Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CAOZi-long ^1,2 , ZHANGZhuo ^1,2 , HUJian-li ^1,2 ,  SHENXuan-san ¹

1. Department of General Surgery, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, China;
2. Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, China;

Corresponding author：

SHENXuan-san, Email: xuansanshen@163.com

Keywords：

Breast carcinoma; Naked cuticle homolog 1; Adenomatouspolyposis coli; Immunohistochemistry

DOI：

10.7507/1007-9424.20150317

Video：

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Objective To detect the expressions of NKD1 and APC in breast carcinoma tissues and to explore the clinical significance of their existence and their correlation. Methods The study selected 75 patients with breast carcinoma as the observation group, and their corresponding normal breast tissues from the breast carcinoma tissues more than 5 cm as the control group. The expressions of two proteins were detected by immunohistochemistry. Their relationship with the pathological characteristics of breast carcinoma and the correlation of the two proteins were analyzed. Results The positive expression rates of NKD1 and APC in normal breast tissues were significantl higher than those in breast carcinoma tissues (82.67% vs. 36.00%, 89.33% vs. 45.33%, P < 0.05). The expression of NKD1 was not correlated with the age of patients with breast carcinoma (P > 0.05), while correlated with the degree of differentiation, TNM stage, lymph node metastasis, and remote organ metastasis of breast carcinoma (P < 0.05). The expression of APC was not correlated with the age of patients with breast carcinoma, the degree of differentiation and lymph node metastasis of breast carcinoma (P > 0.05), while correlated with the TNM stage and remote organ metastasis of breast carcinoma (P < 0.05). The expressions of NKD1 and APC in breast carcinoma was positively correlated (r=0.609, P < 0.05). Conclusion NKD1 and APC may be involved in the development and remote organ metastasis of breast carcinoma, and the two proteins may have a synergistic role in breast carcinoma.

Citation： CAOZi-long, ZHANGZhuo, HUJian-li, SHENXuan-san. Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(10): 1226-1229. doi: 10.7507/1007-9424.20150317 Copy

1.	郑莹, 吴春晓, 张敏璐.乳腺癌在中国的流行状况和疾病特征.中国癌症杂志, 2013, 23(8):561-569.
2.	Borer JS, Hochrcitcr CA, Supino PG, et al. Importance of right ventricu-lar performance measurement in selecting asymptomatic patients with mtral regurgitation for valve surger. Adv Cardio1, 2002, 39:144-152.
3.	唐金海, 姚宇锋.早期乳腺癌的诊断和外科治疗进展.中国普外基础与临床杂志, 2011, 18(9):913-916.
4.	李汛, 孟文勃, 白仲添, 等.信号通路在肝细胞癌发展中的作用.中国普外基础与临床杂志, 2014, 21(7):916-920.
5.	陈莹摘译.根据解剖位置以及遗传不稳定类型, 大肠癌的典型Wnt信号通路表现出不同的突变谱.中国普外基础与临床杂志, 2011, 18(11):1211.
6.	Ono M, Yin P, Navarro A, et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril, 2014, 101(5):1441-1449.
7.	赵静, 张春雷, 房兴堂, 等. WNT信号通路的研究进展.中国牛业科学, 2012, 38(1):33-37.
8.	Larraguibel J, Weiss AR, Pasula DJ, et al. Wnt-ligand dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell, 2015, 26(12):2375-2384.
9.	王亚红, 孙兴华, 朱志图, 等. BUB1与APC蛋白在不同乳腺组织中的表达及临床意义.中国癌症杂志, 2008, 18(12):888-892.
10.	McEwen DG, Peifer M. Wnt signaling:the naked truth? Curr Biol, 2001, 11(13):8524-8526.
11.	GaliatsatosP, Foulkes D. Familial adenomatous polyposis. Am J Gastroenterol, 2006, 101(2):385-398.
12.	余泽兵, 舒亦斌, 雷慧慧.胃腺癌组织Naked1和MMP-9表达及其相关性研究.浙江中西医结合杂志, 2013, 23(1):9-11.
13.	陈巍, 王成盛, 章蔚.乳腺癌组织中NKD1和β-catenin蛋白的表达及对预后判断价值的研究.中国现代医生, 2012, 50(31):62-63.
14.	赵婧, 荆洋, 吕宗舜, 等.有大肠癌家族史的大肠多发性腺瘤患者瘤组织中APC, Survivin蛋白的表达及意义.山东医药, 2015, 55(6):24-27.
15.	Zhang S, Wang Y, Dai SD, et al. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer, 2011, 11:186.
16.	Wharton KA Jr, Zimmermann G, Rousset R, et al. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol, 2001, 234(1):93-106.
17.	闫康. NKD1参与介导miR-195对骨肉瘤转移的抑制作用.第四军医大学, 2013.
18.	李玉婷. NKD1, Wnt2b在胃癌组织及癌前病变中的表达及其相互关系.兰州大学, 2011.
19.	赵月, 孙波, 张盛, 等.非小细胞肺癌中Naked1的表达及意义.临床与实验病理学杂志, 2012, 28(3):257-260.
20.	Lapierre M, Bonnet S, Bascoul-Mollevi C, et al. RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest, 2014, 124(5):1899-1913.
21.	肖忠盛, 梁庆模. APC的结构与功能的研究进展.现代医药卫生, 2010, 26(4):535-537.
22.	戴越盟, 严律南.β-连环蛋白及APC基因与肿瘤.中国普外基础与临床志, 2002, 9(4):291-293.
23.	孙政, 曹杰, 梁立源, 等. CCN2及APC蛋白在结直肠癌组织中的表达及意义.广东医学, 2012, 33(11):1556-1559.
24.	Van Noort M, Meeldijk J, van der Zee R, et al. Wnt si gnaling controls the phosphorylation status of beta-catenin. J Biol Chem, 2002, 277(20):17901-17905.
25.	Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell, 2012, 149(6):1192-1205.

