Review of The Biological Significance of Transmembrane 4 Super Family in Digestive System Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 SHIGang ^1,2 ,  DONGMing ¹

1. Department of Gastrointestinal Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China;
2. Department of Surgery, Liaoning Cancer Hospital and Institute, Shenyang 110042, Liaoning Province, China;

Corresponding author：

DONGMing, Email: cmudongming@sohu.com

Keywords：

Transmembrane 4 super family; Digestive system; Cancer; Progress; Integrin

DOI：

10.7507/1007-9424.20140281

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective o explore the effect and mechanisms of transmembrane 4 super family (TM4SF) in digestive system cancer. Methods Articles were reviewed to discuss the biological characteristics of TM4SF in digestive system cancer. Results TM4SF played an important role in migration and invasion of digestive system cancer, including pancreatic cancer, gastric cancer, colorectal cancer, hepatic cancer, esophageal cancer, and so on. TM4SF modulated the cell biological activities by microdomains which were fixed on cell membrane, such as adhesion, migration, invasion, and proliferation. Conclusion TM4SF may be used to predict the metastasis and prognosis of digestive system cancer and may be the targets of therapy of it in the future.

Citation： SHIGang, DONGMing. Review of The Biological Significance of Transmembrane 4 Super Family in Digestive System Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(9): 1173-1178. doi: 10.7507/1007-9424.20140281 Copy

