Correlation of MSCT Imaging Feature with Pathologic Grading of Pancreatic Neuroen-docrine Neoplasm_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 WANGQi-yan , HUANGZi-xing , WUMing-peng , ZHENGXing-ju , QUYa-li ,  SONGBin

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

SONGBin, Email: cjr.songbin@vip.163.com

Keywords：

Pancreatic neuroendocrine neoplasm; Pathological grading; MSCT

DOI：

10.7507/1007-9424.20160067

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate value of MSCT imaging on differentiating low grade pancreatic neuroendo-crine neoplasms (pNENs) from non-low grade pNENs. Method The clinical and CT data of 32 patients with pNENs,who were confirmed by pathological diagnosis from January 2014 to August 2015,were collected and analyzed retrospec-tively. Results There were 15 patients with grade 1 in the low grade pNENs group,there were 11 patients with grade 2 and 6 patients with grade 3 in the non-low grade pNENs group.Compared with the low grade pNENs,the non-low grade pNENs had the larger diameter of the tumor (P=0.007),irregular tumor shape (P=0.006),obscure tumor margin (P=0.003),peripancreatic tissue or vascular invasion (P=0.036),lymphadenopathy (P=0.003),distant metastasis (P=0.019),lower absolute enhancement of tumor at the arterial (P=0.003) and the relative enhancement of tumor at the arterial (P=0.013). Conclusion The analysis of MSCT features might help for differentiating low grade pNENs from non-low grade pNENs,so that more timely selection of appropriate treatment strategies would be made.

Citation： WANGQi-yan, HUANGZi-xing, WUMing-peng, ZHENGXing-ju, QUYa-li, SONGBin. Correlation of MSCT Imaging Feature with Pathologic Grading of Pancreatic Neuroen-docrine Neoplasm. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(2): 243-247. doi: 10.7507/1007-9424.20160067 Copy

1.	CSCO神经内分泌肿瘤专家委员会.中国胃肠胰神经内分泌肿瘤专家共识. 临床肿瘤学杂志, 2013, 18(9):815-832.
2.	章婷婷, 余永强, 钱银锋, 等. 胰腺神经内分泌肿瘤MSCT表现及良恶性鉴别. 临床放射学杂志, 2014, 33(5):722-726.
3.	Pelosi G, Bresaola E, Bogina G, et al. Endocrine tumors of the pancreas:Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy:a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol, 1996, 27(11):1124-1134.
4.	Gallotti A, Johnston RP, Bonaffini PA, et al. Incidental neuroendo-crine tumors of the pancreas:MDCT findings and features of malignancy. AJR Am J Roentgenol, 2013, 200(2):355-362.
5.	Rodallec M, Vilgrain V, Couvelard A, et al. Endocrine pancreatic tumours and helical CT:contrast enhancement is correlated with microvascular density, histoprognostic factors and survival. Pancreatology, 2006, 6(1-2):77-85.
6.	D'Assignies G, Couvelard A, Bahrami SA, et al. Pancreatic endocrine tumors:tumor blood flow assessed with perfusion CT reflects angiogenesis and correlates with prognostic factors. Radiology, 2009, 250(2):407-416.
7.	Tatsumoto S, Kodama Y, Sakurai Y, et al. Pancreatic neuroendocrine neoplasm:correlation between computed tomography enhancement patterns and prognostic factors of surgical and endoscopic ultra-sound-guided fine-needle aspiration biopsy specimens. Abdom Imaging, 2013, 38(2):358-366.
8.	Rindi G, Arnold R, Bosman F, et al. Nomenclature and classification of neuroendocrine neoplasms of the digestive system//Bosman F, Carneiro F, Hruban R, et al (eds). WHO classification of tumors of the digestive system. Lyon:IARC Press, 2010:13-14.
9.	Rappeport ED, Hansen CP, Kjaer A, et al. Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol, 2006, 47(3):248-256.
10.	Bettini R, Boninsegna L, Mantovaniwet A. Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours. Ann Oncol, 2008, 19(5):903-908.
11.	Foti G, Boninsegna L, Falconi M, et al. Preoperative assessment of nonfunctioning pancreatic endocrine tumours:role of MDCT and MRI. Radiol Med, 2013, 118(7):1082-1101.
12.	徐学勤, 缪飞, 林晓珠, 等. 胰腺神经内分泌肿瘤影像学特征与病理分级的关系. 诊断学理论与实践, 2014, 13(5):481-486.
13.	Luo Y, Dong Z, Chen J, et al. Pancreatic neuroendocrine tumours:correlation between MSCT features and pathological classification. Eur Radiol, 2014, 24(11):2945-2952.
14.	Poultsides GA, Huang LC, Chen Y, et al. Pancreatic neuroendocrine tumors:radiographic calcifications correlate with grade and metastasis. Ann Surg Oncol, 2012,19(7):2295-2303.
15.	Horton KM, Hruban RH, Yeo C, et al. Multi-detector row CT of pancreatic islet cell tumors. Radiographics, 2006, 26(2):453-464.
16.	Rha SE, Jung SE, Lee KH, et al. CT and MR imaging findings of endocrine tumor of the pancreas according to WHO classification. Eur J Radiol, 2007, 62(3):371-377.
17.	Bettini R, Partelli S, Boninsegna L, et al. Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor. Surgery, 2011, 150(1):75-82.
18.	Osawa A, Sumiyama Y, Watanabe M, et al. Single case of renalcell carcinoma and endocrine pancreation head cancer occurring with von Hippel-Lindau disease. J Hepatobiliary Pancreat Surg, 2006, 13(2):174-180.
19.	GrÖzinger G, GrÖzingger A, Horger M. The role of volume perfusion CT in the diagnosis of pathologies of the pancreas. Rofo, 2014, 186(12):1082-1093.
20.	Worhunsky DJ, Krampitz GW, Poullos PD, et al. Pancreatic neuroen-docrine tumours:hypoenhancement on arterial phase computed tomography predicts biological aggressiveness. HPB (Oxford), 2014, 16(4):304-311.

