原发性甲状腺淋巴瘤4例临床分析_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 陈晨 ^1,2 , 高庆军 ¹ ,  赵代伟 ³

1. ;
2. ;
3. ;

Corresponding author：

赵代伟, Email: zhaodw@hotmail.com

Keywords：

甲状腺淋巴瘤; 诊断; 治疗; 预后

DOI：

10.7507/1007-9424.20160066

Video：

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目的总结原发性甲状腺淋巴瘤的临床表现、诊断方法、治疗及预后。方法回顾性分析我院2015年收治的4例原发性甲状腺淋巴瘤的相关资料并结合国内外相关文献进行分析。结果 4例患者术前行细针穿刺吸取细胞学检查未能明确诊断，均诊断为桥本甲状腺炎，术后通过免疫组织化学诊断为淋巴瘤，其中黏膜相关淋巴组织淋巴瘤及弥漫性大B细胞淋巴瘤各2例。结论原发性甲状腺淋巴瘤的治疗以综合治疗为主，术前确诊率低，手术只为明确诊断及缓解症状，确定其组织学分型后采用相应的放化疗，患者的分期、组织学分型及采用合适的治疗方式与预后都是相关的。

Citation： 陈晨, 高庆军, 赵代伟. 原发性甲状腺淋巴瘤4例临床分析. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(2): 240-242. doi: 10.7507/1007-9424.20160066 Copy

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2.	Thieblemont C, Mayer A, Dumontet C, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab, 2002, 87(1):105-111.
3.	Graff-Baker A, Roman SA, Thomas DC, et al. Prognosis of primary thyroid lymphoma:demographic, clinical, and pathologic predictors of survival in 1 408 cases. Surgery, 2009, 146(6):1105-1115.
4.	Avenia N, Ragusa M, Cirocchi R, et al. Surgical treatment of primitive thyroid lymphoma. Tumori, 2010, 95(6):712-719.
5.	Rawal A, Finn WG, Schnitzer B, et al. Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas. Arch Pathol Lab Med, 2007, 131(11):1673-1678.
6.	马艳梅, 吕怀盛. 甲状腺乳头状癌并套细胞淋巴瘤1例. 宁夏医科大学学报, 2015, 37(4):479-480, 封2.
7.	欧阳小明, 郝卓芳, 郅程, 等. 甲状腺原发性结外NK/T细胞淋巴瘤1例并文献复习. 中国普通外科杂志, 2015, 24(5):739-742.
8.	宋扬, 刘华, 卢满存. 13例原发性甲状腺淋巴瘤的临床分析. 重庆医学, 2012, 41(36):3844-3846.
9.	Wang SA, Rahemtullah A, Faquin WC, et al. Hodgkin,s lymphoma of the thyroid:a clinicopathologic study of five cases and review of the literature. Mod Pathol, 2005, 18(12):1577-1584.
10.	Pedersen RK, Pedersen NT. Primary non-Hodgkin,s lymphoma of the thyroid gland:a population based study. Histopathology, 1996, 28(1):25-32.
11.	Kumar R, Khosla D, Kumar N, et al. Survival and failure outcomes in primary thyroid lymphomas:a single centre experience of combined modality approach. J Thyroid Res, 2013, 2013:269034.
12.	杨盼, 孙映荷, 马步云, 等. 原发性甲状腺非霍奇金淋巴瘤的超声征象分析. 中国普外基础与临床杂志, 2014, 21(9):1092-1096.
13.	Cha C, Chen H, Westra WH, et al. Primary thyroid lymphoma:can the diagnosis be made solely by fine-needle aspiration? Ann Surg Oncol, 2002, 9(3):298-302.
14.	Morgen EK, Geddie W, Boerner S, et al. The role of fine-needle aspiration in the diagnosis of thyroid lymphoma:a retrospective study of nine cases and review of published series. J Clin Pathol, 2010, 63(2):129-133.
15.	Sangalli G, Serio G, Zampatti C, et al. Fine needle aspiration cytology of primary lymphoma of the thyroid:a report of 17 cases. Cytopathology, 2001, 12(4):257-263.
16.	Chiofalo MG, Corazzelli G, Franco R, et al. Thyroid lymphoma:early clinical suspicion May be critical for cure. J Endocrinol Invest, 2008, 31(8):739-740.
17.	Klyachkin ML, Schwartz RW, Cibull M, et al. Thyroid lymphoma:is there a role for surgery. Am Surg, 1998, 64(3):234-238.
18.	Sarinah B, Hisham AN. Primary lymphoma of the thyroid:diagnostic and therapeutic considerations. Asian J Surg, 2010, 33(1):20-24.
19.	李昌幼, 罗佐杰. 原发性甲状腺淋巴瘤的发病机制及诊治现状. 实用医学杂志, 2013, 29(3):341-342.
20.	徐晓帆, 顾军, 张新华, 等. 甲状腺黏膜相关淋巴组织淋巴瘤的诊断及治疗. 江苏医药, 2014, 40(20):2485-2487.
21.	Harrington KJ, Michalaki VJ, Vini L, et al. Management of non-Hodgkin,s lymphoma of the thyroid:the royal marsden hospital experience. Br J Radiol, 2005, 78(929):405-410.

