-28.
18. 任玲, 何成奇. 高压氧治疗改善认知功能障碍的研究进展. 华西医学, 2023, 38(4): 597-602.
19. Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci, 2017, 11: 25.
20. Butterfield DA, Lauderback CM. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med, 2002, 32(11): 1050-1060.
21. Schottlender N, Gottfried I, Ashery U. Hyperbaric oxygen treatment: effects on mitochondrial function and oxidative stress. Biomolecules, 2021, 11(12): 1827.
22. Thom SR, Milovanova TN, Yang M, et al. Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. Wound Repair Regen, 2011, 19(2): 149-161.
23. 王晓莉, 杨于嘉, 谢岷, 等. 高压氧治疗促进 HIBD 新生大鼠内源性神经干细胞的迁移与分化. 中国当代儿科杂志, 2009, 11(9): 749-752.
24. 周磊, 应英, 范茂丹, 等. 高压氧治疗对慢性脑缺血大鼠认知功能的影响及其作用机制. 中国卒中杂志, 2020, 15(8): 836-841.
25. Hu HQ, Shu MQ, Xue F, et al. Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. Physiol Behav, 2018, 195: 1-8.
26. Gottfried I, Schottlender N, Ashery U. Hyperbaric oxygen treatment-from mechanisms to cognitive improvement. Biomolecules, 2021, 11(10): 1520.
27. 韩晓云, 解力, 李永安. 高压氧治疗脑小血管病患者对血清 hs-CRP、同型半胱氨酸水平及认知、抑郁相关指标的影响分析. 世界复合医学, 2023, 9(3): 153-155, 159.
28. 陈丹娜, 卢晓航, 陈晓洁, 等. 高压氧联合丁苯酞治疗脑梗死的效果及对血同型半胱氨酸的影响. 中国医药科学, 2022, 12(8): 147-150.
29. 姜如海. 高压氧治疗对脑小血管病患者血清急性时相反应蛋白及认知相关指标的影响研究. 中国医学创新, 2021, 18(22): 106-109.
30. 冼晓琪, 杨杰华, 区大明, 等. 心理干预联合高压氧对脑小血管病患者抑郁症状及认知功能的影响. 实用医技杂志, 2015(9): 922-925.
31. 杨杰华, 冼晓琪, 区大明, 等. 高压氧联合重复经颅磁刺激对脑小血管病伴抑郁患者躯体症状及认知功能的疗效研究. 中国康复医学杂志, 2015, 30(4): 362-365.
32. 秦艳霞, 刘再高, 郑杰, 等. 脑复康方联合高压氧治疗脑小血管病致认知功能障碍疗效及对血清 VEGF、BDNF、hs-CRP 的影响. 现代中西医结合杂志, 2018, 27(19): 2099-2102.
33. 杨杰华, 冼晓琪, 区大明, 等. 高压氧对脑小血管病大鼠学习记忆功能及脑源性神经生长因子、乙酰胆碱表达的影响. 中华物理医学与康复杂志, 2014, 36(7): 508-511.
34. 罗增媛, 李俊, 胡结林, 等. “智三针”联合高压氧对脑梗死后血管性认知障碍患者认知功能及日常生活活动能力的影响. 中国当代医药, 2024, 31(3): 92-95.
35. 边亚礼, 杨艳双, 巩江华. 高压氧联合丁苯肽及艾地苯醌治疗血管性痴呆的疗效及对氧化应激、认知功能的影响. 中华航海医学与高气压医学杂志, 2024, 31(1): 55-58.
36. 江玉英. 高压氧联合有氧运动治疗老年轻度血管性痴呆的疗效观察. 中国标准化, 2022(8): 200-202.
37. 蒋芳况, 王杨, 王丽, 等. 高压氧联合有氧运动治疗老年轻度血管性痴呆的疗效观察. 国际老年医学杂志, 2021, 42(5): 275-278.
38. 武卫周, 员丽娜, 田晋梅, 等. 养血清脑颗粒联合高压氧治疗血管性痴呆的临床研究. 武警后勤学院学报(医学版), 2020, 29(1): 25-28.
39. 刘莉莉, 陈艳芳, 王晓宇. 高压氧联合银杏叶提取物治疗老年血管性痴呆疗效观察. 新乡医学院学报, 2024, 41(5): 477-481.
40. 陈克龙, 宋成城, 陈凌. 益气活血法在脑小血管病认知障碍患者中的临床应用. 中华全科医学, 2023, 21(10): 1767-1769.
41. 石磊, 陈宁宁, 郭亚培, 等. 冬凌草甲素对脑小血管病大鼠认知功能及PERK/CHOP信号通路的影响. 中国药师, 2022, 25(6): 949-954, 980.

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