PROGRESS IN BIOLOGICAL TISSUE ENGINEERING SCAFFOLD MATERIALS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WEIXiaojuan ^1,2 ,  XITingfei ¹ , ZHENGYufeng ²

1. Academy for Advanced Interdisplinary Studies, Peking University, Beijing, 100871, P. R. China;
2. College of Engineering, Peking University;

Corresponding author：

XITingfei, Email: xitingfei@pku.edu.cn

Keywords：

Tissue engineering; Biological scaffold material; Progress

DOI：

10.7507/1002-1892.20140173

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the progress in biological tissue engineering scaffold materials and the clinical application, as well as product development status. Methods Based on extensive investigation in the status of research and application of biological tissue engineering scaffold materials, a comprehensive analysis was made. Meanwhile, a detailed analysis of research and product development was presented. Results Considerable progress has been achieved in research, products transformation, clinical application, and supervision of biological scaffold for tissue engineering. New directions, new technology, and new products are constantly emerging. With the continuous progress of science and technology and continuous improvement of life sciences theory, the new direction and new focus still need to be continuously adjusted in order to meet the clinical needs. Conclusion From the aspect of industrial transformation feasibility, acellular scaffolds and extracellular matrix are the most promising new growth of both research and product development in this field.

Citation： WEIXiaojuan, XITingfei, ZHENGYufeng. PROGRESS IN BIOLOGICAL TISSUE ENGINEERING SCAFFOLD MATERIALS. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(6): 784-788. doi: 10.7507/1002-1892.20140173 Copy