1.	Garcia-España A, Chung PJ, Sarkar IN, et al.Appearance of new tetraspanin genes during vertebrate evolution[J]. Genomics, 2008, 91(4):326-334.
2.	Tarrant JM, Robb L, van Spriel AB, et al.Tetraspanins:molecular organisers of the leukocyte surface[J]. Trends Immunol, 2003, 24(11):610-617.
3.	Haining EJ, Yang J, Bailey RL, et al.The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10(Adam10) and regulates its maturation and cell surface expression[J]. J Biol Chem, 2012, 287(47):39753-39765.
4.	Wang HX, Kolesnikova TV, Denison C, et al.The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization[J]. J Cell Sci, 2011, 124(Pt 16):2702-2710.
5.	Kitadokoro K, Ponassi M, Galli G, et al.Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop[J]. Biol Chem, 2002, 383(9):1447-1452.
6.	Wang X, Veruki ML, Bukoreshtliev NV, et al.Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels[J]. Proc Natl Acad Sci U S A, 2010, 107(40):17194-17199.
7.	Charrin S, le Naour F, Silvie O, et al.Lateral organization of membrane proteins:tetraspanins spin their web[J]. Biochem J, 2009, 420(2):133-154.
8.	Lazo PA.Functional implications of tetraspanin proteins in cancer biology[J]. Cancer Sci, 2007, 98(11):1666-1677.
9.	Yang W, Li P, Lin J, et al.CD151 promotes proliferation and migration of PC3 cells via the formation of CD151-integrinα3/α6 complex[J]. J Huazhong Univ Sci Technolog Med Sci, 2012, 32(3):383-388.
10.	Lekishvili T, Fromm E, Mujoomdar M, et al.The tumourassociated antigen L6(L6-Ag) is recruited to the tetraspaninenriched microdomains:implication for tumour cell motility[J]. J Cell Sci, 2008, 121(Pt 5):685-694.
11.	Yáñez-Mó M, Barreiro O, Gordon-Alonso M, et al.Tetraspanin-enriched microdomains:a functional unit in cell plasma membranes[J]. Trends Cell Biol, 2009, 19(9):434-446.
12.	Zhu YZ, Luo Y, Cao MM, et al.Significance of palmitoylation of CD81 on its association with tetraspanin-enriched microdomains and mediating hepatitis C virus cell entry[J]. Virology, 2012, 429(2):112-123.
13.	Silvie O, Franetich JF, Boucheix C, et al.Alternative invasion pathways for plasmodium berghei sporozoites[J]. Int J Parasitol, 2007, 37(2):173-182.
14.	Richardson MM, Jennings LK, Zhang XA.Tetraspanins and tumor progression[J]. Clin Exp Metastasis, 2011, 28(3):261-270.
15.	Guo Q, Xia B, Zhang F, et al.Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions[J]. PLoS One, 2012, 7(6):e38464.
16.	Ke AW, Shi GM, Zhou J, et al.Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma[J]. Hepatology, 2009, 49(2):491-503.
17.	Wang H, Rana S, Giese N, et al.Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells[J]. Int J Cancer, 2013, 133(2):416-426.
18.	Zhu GH, Huang C, Qiu ZJ, et al.Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma[J]. Dig Dis Sci, 2011, 56(4):1090-1098.
19.	Gesierich S, Berezovskiy I, Ryschich E, et al.Systemic induction of the angiogenesis Switch by the tetraspanin D6.1A/CO-029[J]. Cancer Res, 2006, 66(14):7083-7094.
20.	Chen L, Li X, Wang GL, et al.Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma[J]. Tumori, 2008, 94(4):531-538.
21.	Matsumura N, Zembutsu H, Yamaguchi K, et al.Identification of novel molecular markers for detection of gastric cancer cells in the peripheral blood circulation using genome-wide microarray analysis[J]. Exp Ther Med, 2011, 2(4):705-713.
22.	Chen L, Yuan D, Zhao R, et al.Suppression of TSPAN1 by RNA interference inhibits proliferation and invasion of colon cancer cells in vitro[J]. Tumori, 2010, 96(5):744-750.
23.	李挺, 徐美荣, 王鼎, 等.结肠癌中TSPAN-1和CORTACTIN蛋白的表达及其临床意义[J].中国普通外科杂志, 2010, 19(10):1107-1112.
24.	Debhandari RP, Shi GM, Ke AW, et al.Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrinβ1 complex in the progression of hepatocellular carcinoma[J]. PLoS One, 2011, 6(9):e24901.