1. CSCO神经内分泌肿瘤专家委员会.中国胃肠胰神经内分泌肿瘤专家共识. 临床肿瘤学杂志, 2013, 18(9):815-832.
2. 章婷婷, 余永强, 钱银锋, 等. 胰腺神经内分泌肿瘤MSCT表现及良恶性鉴别. 临床放射学杂志, 2014, 33(5):722-726.
3. Pelosi G, Bresaola E, Bogina G, et al. Endocrine tumors of the pancreas:Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy:a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol, 1996, 27(11):1124-1134.
4. Gallotti A, Johnston RP, Bonaffini PA, et al. Incidental neuroendo-crine tumors of the pancreas:MDCT findings and features of malignancy. AJR Am J Roentgenol, 2013, 200(2):355-362.
5. Rodallec M, Vilgrain V, Couvelard A, et al. Endocrine pancreatic tumours and helical CT:contrast enhancement is correlated with microvascular density, histoprognostic factors and survival. Pancreatology, 2006, 6(1-2):77-85.
6. D'Assignies G, Couvelard A, Bahrami SA, et al. Pancreatic endocrine tumors:tumor blood flow assessed with perfusion CT reflects angiogenesis and correlates with prognostic factors. Radiology, 2009, 250(2):407-416.
7. Tatsumoto S, Kodama Y, Sakurai Y, et al. Pancreatic neuroendocrine neoplasm:correlation between computed tomography enhancement patterns and prognostic factors of surgical and endoscopic ultra-sound-guided fine-needle aspiration biopsy specimens. Abdom Imaging, 2013, 38(2):358-366.
8. Rindi G, Arnold R, Bosman F, et al. Nomenclature and classification of neuroendocrine neoplasms of the digestive system//Bosman F, Carneiro F, Hruban R, et al (eds). WHO classification of tumors of the digestive system. Lyon:IARC Press, 2010:13-14.
9. Rappeport ED, Hansen CP, Kjaer A, et al. Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol, 2006, 47(3):248-256.
10. Bettini R, Boninsegna L, Mantovaniwet A. Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours. Ann Oncol, 2008, 19(5):903-908.
11. Foti G, Boninsegna L, Falconi M, et al. Preoperative assessment of nonfunctioning pancreatic endocrine tumours:role of MDCT and MRI. Radiol Med, 2013, 118(7):1082-1101.
12. 徐学勤, 缪飞, 林晓珠, 等. 胰腺神经内分泌肿瘤影像学特征与病理分级的关系. 诊断学理论与实践, 2014, 13(5):481-486.
13. Luo Y, Dong Z, Chen J, et al. Pancreatic neuroendocrine tumours:correlation between MSCT features and pathological classification. Eur Radiol, 2014, 24(11):2945-2952.
14. Poultsides GA, Huang LC, Chen Y, et al. Pancreatic neuroendocrine tumors:radiographic calcifications correlate with grade and metastasis. Ann Surg Oncol, 2012,19(7):2295-2303.
15. Horton KM, Hruban RH, Yeo C, et al. Multi-detector row CT of pancreatic islet cell tumors. Radiographics, 2006, 26(2):453-464.
16. Rha SE, Jung SE, Lee KH, et al. CT and MR imaging findings of endocrine tumor of the pancreas according to WHO classification. Eur J Radiol, 2007, 62(3):371-377.
17. Bettini R, Partelli S, Boninsegna L, et al. Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor. Surgery, 2011, 150(1):75-82.
18. Osawa A, Sumiyama Y, Watanabe M, et al. Single case of renalcell carcinoma and endocrine pancreation head cancer occurring with von Hippel-Lindau disease. J Hepatobiliary Pancreat Surg, 2006, 13(2):174-180.
19. GrÖzinger G, GrÖzingger A, Horger M. The role of volume perfusion CT in the diagnosis of pathologies of the pancreas. Rofo, 2014, 186(12):1082-1093.
20. Worhunsky DJ, Krampitz GW, Poullos PD, et al. Pancreatic neuroen-docrine tumours:hypoenhancement on arterial phase computed tomography predicts biological aggressiveness. HPB (Oxford), 2014, 16(4):304-311.

Previous Article
原发性甲状腺淋巴瘤4例临床分析
Next Article
Research Progress of Claudins in Breast Cancer

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation of MSCT Imaging Feature with Pathologic Grading of Pancreatic Neuroen-docrine Neoplasm

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content