The research progress of circRNA in the cardiovascular disease_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LEI Kexin ^1,2 , BAI Hetian ^1,2 , LI Tao ¹ ,  QIAN Yongjun ¹

1. Department of Cardiovascular Surgery and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

QIAN Yongjun, Email: qianyongjun@scu.edu.cn

Keywords：

Circular RNA; loop-forming mechanism; biological function; cardiovascular disease; biomarker

DOI：

10.7507/1007-4848.201812073

Video：

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Abstract Full text Figures/Tables Video References Cited by

Circular RNA (circRNA) is a non-coding RNA which exists widely in eukaryotic cells with a structure of covalently closed continuous loop. Its generation, characteristics and functions have received extensive attention, making it one of the hot spots in the field of non-coding RNA research. Many studies have found that circRNA plays an important role in the development of various diseases including cardiovascular disease, nervous system disease and cancer. Cardiovascular disease is a worldwide common disease with high incidence and poor prognosis. Its exact pathogenesis has not been found, which blocks the development of cardiovascular disease treatment. In this review, we summarize the loop-forming mechanisms, the functions and the progress of current researches of circRNA in cardiovascular diseases.

Citation： LEI Kexin, BAI Hetian, LI Tao, QIAN Yongjun. The research progress of circRNA in the cardiovascular disease. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(10): 1021-1025. doi: 10.7507/1007-4848.201812073 Copy

1.	Zhu LP, He YJ, Hou JC, et al. The role of circRNAs in cancers. Biosci Rep, 2017, 37(5): pii: BSR20170750.
2.	Mendis S, Davis S, Norrving B. Organizational update: the world health organization global status report on noncommunicable diseases 2014; one more landmark step in the combat against stroke and vascular disease. Stroke, 2015, 46(5): e121-e122.
3.	Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
4.	Zaphiropoulos PG. Circular RNAs from transcripts of the rat cytochrome P4502C24 gene: correlation with exon skipping. Proc Natl Acad Sci U S A, 1996, 93(13): 6536-6541.
5.	Noto JJ, Schmidt CA, Matera AG. Engineering and expressing circular RNAs via tRNA splicing. RNA Biol, 2017, 14(8): 978-984.
6.	Lei K, Bai H, Wei Z, et al. The mechanism and function of circular RNAs in human diseases. Exp Cell Res, 2018, 368(2): 147-158.
7.	Liu J, Liu T, Wang X, et al. Circles reshaping the RNA world: from waste to treasure. Mol Cancer, 2017, 16(1): 58.
8.	Salzman J. Circular RNA expression: its potential regulation and function. Trends Genet, 2016, 32(5): 309-316.
9.	Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
10.	Rong D, Sun H, Li Z, et al. An emerging function of circRNA-miRNAs-mRNA axis in human diseases. Oncotarget, 2017, 8(42): 73271-73281.
11.	Memczak S, Papavasileiou P, Peters O, et al. Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood. PLoS One, 2015, 10(10): e0141214.
12.	Tan WL, Lim BT, Anene-Nzelu CG, et al. A landscape of circular RNA expression in the human heart. Cardiovasc Res, 2017, 113(3): 298-309.
13.	Wang H, Wang S, Sun G, et al. Could subclinical organ damage markers improve atherosclerotic cardiovascular disease risk assessment in general Chinese population? Int J Cardiol, 2018, 268: 229.
