RESEARCH PROGRESS OF NOVEL CROSS-LINKING METHODS APPLIED IN BIO-DERIVED MATERIALS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

DALincui , GONGMei , WANGMin ,  XIEHuiqi

Laboratory of Stem Cell and Tissue Engineering, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

XIEHuiqi, Email: xiehuiqi@163.com

Keywords：

Bio-derived material; Cross-linking method; Cross-linker; Extracellular matrix

DOI：

10.7507/1002-1892.20140172

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review the research progress of novel cross-linking methods applied in bio-derived materials. Methods The literature about the latest progress in the cross-linking methods of bio-derived materials was reviewed and analyzed. Results The novel cross-linking methods of the bio-derived materials can be divided into chemical methods, physical methods, and biological methods, whose available application and cross-linking properties are greatly depended on their mechanisms. So proper methods should be developed to meet the various application requirements of the materials. A series of studies shows the feasibility and availability of the cross-linked bio-derived materials in the repair and reconstruction of the tissue. Conclusion Bio-derived materials modified by novel cross-linking methods are proved to obtain excellent biocompatibility and tissue repair ability, better mechanical properties and degradation properties, and so on. Those methods provide researchers more choices to cross-linking materials, which are help to obtain the clinical tissue engineering products.

Citation： DALincui, GONGMei, WANGMin, XIEHuiqi. RESEARCH PROGRESS OF NOVEL CROSS-LINKING METHODS APPLIED IN BIO-DERIVED MATERIALS. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(6): 777-783. doi: 10.7507/1002-1892.20140172 Copy

