Radioactive Seeds Iodine-125 Implantation in Treatment of Advanced Colorectal Cancer: Report of Nine Cases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUYan ¹ , LIQing-chun ² ,  HOURui-zhi ²

1. Department of Ultrosonography, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
2. Department of Gastrointestinal Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China;

Corresponding author：

HOURui-zhi, Email: houruizhi821023@126.com

Keywords：

¹²⁵I radioactive particle; Interstitial permanent implantation; Colorectal cancer; Ultrasound

DOI：

10.7507/1007-9424.20150316

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the viability, short-term clinical efficacy, and safety of ultrasound-guided radioactive seed ¹²⁵I permanent implantation in tissue in patients with advanced colorectal cancer. Methods A total of 9 patients were recruited in this study. All of the patients came from China-Japan Union Hospital of Jilin University from October 2012 to October 2014, which had been selected after strict screening. Five cases of male patients, 4 cases of female patients; the age was between 46-78 years old, the median age was 54 years old. There were 5 cases of patients with pain. There were 14 lesions in total, 1 lesion was local tumor recurrence, 2 lesions were pelvic metastasis, 8 lesions were liver metastases, and 3 lesions were abdominal lymph node metastasis. CEA increased in 6 cases before implantation. All patients were confirmed metastasis by CT, MRI examination or pathology. The ¹²⁵I radioactive seed implantation was guided by real-time ultrasound. CT scanning was taken in two months after treatment. The degree of pain relief, tumor local control, and the occurrence of complications were observed. Results In 2 months after implantation of ¹²⁵I radioactive particles, the CT scanning results showed that 2 cases obtained complete response (CR), 5 cases obtained partial response (PR), 1 case got stable disease (SD), and 1 case got progress disease (PD). Total effective was 7/9, and disease control was 8/9. Five cases with pain symptoms were relieved after treatment. One walk metal particle in the abdominal cavity was found by abdominal CT scanning in 1 case. There were no serious complications intraoperative and postoperative. Conclusions Ultrasound guided radioactive seeds ¹²⁵I implantation in the treatment of advanced colorectal cancer can significantly relieve the clinical symptoms, improve the quality of life, and can effectively control the metastasis. It is safe and feasible, and the postoperative hospitalization time is short, it has the avantages of safety, effectiveness, and low incidence of complications.

Citation： LIUYan, LIQing-chun, HOURui-zhi. Radioactive Seeds Iodine-125 Implantation in Treatment of Advanced Colorectal Cancer: Report of Nine Cases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(10): 1222-1225. doi: 10.7507/1007-9424.20150316 Copy

1.	车薛华, 梁伟民. NCCN成人癌痛控制指南解读.中国医药指南, 2010, 8(13):84-85.
2.	Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours:revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45(2):228-247.
3.	梁寒, 郝希山, 王晓娜, 等. 723例结肠癌患者术后多因素分析.中国肿瘤临床, 2004, 31(6):343-348.
4.	赵全德, 董灵, 李向东, 等.吉西他滨联合表柔星治疗移性肝癌的临床研究.现代肿瘤医学, 2011, 19(1):116-117.
5.	Tveit KM, Wiig JN, Clsen DR, et al. Combinedmodality treatment in cluding intraoperative radiotherapy in locally advancedand recurrent rectal cancer. Radiother Oncol, 1997, 44(3):277-282.
6.	Kim SY, Yang ES, Lee J, et al. Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis. Biochimie, 2011, 93(2):269-276.
7.	庄洪卿, 王俊杰, 赵勇, 等. ¹²⁵I粒子对大肠癌CLl87细胞杀伤作用的实验研究.中华放射医学与防护杂志, 2008, 28(2):148-151.
8.	Koutrouvelis PG. Computed tomography-guided salvage brachytherapy of recurrent large non-Resectable familial colo-rectal cancer in the pelvis:case report. Technol Cancer Res Treat, 2002, 1(1):61-64.
9.	Goes RN, Beart RW Jr, Simons AJ, et al. Use of brachytherapy in management of locally recurrent rectal cancer. Dis Colon Rectum, 1997, 40(10):1177-1179.
10.	吴同胜, 韩潞, 谭卫林. ¹²⁵I组织间插植放射治疗腹腔内恶性肿瘤的探讨.中国癌症杂志, 2009, 19(12):947-949.
11.	Wang Z, Lu J, Liu L, et al. Clinical application of CT-guided (125) I seed interstitial implan tatIon for local recurrent rectal carcinoma. Radiat Oncol, 2011, 6:138.
12.	Wang JJ, Yuan HS, Li JN, et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy. Med Oncol, 2010, 27(2):421-429.
13.	张亮, 范卫君, 黄金华, 等. CT导向下¹²⁵I粒子植入治疗直肠癌术后局部复发.中华医学杂志, 2008, 88(19):1335-1338.
14.	张开贤, 李苓, 邢超, 等. CT引导¹²⁵I放射性粒子植入治疗复发性直肠癌32例报告.当代医学, 2009, 15(36):13-15.
15.	吴越窦, 新民, 曲金荣.放射性¹²⁵I粒子植入术治疗直肠癌的临床研究.当代医学, 2009, 10(15):564-565.
16.	柳晨, 袁慧书, 王俊杰.复发性直肠癌:CT引导下植入放射性粒子组织间近距离放疗的疗效.中国介入影像与治疗学, 2012, 9(2):94-98.
17.	元云飞, 李斌奎, 李锦清, 等.巨大肝癌手术切除治疗的远期疗效.癌症, 2004, 23(7):821-824.
18.	芮静安, 王少斌, 陈曙光.肝三叶切除术治疗肝脏巨大肿瘤29例.中华外科杂志, 2001, 39(10):759-763.
19.	Lee SG, Hwang S, Jung JP, et al. Outcome of patients with huge hepatocellular carcinoma after primary resection and treatment of recurrent lesions. Br J Surg, 2007, 94(3):320-326.
20.	Chung GE, Lee JH, Kim HY, et al. Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology, 2011, 258(2):627-634.
21.	Xu LT, Zhou ZH, Lin JH, et al. Clinical study of transarterial chemoembolization combined with 3-dimensional conformal radiotherapy for hepatocellular carcinoma. Eur J Surg Oncol, 2011, 37(3):245-251.
22.	Merle P, Mornex F. Transarterial chemoembolization and conformal radiotherapy for heaptocellular carcinoma. Cancer Radiother, 2011, 15(1):69-71.
23.	范新华, 金利盛. CT引导下125 I粒子永久植入治疗肝转移癌.医学影像学杂志, 2012, 22(4):581-584.
24.	王建新, 王贵吉, 吴洋东. ¹²⁵I粒子植入治疗胃癌肝转移的临床疗效.河南医学研究, 2012, 21(3):321-323.
25.	王俊杰.放射性粒子组织间永久植入治疗肝转移癌.癌症进展, 2009, 7(3):286-290.

