Progress of Clinical Treatment of Hepatic Alveolar Echinococcosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LUYue-qing ¹ , DENGYong ^2,3 , ZHANGLing-qiang ^2,3 , ZHOUYing ^2,3 , RENLi ^2,3 , YANGDANCairang ^2,3 , HOULizhao ^2,3 , WENHao ⁴ , WANGHai-jiu ^2,3 ,  FANHai-ning ^2,3

1. Medical College of Qinghai University, Xining 810001, Qinghai Province, China;
2. Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China;
3. Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, Qinghai Province, China;
4. The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China;

Corresponding author：

FANHai-ning, Email: fanhaining@medmail.com.cn

Keywords：

Hepatic alveolar echinococcosis; surgical treatment; Liver transplantation; Chemical treatment

DOI：

10.7507/1007-9424.20160147

Video：

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Objective To summarize clinical treatments of hepatic alveolar echinococcosis in recent years and provide a new basis for guiding clinical practice. Methods The relevant literatures about treating hepatic alveolar echinococcosis at home and abroad were reviewed. The clinical curative effect and advantages or disadvantages among various treatments were analyzed. Results The radical surgery was still the primary treatment of hepatic alveolar echinococcosis, liver transplantation was more used in the treatment of the late hepatic alveolar echinococcosis. surgery combined with chemical therapy had an obvously clinical curative effect. Conclusions With a high incidence and poor prognosis of hepatic alveolar echinococcosis, it is difficult to cure. Radical surgery, liver transplantation, chemotherapy and radiation therapy have been used in clinical treatment of hepatic alveolar echinococcosis. It is essential to fully acknowledge indications of various treatments. At the same time, if occurrence and development of this disease could be further researched, it might bring us a new hope of curing hepatic alveolar echinococcosis.

Citation： LUYue-qing, DENGYong, ZHANGLing-qiang, ZHOUYing, RENLi, YANGDANCairang, HOULizhao, WENHao, WANGHai-jiu, FANHai-ning. Progress of Clinical Treatment of Hepatic Alveolar Echinococcosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 547-551. doi: 10.7507/1007-9424.20160147 Copy