1.	Fisher MB, Mauck RL. Tissue engineering and regenerative medicine:recent innovations and the transition to translation. Tissue Eng Part B Rev, 2013, 19(1):1-13.
2.	O'Brien FJ. Biomaterials & scaffolds for tissue engineering. Materials Today, 2011, 14(3):88-95.
3.	Tian L, George SC. Biomaterials to prevascularize engineered tissues. J Cardiovasc Transl Res, 2011, 4(5):685-698.
4.	Zeugolis DI, Paul GR, Attenburrow G. Cross-linking of extruded collagen fibers-a biomimetic three-dimensional scaffold for tissue engineering applications. J Biomed Mater Res A, 2009, 89(4):895-908.
5.	李莉, 徐源廷, 陈健, 等. 氧化海藻酸钠交联改性脱细胞基质材料及其细胞相容性研究. 生物医学工程学杂志, 2011, 28(6):1154-1158.
6.	He L, Mu C, Shi J, et al. Modification of collagen with a natural cross-linker, procyanidin. Int J Biol Macromol, 2011, 48(2):354-359.
7.	Lü X, Zhai W, Zhou Y, et al. Crosslinking effect of Nordihydroguaiaretic acid (NDGA) on decellularized heart valve scaffold for tissue engineering. J Mater Sci Mater Med, 2010, 21(2):473-480.
8.	Koch H, Graneist C, Emmrich F, et al. Xenogenic esophagus scaffolds fixed with several agents:comparative in vivo study of rejection and inflammation. J Biomed Biotechnol, 2012, 2012:948320.
9.	Lü JM, Nurko J, Weakley SM, et al. Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives:an update. Med Sci Monit, 2010, 16(5):RA93-100.
10.	Yang C, Xu L, Zhou Y, et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydrate Polymers, 2010, 82(4):1297-1305.
11.	Chan BP. Biomedical applications of photochemistry. Tissue Eng Part B Rev, 2010, 16(5):509-522.
12.	Ramesh B, Mathapati S, Galla S, et al. Crosslinked acellular saphenous vein for small-diameter vascular graft. Asian Cardiovascular and Thoracic Annals, 2013, 21(3):293-302.
13.	Lü WD, Zhang M, Wu ZS, et al. The performance of photooxidatively crosslinked acellular bovine jugular vein conduits in the reconstruction of connections between pulmonary arteries and right ventricles. Biomaterials, 2010, 31(10):2934-2943.
14.	Hennink WE, van Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev, 2002, 54(1):13-36.
15.	Huang X, Zhang Y, Zhang X, et al. Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing. Mater Sci Eng C Mater Biol Appl, 2013, 33(8):4816-4824.
16.	Nho YC, Park JS, Lim YM. Preparation of hydrogel by radiation for the healing of diabetic ulcer. Radiation Physics and Chemistry, 2014, (94):176-180.
17.	Zhou Y, Xu L, Zhang X, et al. Radiation synthesis of gelatin/CM-chitosan/β-tricalcium phosphate composite scaffold for bone tissue engineering. Materials Science and Engineering:C, 2012, 32(4):994-1000.
18.	Koob TJ, Hernandez DJ. Material properties of polymerized NDGA-collagen composite fibers:development of biologically based tendon constructs. Biomaterials, 2002, 23(1):203-212.
19.	Koob TJ, Hernandez DJ. Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels. Biomaterials, 2003, 24(7):1285-1292.
20.	Yu M, Hwang J, Deming TJ. Role of L-3, 4-Dihydroxyphenylalanine in mussel adhesive proteins. J Am Chem Soc, 1999, 121(4):5825-5826.
21.	Ju YM, Yu B, Koob TJ, et al. A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold. J Biomed Mater Res A, 2008, 87(1):136-146.
22.	Ju YM, Yu B, West L, et al. A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. Ⅱ. Long-term in vitro/in vivo sensitivity characteristics of sensors with NDGA-or GA-crosslinked collagen scaffolds. J Biomed Mater Res A, 2010, 92(2):650-658.
23.	Akao T, Kobashi K, Aburada M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull, 1994, 17(12):1573-1576.
24.	Djerassi C, Gray JD, Kincl FA. Naturally occurring oxygen heterocyclics. IX. isolation and characterization of genipin. J Org Chem, 1960, 25 (12):2174-2177.
25.	Raiskup-Wolf F, Hoyer A, Spoerl E, et al. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus:long-term results. J Cataract Refract Surg, 2008, 34(5):796-801.
26.	Nickerson MT, Farnworth R, Wagar E, et al. Some physical and microstructural properties of genipin-crosslinked gelatin-maltodextrin hydrogels. Int J Biol Macromol, 2006, 38(1):40-44.
27.	Nickerson MT, Patel J, Heyd DV, et al. Kinetic and mechanistic considerations in the gelation of genipin-crosslinked gelatin. Int J Biol Macromol, 2006, 39(4-5):298-302.
28.	Butler MF, Ng YF, Pudney PD. Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin. Journal of Polymer Science Part A:Polymer Chemistry, 2003, 41(24):3941-3953.
29.	Silva SS, Motta A, Rodrigues MT, et al. Novel genipin-cross-linked chitosan/silk fibroin sponges for cartilage engineering strategies. Biomacromolecules, 2008, 9(10):2764-2774.
30.	Yan LP, Wang YJ, Ren L, et al. Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. J Biomed Mater Res A, 2010, 95(2):465-475.
31.	Jin J, Song M, Hourston DJ. Novel chitosan-based films cross-linked by genipin with improved physical properties. Biomacromolecules, 2004, 5(1):162-168.
32.	Chen YS, Chang JY, Cheng CY, et al. An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material. Biomaterials, 2005, 26(18):3911-3918.
33.	Muzzarelli RA. Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohydrate Polymers, 2009, 77(1):1-9.
34.	王旻, 笪琳萃, 谢艳, 等. 京尼平作为交联剂在天然生物材料改性中的应用. 中国修复重建外科杂志, 2013, 27(5):558-563.