1.	[No author listed]. Advancing tissue science and engineering:a foundation for the future. A multi-agency strategic plan. Tissue Eng, 2007, 13(12):2825-2826.
2.	Gunatillake P, Mayadunne R, Adhikari R. Recent development in biodegradable synthetic polymers. Biotech Ann Rev, 2006, 12:301-347.
3.	Ma PX. Scaffolds for tissue fabrication. Materials Today, 2004, 7(5):30-40.
4.	Nair LS, Laurencin CT. Biodegradable polymers as biomaterials. Prog Polym Sci, 2007, 32(8-9):762-798.
5.	Radisic M, Park H, Shing H, et al. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A, 2004, 101(52):18129-18134.
6.	Marston WA, Hanft J, Norwood P, et al. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers:results of a prospective randomized trial. Diabetes Care, 2003, 26(6):1701-1705.
7.	Nie X, Zhang JY, Cai KJ, et al. Cosmetic improvement in various acute skin defects treated with tissue engineered skin. Artificial Organs, 2007, 31(9):703-710.
8.	Liu Y, Suwa F, Wang X, et al. Reconstruction of a tissue-engineered skin containing melanocytes. Cell Biol Int, 2007, 31(9):985-990.
9.	Nie X, Cai JK, Yang HM, et al. Successful application of tissue-engineered skin to refractory ulcers. Clin Exp Dermatology, 2007, 32(6):699-701.
10.	Liu P, Deng Z, Han S, et al. Tissue-engineered skin containing mesenchymal stem cells improves burn wounds. Artificial Organs, 2008, 32(12):925-931.
11.	Anders S, Volz M, Frick H, et al. A randomized, controlled trial comparing autologous matrix-induced chondrogenesis (AMIC^®) to microfracture:Analysis of 1-and 2-year follow-up data of 2 centers. Open Orthop J, 2013, 7:133-143.
12.	Gerlier L, Lamotte M, Wille M, et al. The cost utility of autologous chondrocytes implantation using ChondroCelect^® in sympotomatic knee cartilage lesions in Belgium. Pharmacoeconomics, 2010, 28(12):1129-1146.
13.	Crawford DC, Deberardino TM, Williams RJ 3rd. NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions:an FDA phase-Ⅱ prospective, randomized clinical trial after two years. J Bone Joint Surg (Am), 2012, 94(11):979-989.
14.	Petri M, Broese M, Simon A, et al. CaReS^® (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects:a retrospective matched-pair analysis. J Orthop Sci, 2013, 18(1):38-44.
15.	Schüettler KF, Struewer J, Rominer MB, et al. Repair of a chondral defect using a cell free scaffold in a young patient-a case report of successful scaffold transformation and colonization. BMC Surgery, 2013, 13:11-17.
16.	Zhai Y, Cui FZ. Recombinant human-like collagen directed growth of hydroxyapatite nanocrystals. Journal of Crystal Growth, 2006, 291 (1):202-206.
17.	Zhai Y, Cui FZ, Wang Y. Formation of nano-hydroxyapatite on recombinant human-like collagen fibrils. Current Applied Physics, 2005, 5(5):429-432.
18.	Wang Y, Cui FZ, Zhai Y, et al. Investigations of the initial stage of recombinant human-like collagen mineralization. Materials Science and Engineering:C, 2006, 26 (4):635-638.
19.	伍津津. 复合人工皮肤的制备方法:中国, CN01107099. 4. 2001-08-29.
20.	Ding F, Wu J, Yang Y, et al. Use of tissue-engineered nerve grafts consisting of a chitosan/poly (lactic-co-glycolic acid)-based scaffold included with bone marrow mesenchymal cells for bridging 50-mm dog sciatic nerve gaps. Tissue Eng Part A, 2010, 16(12):3779-3790.
21.	张皑峰, 欧喜超, 杨朝阳, 等. 应用结合bFGF的壳聚糖导管修复大鼠坐骨神经损伤的实验研究. 中国康复理论与实践, 2008, 14(12):1133-1135.
22.	Landa N, Miller L, Feinberg MS, et al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation, 2008, 117(11):1388-1396.
23.	Leor J, Tuvia S, Guetta V, et al. Intracornary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11):1014-1023.
24.	Song JJ, Ott HC. Organ engineering based on decellularized matrix scaffold. Trends Mol Med, 2011, 17(8):424-432.
25.	Macchinarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372(9655):2023-2030.
26.	Hu J, Zhu QT, Liu XL, et al. Repair of extended peripheral nerve lesions in rhesus monkeys using acellular allogenic nerve grafts implanted with autologous mesenchymal stem cells. Exp Neurol, 2007, 204(2):658-666.
27.	Wang D, Liu XL, Zhu JK, et al. Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res, 2008, 1188:44-53.
28.	Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decelluarized matrix:using nature's platform to engineer a bioartifical heart. Nat Med, 2008, 14(2):213-221.
29.	Uygun BE, Soto-Gutierrez A, Yagi H, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med, 2010, 16(7):814-820.
30.	Schanz J, Pusch J, Hansmann J, et al. Vascularized human tissue models:a new approach for the refinement of biomedical research. J Biotechnol, 2010, 148(1):56-63.
31.	Song JJ, Kim SS, Liu Z, et al. Enhanced in vivo function of bioartificial lungs in rats. Ann Throac Surg, 2011, 92(3):998-1005.
32.	Petersen TH, Calle EA, Zhao L, et al. Tissue-engineered lungs for in vivo implantation. Science, 2010, 329(5991):538-541.
33.	Yang B, Zhang Y, Zhou L, et al. Development of a porcine bladder acellular matrix with well-preserved extracellular bioactive factors for tissue engineering. Tissue Eng Part C Meyhod, 2010, 16(5):1201-1211.
34.	Nakayama KH, Barchelder CA, Lee CI, et al. Decellularized rhesus monkey kidney as a three-dimensional scaffolds for renal tissue engineering. Tissue Eng Part A, 2010, 16(7):2207-2216.
35.	Nishida K, Yamato M, Hayashida Y, et al. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med, 2004, 351(12):1187-1196.
36.	Shimizu T, Yamato M, Isoi Y, et al. Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ Res, 2002, 90(3):e40.
37.	Miyahara Y, Nagaya N, Kataoka M, et al. Monolayered mesenchymal stem cells repair scared myocardium after myocardial infarction. Nat Med, 2006, 12(4):459-465.
38.	Shimizu T, Yamato M, Kikuchi A, et al. Cell sheet engineering for myocardial tissue reconstruction. Biomaterials, 2003, 24(13):2309-2316.
39.	Memon IA, Sawa Y, Fukushima N, et al. Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J Tharac Cardiovasc Surg, 2005, 130(5):1333-1341.
40.	Ohki T, Yamato M, Murakami D, et al. Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model. Gut, 2006, 55(12):1704-1710.
41.	Akizuki T, Oda S, Komaki M, et al. Application of periodontal ligament cell sheet for periodontal regeneration:a pilot study in beagle dogs. J Periodontal Res, 2005, 40(3):245-251.
42.	Shimizu H, Ohashi K, Utoh R, et al. Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus. Biomaterials, 2009, 30(30):5943-5949.
43.	Pirraco RP, Obokata H, Iwata T, et al. Development of osteogenic cell sheets for bone tissue engineering applications. Tissue Eng Part A, 2011, 17(11-12):1507-1515.
44.	Muraoka M, Shimizu T, Itoga K, et al. Control of the formation of vascular networks in 3D tissue engineered constructs. Biomaterials, 2013, 34(3):696-703.
45.	Nagamori E, Ngo TX, Takezawa Y, et al. Network formation through active migration of human vascular endothelial cells in a multilayered skeletal myoblast sheet. Biomaterials, 2013, 34(3):662-668.

