Progress in Adipose-derived Stromal Cells for the Treatment of Myocardial Infarction_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LI Xiangbo , LI Gang .

Department of Cardiac Surgery，Second Affiliated Hospital of Harbin Medical University，Harbin 150086，P. R. China;

Corresponding author：

Keywords：

Adipose-derived stromal cell; 　Myocardial infarction; 　Heart

DOI：

10.7507/1007-4848.20130180

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The application of stem cell therapy for ischemic heart disease has aroused widespread interest. There have been many experimental studies concerning a variety of tissue stem cells such as bone marrow，blood，skin and skeletalmuscle stem cells，and their origins, differentiation and protein expressions are compared. In recent years，it is found that adipose-derived stromal cells （ADSCs） have potential advantages over other types of stem cells in that they are widely available and easily harvested through a simple liposuction procedure，and have a high regenerative capacity and therapeuticpotential for myocardial infarction. This review describes molecular and biological properties of ADSCs，their differentiationpotential，and regenerative and therapeutic potential for myocardial repair.

Citation： LI Xiangbo,LI Gang .. Progress in Adipose-derived Stromal Cells for the Treatment of Myocardial Infarction. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2013, 20(5): 592-595. doi: 10.7507/1007-4848.20130180 Copy

1.	Zuk PA. The adipose-derived stem cell：looking back and looking ahead. Mol Biol Cell， 2010， 21 （11）：1783-1787.
2.	Dowell JD， Rubart M， Pasumarthi KB， et al. Myocyte and myogenicstem cell transplantation in the heart. Cardiovasc Res， 2003， 58 （2）：336-350.
3.	Jameel MN， Zhang J. Stem cell therapy for ischemic heart disease. Antioxid Redox Signal， 2010， 13 （12）：1879-1897.
4.	Cawthorn WP， Scheller EL， MacDougald OA. Adipose tissue stem cells meet preadipocyte commitment：going back to the future. J LipidRes， 2012， 53 （2）：227-246.
5.	Hamid AA， Idrus RB， Saim AB， et al. Characterization of humanadipose-derived stem cells and expression of chondrogenic genes during induction of cartilage differentiation. Clinics （Sao Paulo），2012，67 （2）：99-106.
6.	Levi B， Longaker MT. Concise review：adipose-derived stromal cells for skeletal regenerative medicine. Stem Cells， 2011， 29 （4）：576-582.
7.	Maumus M， Peyrafitte JA， D'Angelo R， et al. Native human adiposestromal cells：localization， morphology and phenotype. Int J Obes （Lond）， 2011， 35 （9）：1141-1153.
8.	Jang S， Cho HH， Cho YB， et al. unctional neural differentiationof human adipose tissue-derived stem cells using bFGF and forskolin. BMC Cell Biol， 2010， 11：25.
9.	Madonna R， De Caterina R. In vitro neovasculogenic potential of resident adipose tissue precursors. Am J Physiol Cell Physiol， 2008， 295 （5）：1271-1280.
10.	Madonna R， Willerson JT， Geng YJ. Myocardin a enhances telomerase activities in adipose tissue mesenchymal cells and embryonic stem cells undergoing cardiovascular myogenic differentiation. Stem Cells， 2008， 26 （1）：202-211.
11.	Aguiari P， Leo S， Zavan B， et al. High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci USA，2008， 105 （4）：1226-1231.
12.	Thom T， Haase N， Rosamond W， et al. Heart disease and stroke statistics——2006 update：a report from the American Heart Associ-ation Statistics Committee and Stroke Statistics Subcommittee.Circulation， 2006， 113 （6）：e85-151.
13.	Fonarow GC. Heart failure：recent advances in prevention and treatment. Rev Cardiovasc Med， 2000 ， 1 （1）：25-33， 54.