35.	Sung HW, Chang Y, Liang IL, et al. Fixation of biological tissues with a naturally occurring crosslinking agent:fixation rate and effects of pH, temperature, and initial fixative concentration. J Biomed Mater Res, 2000, 52(1):77-87.
36.	Xu Y, Li L, Yu X, et al. Feasibility study of a novel crosslinking reagent (alginate dialdehyde) for biological tissue fixation. Carbohydrate Polymers, 2012, 87(2):1589-1595.
37.	梁晔, 刘万顺, 韩宝芹, 等. 一种新型生物交联剂的制备及其性质. 中国海洋大学学报, 2008, 38(4):590-594.
38.	Balakrishnan B, Jayakrishnan A. Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials, 2005, 26(18):3941-3951.
39.	Draye JP, Delaey B, Van de Voorde A, et al. In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials, 1998, 19(1-3):99-107.
40.	Draye JP, Delaey B, Van de Voorde A, et al. In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials, 1998, 19(18):1677-1687.
41.	Mateo C, Palomo JM, van Langen LM, et al. A new, mild cross-linking methodology to prepare cross-linked enzyme aggregates. Biotechnol Bioeng, 2004, 86(3):273-276.
42.	Konno K, Hirayama C, Yasui H, et al. Enzymatic activation of oleuropein:a protein crosslinker used as a chemical defense in the privet tree. Proc Natl Acad Sci U S A, 1999, 96(16):9159-9164.
43.	Mitra T, Sailakshmi G, Gnanamani A, et al. Preparation and characterization of a thermostable and biodegradable biopolymers using natural cross-linker. Int J Biol Macromol, 2011, 48(2):276-285.
44.	Lee H, Jeong C, Ghafoor K, et al. Oral delivery of insulin using chitosan capsules cross-linked with phytic acid. Biomed Mater Eng, 2011, 21(1):25-36.
45.	何淑兰. 可降解海藻酸盐水凝胶的研究. 天津:天津大学, 2005.
46.	Nie H, Shen X, Zhou Z, et al. Electrospinning and characterization of konjac glucomannan/chitosan nanofibrous scaffolds favoring the growth of bone mesenchymal stem cells. Carbohydrate Polymers, 2011, 85(3):681-686.
47.	Kuo CK, Ma PX. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering:part 1. Structure, gelation rate and mechanical properties. Biomaterials, 2001, 22(6):511-521.
48.	Gillette BM, Jensen JA, Wang M, et al. Dynamic hydrogels:switching of 3D microenvironments using two-component naturally derived extracellular matrices. Adv Mater, 2010, 22(6):686-691.
49.	Janes KA, Fresneau MP, Marazuela A, et al. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release, 2001, 73(2-3):255-267.
50.	叶菁芸. 物理交联壳聚糖水凝胶的构建及复合大分子液晶的研究. 广州:暨南大学, 2012.
51.	Han B, Jaurequi J, Tang BW, et al. Proanthocyanidin:a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A, 2003, 65(1):118-124.
52.	Nuthong P, Benjakul S, Prodpran T. Characterization of porcine plasma protein-based films as affected by pretreatment and cross-linking agents. Int J Biol Macromol, 2009, 44(2):143-148.
53.	Zhai W, Lü X, Chang J, et al. Quercetin-crosslinked porcine heart valve matrix:mechanical properties, stability, anticalcification and cytocompatibility. Acta Biomater, 2010, 6(2):389-395.
54.	Kretlow JD, Klouda L, Mikos AG. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev, 2007, 59(4-5):263-273.
55.	Collighan RJ, Griffin M. Transglutaminase 2 cross-linking of matrix proteins:biological significance and medical applications. Amino Acids, 2009, 36(4):659-670.
56.	Jin R, Moreira Teixeira LS, Dijkstra PJ, et al. Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering. Tissue Eng Part A, 2010, 16(8):2429-2440.
57.	Jus S, Stachel I, Fairhead M, et al. Enzymatic cross-linking of gelatine with laccase and tyrosinase. Biocatalysis and Biotransformation, 2012, 30(1):86-95.
58.	Taddei P, Chiono V, Anghileri A, et al. Silk fibroin/gelatin blend films crosslinked with enzymes for biomedical applications. Macromol Biosci, 2013, 13(11):1492-1510.
59.	Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol, 2010, 22(5):697-706.
60.	Teixeira LS, Feijen J, van Blitterswijk CA, et al. Enzyme-catalyzed crosslinkable hydrogels:emerging strategies for tissue engineering. Biomaterials, 2012, 33(5):1281-1290.
61.	Sperinde JJ, Griffith LG. Synthesis and characterization of enzymatically-cross-linked poly (ethylene glycol) hydrogels. Macromolecules, 1997, 30:5255-5264.
62.	Stachel I, Schwarzenbolz U, Henle T, et al. Cross-linking of type I collagen with microbial transglutaminase:identification of cross-linking sites. Biomacromolecules, 2010, 11(3):698-705.
63.	Verderio EA, Johnson T, Griffin M. Tissue transglutaminase in normal and abnormal wound healing:review article. Amino Acids, 2004, 26(4):387-404.
64.	Westhaus E, Messersmith PB. Triggered release of calcium from lipid vesicles:a bioinspired strategy for rapid gelation of polysaccharide and protein hydrogels. Biomaterials, 2001, 22(5):453-462.
65.	Chau DY, Collighan RJ, Verderio EA, et al. The cellular response to transglutaminase-cross-linked collagen. Biomaterials, 2005, 26(33):6518-6529.
66.	Lee PF, Bai Y, Smith RL, et al. Angiogenic responses are enhanced in mechanically and microscopically characterized, microbial transglutaminase crosslinked collagen matrices with increased stiffness. Acta Biomater, 2013, 9(7):7178-7190.
67.	Wen C, Lu L, Li X. Mechanically robust gelatin-alginate IPN hydrogels by a combination of enzymaticand ionic crosslinking approaches. Macromolecular Materials and Engineering, 2013, 299(4):504-513.