1.	邵英梅, 蒋铁民, 吐尔干艾力·阿吉, 等. 根治性及准根治性手术治疗终末期肝泡型包虫病. 中华消化外科杂志, 2011, 10(4):296-298.
2.	McManus DP, Zhang W, Li J, et al. Echinococcosis. Lancet, 2003, 362(9392):1295-1304.
3.	Buttenschoen K, Carli Buttenschoen D, Gruener B, et al. Long-term experience on surgical treatment of alveolar echinococcosis. Langenbecks Arch Surg, 2009, 394(4):689-698.
4.	温浩. 两型肝包虫病手术疗效547例临床分析. 中华消化外科杂志, 2007, 6(1):13-18.
5.	阿依甫汗·阿汗, 吐尔干艾力, 邵英梅, 等. 肝包虫病的外科治疗现状. 肝胆外科杂志, 2009, 17(1):13-14.
6.	温浩, 刘文亚, 邵英梅, 等. 包虫病影像诊断技术和手术治疗进展. 国际医学寄生虫病学杂志, 2009, 36(5):299-306.
7.	Alonso Casado O, Moreno González E, Loinaz segurola C, et al. Results of 22 years of experience in radical surgical treatment of hepatic hydatid cysts. Hepatogastroenterology, 2001, 48(37):235-243.
8.	姚秉礼. 肝泡胀状棘球蚴的诊断和治疗. 中华外科杂志, 1965, 13(6):461.
9.	邵英梅, 蒋铁民, 吐尔干·艾力, 等. 根治性及准根治性手术治疗终末期肝泡型包虫病. 中华消化外科杂志, 2011, 10(4):296-298.
10.	张瑞青, 邵英梅. 肝泡型包虫病不同手术方式的临床疗效分析. 新疆医科大学, 2013:3.
11.	Aydin U, Yazici P, Onen Z, et al. The optimal treatment of hydatid cyst of the liver:radical surgery with a significant reduced risk of recurrence. Turk J Gastroenterol, 2008, 19(1):33-39.
12.	Tagliacozzo s, Miccini M, Amore Bonapasta s, et al. surgical treatment of hydatid disease of the liver:25 years of experience. Am J Surg, 2011, 201(6):797-804.
13.	Kadry Z, Renner EC, Bachmann LM, et al. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg, 2005, 92(9):1110-1116.
14.	罗兰云, 姚豫桐, 邹海波, 等."掏核式肝切除法"治疗晚期巨大肝泡型包虫病9例临床分析. 实用医院临床杂志, 2015, 12(2):56-58.
15.	李作安, 吐尔干艾力·阿吉, 冉博, 等."减体积式病灶肝切除" 治疗晚期肝巨大泡型包虫病的临床应用. 中国普通外科杂志, 2012, 21(7):864-868.
16.	Katkhouda N, Fabiani P, Benizri E, et al. Laser resection of a liver hydatid cyst under video laparoscopy. Br J Surg, 1992, 79(6):560-561.
17.	Nari GA, Palacios Rodriguez Ó, Russo N, et al. Laparoscopic approach to liver hydatidosis:initial experience. Cir Esp, 2015, 93(4):248-251.
18.	Gillet M, Miguet JP, Mantion G, et al. Orthotopic liver transplantation in alveolar echinococcosis of the liver:analysis of a series of six patients. Transplant Proc, 1988, 20(1 suppl 1):573-576.
19.	温浩, 栾梅香, 王喜燕, 等. 国内首例肝移植治疗肝泡型包虫病报告. 地方病通报, 2001, 16(3):100.
20.	Bresson-Hadni s, Koch s, Miguet JP, et al. Indications and results of liver transplantation for Echinococcus alveolar infection:an overview. Langenbecks Arch Surg, 2003, 388(4):231-238.
21.	温浩. 肝包虫病诊断和手术技术治疗新进展. 中华消化外科杂志, 2011, 10(4):290-292.
22.	温浩, 董家鸿, 张金辉, 等. 体外肝切除联合自体肝移植治疗肝泡型包虫病. 中华消化外科杂志, 2011, 10(2):148-149.
23.	王海, 景鸿恩, 徐小青, 等. 自体肝脏移植治疗晚期泡型肝包虫病. 腹部外科, 2011, 24(2):99-100.
24.	WHO Informal Working Group on Echinococcosis. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ, 1996, 74(3):231-242.
25.	Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop, 2010, 114(1):1-16.
26.	Wen H, New RR, Muhmut M, et al. Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine. Parasitology, 1996, 113(Pt 2):111-121.
27.	Cobo F, Yarnoz C, sesma B, et al. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intraabdominal hydatisosis caused by echinococcus granulosus. Trop Med Int Health, 1998, 3(6):462-466.
28.	Kern P, Abboud P, Kern WV, stich A, et al. Critical appraisal of nitazoxanide for the treatment of alveolar echinococcosis. Am J Trop Med Hyg, 2008, 79(1):119.