25.	Huang YK, Fan XG, Qiu F, et al.Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray[J]. Chin Med J (Engl), 2011, 124(13):2057-2064.
26.	Botelho NK, Schneiders FI, Lord SJ, et al.Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues[J]. Cancer Biol Ther, 2010, 10(2):172-179.
27.	Liu L, He B, Liu WM, et al.Tetraspanin CD151 promotes cell migration by regulating integrin trafficking[J]. J Biol Chem, 2007, 282(43):31631-31642.
28.	Knoblich K, Wang HX, Sharma C, et al.Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibitsβ-catenin degradation[J]. Cell Mol Life Sci, 2014, 71(7):1305-1314.
29.	Kuhn S, Koch M, Nübel T, et al.A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression[J]. Mol Cancer Res, 2007, 5(6):553-567.
30.	Takeda Y, Li Q, Kazarov AR, et al.Diminished metastasis in tetraspanin CD151-knockout mice[J]. Blood, 2011, 118(2):464-472.
31.	Fei Y, Wang J, Liu W, et al.CD151 promotes cancer cell metastasis via integrinsα3β1 andα6β1 in vitro[J]. Mol Med Rep, 2012, 6(6):1226-1230.
32.	Takahashi M, Sugiura T, Abe M, et al.Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration[J]. Int J Cancer, 2007, 121(9):1919-1929.
33.	Herlevsen M, Schmidt DS, Miyazaki K, et al.The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation[J]. J Cell Sci, 2003, 116(Pt 21):4373-4390.
34.	Zevian S, Winterwood NE, Stipp CS.Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated byα3β1 versusα6β4 integrin[J]. J Biol Chem, 2011, 286(9):7496-7506.
35.	Chen L, Yuan D, Wang GL, et al.Clinicopathological significance of expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma[J]. J Korean Med Sci, 2010, 25(10):1438-1442.
36.	Liu WF, Zuo HJ, Chai BL, et al.Role of tetraspanin CD151-α3/α6 integrin complex:implication in angiogenesis CD151-integrin complex in angiogenesis[J]. Int J Biochem Cell Biol, 2011, 43(4):642-650.
37.	Rana S, Claas C, Kretz CC, et al.Activation-induced internalization differs for the tetraspanins CD9 and Tspan8:impact on tumor cell motility[J]. Int J Biochem Cell Biol, 2011, 43(1):106-119.
38.	Greco C, Bralet MP, Ailane N, et al.E-cadherin/p120-catenin and tetraspanin Co-029 cooperate for cell motility control in human colon carcinoma[J]. Cancer Res, 2010, 70(19):7674-7683.
39.	Dornier E, Coumailleau F, Ottavi JF, et al.TspanC8 tetraspanins regulate Adam10/Kuzbanian trafficking and promote Notch activation in flies and mammals[J]. J Cell Biol, 2012, 199(3):481-496.
40.	Dunn CD, Sulis ML, Ferrando AA, et al.A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells[J]. Proc Natl Acad Sci U S A, 2010, 107(13):5907-5912.
41.	Costa NR, Paulo P, Caffrey T, et al.Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line[J]. PLoS One, 2011, 6(11):e26970.
42.	Wang GL, Chen L, Wei YZ, et al.The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line[J]. Oncol Rep, 2012, 27(6):1944-1952.
43.	Kuhn S, Koch M, Nübel T, et al.A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression[J]. Mol Cancer Res, 2007, 5(6):553-556.
44.	Zhang F, Michaelson JE, Moshiach S, et al.Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension[J]. Blood, 2011, 118(15):4274-4284.
45.	Maghzal N, Vogt E, Reintsch W, et al.The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling[J]. J Cell Biol, 2010, 191(3):645-659.
46.	颜登国, 王国栋, 程海玉.基因芯片技术分析结直肠癌肝转移患者免疫基因表达的变化[J].中国普外基础与临床杂志, 2012, 19(11):1182-1186.
47.	Haeuw JF, Goetsch L, Bailly C, et al.Tetraspanin CD151 as a target for antibody-based cancer immunotherapy[J]. Biochem Soc Trans, 2011, 39(2):553-558.
48.	Zhou J, Shum KT, Burnett JC, et al.Nanoparticle-based delivery of RNAi therapeutics:progress and challenges[J]. Pharmaceuticals (Basel), 2013, 6(1):85-107.
49.	Bae S, Shim SH, Park CW, et al.Combined omics analysis identifies transmembrane 4 L6 family member 1 as a surface protein marker specific to human mesenchymal stem cells[J]. Stem Cells Dev, 2011, 20(2):197-203.