14.	Oh H， Bradfute SB， Gallardo TD， et al. Cardiac progenitor cells from adult myocardium：homing， differentiation， and fusion afterinfarction. Proc Natl Acad Sci USA， 2003， 100 （21）：12313-12318.
15.	Halvorsen YD， Franklin D， Bond AL， et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng， 2001， 7 （6）：729-741.
16.	Dragoo JL， Choi JY， Lieberman JR， et al. Bone induction by BMP-2transduced stem cells derived from human fat. J Orthop Res， 2003， 21 （4）：622-629.
17.	Cowan CM， Shi YY， Aalami OO， et al. Adipose-derived adult stromalcells heal critical-size mouse calvarial defects. Nat Biotechnol， 2004， 22 （5）：560-567.
18.	Winter A， Breit S， Parsch D， et al. Cartilage-like gene expression in differentiated human stem cell spheroids：a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum， 2003， 48 （2）：418-429.
19.	Fujimura J， Ogawa R， Mizuno H， et al. Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice. BiochemBiophys Res Commun， 2005， 333 （1）：116-121.
20.	Rehman J， Traktuev D， Li J， et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation， 2004， 109 （10）：1292-1298.
21.	van Dijk A， Niessen HW， Zandieh Doulabi B， et al. Differentiationof human adipose-derived stem cells towards cardiomyocytes isfacilitated by laminin. Cell Tissue Res， 2008， 334 （3）：457-467.
22.	Rangappa S， Fen C， Lee EH， et al. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thorac Surg， 2003， 75 （3）：775-779.
23.	Planat-Bénard V， Menard C， André M， et al. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res， 2004， 94 （2）：223-229.
24.	De Ugarte DA， Morizono K， Elbarbary A， et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs， 2003， 174 （3）：101-109.
25.	McIntosh K， Zvonic S， Garrett S， et al. The immunogenicity of human adipose-derived cells：temporal changes in vitro. Stem Cells， 2006， 24 （5）：1246-1253.
26.	Madonna R， Renna FV， Cellini C， et al. Age-dependent impairment of number and angiogenic potential of adipose tissue-derived progenitorcells. Eur J Clin Invest， 2011， 41 （2）：126-133.
27.	Williams SK， McKenney S， Jarrell BE. Collagenase lot selection and purification for adipose tissue digestion. Cell Transplant， 1995， 4 （3）：281-289.
28.	Wang L， Deng J， Tian W， et al. Adipose-derived stem cells are an effective cell candidate for treatment of heart failure：an Mr imaging study of rat hearts. Am J Physiol Heart Circ Physiol， 2009， 297 （3）：1020-1031.
29.	Schenke-Layland K， Strem BM， Jordan MC， et al. Adipose tissue-derived cells improve cardiac function following myocardial infarction.J Surg Res， 2009， 153 （2）：217-223.
30.	Suga H， Eto H， Shigeura T， et al. IFATS collection：Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism. Stem Cells， 2009， 27 （1）：238-249.
31.	Miyahara Y， Nagaya N， Kataoka M， et al. Monolayered mesenchymalstem cells repair scarred myocardium after myocardial infarction. Nat Med， 2006， 12 （4）：459-465.
32.	Beltrami AP， Barlucchi L， Torella D， et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell， 2003， 114 （6）：763-776.
33.	Spinale FG. Matrix metalloproteinases：regulation and dysregulation in the failing heart. Circ Res， 2002， 90 （5）：520-530.
34.	Zhu XY， Zhang XZ， Xu L， et al. Transplantation of adipose-derived stem cells overexpressing hHGF into cardiac tissue. Biochem Biophys Res Commun， 2009， 379 （4）：1084-1090.
35.	Léobon B， Roncalli J， Joffre C， et al. Adipose-derived cardiomyogenic cells：in vitro expansion and functional improvement in a mouse model of myocardial infarction. Cardiovasc Res， 2009， 83 （4）：757-767.
36.	Mazo M， Planat-Bénard V， Abizanda G， et al. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail， 2008， 10 （5）：454-462.