29.	Tappe D, Müller A, Frosch M, et al. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. Ann Trop Med Parasitol, 2009, 103(2):177-181.
30.	宋书邦. 人体包虫病的超声引导穿刺硬化治疗. 中国超声医学杂志, 1996, 12(增刊):60-62.
31.	Karaman B, Battal B, Ustunsoz B, et al. Percutaneous treatment of a primary pancreatic hydatid cyst using a catheterization technique. Korean J Radiol, 2012, 13(2):232-236.
32.	Brunetti E, Filice C. Radiofrequency thermal ablation of echinococcal liver cysts. Lancet, 2001, 358(9291):1464.
33.	Bastid C, Ayela P, sahel J. Percutaneous treatment of a complex hydatid cyst of the liver under sonographic control. Report of the first case. Gastroenterol Clin Biol, 2005, 29(2):191-192.
34.	Du XL, Ma QJ, Wu T, et al. Treatment of hepatic cysts by B-ultrasoundguided radiofrequency ablation. Hepatobiliary Pancreat Dis Int, 2007, 6(3):330-332.
35.	Papaconstantinou I, Kontos M, Prassas E, et al. Radio frequency ablation (RFA)-assisted pericystectomy for hepatic echinococcosis:an alternative technique. Surg Laparosc Endosc Percutan Tech, 2006, 16(5):338-341.
36.	Zacharoulis D, Poultsidis A, Roundas C, et al. Liver hydatid disease:radiofrequency-assisted pericystectomy. Ann R Coll Surg Engl, 2006, 88(5):499-500.
37.	Vuitton DA, Millon L, Gottstein B, et al. Proceedings of the International symposium-Innovation for the management of echinococcosis. Besançon, March 27-29, 2014. Parasite, 2014, 21:28.
38.	张永国, 张成武, 窦拉加. 高强度聚焦超声治疗巨大肝泡球蚴病一例. 中国寄生虫学与寄生虫病杂志, 2005, 23(4):256.
39.	叶华, 王炜, 景涛, 等. 复频高能聚焦超声治疗小鼠泡球蚴病的实验研究. 中国寄生虫学与寄生虫病杂志, 2011, 29(5):353-357.
40.	陈亮. 包虫病放射治疗的研究进展. 新疆医科大学学报, 2013, 36(4):557-559.
41.	Ulger s, Barut H, Tunc M, et al. Radiation therapy for resistant sternal hydatid disease. Strahlenther Onkol, 2013, 189(6):508-509.
42.	包永星, 张月芬, 倪雅琼, 等. 电子线治疗大鼠继发性泡球蚴病的实验研究. 中国寄生虫学与寄生虫病杂志, 2011, 29(2):127-129.
43.	包永星, 毛睿, 齐洪志, 等. X线照射泡球蚴原头节的体外实验研究. 中国寄生虫学与寄生虫病杂志, 2011, 29(3):208-211.
44.	包永星, 毛睿, 谢增如, 等. 放射治疗骨棘球蚴病一例. 中国寄生虫学与寄生虫病杂志, 2010, 28(4):F0003.
45.	王欣, 王小虎, 包根书, 等. 放射线治疗包虫病的实验研究. 中国人兽共患病学报, 2009, 25(7):653-656.
46.	schmid M, Pendl G, samonigg H, et al. Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis, 1998, 26(6):1379-1382.
47.	Zhang YF, Xie ZR, Ni YQ, et al. Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats. Chin Med J (Engl), 2011, 124(18):2845-2848.
48.	Gschwantler M, Brownstone E, Erben WD, et al. Combined endoscopic and pharmaceutical treatment of alveolar echinococcosis with rupture into the biliary tree. Gastrointest Endosc, 1994, 40(2 Pt 1):238-241.
49.	Adas G, Arikan s, Gurbuz E, et al. Comparison of endoscopic therapeutic modalities for postoperative biliary fistula of liver hydatid cyst:a retrospective multicentric study. Surg Laparosc Endosc Percutan Tech, 2010, 20(4):223-227.
50.	Akbulut s, senol A, sezgin A, et al. Radical vs conservative surgery for hydatid liver cysts:experience from single center. World J Gastroenterol, 2010, 16(8):953-959.
51.	Krasniqi A, Bicaj B, Limani D, et al. The role of perioperative endoscopic retrograde cholangiopancreatography and biliary drainage in large liver hydatid cysts. Sci World J, 2014, 2014:301891.
52.	王科燕, 杜新远, 张永军, 等. 中草药治疗棘球蚴病的研究概况. 西北药学杂志, 2009, 24(3):240-242.