1. 郑莹, 吴春晓, 张敏璐.乳腺癌在中国的流行状况和疾病特征.中国癌症杂志, 2013, 23(8):561-569.
2. Borer JS, Hochrcitcr CA, Supino PG, et al. Importance of right ventricu-lar performance measurement in selecting asymptomatic patients with mtral regurgitation for valve surger. Adv Cardio1, 2002, 39:144-152.
3. 唐金海, 姚宇锋.早期乳腺癌的诊断和外科治疗进展.中国普外基础与临床杂志, 2011, 18(9):913-916.
4. 李汛, 孟文勃, 白仲添, 等.信号通路在肝细胞癌发展中的作用.中国普外基础与临床杂志, 2014, 21(7):916-920.
5. 陈莹摘译.根据解剖位置以及遗传不稳定类型, 大肠癌的典型Wnt信号通路表现出不同的突变谱.中国普外基础与临床杂志, 2011, 18(11):1211.
6. Ono M, Yin P, Navarro A, et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril, 2014, 101(5):1441-1449.
7. 赵静, 张春雷, 房兴堂, 等. WNT信号通路的研究进展.中国牛业科学, 2012, 38(1):33-37.
8. Larraguibel J, Weiss AR, Pasula DJ, et al. Wnt-ligand dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell, 2015, 26(12):2375-2384.
9. 王亚红, 孙兴华, 朱志图, 等. BUB1与APC蛋白在不同乳腺组织中的表达及临床意义.中国癌症杂志, 2008, 18(12):888-892.
10. McEwen DG, Peifer M. Wnt signaling:the naked truth? Curr Biol, 2001, 11(13):8524-8526.
11. GaliatsatosP, Foulkes D. Familial adenomatous polyposis. Am J Gastroenterol, 2006, 101(2):385-398.
12. 余泽兵, 舒亦斌, 雷慧慧.胃腺癌组织Naked1和MMP-9表达及其相关性研究.浙江中西医结合杂志, 2013, 23(1):9-11.
13. 陈巍, 王成盛, 章蔚.乳腺癌组织中NKD1和β-catenin蛋白的表达及对预后判断价值的研究.中国现代医生, 2012, 50(31):62-63.
14. 赵婧, 荆洋, 吕宗舜, 等.有大肠癌家族史的大肠多发性腺瘤患者瘤组织中APC, Survivin蛋白的表达及意义.山东医药, 2015, 55(6):24-27.
15. Zhang S, Wang Y, Dai SD, et al. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer, 2011, 11:186.
16. Wharton KA Jr, Zimmermann G, Rousset R, et al. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol, 2001, 234(1):93-106.
17. 闫康. NKD1参与介导miR-195对骨肉瘤转移的抑制作用.第四军医大学, 2013.
18. 李玉婷. NKD1, Wnt2b在胃癌组织及癌前病变中的表达及其相互关系.兰州大学, 2011.
19. 赵月, 孙波, 张盛, 等.非小细胞肺癌中Naked1的表达及意义.临床与实验病理学杂志, 2012, 28(3):257-260.
20. Lapierre M, Bonnet S, Bascoul-Mollevi C, et al. RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest, 2014, 124(5):1899-1913.
21. 肖忠盛, 梁庆模. APC的结构与功能的研究进展.现代医药卫生, 2010, 26(4):535-537.
22. 戴越盟, 严律南.β-连环蛋白及APC基因与肿瘤.中国普外基础与临床志, 2002, 9(4):291-293.
23. 孙政, 曹杰, 梁立源, 等. CCN2及APC蛋白在结直肠癌组织中的表达及意义.广东医学, 2012, 33(11):1556-1559.
24. Van Noort M, Meeldijk J, van der Zee R, et al. Wnt si gnaling controls the phosphorylation status of beta-catenin. J Biol Chem, 2002, 277(20):17901-17905.
25. Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell, 2012, 149(6):1192-1205.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma

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