1. Fisher MB, Mauck RL. Tissue engineering and regenerative medicine:recent innovations and the transition to translation. Tissue Eng Part B Rev, 2013, 19(1):1-13.
2. O'Brien FJ. Biomaterials & scaffolds for tissue engineering. Materials Today, 2011, 14(3):88-95.
3. Tian L, George SC. Biomaterials to prevascularize engineered tissues. J Cardiovasc Transl Res, 2011, 4(5):685-698.
4. Zeugolis DI, Paul GR, Attenburrow G. Cross-linking of extruded collagen fibers-a biomimetic three-dimensional scaffold for tissue engineering applications. J Biomed Mater Res A, 2009, 89(4):895-908.
5. 李莉, 徐源廷, 陈健, 等. 氧化海藻酸钠交联改性脱细胞基质材料及其细胞相容性研究. 生物医学工程学杂志, 2011, 28(6):1154-1158.
6. He L, Mu C, Shi J, et al. Modification of collagen with a natural cross-linker, procyanidin. Int J Biol Macromol, 2011, 48(2):354-359.
7. Lü X, Zhai W, Zhou Y, et al. Crosslinking effect of Nordihydroguaiaretic acid (NDGA) on decellularized heart valve scaffold for tissue engineering. J Mater Sci Mater Med, 2010, 21(2):473-480.
8. Koch H, Graneist C, Emmrich F, et al. Xenogenic esophagus scaffolds fixed with several agents:comparative in vivo study of rejection and inflammation. J Biomed Biotechnol, 2012, 2012:948320.
9. Lü JM, Nurko J, Weakley SM, et al. Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives:an update. Med Sci Monit, 2010, 16(5):RA93-100.
10. Yang C, Xu L, Zhou Y, et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydrate Polymers, 2010, 82(4):1297-1305.
11. Chan BP. Biomedical applications of photochemistry. Tissue Eng Part B Rev, 2010, 16(5):509-522.
12. Ramesh B, Mathapati S, Galla S, et al. Crosslinked acellular saphenous vein for small-diameter vascular graft. Asian Cardiovascular and Thoracic Annals, 2013, 21(3):293-302.
13. Lü WD, Zhang M, Wu ZS, et al. The performance of photooxidatively crosslinked acellular bovine jugular vein conduits in the reconstruction of connections between pulmonary arteries and right ventricles. Biomaterials, 2010, 31(10):2934-2943.
14. Hennink WE, van Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev, 2002, 54(1):13-36.
15. Huang X, Zhang Y, Zhang X, et al. Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing. Mater Sci Eng C Mater Biol Appl, 2013, 33(8):4816-4824.
16. Nho YC, Park JS, Lim YM. Preparation of hydrogel by radiation for the healing of diabetic ulcer. Radiation Physics and Chemistry, 2014, (94):176-180.
17. Zhou Y, Xu L, Zhang X, et al. Radiation synthesis of gelatin/CM-chitosan/β-tricalcium phosphate composite scaffold for bone tissue engineering. Materials Science and Engineering:C, 2012, 32(4):994-1000.
18. Koob TJ, Hernandez DJ. Material properties of polymerized NDGA-collagen composite fibers:development of biologically based tendon constructs. Biomaterials, 2002, 23(1):203-212.
19. Koob TJ, Hernandez DJ. Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels. Biomaterials, 2003, 24(7):1285-1292.
20. Yu M, Hwang J, Deming TJ. Role of L-3, 4-Dihydroxyphenylalanine in mussel adhesive proteins. J Am Chem Soc, 1999, 121(4):5825-5826.
21. Ju YM, Yu B, Koob TJ, et al. A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold. J Biomed Mater Res A, 2008, 87(1):136-146.
22. Ju YM, Yu B, West L, et al. A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. Ⅱ. Long-term in vitro/in vivo sensitivity characteristics of sensors with NDGA-or GA-crosslinked collagen scaffolds. J Biomed Mater Res A, 2010, 92(2):650-658.
23. Akao T, Kobashi K, Aburada M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull, 1994, 17(12):1573-1576.