1. 邵英梅, 蒋铁民, 吐尔干艾力·阿吉, 等. 根治性及准根治性手术治疗终末期肝泡型包虫病. 中华消化外科杂志, 2011, 10(4):296-298.
2. McManus DP, Zhang W, Li J, et al. Echinococcosis. Lancet, 2003, 362(9392):1295-1304.
3. Buttenschoen K, Carli Buttenschoen D, Gruener B, et al. Long-term experience on surgical treatment of alveolar echinococcosis. Langenbecks Arch Surg, 2009, 394(4):689-698.
4. 温浩. 两型肝包虫病手术疗效547例临床分析. 中华消化外科杂志, 2007, 6(1):13-18.
5. 阿依甫汗·阿汗, 吐尔干艾力, 邵英梅, 等. 肝包虫病的外科治疗现状. 肝胆外科杂志, 2009, 17(1):13-14.
6. 温浩, 刘文亚, 邵英梅, 等. 包虫病影像诊断技术和手术治疗进展. 国际医学寄生虫病学杂志, 2009, 36(5):299-306.
7. Alonso Casado O, Moreno González E, Loinaz segurola C, et al. Results of 22 years of experience in radical surgical treatment of hepatic hydatid cysts. Hepatogastroenterology, 2001, 48(37):235-243.
8. 姚秉礼. 肝泡胀状棘球蚴的诊断和治疗. 中华外科杂志, 1965, 13(6):461.
9. 邵英梅, 蒋铁民, 吐尔干·艾力, 等. 根治性及准根治性手术治疗终末期肝泡型包虫病. 中华消化外科杂志, 2011, 10(4):296-298.
10. 张瑞青, 邵英梅. 肝泡型包虫病不同手术方式的临床疗效分析. 新疆医科大学, 2013:3.
11. Aydin U, Yazici P, Onen Z, et al. The optimal treatment of hydatid cyst of the liver:radical surgery with a significant reduced risk of recurrence. Turk J Gastroenterol, 2008, 19(1):33-39.
12. Tagliacozzo s, Miccini M, Amore Bonapasta s, et al. surgical treatment of hydatid disease of the liver:25 years of experience. Am J Surg, 2011, 201(6):797-804.
13. Kadry Z, Renner EC, Bachmann LM, et al. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg, 2005, 92(9):1110-1116.
14. 罗兰云, 姚豫桐, 邹海波, 等."掏核式肝切除法"治疗晚期巨大肝泡型包虫病9例临床分析. 实用医院临床杂志, 2015, 12(2):56-58.
15. 李作安, 吐尔干艾力·阿吉, 冉博, 等."减体积式病灶肝切除" 治疗晚期肝巨大泡型包虫病的临床应用. 中国普通外科杂志, 2012, 21(7):864-868.
16. Katkhouda N, Fabiani P, Benizri E, et al. Laser resection of a liver hydatid cyst under video laparoscopy. Br J Surg, 1992, 79(6):560-561.
17. Nari GA, Palacios Rodriguez Ó, Russo N, et al. Laparoscopic approach to liver hydatidosis:initial experience. Cir Esp, 2015, 93(4):248-251.
18. Gillet M, Miguet JP, Mantion G, et al. Orthotopic liver transplantation in alveolar echinococcosis of the liver:analysis of a series of six patients. Transplant Proc, 1988, 20(1 suppl 1):573-576.
19. 温浩, 栾梅香, 王喜燕, 等. 国内首例肝移植治疗肝泡型包虫病报告. 地方病通报, 2001, 16(3):100.
20. Bresson-Hadni s, Koch s, Miguet JP, et al. Indications and results of liver transplantation for Echinococcus alveolar infection:an overview. Langenbecks Arch Surg, 2003, 388(4):231-238.
21. 温浩. 肝包虫病诊断和手术技术治疗新进展. 中华消化外科杂志, 2011, 10(4):290-292.
22. 温浩, 董家鸿, 张金辉, 等. 体外肝切除联合自体肝移植治疗肝泡型包虫病. 中华消化外科杂志, 2011, 10(2):148-149.
23. 王海, 景鸿恩, 徐小青, 等. 自体肝脏移植治疗晚期泡型肝包虫病. 腹部外科, 2011, 24(2):99-100.
24. WHO Informal Working Group on Echinococcosis. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ, 1996, 74(3):231-242.
25. Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop, 2010, 114(1):1-16.
26. Wen H, New RR, Muhmut M, et al. Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine. Parasitology, 1996, 113(Pt 2):111-121.
27. Cobo F, Yarnoz C, sesma B, et al. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intraabdominal hydatisosis caused by echinococcus granulosus. Trop Med Int Health, 1998, 3(6):462-466.
28. Kern P, Abboud P, Kern WV, stich A, et al. Critical appraisal of nitazoxanide for the treatment of alveolar echinococcosis. Am J Trop Med Hyg, 2008, 79(1):119.