1. [No author listed]. Advancing tissue science and engineering:a foundation for the future. A multi-agency strategic plan. Tissue Eng, 2007, 13(12):2825-2826.
2. Gunatillake P, Mayadunne R, Adhikari R. Recent development in biodegradable synthetic polymers. Biotech Ann Rev, 2006, 12:301-347.
3. Ma PX. Scaffolds for tissue fabrication. Materials Today, 2004, 7(5):30-40.
4. Nair LS, Laurencin CT. Biodegradable polymers as biomaterials. Prog Polym Sci, 2007, 32(8-9):762-798.
5. Radisic M, Park H, Shing H, et al. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A, 2004, 101(52):18129-18134.
6. Marston WA, Hanft J, Norwood P, et al. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers:results of a prospective randomized trial. Diabetes Care, 2003, 26(6):1701-1705.
7. Nie X, Zhang JY, Cai KJ, et al. Cosmetic improvement in various acute skin defects treated with tissue engineered skin. Artificial Organs, 2007, 31(9):703-710.
8. Liu Y, Suwa F, Wang X, et al. Reconstruction of a tissue-engineered skin containing melanocytes. Cell Biol Int, 2007, 31(9):985-990.
9. Nie X, Cai JK, Yang HM, et al. Successful application of tissue-engineered skin to refractory ulcers. Clin Exp Dermatology, 2007, 32(6):699-701.
10. Liu P, Deng Z, Han S, et al. Tissue-engineered skin containing mesenchymal stem cells improves burn wounds. Artificial Organs, 2008, 32(12):925-931.
11. Anders S, Volz M, Frick H, et al. A randomized, controlled trial comparing autologous matrix-induced chondrogenesis (AMIC^®) to microfracture:Analysis of 1-and 2-year follow-up data of 2 centers. Open Orthop J, 2013, 7:133-143.
12. Gerlier L, Lamotte M, Wille M, et al. The cost utility of autologous chondrocytes implantation using ChondroCelect^® in sympotomatic knee cartilage lesions in Belgium. Pharmacoeconomics, 2010, 28(12):1129-1146.
13. Crawford DC, Deberardino TM, Williams RJ 3rd. NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions:an FDA phase-Ⅱ prospective, randomized clinical trial after two years. J Bone Joint Surg (Am), 2012, 94(11):979-989.
14. Petri M, Broese M, Simon A, et al. CaReS^® (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects:a retrospective matched-pair analysis. J Orthop Sci, 2013, 18(1):38-44.
15. Schüettler KF, Struewer J, Rominer MB, et al. Repair of a chondral defect using a cell free scaffold in a young patient-a case report of successful scaffold transformation and colonization. BMC Surgery, 2013, 13:11-17.
16. Zhai Y, Cui FZ. Recombinant human-like collagen directed growth of hydroxyapatite nanocrystals. Journal of Crystal Growth, 2006, 291 (1):202-206.
17. Zhai Y, Cui FZ, Wang Y. Formation of nano-hydroxyapatite on recombinant human-like collagen fibrils. Current Applied Physics, 2005, 5(5):429-432.
18. Wang Y, Cui FZ, Zhai Y, et al. Investigations of the initial stage of recombinant human-like collagen mineralization. Materials Science and Engineering:C, 2006, 26 (4):635-638.
19. 伍津津. 复合人工皮肤的制备方法:中国, CN01107099. 4. 2001-08-29.
20. Ding F, Wu J, Yang Y, et al. Use of tissue-engineered nerve grafts consisting of a chitosan/poly (lactic-co-glycolic acid)-based scaffold included with bone marrow mesenchymal cells for bridging 50-mm dog sciatic nerve gaps. Tissue Eng Part A, 2010, 16(12):3779-3790.
21. 张皑峰, 欧喜超, 杨朝阳, 等. 应用结合bFGF的壳聚糖导管修复大鼠坐骨神经损伤的实验研究. 中国康复理论与实践, 2008, 14(12):1133-1135.
22. Landa N, Miller L, Feinberg MS, et al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation, 2008, 117(11):1388-1396.
23. Leor J, Tuvia S, Guetta V, et al. Intracornary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11):1014-1023.