1. 　Zuk PA. The adipose-derived stem cell：looking back and looking ahead. Mol Biol Cell， 2010， 21 （11）：1783-1787.
2. 　Dowell JD， Rubart M， Pasumarthi KB， et al. Myocyte and myogenicstem cell transplantation in the heart. Cardiovasc Res， 2003， 58 （2）：336-350.
3. 　Jameel MN， Zhang J. Stem cell therapy for ischemic heart disease. Antioxid Redox Signal， 2010， 13 （12）：1879-1897.
4. 　Cawthorn WP， Scheller EL， MacDougald OA. Adipose tissue stem cells meet preadipocyte commitment：going back to the future. J LipidRes， 2012， 53 （2）：227-246.
5. 　Hamid AA， Idrus RB， Saim AB， et al. Characterization of humanadipose-derived stem cells and expression of chondrogenic genes during induction of cartilage differentiation. Clinics （Sao Paulo），2012，67 （2）：99-106.
6. 　Levi B， Longaker MT. Concise review：adipose-derived stromal cells for skeletal regenerative medicine. Stem Cells， 2011， 29 （4）：576-582.
7. 　Maumus M， Peyrafitte JA， D'Angelo R， et al. Native human adiposestromal cells：localization， morphology and phenotype. Int J Obes （Lond）， 2011， 35 （9）：1141-1153.
8. 　Jang S， Cho HH， Cho YB， et al. unctional neural differentiationof human adipose tissue-derived stem cells using bFGF and forskolin. BMC Cell Biol， 2010， 11：25.
9. 　Madonna R， De Caterina R. In vitro neovasculogenic potential of resident adipose tissue precursors. Am J Physiol Cell Physiol， 2008， 295 （5）：1271-1280.
10. 　Madonna R， Willerson JT， Geng YJ. Myocardin a enhances telomerase activities in adipose tissue mesenchymal cells and embryonic stem cells undergoing cardiovascular myogenic differentiation. Stem Cells， 2008， 26 （1）：202-211.
11. 　Aguiari P， Leo S， Zavan B， et al. High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci USA，2008， 105 （4）：1226-1231.
12. 　Thom T， Haase N， Rosamond W， et al. Heart disease and stroke statistics——2006 update：a report from the American Heart Associ-ation Statistics Committee and Stroke Statistics Subcommittee.Circulation， 2006， 113 （6）：e85-151.
13. 　Fonarow GC. Heart failure：recent advances in prevention and treatment. Rev Cardiovasc Med， 2000 ， 1 （1）：25-33， 54.
14. 　Oh H， Bradfute SB， Gallardo TD， et al. Cardiac progenitor cells from adult myocardium：homing， differentiation， and fusion afterinfarction. Proc Natl Acad Sci USA， 2003， 100 （21）：12313-12318.
15. 　Halvorsen YD， Franklin D， Bond AL， et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng， 2001， 7 （6）：729-741.
16. 　Dragoo JL， Choi JY， Lieberman JR， et al. Bone induction by BMP-2transduced stem cells derived from human fat. J Orthop Res， 2003， 21 （4）：622-629.
17. 　Cowan CM， Shi YY， Aalami OO， et al. Adipose-derived adult stromalcells heal critical-size mouse calvarial defects. Nat Biotechnol， 2004， 22 （5）：560-567.
18. 　Winter A， Breit S， Parsch D， et al. Cartilage-like gene expression in differentiated human stem cell spheroids：a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum， 2003， 48 （2）：418-429.
19. 　Fujimura J， Ogawa R， Mizuno H， et al. Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice. BiochemBiophys Res Commun， 2005， 333 （1）：116-121.
20. 　Rehman J， Traktuev D， Li J， et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation， 2004， 109 （10）：1292-1298.
21. 　van Dijk A， Niessen HW， Zandieh Doulabi B， et al. Differentiationof human adipose-derived stem cells towards cardiomyocytes isfacilitated by laminin. Cell Tissue Res， 2008， 334 （3）：457-467.
22. 　Rangappa S， Fen C， Lee EH， et al. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thorac Surg， 2003， 75 （3）：775-779.
23. 　Planat-Bénard V， Menard C， André M， et al. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res， 2004， 94 （2）：223-229.
24. 　De Ugarte DA， Morizono K， Elbarbary A， et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs， 2003， 174 （3）：101-109.
25. 　McIntosh K， Zvonic S， Garrett S， et al. The immunogenicity of human adipose-derived cells：temporal changes in vitro. Stem Cells， 2006， 24 （5）：1246-1253.
26. 　Madonna R， Renna FV， Cellini C， et al. Age-dependent impairment of number and angiogenic potential of adipose tissue-derived progenitorcells. Eur J Clin Invest， 2011， 41 （2）：126-133.
27. 　Williams SK， McKenney S， Jarrell BE. Collagenase lot selection and purification for adipose tissue digestion. Cell Transplant， 1995， 4 （3）：281-289.
28. 　Wang L， Deng J， Tian W， et al. Adipose-derived stem cells are an effective cell candidate for treatment of heart failure：an Mr imaging study of rat hearts. Am J Physiol Heart Circ Physiol， 2009， 297 （3）：1020-1031.
29. 　Schenke-Layland K， Strem BM， Jordan MC， et al. Adipose tissue-derived cells improve cardiac function following myocardial infarction.J Surg Res， 2009， 153 （2）：217-223.
30. 　Suga H， Eto H， Shigeura T， et al. IFATS collection：Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism. Stem Cells， 2009， 27 （1）：238-249.
31. 　Miyahara Y， Nagaya N， Kataoka M， et al. Monolayered mesenchymalstem cells repair scarred myocardium after myocardial infarction. Nat Med， 2006， 12 （4）：459-465.
32. 　Beltrami AP， Barlucchi L， Torella D， et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell， 2003， 114 （6）：763-776.
33. 　Spinale FG. Matrix metalloproteinases：regulation and dysregulation in the failing heart. Circ Res， 2002， 90 （5）：520-530.
34. 　Zhu XY， Zhang XZ， Xu L， et al. Transplantation of adipose-derived stem cells overexpressing hHGF into cardiac tissue. Biochem Biophys Res Commun， 2009， 379 （4）：1084-1090.
35. 　Léobon B， Roncalli J， Joffre C， et al. Adipose-derived cardiomyogenic cells：in vitro expansion and functional improvement in a mouse model of myocardial infarction. Cardiovasc Res， 2009， 83 （4）：757-767.
36. 　Mazo M， Planat-Bénard V， Abizanda G， et al. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail， 2008， 10 （5）：454-462.

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