29. Tappe D, Müller A, Frosch M, et al. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. Ann Trop Med Parasitol, 2009, 103(2):177-181.
30. 宋书邦. 人体包虫病的超声引导穿刺硬化治疗. 中国超声医学杂志, 1996, 12(增刊):60-62.
31. Karaman B, Battal B, Ustunsoz B, et al. Percutaneous treatment of a primary pancreatic hydatid cyst using a catheterization technique. Korean J Radiol, 2012, 13(2):232-236.
32. Brunetti E, Filice C. Radiofrequency thermal ablation of echinococcal liver cysts. Lancet, 2001, 358(9291):1464.
33. Bastid C, Ayela P, sahel J. Percutaneous treatment of a complex hydatid cyst of the liver under sonographic control. Report of the first case. Gastroenterol Clin Biol, 2005, 29(2):191-192.
34. Du XL, Ma QJ, Wu T, et al. Treatment of hepatic cysts by B-ultrasoundguided radiofrequency ablation. Hepatobiliary Pancreat Dis Int, 2007, 6(3):330-332.
35. Papaconstantinou I, Kontos M, Prassas E, et al. Radio frequency ablation (RFA)-assisted pericystectomy for hepatic echinococcosis:an alternative technique. Surg Laparosc Endosc Percutan Tech, 2006, 16(5):338-341.
36. Zacharoulis D, Poultsidis A, Roundas C, et al. Liver hydatid disease:radiofrequency-assisted pericystectomy. Ann R Coll Surg Engl, 2006, 88(5):499-500.
37. Vuitton DA, Millon L, Gottstein B, et al. Proceedings of the International symposium-Innovation for the management of echinococcosis. Besançon, March 27-29, 2014. Parasite, 2014, 21:28.
38. 张永国, 张成武, 窦拉加. 高强度聚焦超声治疗巨大肝泡球蚴病一例. 中国寄生虫学与寄生虫病杂志, 2005, 23(4):256.
39. 叶华, 王炜, 景涛, 等. 复频高能聚焦超声治疗小鼠泡球蚴病的实验研究. 中国寄生虫学与寄生虫病杂志, 2011, 29(5):353-357.
40. 陈亮. 包虫病放射治疗的研究进展. 新疆医科大学学报, 2013, 36(4):557-559.
41. Ulger s, Barut H, Tunc M, et al. Radiation therapy for resistant sternal hydatid disease. Strahlenther Onkol, 2013, 189(6):508-509.
42. 包永星, 张月芬, 倪雅琼, 等. 电子线治疗大鼠继发性泡球蚴病的实验研究. 中国寄生虫学与寄生虫病杂志, 2011, 29(2):127-129.
43. 包永星, 毛睿, 齐洪志, 等. X线照射泡球蚴原头节的体外实验研究. 中国寄生虫学与寄生虫病杂志, 2011, 29(3):208-211.
44. 包永星, 毛睿, 谢增如, 等. 放射治疗骨棘球蚴病一例. 中国寄生虫学与寄生虫病杂志, 2010, 28(4):F0003.
45. 王欣, 王小虎, 包根书, 等. 放射线治疗包虫病的实验研究. 中国人兽共患病学报, 2009, 25(7):653-656.
46. schmid M, Pendl G, samonigg H, et al. Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis, 1998, 26(6):1379-1382.
47. Zhang YF, Xie ZR, Ni YQ, et al. Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats. Chin Med J (Engl), 2011, 124(18):2845-2848.
48. Gschwantler M, Brownstone E, Erben WD, et al. Combined endoscopic and pharmaceutical treatment of alveolar echinococcosis with rupture into the biliary tree. Gastrointest Endosc, 1994, 40(2 Pt 1):238-241.
49. Adas G, Arikan s, Gurbuz E, et al. Comparison of endoscopic therapeutic modalities for postoperative biliary fistula of liver hydatid cyst:a retrospective multicentric study. Surg Laparosc Endosc Percutan Tech, 2010, 20(4):223-227.
50. Akbulut s, senol A, sezgin A, et al. Radical vs conservative surgery for hydatid liver cysts:experience from single center. World J Gastroenterol, 2010, 16(8):953-959.
51. Krasniqi A, Bicaj B, Limani D, et al. The role of perioperative endoscopic retrograde cholangiopancreatography and biliary drainage in large liver hydatid cysts. Sci World J, 2014, 2014:301891.
52. 王科燕, 杜新远, 张永军, 等. 中草药治疗棘球蚴病的研究概况. 西北药学杂志, 2009, 24(3):240-242.

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