24. Djerassi C, Gray JD, Kincl FA. Naturally occurring oxygen heterocyclics. IX. isolation and characterization of genipin. J Org Chem, 1960, 25 (12):2174-2177.
25. Raiskup-Wolf F, Hoyer A, Spoerl E, et al. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus:long-term results. J Cataract Refract Surg, 2008, 34(5):796-801.
26. Nickerson MT, Farnworth R, Wagar E, et al. Some physical and microstructural properties of genipin-crosslinked gelatin-maltodextrin hydrogels. Int J Biol Macromol, 2006, 38(1):40-44.
27. Nickerson MT, Patel J, Heyd DV, et al. Kinetic and mechanistic considerations in the gelation of genipin-crosslinked gelatin. Int J Biol Macromol, 2006, 39(4-5):298-302.
28. Butler MF, Ng YF, Pudney PD. Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin. Journal of Polymer Science Part A:Polymer Chemistry, 2003, 41(24):3941-3953.
29. Silva SS, Motta A, Rodrigues MT, et al. Novel genipin-cross-linked chitosan/silk fibroin sponges for cartilage engineering strategies. Biomacromolecules, 2008, 9(10):2764-2774.
30. Yan LP, Wang YJ, Ren L, et al. Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. J Biomed Mater Res A, 2010, 95(2):465-475.
31. Jin J, Song M, Hourston DJ. Novel chitosan-based films cross-linked by genipin with improved physical properties. Biomacromolecules, 2004, 5(1):162-168.
32. Chen YS, Chang JY, Cheng CY, et al. An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material. Biomaterials, 2005, 26(18):3911-3918.
33. Muzzarelli RA. Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohydrate Polymers, 2009, 77(1):1-9.
34. 王旻, 笪琳萃, 谢艳, 等. 京尼平作为交联剂在天然生物材料改性中的应用. 中国修复重建外科杂志, 2013, 27(5):558-563.
35. Sung HW, Chang Y, Liang IL, et al. Fixation of biological tissues with a naturally occurring crosslinking agent:fixation rate and effects of pH, temperature, and initial fixative concentration. J Biomed Mater Res, 2000, 52(1):77-87.
36. Xu Y, Li L, Yu X, et al. Feasibility study of a novel crosslinking reagent (alginate dialdehyde) for biological tissue fixation. Carbohydrate Polymers, 2012, 87(2):1589-1595.
37. 梁晔, 刘万顺, 韩宝芹, 等. 一种新型生物交联剂的制备及其性质. 中国海洋大学学报, 2008, 38(4):590-594.
38. Balakrishnan B, Jayakrishnan A. Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials, 2005, 26(18):3941-3951.
39. Draye JP, Delaey B, Van de Voorde A, et al. In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials, 1998, 19(1-3):99-107.
40. Draye JP, Delaey B, Van de Voorde A, et al. In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials, 1998, 19(18):1677-1687.
41. Mateo C, Palomo JM, van Langen LM, et al. A new, mild cross-linking methodology to prepare cross-linked enzyme aggregates. Biotechnol Bioeng, 2004, 86(3):273-276.
42. Konno K, Hirayama C, Yasui H, et al. Enzymatic activation of oleuropein:a protein crosslinker used as a chemical defense in the privet tree. Proc Natl Acad Sci U S A, 1999, 96(16):9159-9164.
43. Mitra T, Sailakshmi G, Gnanamani A, et al. Preparation and characterization of a thermostable and biodegradable biopolymers using natural cross-linker. Int J Biol Macromol, 2011, 48(2):276-285.
44. Lee H, Jeong C, Ghafoor K, et al. Oral delivery of insulin using chitosan capsules cross-linked with phytic acid. Biomed Mater Eng, 2011, 21(1):25-36.
45. 何淑兰. 可降解海藻酸盐水凝胶的研究. 天津:天津大学, 2005.
46. Nie H, Shen X, Zhou Z, et al. Electrospinning and characterization of konjac glucomannan/chitosan nanofibrous scaffolds favoring the growth of bone mesenchymal stem cells. Carbohydrate Polymers, 2011, 85(3):681-686.
47. Kuo CK, Ma PX. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering:part 1. Structure, gelation rate and mechanical properties. Biomaterials, 2001, 22(6):511-521.