1. 车薛华, 梁伟民. NCCN成人癌痛控制指南解读.中国医药指南, 2010, 8(13):84-85.
2. Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours:revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45(2):228-247.
3. 梁寒, 郝希山, 王晓娜, 等. 723例结肠癌患者术后多因素分析.中国肿瘤临床, 2004, 31(6):343-348.
4. 赵全德, 董灵, 李向东, 等.吉西他滨联合表柔星治疗移性肝癌的临床研究.现代肿瘤医学, 2011, 19(1):116-117.
5. Tveit KM, Wiig JN, Clsen DR, et al. Combinedmodality treatment in cluding intraoperative radiotherapy in locally advancedand recurrent rectal cancer. Radiother Oncol, 1997, 44(3):277-282.
6. Kim SY, Yang ES, Lee J, et al. Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis. Biochimie, 2011, 93(2):269-276.
7. 庄洪卿, 王俊杰, 赵勇, 等. ¹²⁵I粒子对大肠癌CLl87细胞杀伤作用的实验研究.中华放射医学与防护杂志, 2008, 28(2):148-151.
8. Koutrouvelis PG. Computed tomography-guided salvage brachytherapy of recurrent large non-Resectable familial colo-rectal cancer in the pelvis:case report. Technol Cancer Res Treat, 2002, 1(1):61-64.
9. Goes RN, Beart RW Jr, Simons AJ, et al. Use of brachytherapy in management of locally recurrent rectal cancer. Dis Colon Rectum, 1997, 40(10):1177-1179.
10. 吴同胜, 韩潞, 谭卫林. ¹²⁵I组织间插植放射治疗腹腔内恶性肿瘤的探讨.中国癌症杂志, 2009, 19(12):947-949.
11. Wang Z, Lu J, Liu L, et al. Clinical application of CT-guided (125) I seed interstitial implan tatIon for local recurrent rectal carcinoma. Radiat Oncol, 2011, 6:138.
12. Wang JJ, Yuan HS, Li JN, et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy. Med Oncol, 2010, 27(2):421-429.
13. 张亮, 范卫君, 黄金华, 等. CT导向下¹²⁵I粒子植入治疗直肠癌术后局部复发.中华医学杂志, 2008, 88(19):1335-1338.
14. 张开贤, 李苓, 邢超, 等. CT引导¹²⁵I放射性粒子植入治疗复发性直肠癌32例报告.当代医学, 2009, 15(36):13-15.
15. 吴越窦, 新民, 曲金荣.放射性¹²⁵I粒子植入术治疗直肠癌的临床研究.当代医学, 2009, 10(15):564-565.
16. 柳晨, 袁慧书, 王俊杰.复发性直肠癌:CT引导下植入放射性粒子组织间近距离放疗的疗效.中国介入影像与治疗学, 2012, 9(2):94-98.
17. 元云飞, 李斌奎, 李锦清, 等.巨大肝癌手术切除治疗的远期疗效.癌症, 2004, 23(7):821-824.
18. 芮静安, 王少斌, 陈曙光.肝三叶切除术治疗肝脏巨大肿瘤29例.中华外科杂志, 2001, 39(10):759-763.
19. Lee SG, Hwang S, Jung JP, et al. Outcome of patients with huge hepatocellular carcinoma after primary resection and treatment of recurrent lesions. Br J Surg, 2007, 94(3):320-326.
20. Chung GE, Lee JH, Kim HY, et al. Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology, 2011, 258(2):627-634.
21. Xu LT, Zhou ZH, Lin JH, et al. Clinical study of transarterial chemoembolization combined with 3-dimensional conformal radiotherapy for hepatocellular carcinoma. Eur J Surg Oncol, 2011, 37(3):245-251.
22. Merle P, Mornex F. Transarterial chemoembolization and conformal radiotherapy for heaptocellular carcinoma. Cancer Radiother, 2011, 15(1):69-71.
23. 范新华, 金利盛. CT引导下125 I粒子永久植入治疗肝转移癌.医学影像学杂志, 2012, 22(4):581-584.
24. 王建新, 王贵吉, 吴洋东. ¹²⁵I粒子植入治疗胃癌肝转移的临床疗效.河南医学研究, 2012, 21(3):321-323.
25. 王俊杰.放射性粒子组织间永久植入治疗肝转移癌.癌症进展, 2009, 7(3):286-290.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Radioactive Seeds Iodine-125 Implantation in Treatment of Advanced Colorectal Cancer: Report of Nine Cases

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content