1. Derringer GA, Thompson LD, Frommelt RA, et al. Malignant lymphoma of the thyroid gland:a clinicopathologic study of 108 cases. Am J Surg Pathol, 2000, 24(5):623-639.
2. Thieblemont C, Mayer A, Dumontet C, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab, 2002, 87(1):105-111.
3. Graff-Baker A, Roman SA, Thomas DC, et al. Prognosis of primary thyroid lymphoma:demographic, clinical, and pathologic predictors of survival in 1 408 cases. Surgery, 2009, 146(6):1105-1115.
4. Avenia N, Ragusa M, Cirocchi R, et al. Surgical treatment of primitive thyroid lymphoma. Tumori, 2010, 95(6):712-719.
5. Rawal A, Finn WG, Schnitzer B, et al. Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas. Arch Pathol Lab Med, 2007, 131(11):1673-1678.
6. 马艳梅, 吕怀盛. 甲状腺乳头状癌并套细胞淋巴瘤1例. 宁夏医科大学学报, 2015, 37(4):479-480, 封2.
7. 欧阳小明, 郝卓芳, 郅程, 等. 甲状腺原发性结外NK/T细胞淋巴瘤1例并文献复习. 中国普通外科杂志, 2015, 24(5):739-742.
8. 宋扬, 刘华, 卢满存. 13例原发性甲状腺淋巴瘤的临床分析. 重庆医学, 2012, 41(36):3844-3846.
9. Wang SA, Rahemtullah A, Faquin WC, et al. Hodgkin,s lymphoma of the thyroid:a clinicopathologic study of five cases and review of the literature. Mod Pathol, 2005, 18(12):1577-1584.
10. Pedersen RK, Pedersen NT. Primary non-Hodgkin,s lymphoma of the thyroid gland:a population based study. Histopathology, 1996, 28(1):25-32.
11. Kumar R, Khosla D, Kumar N, et al. Survival and failure outcomes in primary thyroid lymphomas:a single centre experience of combined modality approach. J Thyroid Res, 2013, 2013:269034.
12. 杨盼, 孙映荷, 马步云, 等. 原发性甲状腺非霍奇金淋巴瘤的超声征象分析. 中国普外基础与临床杂志, 2014, 21(9):1092-1096.
13. Cha C, Chen H, Westra WH, et al. Primary thyroid lymphoma:can the diagnosis be made solely by fine-needle aspiration? Ann Surg Oncol, 2002, 9(3):298-302.
14. Morgen EK, Geddie W, Boerner S, et al. The role of fine-needle aspiration in the diagnosis of thyroid lymphoma:a retrospective study of nine cases and review of published series. J Clin Pathol, 2010, 63(2):129-133.
15. Sangalli G, Serio G, Zampatti C, et al. Fine needle aspiration cytology of primary lymphoma of the thyroid:a report of 17 cases. Cytopathology, 2001, 12(4):257-263.
16. Chiofalo MG, Corazzelli G, Franco R, et al. Thyroid lymphoma:early clinical suspicion May be critical for cure. J Endocrinol Invest, 2008, 31(8):739-740.
17. Klyachkin ML, Schwartz RW, Cibull M, et al. Thyroid lymphoma:is there a role for surgery. Am Surg, 1998, 64(3):234-238.
18. Sarinah B, Hisham AN. Primary lymphoma of the thyroid:diagnostic and therapeutic considerations. Asian J Surg, 2010, 33(1):20-24.
19. 李昌幼, 罗佐杰. 原发性甲状腺淋巴瘤的发病机制及诊治现状. 实用医学杂志, 2013, 29(3):341-342.
20. 徐晓帆, 顾军, 张新华, 等. 甲状腺黏膜相关淋巴组织淋巴瘤的诊断及治疗. 江苏医药, 2014, 40(20):2485-2487.
21. Harrington KJ, Michalaki VJ, Vini L, et al. Management of non-Hodgkin,s lymphoma of the thyroid:the royal marsden hospital experience. Br J Radiol, 2005, 78(929):405-410.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

原发性甲状腺淋巴瘤4例临床分析

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