1. Garcia-España A, Chung PJ, Sarkar IN, et al.Appearance of new tetraspanin genes during vertebrate evolution[J]. Genomics, 2008, 91(4):326-334.
2. Tarrant JM, Robb L, van Spriel AB, et al.Tetraspanins:molecular organisers of the leukocyte surface[J]. Trends Immunol, 2003, 24(11):610-617.
3. Haining EJ, Yang J, Bailey RL, et al.The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10(Adam10) and regulates its maturation and cell surface expression[J]. J Biol Chem, 2012, 287(47):39753-39765.
4. Wang HX, Kolesnikova TV, Denison C, et al.The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization[J]. J Cell Sci, 2011, 124(Pt 16):2702-2710.
5. Kitadokoro K, Ponassi M, Galli G, et al.Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop[J]. Biol Chem, 2002, 383(9):1447-1452.
6. Wang X, Veruki ML, Bukoreshtliev NV, et al.Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels[J]. Proc Natl Acad Sci U S A, 2010, 107(40):17194-17199.
7. Charrin S, le Naour F, Silvie O, et al.Lateral organization of membrane proteins:tetraspanins spin their web[J]. Biochem J, 2009, 420(2):133-154.
8. Lazo PA.Functional implications of tetraspanin proteins in cancer biology[J]. Cancer Sci, 2007, 98(11):1666-1677.
9. Yang W, Li P, Lin J, et al.CD151 promotes proliferation and migration of PC3 cells via the formation of CD151-integrinα3/α6 complex[J]. J Huazhong Univ Sci Technolog Med Sci, 2012, 32(3):383-388.
10. Lekishvili T, Fromm E, Mujoomdar M, et al.The tumourassociated antigen L6(L6-Ag) is recruited to the tetraspaninenriched microdomains:implication for tumour cell motility[J]. J Cell Sci, 2008, 121(Pt 5):685-694.
11. Yáñez-Mó M, Barreiro O, Gordon-Alonso M, et al.Tetraspanin-enriched microdomains:a functional unit in cell plasma membranes[J]. Trends Cell Biol, 2009, 19(9):434-446.
12. Zhu YZ, Luo Y, Cao MM, et al.Significance of palmitoylation of CD81 on its association with tetraspanin-enriched microdomains and mediating hepatitis C virus cell entry[J]. Virology, 2012, 429(2):112-123.
13. Silvie O, Franetich JF, Boucheix C, et al.Alternative invasion pathways for plasmodium berghei sporozoites[J]. Int J Parasitol, 2007, 37(2):173-182.
14. Richardson MM, Jennings LK, Zhang XA.Tetraspanins and tumor progression[J]. Clin Exp Metastasis, 2011, 28(3):261-270.
15. Guo Q, Xia B, Zhang F, et al.Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions[J]. PLoS One, 2012, 7(6):e38464.
16. Ke AW, Shi GM, Zhou J, et al.Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma[J]. Hepatology, 2009, 49(2):491-503.
17. Wang H, Rana S, Giese N, et al.Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells[J]. Int J Cancer, 2013, 133(2):416-426.
18. Zhu GH, Huang C, Qiu ZJ, et al.Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma[J]. Dig Dis Sci, 2011, 56(4):1090-1098.
19. Gesierich S, Berezovskiy I, Ryschich E, et al.Systemic induction of the angiogenesis Switch by the tetraspanin D6.1A/CO-029[J]. Cancer Res, 2006, 66(14):7083-7094.
20. Chen L, Li X, Wang GL, et al.Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma[J]. Tumori, 2008, 94(4):531-538.
21. Matsumura N, Zembutsu H, Yamaguchi K, et al.Identification of novel molecular markers for detection of gastric cancer cells in the peripheral blood circulation using genome-wide microarray analysis[J]. Exp Ther Med, 2011, 2(4):705-713.
22. Chen L, Yuan D, Zhao R, et al.Suppression of TSPAN1 by RNA interference inhibits proliferation and invasion of colon cancer cells in vitro[J]. Tumori, 2010, 96(5):744-750.
23. 李挺, 徐美荣, 王鼎, 等.结肠癌中TSPAN-1和CORTACTIN蛋白的表达及其临床意义[J].中国普通外科杂志, 2010, 19(10):1107-1112.
24. Debhandari RP, Shi GM, Ke AW, et al.Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrinβ1 complex in the progression of hepatocellular carcinoma[J]. PLoS One, 2011, 6(9):e24901.
25. Huang YK, Fan XG, Qiu F, et al.Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray[J]. Chin Med J (Engl), 2011, 124(13):2057-2064.