24. Song JJ, Ott HC. Organ engineering based on decellularized matrix scaffold. Trends Mol Med, 2011, 17(8):424-432.
25. Macchinarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372(9655):2023-2030.
26. Hu J, Zhu QT, Liu XL, et al. Repair of extended peripheral nerve lesions in rhesus monkeys using acellular allogenic nerve grafts implanted with autologous mesenchymal stem cells. Exp Neurol, 2007, 204(2):658-666.
27. Wang D, Liu XL, Zhu JK, et al. Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res, 2008, 1188:44-53.
28. Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decelluarized matrix:using nature's platform to engineer a bioartifical heart. Nat Med, 2008, 14(2):213-221.
29. Uygun BE, Soto-Gutierrez A, Yagi H, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med, 2010, 16(7):814-820.
30. Schanz J, Pusch J, Hansmann J, et al. Vascularized human tissue models:a new approach for the refinement of biomedical research. J Biotechnol, 2010, 148(1):56-63.
31. Song JJ, Kim SS, Liu Z, et al. Enhanced in vivo function of bioartificial lungs in rats. Ann Throac Surg, 2011, 92(3):998-1005.
32. Petersen TH, Calle EA, Zhao L, et al. Tissue-engineered lungs for in vivo implantation. Science, 2010, 329(5991):538-541.
33. Yang B, Zhang Y, Zhou L, et al. Development of a porcine bladder acellular matrix with well-preserved extracellular bioactive factors for tissue engineering. Tissue Eng Part C Meyhod, 2010, 16(5):1201-1211.
34. Nakayama KH, Barchelder CA, Lee CI, et al. Decellularized rhesus monkey kidney as a three-dimensional scaffolds for renal tissue engineering. Tissue Eng Part A, 2010, 16(7):2207-2216.
35. Nishida K, Yamato M, Hayashida Y, et al. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med, 2004, 351(12):1187-1196.
36. Shimizu T, Yamato M, Isoi Y, et al. Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ Res, 2002, 90(3):e40.
37. Miyahara Y, Nagaya N, Kataoka M, et al. Monolayered mesenchymal stem cells repair scared myocardium after myocardial infarction. Nat Med, 2006, 12(4):459-465.
38. Shimizu T, Yamato M, Kikuchi A, et al. Cell sheet engineering for myocardial tissue reconstruction. Biomaterials, 2003, 24(13):2309-2316.
39. Memon IA, Sawa Y, Fukushima N, et al. Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J Tharac Cardiovasc Surg, 2005, 130(5):1333-1341.
40. Ohki T, Yamato M, Murakami D, et al. Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model. Gut, 2006, 55(12):1704-1710.
41. Akizuki T, Oda S, Komaki M, et al. Application of periodontal ligament cell sheet for periodontal regeneration:a pilot study in beagle dogs. J Periodontal Res, 2005, 40(3):245-251.
42. Shimizu H, Ohashi K, Utoh R, et al. Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus. Biomaterials, 2009, 30(30):5943-5949.
43. Pirraco RP, Obokata H, Iwata T, et al. Development of osteogenic cell sheets for bone tissue engineering applications. Tissue Eng Part A, 2011, 17(11-12):1507-1515.
44. Muraoka M, Shimizu T, Itoga K, et al. Control of the formation of vascular networks in 3D tissue engineered constructs. Biomaterials, 2013, 34(3):696-703.
45. Nagamori E, Ngo TX, Takezawa Y, et al. Network formation through active migration of human vascular endothelial cells in a multilayered skeletal myoblast sheet. Biomaterials, 2013, 34(3):662-668.

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Chinese Journal of Reparative and Reconstructive Surgery

PROGRESS IN BIOLOGICAL TISSUE ENGINEERING SCAFFOLD MATERIALS

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