14.	Yari M, Bitarafan S, Broumand MA, et al. Association between long noncoding RNA ANRIL expression variants and susceptibility to coronary artery disease. Int J Mol Cell Med, 2018, 7(1): 1-7.
15.	Pan RY, Liu P, Zhou HT, et al. Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. Oncotarget, 2017, 8(36): 60280-60290.
16.	Huang X, Chen Y, Xiao J, et al. Identification of differentially expressed circular RNAs during TGF-ß1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. Anatol J Cardiol, 2018, 19(3): 192-197.
17.	Orogo AM, Gustafsson AB. Cell death in the myocardium: my heart won’t go on. IUBMB Life, 2013, 65(8): 651-656.
18.	Fan X, Weng X, Zhao Y, et al. Circular RNAs in cardiovascular disease: an overview. Biomed Res Int, 2017, 2017: 5135781.
19.	Guo Y, Luo F, Liu Q, et al. Regulatory non-coding RNAs in acute myocardial infarction. J Cell Mol Med, 2017, 21(5): 1013-1023.
20.	Geng HH, Li R, Su YM, et al. The circular RNA cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. PLoS One, 2016, 11(3): e0151753.
21.	Vausort M, Salgado-Somoza A, Zhang L, et al. Myocardial infarction-associated circular RNA predicting left ventricular dysfunction. J Am Coll Cardiol, 2016, 68(11): 1247-1248.
22.	Vausort M, Wagner DR, Devaux Y. Long noncoding RNAs in patients with acute myocardial infarction. Circ Res, 2014, 115(7): 668-677.
23.	Wang K, Long B, Liu F, et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J, 2016, 37(33): 2602-2611.
24.	Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J, 2017, 38(18): 1402-1412.
25.	Wu HJ, Zhang CY, Zhang S, et al. Microarray expression profile of circular RNAs in heart tissue of mice with myocardial infarction-induced heart failure. Cell Physiol Biochem, 2016, 39(1): 205-216.
26.	朱悉煜, 公兵, 汤鑫龙, 等. 心房颤动患者左心耳组织中mRNA表达谱的变化以及相关生物信息学分析. 中国循环杂志, 2017, 32(z1): 30-31.
27.	周庆, 公兵, 田聪聪, 等. 环状RNA在心房颤动患者左心耳组织中的变化及相关生物信息学分析. 中国循环杂志, 2017, 32(z1): 30.
28.	Zhang J, Xu YL, Xu S, et al. Plasma circular RNAs, Hsa_circRNA_025016, predict postoperative atrial fibrillation after isolated off-pump coronary artery bypass grafting. J Am Heart Assoc, 2018, 7(2).
29.	Floriani C, Gencer B, Collet TH, et al. Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update. Eur Heart J, 2018, 39(7): 503-507.
30.	Kirchhof P, Kahr PC, Kaese S, et al. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Circ Cardiovasc Genet, 2011, 4(2): 123-133.
31.	Biswas H, Longmore GD. Action of SNAIL1 in cardiac myofibroblasts is important for cardiac fibrosis following hypoxic injury. PLoS One, 2016, 11(10): e0162636.
32.	Tang CM, Zhang M, Huang L, et al. CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep, 2017, 7: 40342.
33.	Zhou B, Yu JW. A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1. Biochem Biophys Res Commun, 2017, 487(4): 769-775.
34.	Bao X, Zheng S, Mao S, et al. A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911. Biochem Biophys Res Commun, 2018, 498(4): 789-794.
35.	Zheng S, Gu T, Bao X, et al. Circular RNA hsa_circ_0014243 may serve as a diagnostic biomarker for essential hypertension. Exp Ther Med, 2019, 17(3): 1728-1736.
36.	Zhang H, Zhu L, Bai M, et al. Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer, 2018, [Epub ahead of print].
37.	Zhao SY, Wang J, Ouyang SB, et al. Salivary circular RNAs Hsa_circ_0001874 and Hsa_circ_0001971 as novel biomarkers for the diagnosis of oral squamous cell carcinoma. Cell Physiol Biochem, 2018, 47(6): 2511-2521.
38.	Tan S, Gou Q, Pu W, et al. Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer. Cell Res, 2018, 28(6): 693-695.