26. Botelho NK, Schneiders FI, Lord SJ, et al.Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues[J]. Cancer Biol Ther, 2010, 10(2):172-179.
27. Liu L, He B, Liu WM, et al.Tetraspanin CD151 promotes cell migration by regulating integrin trafficking[J]. J Biol Chem, 2007, 282(43):31631-31642.
28. Knoblich K, Wang HX, Sharma C, et al.Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibitsβ-catenin degradation[J]. Cell Mol Life Sci, 2014, 71(7):1305-1314.
29. Kuhn S, Koch M, Nübel T, et al.A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression[J]. Mol Cancer Res, 2007, 5(6):553-567.
30. Takeda Y, Li Q, Kazarov AR, et al.Diminished metastasis in tetraspanin CD151-knockout mice[J]. Blood, 2011, 118(2):464-472.
31. Fei Y, Wang J, Liu W, et al.CD151 promotes cancer cell metastasis via integrinsα3β1 andα6β1 in vitro[J]. Mol Med Rep, 2012, 6(6):1226-1230.
32. Takahashi M, Sugiura T, Abe M, et al.Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration[J]. Int J Cancer, 2007, 121(9):1919-1929.
33. Herlevsen M, Schmidt DS, Miyazaki K, et al.The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation[J]. J Cell Sci, 2003, 116(Pt 21):4373-4390.
34. Zevian S, Winterwood NE, Stipp CS.Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated byα3β1 versusα6β4 integrin[J]. J Biol Chem, 2011, 286(9):7496-7506.
35. Chen L, Yuan D, Wang GL, et al.Clinicopathological significance of expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma[J]. J Korean Med Sci, 2010, 25(10):1438-1442.
36. Liu WF, Zuo HJ, Chai BL, et al.Role of tetraspanin CD151-α3/α6 integrin complex:implication in angiogenesis CD151-integrin complex in angiogenesis[J]. Int J Biochem Cell Biol, 2011, 43(4):642-650.
37. Rana S, Claas C, Kretz CC, et al.Activation-induced internalization differs for the tetraspanins CD9 and Tspan8:impact on tumor cell motility[J]. Int J Biochem Cell Biol, 2011, 43(1):106-119.
38. Greco C, Bralet MP, Ailane N, et al.E-cadherin/p120-catenin and tetraspanin Co-029 cooperate for cell motility control in human colon carcinoma[J]. Cancer Res, 2010, 70(19):7674-7683.
39. Dornier E, Coumailleau F, Ottavi JF, et al.TspanC8 tetraspanins regulate Adam10/Kuzbanian trafficking and promote Notch activation in flies and mammals[J]. J Cell Biol, 2012, 199(3):481-496.
40. Dunn CD, Sulis ML, Ferrando AA, et al.A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells[J]. Proc Natl Acad Sci U S A, 2010, 107(13):5907-5912.
41. Costa NR, Paulo P, Caffrey T, et al.Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line[J]. PLoS One, 2011, 6(11):e26970.
42. Wang GL, Chen L, Wei YZ, et al.The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line[J]. Oncol Rep, 2012, 27(6):1944-1952.
43. Kuhn S, Koch M, Nübel T, et al.A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression[J]. Mol Cancer Res, 2007, 5(6):553-556.
44. Zhang F, Michaelson JE, Moshiach S, et al.Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension[J]. Blood, 2011, 118(15):4274-4284.
45. Maghzal N, Vogt E, Reintsch W, et al.The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling[J]. J Cell Biol, 2010, 191(3):645-659.
46. 颜登国, 王国栋, 程海玉.基因芯片技术分析结直肠癌肝转移患者免疫基因表达的变化[J].中国普外基础与临床杂志, 2012, 19(11):1182-1186.
47. Haeuw JF, Goetsch L, Bailly C, et al.Tetraspanin CD151 as a target for antibody-based cancer immunotherapy[J]. Biochem Soc Trans, 2011, 39(2):553-558.
48. Zhou J, Shum KT, Burnett JC, et al.Nanoparticle-based delivery of RNAi therapeutics:progress and challenges[J]. Pharmaceuticals (Basel), 2013, 6(1):85-107.
49. Bae S, Shim SH, Park CW, et al.Combined omics analysis identifies transmembrane 4 L6 family member 1 as a surface protein marker specific to human mesenchymal stem cells[J]. Stem Cells Dev, 2011, 20(2):197-203.

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Review of The Biological Significance of Transmembrane 4 Super Family in Digestive System Cancer

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