48. Gillette BM, Jensen JA, Wang M, et al. Dynamic hydrogels:switching of 3D microenvironments using two-component naturally derived extracellular matrices. Adv Mater, 2010, 22(6):686-691.
49. Janes KA, Fresneau MP, Marazuela A, et al. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release, 2001, 73(2-3):255-267.
50. 叶菁芸. 物理交联壳聚糖水凝胶的构建及复合大分子液晶的研究. 广州:暨南大学, 2012.
51. Han B, Jaurequi J, Tang BW, et al. Proanthocyanidin:a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A, 2003, 65(1):118-124.
52. Nuthong P, Benjakul S, Prodpran T. Characterization of porcine plasma protein-based films as affected by pretreatment and cross-linking agents. Int J Biol Macromol, 2009, 44(2):143-148.
53. Zhai W, Lü X, Chang J, et al. Quercetin-crosslinked porcine heart valve matrix:mechanical properties, stability, anticalcification and cytocompatibility. Acta Biomater, 2010, 6(2):389-395.
54. Kretlow JD, Klouda L, Mikos AG. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev, 2007, 59(4-5):263-273.
55. Collighan RJ, Griffin M. Transglutaminase 2 cross-linking of matrix proteins:biological significance and medical applications. Amino Acids, 2009, 36(4):659-670.
56. Jin R, Moreira Teixeira LS, Dijkstra PJ, et al. Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering. Tissue Eng Part A, 2010, 16(8):2429-2440.
57. Jus S, Stachel I, Fairhead M, et al. Enzymatic cross-linking of gelatine with laccase and tyrosinase. Biocatalysis and Biotransformation, 2012, 30(1):86-95.
58. Taddei P, Chiono V, Anghileri A, et al. Silk fibroin/gelatin blend films crosslinked with enzymes for biomedical applications. Macromol Biosci, 2013, 13(11):1492-1510.
59. Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol, 2010, 22(5):697-706.
60. Teixeira LS, Feijen J, van Blitterswijk CA, et al. Enzyme-catalyzed crosslinkable hydrogels:emerging strategies for tissue engineering. Biomaterials, 2012, 33(5):1281-1290.
61. Sperinde JJ, Griffith LG. Synthesis and characterization of enzymatically-cross-linked poly (ethylene glycol) hydrogels. Macromolecules, 1997, 30:5255-5264.
62. Stachel I, Schwarzenbolz U, Henle T, et al. Cross-linking of type I collagen with microbial transglutaminase:identification of cross-linking sites. Biomacromolecules, 2010, 11(3):698-705.
63. Verderio EA, Johnson T, Griffin M. Tissue transglutaminase in normal and abnormal wound healing:review article. Amino Acids, 2004, 26(4):387-404.
64. Westhaus E, Messersmith PB. Triggered release of calcium from lipid vesicles:a bioinspired strategy for rapid gelation of polysaccharide and protein hydrogels. Biomaterials, 2001, 22(5):453-462.
65. Chau DY, Collighan RJ, Verderio EA, et al. The cellular response to transglutaminase-cross-linked collagen. Biomaterials, 2005, 26(33):6518-6529.
66. Lee PF, Bai Y, Smith RL, et al. Angiogenic responses are enhanced in mechanically and microscopically characterized, microbial transglutaminase crosslinked collagen matrices with increased stiffness. Acta Biomater, 2013, 9(7):7178-7190.
67. Wen C, Lu L, Li X. Mechanically robust gelatin-alginate IPN hydrogels by a combination of enzymaticand ionic crosslinking approaches. Macromolecular Materials and Engineering, 2013, 299(4):504-513.

Previous Article
EXPERIMENTAL ASSESSMENT OF BLADDER REGENERATION BY COLLAGEN MEMBRANE SCAFFOLDS
Next Article
PROGRESS IN BIOLOGICAL TISSUE ENGINEERING SCAFFOLD MATERIALS

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF NOVEL CROSS-LINKING METHODS APPLIED IN BIO-DERIVED MATERIALS

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content