1. Zhu LP, He YJ, Hou JC, et al. The role of circRNAs in cancers. Biosci Rep, 2017, 37(5): pii: BSR20170750.
2. Mendis S, Davis S, Norrving B. Organizational update: the world health organization global status report on noncommunicable diseases 2014; one more landmark step in the combat against stroke and vascular disease. Stroke, 2015, 46(5): e121-e122.
3. Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014, 56(1): 55-66.
4. Zaphiropoulos PG. Circular RNAs from transcripts of the rat cytochrome P4502C24 gene: correlation with exon skipping. Proc Natl Acad Sci U S A, 1996, 93(13): 6536-6541.
5. Noto JJ, Schmidt CA, Matera AG. Engineering and expressing circular RNAs via tRNA splicing. RNA Biol, 2017, 14(8): 978-984.
6. Lei K, Bai H, Wei Z, et al. The mechanism and function of circular RNAs in human diseases. Exp Cell Res, 2018, 368(2): 147-158.
7. Liu J, Liu T, Wang X, et al. Circles reshaping the RNA world: from waste to treasure. Mol Cancer, 2017, 16(1): 58.
8. Salzman J. Circular RNA expression: its potential regulation and function. Trends Genet, 2016, 32(5): 309-316.
9. Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
10. Rong D, Sun H, Li Z, et al. An emerging function of circRNA-miRNAs-mRNA axis in human diseases. Oncotarget, 2017, 8(42): 73271-73281.
11. Memczak S, Papavasileiou P, Peters O, et al. Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood. PLoS One, 2015, 10(10): e0141214.
12. Tan WL, Lim BT, Anene-Nzelu CG, et al. A landscape of circular RNA expression in the human heart. Cardiovasc Res, 2017, 113(3): 298-309.
13. Wang H, Wang S, Sun G, et al. Could subclinical organ damage markers improve atherosclerotic cardiovascular disease risk assessment in general Chinese population? Int J Cardiol, 2018, 268: 229.
14. Yari M, Bitarafan S, Broumand MA, et al. Association between long noncoding RNA ANRIL expression variants and susceptibility to coronary artery disease. Int J Mol Cell Med, 2018, 7(1): 1-7.
15. Pan RY, Liu P, Zhou HT, et al. Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. Oncotarget, 2017, 8(36): 60280-60290.
16. Huang X, Chen Y, Xiao J, et al. Identification of differentially expressed circular RNAs during TGF-ß1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. Anatol J Cardiol, 2018, 19(3): 192-197.
17. Orogo AM, Gustafsson AB. Cell death in the myocardium: my heart won’t go on. IUBMB Life, 2013, 65(8): 651-656.
18. Fan X, Weng X, Zhao Y, et al. Circular RNAs in cardiovascular disease: an overview. Biomed Res Int, 2017, 2017: 5135781.
19. Guo Y, Luo F, Liu Q, et al. Regulatory non-coding RNAs in acute myocardial infarction. J Cell Mol Med, 2017, 21(5): 1013-1023.
20. Geng HH, Li R, Su YM, et al. The circular RNA cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. PLoS One, 2016, 11(3): e0151753.
21. Vausort M, Salgado-Somoza A, Zhang L, et al. Myocardial infarction-associated circular RNA predicting left ventricular dysfunction. J Am Coll Cardiol, 2016, 68(11): 1247-1248.
22. Vausort M, Wagner DR, Devaux Y. Long noncoding RNAs in patients with acute myocardial infarction. Circ Res, 2014, 115(7): 668-677.
23. Wang K, Long B, Liu F, et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J, 2016, 37(33): 2602-2611.
24. Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J, 2017, 38(18): 1402-1412.
25. Wu HJ, Zhang CY, Zhang S, et al. Microarray expression profile of circular RNAs in heart tissue of mice with myocardial infarction-induced heart failure. Cell Physiol Biochem, 2016, 39(1): 205-216.
26. 朱悉煜, 公兵, 汤鑫龙, 等. 心房颤动患者左心耳组织中mRNA表达谱的变化以及相关生物信息学分析. 中国循环杂志, 2017, 32(z1): 30-31.
27. 周庆, 公兵, 田聪聪, 等. 环状RNA在心房颤动患者左心耳组织中的变化及相关生物信息学分析. 中国循环杂志, 2017, 32(z1): 30.
28. Zhang J, Xu YL, Xu S, et al. Plasma circular RNAs, Hsa_circRNA_025016, predict postoperative atrial fibrillation after isolated off-pump coronary artery bypass grafting. J Am Heart Assoc, 2018, 7(2).
29. Floriani C, Gencer B, Collet TH, et al. Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update. Eur Heart J, 2018, 39(7): 503-507.
30. Kirchhof P, Kahr PC, Kaese S, et al. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Circ Cardiovasc Genet, 2011, 4(2): 123-133.
31. Biswas H, Longmore GD. Action of SNAIL1 in cardiac myofibroblasts is important for cardiac fibrosis following hypoxic injury. PLoS One, 2016, 11(10): e0162636.
32. Tang CM, Zhang M, Huang L, et al. CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep, 2017, 7: 40342.
33. Zhou B, Yu JW. A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1. Biochem Biophys Res Commun, 2017, 487(4): 769-775.
34. Bao X, Zheng S, Mao S, et al. A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911. Biochem Biophys Res Commun, 2018, 498(4): 789-794.
35. Zheng S, Gu T, Bao X, et al. Circular RNA hsa_circ_0014243 may serve as a diagnostic biomarker for essential hypertension. Exp Ther Med, 2019, 17(3): 1728-1736.
36. Zhang H, Zhu L, Bai M, et al. Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer, 2018, [Epub ahead of print].
37. Zhao SY, Wang J, Ouyang SB, et al. Salivary circular RNAs Hsa_circ_0001874 and Hsa_circ_0001971 as novel biomarkers for the diagnosis of oral squamous cell carcinoma. Cell Physiol Biochem, 2018, 47(6): 2511-2521.
38. Tan S, Gou Q, Pu W, et al. Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer. Cell Res, 2018, 28(6): 693-695.

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